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1. Full Text LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
by Coskun, Tamer and Sloop, Kyle W and Loghin, Corina and Alsina-Fernandez, Jorge and Urva, Shweta and Bokvist, Krister B and Cui, Xuewei and Briere, Daniel A and Cabrera, Over and Roell, William C and Kuchibhotla, Uma and Moyers, Julie S and Benson, Charles T and Gimeno, Ruth E and D'Alessio, David A and Haupt, Axel
Molecular Metabolism, ISSN 2212-8778, 12/2018, Volume 18, pp. 3 - 14
A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to determine whether the metabolic action of GIP adds to the established clinical... 
Obesity | Glucagon-like peptide-1 | LY3298176 | Glucose-dependent insulinotropic polypeptide | Type 2 diabetes mellitus | ANALOG | PHARMACODYNAMICS | LIPOPROTEIN-LIPASE | PHARMACOKINETICS | ENDOCRINOLOGY & METABOLISM | DEPENDENT INSULINOTROPIC POLYPEPTIDE | SECRETION | GASTRIC-INHIBITORY POLYPEPTIDE | INCRETIN | BLOOD-GLUCOSE IMPROVES
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2. Full Text First determination of the CP content of D -> pi(+)pi(-)pi(+)pi(-) and updated determination of the CP contents of D -> pi(+)pi(-)pi(0) and D -> K+K-pi(0)
by Malde, S and Thomas, C and Wilkinson, G and Naik, P and Prouve, C and Rademacker, J and Libby, J and Nayak, M and Gershon, T and Briere, RA
PHYSICS LETTERS B, ISSN 0370-2693, 07/2015, Volume 747, pp. 9 - 17
Quantum-correlated psi(3770) -> D (D) over bar decays collected by the CLEO-c experiment are used to perform a first measurement of F-+(4 pi), the fractional... 
PHASE | Quantum correlations | CP violation | SEARCH | Charm decay | D-0 | ASTRONOMY & ASTROPHYSICS | DETECTOR | PHYSICS, NUCLEAR | DECAYS | VIOLATION | PHYSICS, PARTICLES & FIELDS
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3. Full Text Observation of a Charged Charmoniumlike Structure in e(+)e(-) -> pi(+)pi(-) J/psi at root s=4.26 GeV
by Ablikim, M and Achasov, M. N and Ai, X. C and Albayrak, O and Ambrose, D. J and An, F. F and An, Q and Bai, J. Z and Ferroli, R. Baldini and Ban, Y and Becker, J and Bennett, J. V and Bertani, M and Bian, J. M and Boger, E and Bondarenko, O and Boyko, I and Briere, R. A and Bytev, V and Cai, H and Cai, X and Cakir, O and Calcaterra, A and Cao, G. F and Cetin, S. A and Chang, J. F and Chelkov, G and Chen, G and Chen, H. S and Chen, J.C and Chen, M.L and Chen, S. J and Chen, X and Chen, Y.B and Cheng, H. P and Chu, Y. P and Cronin-Hennessy, D and Dai, H. L and Dai, J.P and Dedovich, D and Deng, Z. Y and Denig, A and Denysenko, I and Destefanis, M and Ding, W. M and Ding, Y and Dong, L. Y and Dong, M. Y and Du, S. X and Fang, J and Fang, S. S and Fava, L and Feng, C. Q and Friedel, P and Fu, C. D and Fu, J. L and Fuks, O and Gao, Q and Gao, Y and Geng, C and Goetzen, K and Gong, W. X and Gradl, W and Greco, M and Gu, M. H and Gu, Y. T and Guan, Y. H and Guo, A.Q and Guo, L. B and Guo, T and Guo, Y. P and Han, Y. L and Harris, F. A and He, K. L and He, M and He, Z. Y and Held, T and Heng, Y. K and Hou, Z. L and Hu, C and Hu, H. M and Hu, J. F and Hu, T and Huang, G. M and Huang, G. S and Huang, J.S and Huang, L and Huang, X.T and Huang, Y and Huang, Y.P and Hussain, T and Ji, C. S and Ji, Q and Ji, Q. P and Ji, X. B and Ji, X. L and Jiang, L.L and Jiang, X. S and Jiao, J. B and Jiao, Z and ... and BESIII Collaboration
Physical Review Letters, ISSN 0031-9007, 06/2013, Volume 110, Issue 25
We study the process e(+)e(-) -> pi(+)pi(-) J/psi at a center-of-mass energy of 4.260 GeV using a 525 pb(-1) data sample collected with the BESIII detector... 
PHYSICS, MULTIDISCIPLINARY
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4. Full Text Expanding the Spectrum of BAF-Related Disorders: De Novo Variants in SMARCC2 Cause a Syndrome with Intellectual Disability and Developmental Delay
by Machol, Keren and Rousseau, Justine and Ehresmann, Sophie and Garcia, Thomas and Nguyen, Thi Tuyet Mai and Spillmann, Rebecca C and Sullivan, Jennifer A and Shashi, Vandana and Jiang, Yong-hui and Stong, Nicholas and Fiala, Elise and Willing, Marcia and Pfundt, Rolph and Kleefstra, Tjitske and Cho, Megan T and McLaughlin, Heather and Rosello Piera, Monica and Orellana, Carmen and Martínez, Francisco and Caro-Llopis, Alfonso and Monfort, Sandra and Roscioli, Tony and Nixon, Cheng Yee and Buckley, Michael F and Turner, Anne and Jones, Angela L and Jones, Wendy D and van Hasselt, Peter M and Hofstede, Floris C and van Gassen, Koen L.I and Brooks, Alice S and van Slegtenhorst, Marjon A and Lachlan, Katherine and Sebastian, Jessica and Madan-Khetarpal, Suneeta and Sonal, Desai and Sakkubai, Naidu and Thevenon, Julien and Faivre, Laurence and Maurel, Alice and Petrovski, Slavé and Krantz, Ian D and Tarpinian, Jennifer M and Rosenfeld, Jill A and Lee, Brendan H and Lee, Hane and Adams, David R and Alejandro, Mercedes E and Allard, Patrick and Azamian, Mahshid S and Bacino, Carlos A and Balasubramanyam, Ashok and Barseghyan, Hayk and Batzli, Gabriel F and Beggs, Alan H and Behnam, Babak and Bican, Anna and Bick, David P and Birch, Camille L and Bonner, Devon and Boone, Braden E and Bostwick, Bret L and Briere, Lauren C and Brown, Donna M and Brush, Matthew and Burke, Elizabeth A and Burrage, Lindsay C and Chen, Shan and Clark, Gary D and Coakley, Terra R and Cogan, Joy D and Cooper, Cynthia M and Cope, Heidi and Craigen, William J and D’Souza, Precilla and Davids, Mariska and Dayal, Jyoti G and Dell’Angelica, Esteban C and Dhar, Shweta U and Dillon, Ani and Dipple, Katrina M and Donnell-Fink, Laurel A and Dorrani, Naghmeh and Dorset, Daniel C and Douine, Emilie D and Draper, David D and Eckstein, David J and Emrick, Lisa T and Eng, Christine M and Eskin, Ascia and Esteves, Cecilia and Estwick, Tyra and Ferreira, Carlos and Fogel, Brent L and Friedman, Noah D and Gahl, William A and Glanton, Emily and Godfrey, Rena A and Goldstein, David B and Gould, Sarah E and ... and Undiagnosed Dis Network and Undiagnosed Diseases Network
The American Journal of Human Genetics, ISSN 0002-9297, 01/2019, Volume 104, Issue 1, pp. 164 - 178
SMARCC2 (BAF170) is one of the invariable core subunits of the ATP-dependent chromatin remodeling BAF (BRG1-associated factor) complex and plays a crucial role... 
neurodevelopmental disorder | transcriptome | genotype-phenotype correlation | Bafopathy | speech delay | developmental delay | dysmorphisms | intellectual disability | NEURAL DEVELOPMENT | REGULATOR | SWI/SNF COMPLEX | COFFIN-SIRIS SYNDROME | GENETICS & HEREDITY | MSWI/SNF COMPLEXES | GATED CALCIUM-CHANNELS | GENOTYPE-PHENOTYPE | MISSENSE MUTATIONS | NEURODEVELOPMENTAL DISORDER | GENE-TRANSCRIPTION | Child development deviations | Genetic aspects | Disease susceptibility | Research | Mental retardation | Risk factors | Developmental disabilities | Report
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5. Full Text A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative
by Shashi, Vandana and Schoch, Kelly and Spillmann, Rebecca and Cope, Heidi and Tan, Queenie K.-G and Walley, Nicole and Pena, Loren and McConkie-Rosell, Allyn and Jiang, Yong-Hui and Stong, Nicholas and Need, Anna C and Goldstein, David B and Adams, David R and Alejandro, Mercedes E and Allard, Patrick and Ashley, Euan A and Azamian, Mahshid S and Bacino, Carlos A and Balasubramanyam, Ashok and Barseghyan, Hayk and Batzli, Gabriel F and Beggs, Alan H and Behnam, Babak and Bellen, Hugo J and Bernstein, Jonathan A and Bican, Anna and Bick, David P and Birch, Camille L and Bonner, Devon and Boone, Braden E and Bostwick, Bret L and Briere, Lauren C and Brown, Donna M and Brush, Matthew and Burke, Elizabeth A and Burrage, Lindsay C and Butte, Manish J and Chen, Shan and Clark, Gary D and Coakley, Terra R and Cogan, Joy D and Cooper, Cynthia M and Cope, Heidi and Craigen, William J and D’Souza, Precilla and Davids, Mariska and Davidson, Jean M and Dayal, Jyoti G and Dell’Angelica, Esteban C and Dhar, Shweta U and Dipple, Katrina M and Donnell-Fink, Laurel A and Dorrani, Naghmeh and Dorset, Daniel C and Douine, Emilie D and Draper, David D and Dries, Annika M and Eckstein, David J and Emrick, Lisa T and Eng, Christine M and Enns, Gregory M and Eskin, Ascia and Esteves, Cecilia and Estwick, Tyra and Fernandez, Liliana and Ferreira, Carlos and Fisher, Paul G and Fogel, Brent L and Friedman, Noah D and Gahl, William A and Glanton, Emily and Godfrey, Rena A and Goldstein, David B and Gould, Sarah E and Gourdine, Jean-Philippe F and Groden, Catherine A and Gropman, Andrea L and Haendel, Melissa and Hamid, Rizwan and Hanchard, Neil A and Handley, Lori H and Herzog, Matthew R and Holm, Ingrid A and Hom, Jason and Howerton, Ellen M and Huang, Yong and Jacob, Howard J and Jain, Mahim and Jiang, Yong-hui and Johnston, Jean M and Jones, Angela L and Koeller, David M and Kohane, Isaac S and Kohler, Jennefer N and Krasnewich, Donna M and Krieg, Elizabeth L and Krier, Joel B and Kyle, Jennifer E and Lalani, Seema R and Lau, C. Christopher and ... and Undiagnosed Dis Network and Undiagnosed Diseases Network
Genetics in Medicine, ISSN 1098-3600, 01/2019, Volume 21, Issue 1, pp. 161 - 172
Purpose: Sixty to seventy-five percent of individuals with rare and undiagnosed phenotypes remain undiagnosed after exome sequencing (ES). With standard ES... 
Rare diseases | Genome sequencing | Undiagnosed diseases | Exome sequencing | Phenotyping | REANALYSIS | VARIANTS | GENETICS & HEREDITY | MEDICAL GENETICS | WHOLE GENOME | whole genome sequencing | rare diseases | undiagnosed diseases | Whole exome sequencing | phenotyping
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6. Full Text Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate–binding region
by Kelly, McKenna and Park, Meredith and Mihalek, Ivana and Rochtus, Anne and Gramm, Marie and Pérez‐Palma, Eduardo and Axeen, Erika Takle and Hung, Christina Y and Olson, Heather and Swanson, Lindsay and Anselm, Irina and Briere, Lauren C and High, Frances A and Sweetser, David A and Kayani, Saima and Snyder, Molly and Calvert, Sophie and Scheffer, Ingrid E and Yang, Edward and Waugh, Jeff L and Lal, Dennis and Bodamer, Olaf and Poduri, Annapurna and Adams, David R and Aday, Aaron and Alejandro, Mercedes E and Allard, Patrick and Ashley, Euan A and Azamian, Mahshid S and Bacino, Carlos A and Baker, Eva and Balasubramanyam, Ashok and Barseghyan, Hayk and Batzli, Gabriel F and Beggs, Alan H and Behnam, Babak and Bellen, Hugo J and Bernstein, Jonathan A and Bican, Anna and Bick, David P and Birch, Camille L and Bonner, Devon and Boone, Braden E and Bostwick, Bret L and Brokamp, Elly and Brown, Donna M and Brush, Matthew and Burke, Elizabeth A and Burrage, Lindsay C and Butte, Manish J and Chen, Shan and Clark, Gary D and Coakley, Terra R and Cogan, Joy D and Colley, Heather A and Cooper, Cynthia M and Cope, Heidi and Craigen, William J and D’Souza, Precilla and Davids, Mariska and Davidson, Jean M and Dayal, Jyoti G and Dell’Angelica, Esteban C and Dhar, Shweta U and Dipple, Katrina M and Donnell‐Fink, Laurel A and Dorrani, Naghmeh and Dorset, Daniel C and Douine, Emilie D and Draper, David D and Dries, Annika M and Eckstein, David J and Emrick, Lisa T and Eng, Christine M and Enns, Gregory M and Eskin, Ascia and Esteves, Cecilia and Estwick, Tyra and Fairbrother, Laura and Fernandez, Liliana and Ferreira, Carlos and Fieg, Elizabeth L and Fisher, Paul G and Fogel, Brent L and Friedman, Noah D and Gahl, William A and Glanton, Emily and Godfrey, Rena A and Goldman, Alica M and Goldstein, David B and Gould, Sarah E and Gourdine, Jean‐Philippe F and Groden, Catherine A and Gropman, Andrea L and Haendel, Melissa and Hamid, Rizwan and Hanchard, Neil A and High, Francis and Holm, Ingrid A and Hom, Jason and ... and Undiagnosed Dis Network and Undiagnosed Diseases Network
Epilepsia, ISSN 0013-9580, 03/2019, Volume 60, Issue 3, pp. 406 - 418
Objective To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype-protein structure-phenotype relationships. Methods We... 
GNAO1 | developmental and epileptic encephalopathy | movement disorders | mosaicism | DE-NOVO MUTATIONS | MOVEMENT-DISORDER | PHENOTYPE | MODEL | VARIANT | EPILEPTIC ENCEPHALOPATHY | G-ALPHA(O) | CLINICAL NEUROLOGY | Medicine, Experimental | Medical research | Amino acids | Seizures (Medicine) | Analysis | Epilepsy | GTP | Phenotypes | Guanosine | Chorea | Neurodevelopmental disorders | Pathogenicity | Proteins | Convulsions & seizures | Encephalopathy | Ataxia | Mosaicism | Dystonia | Protein structure | Movement disorders | Genotypes | Seizures | Dyskinesia
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7. Full Text Observation of a Charged Charmoniumlike Structure Z(c) (4020) and Search for the Z(c) (3900) in e(+)e(-) -> pi(+) pi(-)h(c)
by Ablikim, M and Achasov, M. N and Albayrak, O and Ambrose, D. J and An, F. F and An, Q and Bai, J. Z and Ferroli, R. Baldini and Ban, Y and Becker, J and Bennett, J. V and Bertani, M and Bian, J. M and Boger, E and Bondarenko, O and Boyko, I and Braun, S and Briere, R. A and Bytev, V and Cai, H and Cai, X and Cakir, O and Calcaterra, A and Cao, G. F and Cetin, S. A and Chang, J. F and Chelkov, G and Chen, G and Chen, H. S and Chen, J. C and Chen, S. J and Chen, X. R and Chen, Y. B and Cheng, H. P and Chu, X. K and Chu, Y. P and Cronin-Hennessy, D and Dai, H. L and Dedovich, D and Deng, Z. Y and Denig, A and Denysenko, I and Destefanis, M and Ding, W. M and Ding, Y and Dong, L. Y and Dong, M. Y and Du, S. X and Fang, J and Fang, S. S and Fava, L and Feng, C. Q and Friedel, P and Fu, C. D and Fu, J. L and Fuks, O and Geng, C and Goetzen, K and Gong, W. X and Gradl, W and Greco, M and Gu, M. H and Gu, Y. T and Guan, Y. H and Guo, A. Q and Guo, L. B and Guo, T and Guo, Y. P and Han, Y. L and Harris, F. A and He, K. L and He, M and He, Z. Y and Held, T and Heng, Y. K and Hou, Z. L and Hu, C and Hu, H. M and Hu, J. F and Hu, T and Huang, G. M and Huang, G. S and Huang, J. S and Huang, L and Huang, X. T and Huang, Y and Hussain, T and Ji, C. S and Ji, Q and Ji, Q. P and Ji, X. B and Ji, X. L and Jiang, L. L and Jiang, X. S and Jiao, J. B and Jiao, Z and Jin, D. P and Jin, S and Jing, F. F and Kalantar-Nayestanaki, N and ... and BESIII Collaboration
Physical Review Letters, ISSN 0031-9007, 12/2013, Volume 111, Issue 24
We study e(+)e(-) -> pi(+) pi(-)h(c) at center-of-mass energies from 3.90 to 4.42 GeV by using data samples collected with the BESIII detector operating at the... 
PHYSICS, MULTIDISCIPLINARY
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8. Full Text Heterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis
by Shashi, Vandana and Geist, Janelle and Lee, Youngha and Yoo, Yongjin and Shin, Unbeom and Schoch, Kelly and Sullivan, Jennifer and Stong, Nicholas and Smith, Edward and Jasien, Joan and Kranz, Peter and Lee, Yoonsung and Shin, Yong Beom and Wright, Nathan T and Choi, Murim and Kontrogianni‐Konstantopoulos, Aikaterini and Acosta, Maria T and Adams, David R and Aday, Aaron and Alejandro, Mercedes E and Allard, Patrick and Ashley, Euan A and Azamian, Mahshid S and Bacino, Carlos A and Bademci, Guney and Baker, Eva and Balasubramanyam, Ashok and Baldridge, Dustin and Barbouth, Deborah and Batzli, Gabriel F and Beggs, Alan H and Bellen, Hugo J and Bernstein, Jonathan A and Berry, Gerard T and Bican, Anna and Bick, David P and Birch, Camille L and Bivona, Stephanie and Bonnenmann, Carsten and Bonner, Devon and Boone, Braden E and Bostwick, Bret L and Briere, Lauren C and Brokamp, Elly and Brown, Donna M and Brush, Matthew and Burke, Elizabeth A and Burrage, Lindsay C and Butte, Manish J and Carrasquillo, Olveen and Chang, Ta Chen Peter and Chao, Hsiao‐Tuan and Clark, Gary D and Coakley, Terra R and Cobban, Laurel A and Cogan, Joy D and Cole, F. Sessions and Colley, Heather A and Cooper, Cynthia M and Cope, Heidi and Craigen, William J and D'Souza, Precilla and Dasari, Surendra and Davids, Mariska and Davidson, Jean M and Dayal, Jyoti G and Dell'Angelica, Esteban C and Dhar, Shweta U and Dorrani, Naghmeh and Dorset, Daniel C and Douine, Emilie D and Draper, David D and Dries, Annika M and Duncan, Laura and Eckstein, David J and Emrick, Lisa T and Eng, Christine M and Enns, Gregory M and Esteves, Cecilia and Estwick, Tyra and Fernandez, Liliana and Ferreira, Carlos and Fieg, Elizabeth L and Fisher, Paul G and Fogel, Brent L and Forghani, Irman and Friedman, Noah D and Gahl, William A and Godfrey, Rena A and Goldman, Alica M and Goldstein, David B and Gourdine, Jean‐Philippe F and Grajewski, Alana and Groden, Catherine A and Gropman, Andrea L and Haendel, Melissa and Hamid, Rizwan and Hanchard, Neil A and High, Frances and Holm, Ingrid A and ... and Undiagnosed Dis Network and Undiagnosed Diseases Network
Human Mutation, ISSN 1059-7794, 08/2019, Volume 40, Issue 8, pp. 1115 - 1126
Encoding the slow skeletal muscle isoform of myosin binding protein‐C, MYBPC1 is associated with autosomal dominant and recessive forms of arthrogryposis. The... 
arthrogryposis | tremor | MYBPC1 | myosin binding protein‐C | myopathy | hypotonia | BINDING-PROTEIN-C | DIFFERENTIAL EXPRESSION | myosin binding protein-C | GENETICS | SLOW | GENETICS & HEREDITY | MUTATIONS | Wildlife conservation | Analysis | Myosin | Muscles | Genetic aspects | Muscle proteins | Protein binding
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9. Full Text Physics Accomplishments and Future Prospects of the BES Experiments at the Beijing Electron--Positron Collider
by Briere, Roy A and Harris, Frederick A and Mitchell, Ryan E
Annual Review of Nuclear and Particle Science, ISSN 0163-8998, 10/2016, Volume 66, Issue 1, pp. 143 - 170
The cornerstone of the Chinese experimental particle physics program is a series of experiments performed in the τ-charm energy region. China began building e... 
XYZ | BES | tau | charm | charmonium | Tau | Charmonium | Charm | RADIATIVE DECAY | ENERGY | HADRONIC CONTRIBUTION | TAU MASS | J/PSI | PHYSICS, NUCLEAR | E(+)E(-) ANNIHILATION | E+E-ANNIHILATION | BRANCHING FRACTIONS | RESONANCE | TOTAL CROSS-SECTION | PHYSICS, PARTICLES & FIELDS | Collisions (Nuclear physics) | Research
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