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Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6005, pp. 831 - 835
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that... 
Enzymes | Anaerobic bacteria | Toxicity | REPORTS | Colorectal cancer | Diarrhea | Anaerobic conditions | Bacteria | Mice | Monomers | Crystal structure | IRINOTECAN CPT-11 | DIARRHEA | METABOLISM | COLITIS | MULTIDISCIPLINARY SCIENCES | BETA-GLUCURONIDASE | CAMPTOTHECINS | TOPOISOMERASE-I | PHARMACOGENETICS | GUT FLORA | CARCINOMA | Camptothecin - toxicity | Humans | Colon - drug effects | Glucuronidase - metabolism | Crystallography, X-Ray | Diarrhea - prevention & control | Intestinal Mucosa - drug effects | Prodrugs - metabolism | Enzyme Inhibitors - chemistry | Female | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Bacteria, Anaerobic - drug effects | Drug Evaluation, Preclinical | Camptothecin - analogs & derivatives | Camptothecin - metabolism | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Colon - pathology | Glucuronidase - isolation & purification | Enzyme Inhibitors - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Glucuronidase - chemistry | Intestinal Mucosa - microbiology | Escherichia coli Proteins - isolation & purification | Antineoplastic Agents, Phytogenic - toxicity | Animals | Prodrugs - toxicity | Cell Line, Tumor | Protein Conformation | Colon - microbiology | Mice, Inbred BALB C | Glucuronidase - pharmacology | Escherichia coli Proteins - chemistry | Intestinal Mucosa - pathology | Antimitotic agents | Drugs | Prevention | Complications and side effects | Care and treatment | Dosage and administration | Antineoplastic agents | Health aspects | Cancer | Chemotherapy | Side effects | Index Medicus | Microorganisms | Inhibitors | LARGE INTESTINE | BACTERIA | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | TOXICITY | 60 APPLIED LIFE SCIENCES | ENZYMES | ORAL ADMINISTRATION | TARGETS | MICE | SIDE EFFECTS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, p. 304
  The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'-5' nucleolytic resection of oxidative DNA damage and activation of... 
Proteins | Frogs | Chromatin | DNA damage | Mutation | Binding sites
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 3985 - 3985
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 06/2013, Volume 17, Issue 3, pp. 379 - 384
It was appreciated early in drug discovery that the microbiota play an important role in the efficacy of therapeutic compounds. Indeed, the first antibiotic... 
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, p. 304
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, pp. 304 - 304
The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'-5' nucleolytic resection of oxidative DNA damage and activation of... 
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 06/2013, Volume 17, Issue 3, pp. 379 - 384
Journal Article
Biophysical Journal, ISSN 0006-3495, 2007, Volume 92, Issue 3, pp. 959 - 965
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2013, Volume 425, Issue 14, p. 2561
The human nuclear xenobiotic receptor PXR recognizes a range of potentially harmful drugs and endobiotic chemicals but must complex with the nuclear receptor... 
Analysis | Crystals | Physiological aspects | Gene expression | Structure
Journal Article
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 01/2015, Volume 56, Issue 1, pp. 1 - 21
Journal Article