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PLoS ONE, ISSN 1932-6203, 04/2018, Volume 13, Issue 4, pp. e0191926 - e0191926
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with... 
UNTREATED MELANOMA | CYTOKINE RELEASE ASSAYS | LUNG-CANCER | IN-VITRO | MEDIATED CYTOTOXICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | CTLA-4 | ANTITUMOR ACTIVITIES | NIVOLUMAB PLUS IPILIMUMAB | Antineoplastic Agents, Immunological - toxicity | Epitope Mapping | Adjuvants, Immunologic - pharmacology | Antineoplastic Agents, Immunological - pharmacokinetics | Cricetulus | Cancer Vaccines - pharmacology | Humans | Immunoglobulin G - toxicity | Macaca fascicularis | Antineoplastic Agents, Immunological - chemistry | T-Lymphocytes, Regulatory - immunology | Adjuvants, Immunologic - pharmacokinetics | Neoplasms - therapy | Immunity, Cellular - drug effects | Adjuvants, Immunologic - chemistry | Immunoglobulin G - pharmacology | CHO Cells | Amino Acid Sequence | Immunoglobulin G - chemistry | Cells, Cultured | Models, Molecular | Adjuvants, Immunologic - toxicity | CTLA-4 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Neoplasms - immunology | Antibody Formation - drug effects | CTLA-4 Antigen - antagonists & inhibitors | Toxicology | Pharmacology, Experimental | Research | Immunoglobulin G | Analysis | CD86 antigen | PD-1 protein | Lung cancer | Antibodies | Biochemistry | Lymphocytes T | CD28 antigen | Immunity | CTLA-4 protein | Lymphocytes | Immunotherapy | Combined vaccines | Primates | Repressing | Medical research | Immunoglobulins | Cytokines | Immunoregulation | Immunomodulation | Research & development--R&D | CD80 antigen | Pharmacology | T cell receptors | Chemical compounds | Signaling | Antigen-presenting cells | Biomarkers | Index Medicus | Research & development | R&D
Journal Article
Journal Article
Current Opinion in Toxicology, ISSN 2468-2020, 03/2020
Journal Article
11/2018
The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions... 
METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
04/2019
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
03/2019
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
03/2019
본 개시내용은 TIM-3(예컨대, 인간 TIM-3)에 특이적으로 결합하고 TIM-3 기능에 길항작용하는 항체를 제공한다. 또한, 이러한 항체를 포함하는 약제학적 조성물, 이러한 항체를 암호화하는 핵산, 이러한 항체를 제조하기 위한 발현 벡터 및 숙주 세포, 및 이러한 항체를 사용하여... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
01/2019
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
12/2018
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
12/2017
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
11/2017
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
11/2017
The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical... 
HYGIENE | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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