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PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0159983 - e0159983
Purpose To investigate the pro-inflammatory intracellular mechanisms induced by an in vitro model of dry eye disease (DED) on a Hela-modified... 
KERATOCONJUNCTIVITIS SICCA | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | CORNEAL EPITHELIAL-CELLS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GENE-EXPRESSION | DRY EYE DISEASE | NF-KAPPA-B | BENZALKONIUM CHLORIDE | NERVE GROWTH-FACTOR | INFLAMMATORY MARKERS | Cell Line | Transcription Factors - physiology | Cyclosporine - pharmacology | Humans | Chemokine CCL2 - genetics | Protein Transport - drug effects | Down-Regulation - drug effects | Down-Regulation - genetics | Protein Transport - genetics | Conjunctiva - metabolism | Gene Expression Regulation - drug effects | Dexamethasone - pharmacology | Conjunctiva - drug effects | Chemokine CCL2 - metabolism | HeLa Cells | Osmotic Pressure - physiology | Conjunctiva - cytology | Enzymes | Dexamethasone | Analysis | Central nervous system depressants | Eye diseases | Cyclosporine | T cells | Gene expression | Mitogens | Protein kinases | Enzyme-linked immunosorbent assay | Steroids | Cornea | Transcription factors | Cyclosporins | Kinases | Experiments | Proteins | Inhibition | Growth factors | Translocation | Cytokines | Secretion | Aquaporins | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Pharmacology | Inflammation | Actors | siRNA | Conjunctiva | Sodium chloride | Chemical compounds | Pathology | Inhibitors | Doxycycline | Intracellular | Osmotic pressure | Viability | Monocyte chemoattractant protein 1 | Apoptosis | Index Medicus | Life Sciences | Human health and pathology | Sensory Organs | Pharmaceutical sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e50180 - e50180
We investigated in a rabbit model, the eye distribution of topically instilled benzalkonium (BAK) chloride a commonly used preservative in eye drops using mass... 
TRIAL | LECTURE | PROTEIN | DRUG-DELIVERY | MULTIDISCIPLINARY SCIENCES | TISSUE | OCULAR HYPERTENSION | TOXICITY | EXPRESSION | Retina - drug effects | Eye - pathology | Rabbits | Vimentin - biosynthesis | Benzalkonium Compounds - adverse effects | Anti-Infective Agents, Local - adverse effects | Leukocyte Common Antigens - biosynthesis | Ophthalmic Solutions - adverse effects | Glaucoma - drug therapy | Ions | Inflammation | Immunohistochemistry - methods | Neuroglia - cytology | Animals | Time Factors | Eye - drug effects | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Glaucoma - metabolism | Safety | Optic Nerve - drug effects | Mass Spectrometry - methods | Glaucoma | Surface active agents | Ophthalmic drugs | Spectrum analysis | Research | Information management | Ophthalmology | Intermediate filament proteins | Vimentin | Steel plates | Benzalkonium chloride | Retina | Lipids | Activation | Tissues | CD45 antigen | Eye | Cell activation | Sample preparation | Lasers | Chlorides | Toxicity testing | Eye (anatomy) | Spectroscopy | Data analysis | Optic nerve | Mass spectroscopy | Data processing | Desorption | Tragacanth | Steel | Mass spectrometers | Ionization | Spectrometers | Stainless steel | Sampling methods | Scientific imaging | Infiltration | Mass spectrometry | Apoptosis | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Journal Article
Acta Ophthalmologica, ISSN 1755-375X, 11/2011, Volume 89, Issue 7, pp. e591 - e597
Journal Article
Journal Article
Journal Article
Molecular Vision, ISSN 1090-0535, 04/2012, Volume 18, Issue 90-91, pp. 851 - 863
Purpose: Benzalkonium chloride (BAK), the most commonly used preservative in eye drops, is known to induce ocular irritation symptoms and dry eye in long-term... 
OCULAR SURFACE | APOPTOSIS-INDUCING FACTOR | CHANG CONJUNCTIVAL | KERATOCONJUNCTIVITIS SICCA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESERVATIVE-FREE TAFLUPROST | SJOGRENS-SYNDROME | GLAUCOMA PATIENTS | OPHTHALMOLOGY | FLOW-CYTOMETRIC ANALYSIS | DRY EYE MODEL | INFLAMMATORY MARKERS | Cell Line | Cell Survival - drug effects | Chromatin - metabolism | Preservatives, Pharmaceutical - adverse effects | Oxidative Stress | Apoptosis - drug effects | Microscopy, Phase-Contrast | Benzalkonium Compounds - adverse effects | Epithelial Cells - drug effects | Humans | Ophthalmic Solutions - adverse effects | Cytochromes c - analysis | Mitochondria - drug effects | Xerophthalmia - drug therapy | Conjunctiva - pathology | Osmolar Concentration | Conjunctiva - drug effects | Apoptosis Inducing Factor - analysis | Cell Membrane Permeability - drug effects | Caspase 3 - analysis | Epithelial Cells - cytology | Sodium Chloride - chemistry | Xerophthalmia - pathology | Index Medicus | Oxidative stress | Chromatin | Epithelial cells | Mitochondrial permeability transition pore | Apoptosis-inducing factor | Membrane permeability | Benzalkonium chloride | Cytotoxicity | Cell membranes | BAK protein | Caspase-3 | Condensation | imaging | Atrophy | Cytochrome c | Eye | Osmotic pressure | Tears | Apoptosis | Life Sciences | Human health and pathology | Sensory Organs | Pharmaceutical sciences
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 5/2013, Volume 405, Issue 12, pp. 4039 - 4049
Journal Article