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1. Full Text Using Genetics To Dissect SARS-CoV-2 Infection
by Brest, Patrick and Mograbi, Baharia and Hofman, Paul and Milano, Gerard
Trends in genetics, ISSN 0168-9525, 11/2020
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2. Full Text Host Polymorphisms May Impact SARS-CoV-2 Infectivity
by Brest, Patrick and Refae, Sadal and Mograbi, Baharia and Hofman, Paul and Milano, Gerard
Trends in genetics, ISSN 0168-9525, 11/2020, Volume 36, Issue 11, pp. 813 - 815
genetic variation | coronavirus | infection | SNP | pharmacogenetics | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Disease Susceptibility | Pandemics | Humans | Coronavirus Infections - genetics | Virus Shedding | Promoter Regions, Genetic - genetics | Virus Internalization | ADAM17 Protein - metabolism | COVID-19 | Angiotensin-Converting Enzyme 2 | Peptidyl-Dipeptidase A - genetics | ADAM17 Protein - genetics | SARS-CoV-2 | Pneumonia, Viral - genetics | Coronavirus Infections - virology | Betacoronavirus - physiology | Peptidyl-Dipeptidase A - metabolism | Serine Endopeptidases - genetics | Polymorphism, Single Nucleotide - genetics | Polymorphism, Genetic - genetics | Serine Endopeptidases - metabolism | Pneumonia, Viral - virology | Index Medicus
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3. Full Text Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry
by Hofman, Paul and Puchois, Pascal and Brest, Patrick and Lahlou, Hicham and Simeon-Dubach, Daniel
Nature medicine, ISSN 1078-8956, 06/2020, Volume 26, Issue 6, pp. 809 - 810
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Betacoronavirus - pathogenicity | Humans | Pandemics - prevention & control | Biological Specimen Banks - trends | Biomedical Research - trends | COVID-19 | Neoplasms - complications | Neoplasms - virology | SARS-CoV-2 | Coronavirus Infections - epidemiology | Coronavirus Infections - virology | Pneumonia, Viral - epidemiology | Pneumonia, Viral - complications | Coronavirus Infections - complications | Pneumonia, Viral - virology | Neoplasms - epidemiology | Epidemics | Biological specimens | Oncology, Experimental | Economic aspects | Forecasts and trends | Management | Research | Collections and collecting | Infection control | Complications and side effects | Control | France | Cancer | Pandemics | Index Medicus
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4. Full Text A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
by Brest, Patrick and Lebrigand, Kevin and Hofman, Paul and Mari, Bernard and Hébuterne, Xavier and Mograbi, Baharia and Vouret-Craviari, Valérie and Barbry, Pascal and Mosnier, Jean-François and Darfeuille-Michaud, Arlette and Harel-Bellan, Annick and Souidi, Mouloud and Lapaquette, Pierre and Cesaro, Annabelle
Nature genetics, ISSN 1061-4036, 03/2011, Volume 43, Issue 3, pp. 242 - 245
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Other diseases. Semiology | Crohn Disease - genetics | Humans | Gene Expression Regulation | HEK293 Cells | MicroRNAs - metabolism | Intestines - metabolism | Polymorphism, Single Nucleotide | Autophagy - genetics | HeLa Cells | Binding Sites | GTP-Binding Proteins - genetics | Crohn's disease | Genetic aspects | Disease susceptibility | Research | Genetic polymorphisms | Haplotypes | Inflammatory bowel disease | Bacteria | E coli | Autophagy | Index Medicus | Intestines | Biochemistry, Molecular Biology | Crohn Disease | Cellular Biology | Life Sciences | Human health and pathology | Microbiology and Parasitology | MicroRNAs | Genetics | GTP-Binding Proteins | Hela Cells
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5. Full Text Author Correction: Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics
by Refae, Sadal and Gal, Jocelyn and Brest, Patrick and Giacchero, Damien and Borchiellini, Delphine and Ebran, Nathalie and Peyrade, Frederic and Guigay, Joël and Milano, Gérard and Saada-Bouzid, Esma
Scientific reports, ISSN 2045-2322, 06/2020, Volume 10, Issue 1, pp. 9857 - 9857
Immune checkpoint | Index Medicus
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6. Full Text Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics
by Refae, Sadal and Gal, Jocelyn and Brest, Patrick and Giacchero, Damien and Borchiellini, Delphine and Ebran, Nathalie and Peyrade, Frederic and Guigay, Joël and Milano, Gérard and Saada-Bouzid, Esma
Scientific reports, ISSN 2045-2322, 02/2020, Volume 10, Issue 1, pp. 3565 - 3565
Cell Proliferation | Humans | Middle Aged | Neoplasms - mortality | Male | Antineoplastic Agents - administration & dosage | Vascular Endothelial Growth Factor Receptor-2 - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Disease Progression | Neoplasms - drug therapy | Vascular Endothelial Growth Factor Receptor-2 - genetics | Immunogenetics | Neoplasms - genetics | Neoplasms - immunology | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Immune Checkpoint Inhibitors - administration & dosage | Immune checkpoint | Immune response | PD-1 protein | Toxicity | Immunotherapy | PD-L1 protein | Single-nucleotide polymorphism | Multivariate analysis | Index Medicus | Life Sciences | Immunology | Cancer
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7. Full Text Etiology of Crohn’s disease: many roads lead to autophagy
by Lapaquette, Pierre and Brest, Patrick and Hofman, Paul and Darfeuille-Michaud, Arlette
Journal of molecular medicine (Berlin, Germany), ISSN 0946-2716, 9/2012, Volume 90, Issue 9, pp. 987 - 996
Human Genetics | Biomedicine | MicroRNA | Internal Medicine | Molecular Medicine | IBD | Host susceptibility | Autophagy | E. coli | Crohn’s disease | Crohn's disease | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | General aspects | Medical sciences | Other diseases. Semiology | Crohn Disease - genetics | Genetic Predisposition to Disease | Humans | Gene Expression Regulation | Gastrointestinal Tract - microbiology | GTP-Binding Proteins - genetics | Gastrointestinal Tract - metabolism | Polymorphism, Genetic | Animals | Crohn Disease - microbiology | MicroRNAs - genetics | Crohn Disease - etiology | Index Medicus | Life Sciences
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8. Full Text Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?
by Brest, Patrick and Benzaquen, Jonathan and Klionsky, Daniel J and Hofman, Paul and Mograbi, Baharia
Autophagy, ISSN 1554-8627, 12/2020, Volume 16, Issue 12, pp. 2267 - 2270
COVID-19 | Anti-viral | infection | hydroxychloroquine | inflammation | microbiology | plaquenil | virophagy | lysophagy | immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | COVID-19 - immunology | Hydroxychloroquine - therapeutic use | Pandemics | History, 21st Century | Humans | Autophagy - physiology | Disease Eradication - methods | Autophagy - drug effects | HIV - drug effects | Chloroquine - analogs & derivatives | Ebolavirus - drug effects | Chloroquine - pharmacology | Signal Transduction - immunology | Plasmodium malariae - drug effects | Anti-Inflammatory Agents - therapeutic use | SARS-CoV-2 - drug effects | SARS-CoV-2 - immunology | COVID-19 - epidemiology | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Antiviral Agents - therapeutic use | Chloroquine - therapeutic use | COVID-19 - drug therapy | Drug-Related Side Effects and Adverse Reactions - epidemiology | SARS-CoV-2 - pathogenicity | Signal Transduction - drug effects | Drug Repositioning - trends | Drug Repositioning - methods | COVID-19 - pathology | Hydroxychloroquine - pharmacology | Malaria - drug therapy | Index Medicus
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9. Full Text Germinal Immunogenetics predict treatment outcome for PD-1/PD-L1 checkpoint inhibitors
by Refae, Sadal and Gal, Jocelyn and Ebran, Nathalie and Otto, Josiane and Borchiellini, Delphine and Peyrade, Frederic and Chamorey, Emmanuel and Brest, Patrick and Milano, Gerard and Saada-Bouzid, Esma
Investigational new drugs, ISSN 0167-6997, 02/2020, Volume 38, Issue 1, pp. 160 - 171
Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Science & Technology | PD-1 protein | Toxicity | Immunoregulation | Genes | Single-nucleotide polymorphism | CXCR3 protein | Nucleotides | Gene expression | Quantitative trait loci | Interleukin 6 | CTLA-4 protein | Immunogenetics | Inhibitors | Immune checkpoint | Precision medicine | Interleukin 6 receptors | PD-L1 protein | Computer applications | Interleukin 1 | Biomarkers | Genetics | Gene mapping | Monocyte chemoattractant protein 1 | Deoxyribonucleic acid--DNA | Index Medicus | Life Sciences | Cancer
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10. Full Text Germinal immunogenetics as a predictive factor for immunotherapy
by Refae, Sadal and Gal, Jocelyn and Brest, Patrick and Milano, Gerard
Critical reviews in oncology/hematology, ISSN 1040-8428, 09/2019, Volume 141, pp. 146 - 152
Check-point inhibitors | Germinal immunogenetics | Predictive factors | Immunotherapy | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Medicine, Experimental | Medical research | Immunogenetics | Single nucleotide polymorphisms | Epidemiology | Index Medicus | Life Sciences | Genetics | Immunology | Cancer
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11. Full Text GC content shapes mRNA storage and decay in human cells
by Courel, Maite and Clement, Yves and Bossevain, Clementine and Foretek, Dominika and Cruchez, Olivia Vidal and Yi, Zhou and Benard, Marianne and Benassy, Marie-Noelle and Kress, Michel and Vindry, Caroline and Ernoult-Lange, Michele and Antoniewski, Christophe and Morillon, Antonin and Brest, Patrick and Hubstenberger, Arnaud and Crollius, Hugues Roest and Standart, Nancy and Weil, Dominique
eLife, ISSN 2050-084X, 12/2019, Volume 8
Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Post-transcription | Translation | Gene expression | Localization | mRNA turnover | mRNA stability | Index Medicus | Life Sciences
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12. Full Text A multifactorial score including autophagy for prognosis and care of COVID-19 patients
by Domdom, Marie-Angela and Brest, Patrick and Grosjean, Iris and Roméo, Barnabé and Landi, Maria Teresa and Gal, Jocelyn and Klionsky, Daniel J and Hofman, Paul and Mograbi, Baharia
Autophagy, ISSN 1554-8627, 12/2020, Volume 16, Issue 12, pp. 2276 - 2281
SARS-CoV-2 | autophagy | susceptibility | Covid-19 | intensive care | screening test | Antiviral | coronavirus | polymorphism | risk | virophagy | polygenic score | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Biomarkers - metabolism | Severity of Illness Index | Infectious bronchitis virus - physiology | Genetic Predisposition to Disease | Molecular Diagnostic Techniques - methods | Prognosis | Humans | Risk Factors | Biomarkers - analysis | Autophagy-Related Proteins - analysis | Autophagy - physiology | SARS-CoV-2 - physiology | COVID-19 - diagnosis | COVID-19 - therapy | Animals | COVID-19 - pathology | Mice | Autophagy - genetics | Transcriptome - physiology | Autophagy-Related Proteins - genetics | Research Design | Middle East Respiratory Syndrome Coronavirus - physiology | COVID-19 - genetics | Index Medicus
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13. Autophagy : Moving benchside promises to patient bedsides
by Belaid, Amine and Ndiaye, Papa Diogop and Filippakis, Harilaos and Roux, Jérémie and Röttinger, Éric and Graba, Yacine and Brest, Patrick and Hofman, Paul and Mograbi, Baharia
Current cancer drug targets, ISSN 1568-0096, 10/2015, Volume 15, Issue 8, pp. 684 - 702
Tumor metabolism | Drug effects | Autophagy addiction | Translational medicine | Tumor resistance | Autophagy targeted therapy | KRAS | Antineoplastic agents | Tumor dormancy | Tumor relapse | BRAF-driven cancers | Tumor metastasis | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasm Recurrence, Local - pathology | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - pathology | Point-of-Care Testing | Humans | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Autophagy | Drug Delivery Systems | Neoplasms - drug therapy
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