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1. Full Text Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
by Hughes, Richard AC, MD and Donofrio, Peter, MD and Bril, Vera, MD and Dalakas, Marinos C, MD and Deng, Chunqin, PhD and Hanna, Kim, MSc and Hartung, Hans-Peter, MD and Latov, Norman, MD and Merkies, Ingemar SJ, MD and van Doorn, Pieter A, MD and ICE Study Grp and ICE Study Group
Lancet Neurology, The, ISSN 1474-4422, 2008, Volume 7, Issue 2, pp. 136 - 144
Summary Background Short-term studies suggest that intravenous immunoglobulin might reduce disability caused by chronic inflammatory demyelinating... 
Neurology | CRITERIA | DIAGNOSIS | IMMUNOGLOBULIN TREATMENT | DOUBLE-BLIND | STRENGTH | MEDIATED POLYNEUROPATHIES | CIDP | CLINICAL NEUROLOGY | Disability Evaluation | Recurrence | Double-Blind Method | Immunoglobulins, Intravenous - isolation & purification | Humans | Middle Aged | Male | Treatment Outcome | Chromatography | Cross-Over Studies | Immunoglobulins, Intravenous - therapeutic use | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - therapy | Adolescent | Endpoint Determination | Aged, 80 and over | Adult | Female | Aged | Research Design | Caprylates | Index Medicus
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2. Full Text Fatigue is a relevant outcome in patients with myasthenia gravis
by Tran, Christopher and Bril, Vera and Katzberg, Hans D and Barnett, Carolina
Muscle & Nerve, ISSN 0148-639X, 08/2018, Volume 58, Issue 2, pp. 197 - 203
Introduction : Patients with myasthenia gravis often experience fatigue, but its effect on quality of life (QoL) is underestimated, and fatigue is rarely... 
myasthenia gravis | fatigue | quality of life | disease severity | responsiveness | CLINICAL-RESEARCH | NEUROSCIENCES | CLINICAL NEUROLOGY | Myasthenia Gravis - complications | Myasthenia Gravis - psychology | Humans | Middle Aged | Myasthenia Gravis - therapy | Anxiety - psychology | Eye Diseases - etiology | Fatigue - etiology | Fatigue - psychology | Male | Treatment Outcome | Sex Characteristics | Disease Progression | Depression - etiology | Neurotransmitter Agents - therapeutic use | Depression - psychology | Quality of Life | Adult | Female | Surveys and Questionnaires | Aged | Anxiety - etiology | Medical research | Care and treatment | Myasthenia gravis | Patient outcomes | Analysis | Medicine, Experimental | Fatigue | Immunomodulation | Clinical trials | Muscles | Mental depression | Patients | Quality of life | Muscular fatigue | Demographic variables | Demographics | Neuromuscular junctions | Remission | Myasthenia | Anxiety | Females | Index Medicus
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3. Full Text Does the prevailing hypothesis that small-fiber dysfunction precedes large-fiber dysfunction apply to type 1 diabetic patients?
by Breiner, Ari and Lovblom, Leif Erik and Perkins, Bruce A and Bril, Vera
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 5, pp. 1418 - 1424
OBJECTIVEThe prevailing hypothesis that early subclinical small-fiber injury precedes large-fiber damage in diabetic sensorimotor polyneuropathy (DSP) is based... 
SENSORIMOTOR POLYNEUROPATHY | DENSITY | DIAGNOSIS | NERVES | ENDOCRINOLOGY & METABOLISM | PERIPHERAL NEUROPATHY | CORNEAL CONFOCAL MICROSCOPY | Heart Rate | Diabetes Mellitus, Type 1 - physiopathology | Humans | Middle Aged | Male | Diabetes Mellitus, Type 1 - complications | Young Adult | Microscopy, Confocal | Nerve Fibers - physiology | Adult | Cornea - innervation | Female | Prediabetic State | Diabetic Neuropathies - physiopathology | Diabetics | Type 1 diabetes | Care and treatment | Heart rate | Clinical trials | Diabetes | Sensory perception | Index Medicus
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4. Full Text Baseline Decrement in Patients with Mild Myasthenia Gravis Predicts Immunomodulation Treatment
by Abraham, Alon and Lovblom, Leif E and Bril, Vera
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, ISSN 0317-1671, 07/2019, pp. 1 - 12
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5. Full Text Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: A concurrent validity study
by Ahmed, Ausma and Bril, Vera and Orszag, Andrej and Paulson, Jenna and Yeung, Emily and Ngo, Mylan and Orlov, Steven and Perkins, Bruce A
Diabetes Care, ISSN 0149-5992, 04/2012, Volume 35, Issue 4, pp. 821 - 828
OBJECTIVE-We aimed to determine the corneal confocal microscopy (CCM) parameter that best identifies diabetic sensorimotor polyneuropathy (DSP) in type 1... 
SMALL FIBER DAMAGE | SURROGATE | PHYSICAL-MEDICINE | EPITHELIUM | ELECTRODIAGNOSTIC-MEDICINE | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | PERIPHERAL NEUROPATHY | DISTAL SYMMETRIC POLYNEUROPATHY | AMERICAN-ASSOCIATION | MORPHOLOGY | Cornea - ultrastructure | Optic Nerve - pathology | Cross-Sectional Studies | Diabetic Neuropathies - etiology | Humans | Middle Aged | Oculomotor Nerve Diseases - etiology | Organ Size | Male | Oculomotor Nerve Diseases - diagnosis | Diabetes Mellitus, Type 1 - complications | Optic Nerve - ultrastructure | Microscopy, Confocal - methods | Young Adult | Diabetes Mellitus, Type 1 - diagnosis | Photic Stimulation - methods | Adult | Diabetic Neuropathies - diagnosis | Female | Cornea - pathology | Diagnostic Techniques, Ophthalmological | Complications and side effects | Usage | Type 1 diabetes | Confocal microscopy | Diagnosis | Research | Neuropathies, Hereditary motor and sensory | Risk factors | Studies | Diabetic neuropathy | Accuracy | Clinical medicine | Manuscripts | Index Medicus | Original Research
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6. Full Text Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy
by Katzberg, Hans D and Rasutis, Vilija and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 11/2016, Volume 54, Issue 5, pp. 856 - 863
Introduction : Subcutaneous immunoglobulin (SCIg) has been used for treatment of immune neuropathies. Methods : We evaluated the safety and efficacy of 1.53:1... 
SCIg | multifocal motor neuropathy | immunoglobulin | subcutaneous immunoglobulin | MMN | IGG | INFLAMMATORY DEMYELINATING POLYNEUROPATHY | DISABILITY SCALE | CIDP | NEUROSCIENCES | CLINICAL NEUROLOGY | THERAPY | DISEASES | MUSCLE STRENGTH | INTRAVENOUS IMMUNOGLOBULIN | PRIMARY IMMUNODEFICIENCY | HOME | Severity of Illness Index | Infusions, Subcutaneous - methods | Muscle Strength Dynamometer | Outcome Assessment (Health Care) | Humans | Middle Aged | Immunologic Factors - administration & dosage | Male | Immunoglobulins - administration & dosage | Aged, 80 and over | Adult | Female | Motor Neuron Disease - drug therapy | Aged | Immunoglobulins | Index Medicus
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7. Full Text Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy
: SCIg for Treatment of MMN
by Katzberg, Hans D and Rasutis, Vilija and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 11/2016, Volume 54, Issue 5, pp. 856 - 863
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8. Full Text Incat disability score: A critical analysis of its measurement properties
by Breiner, Ari and Barnett, Carolina and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 08/2014, Volume 50, Issue 2, pp. 164 - 169
Background : The INCAT (Inflammatory Neuropathy Cause and Treatment) disability score is a measure of activity limitation. It is used frequently as a primary... 
chronic inflammatory demyelinating polyneuropathy | reliability | interpretability | validity | CIDP | peripheral neuropathy | measurement | responsiveness | Measurement | Responsiveness | Validity | Interpretability | Peripheral neuropathy | Reliability | Chronic inflammatory demyelinating polyneuropathy | SYSTEM | QUALITY | FATIGUE | IMMUNE-MEDIATED NEUROPATHIES | CLINICAL-FEATURES | INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY | PREDNISOLONE | NEUROSCIENCES | CLINICAL NEUROLOGY | INTRAVENOUS IMMUNOGLOBULIN | SCALE | Disability Evaluation | Severity of Illness Index | Reproducibility of Results | Humans | Autoimmune Diseases of the Nervous System - therapy | Disabled Persons | Autoimmune Diseases of the Nervous System - complications | Autoimmune Diseases of the Nervous System - diagnosis | Multiple sclerosis | Analysis | Index Medicus
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9. Full Text Normative values for corneal nerve morphology assessed using corneal confocal microscopy: A multinational normative data set
by Tavakoli, Mitra and Ferdousi, Maryam and Petropoulos, Ioannis N and Morris, Julie and Pritchard, Nicola and Zhivov, Andrey and Ziegler, Dan and Pacaud, Danièle and Romanchuk, Kenneth and Perkins, Bruce A and Lovblom, Leif E and Bril, Vera and Robinson Singleton, J and Smith, Gordon and Boulton, Andrew J.M and Efron, Nathan and Malik, Rayaz A
Diabetes Care, ISSN 0149-5992, 05/2015, Volume 38, Issue 5, pp. 838 - 843
Corneal confocal microscopy is a novel diagnostic technique for the detection of nerve damage and repair in a range of peripheral neuropathies, in particular... 
Nerve Fibers - pathology | Age Factors | Humans | Middle Aged | Linear Models | Male | Reference Values | Healthy Volunteers | Microscopy, Confocal - methods | Case-Control Studies | Young Adult | Adolescent | Diabetic Neuropathies - pathology | Sex Factors | Aged, 80 and over | Adult | Cornea - innervation | Female | Aged | Wound Healing - physiology | Child | Diabetic Neuropathies - physiopathology | Nerves, Peripheral | Complications and side effects | Usage | Diabetic neuropathies | Care and treatment | Confocal microscopy | Research | Diabetic neuropathy | Cornea | Clinical medicine | Microscopy | Morphology | Index Medicus | Pathophysiology | Complications
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10. Full Text Peripheral nerve high‐resolution ultrasound in diabetes
by Breiner, Ari and Qrimli, Mohammad and Ebadi, Hamid and Alabdali, Majed and Lovblom, Leif E and Abraham, Alon and Albulahi, Hana and Perkins, Bruce A and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 02/2017, Volume 55, Issue 2, pp. 171 - 178
IntroductionHigh-resolution ultrasound (HRU) is used in the diagnosis of peripheral neuropathies. There are conflicting data regarding HRU findings in patients... 
neuropathy | diabetic neuropathy | peripheral nerve | diabetes | ultrasound | DEFINITION | POLYNEUROPATHY | PROGNOSIS | SIZE | TIME | NEUROSCIENCES | CLINICAL NEUROLOGY | PATTERN | Diabetes Mellitus - pathology | Humans | Middle Aged | Male | Peripheral Nerves - physiopathology | Young Adult | Diabetes Mellitus - diagnostic imaging | Peripheral Nerves - diagnostic imaging | Statistics, Nonparametric | Ultrasonography | Diabetic Neuropathies - diagnostic imaging | Adult | Female | ROC Curve | Aged | Cohort Studies | Evaluation | Diabetics | Usage | Diabetic neuropathies | Digital signal processors | Ultrasonic imaging | Diabetes | Index Medicus
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11. Full Text Structure-function relationship between corneal nerves and conventional small-fiber tests in type 1 diabetes
by Sivaskandarajah, Gavasker A and Halpern, Elise M and Lovblom, Leif E and Weisman, Alanna and Orlov, Steven and Bril, Vera and Perkins, Bruce A
Diabetes Care, ISSN 0149-5992, 09/2013, Volume 36, Issue 9, pp. 2748 - 2755
OBJECTIVE In vivo corneal confocal microscopy (IVCCM) has been proposed as a noninvasive technique to assess small nerve fiber structural morphology. We... 
SENSORIMOTOR POLYNEUROPATHY | COOLING DETECTION THRESHOLDS | CONFOCAL MICROSCOPY | PHYSICAL-MEDICINE | NEUROPATHY | ELECTRODIAGNOSTIC-MEDICINE | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | DISTAL SYMMETRIC POLYNEUROPATHY | AMERICAN-ASSOCIATION | SEVERITY | Young Adult | Microscopy, Confocal | Humans | Middle Aged | Diabetes Mellitus, Type 1 - pathology | Diabetic Neuropathies - pathology | Adult | Cornea - innervation | Female | Male | Aged | Cornea - pathology | Physiological aspects | Complications and side effects | Care and treatment | Optic nerve | Polyneuropathies | Type 1 diabetes | Heart rate | Cornea | Diabetes | Regression analysis | Morphology | Index Medicus | Original Research
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12. Full Text Reference values for ultrasonograpy of peripheral nerves
by Qrimli, Mohammad and Ebadi, Hamid and Breiner, Ari and Siddiqui, Hafsah and Alabdali, Majed and Abraham, Alon and Lovblom, Leif E and Perkins, Bruce A and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 04/2016, Volume 53, Issue 4, pp. 538 - 544
Introduction: High‐resolution ultrasonography (HRU) is a novel method that provides morphological information about peripheral nerves. We aimed to determine... 
neuropathy | reference values | cross‐sectional area | peripheral nerve | ultrasound | Peripheral nerve | Neuropathy | Cross-sectional area | Ultrasound | Reference values | cross-sectional area | POLYNEUROPATHY | MANAGEMENT | SONOGRAPHY | DISORDERS | RELIABILITY | NEUROSCIENCES | CLINICAL NEUROLOGY | Ultrasonography, Interventional - methods | Humans | Middle Aged | Male | Neural Conduction - physiology | Reference Values | Ultrasonography, Interventional - standards | Young Adult | Peripheral Nerves - physiology | Adolescent | Peripheral Nerves - diagnostic imaging | Aged, 80 and over | Adult | Female | Aged | Ultrasound imaging | Nervous system | Gender | Index Medicus
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13. Full Text Cost‐minimization analysis comparing intravenous immunoglobulin with plasma exchange in the management of patients with myasthenia gravis
by Furlan, Julio C and Barth, David and Barnett, Carolina and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 06/2016, Volume 53, Issue 6, pp. 872 - 876
Introduction: Myasthenia gravis (MG) exacerbations may be treated with intravenous immunoglobulin (IVIg) or plasma exchange (PLEX), which have equivalent... 
myasthenia gravis | cost‐minimization analysis | neuromuscular junction disease | plasma exchange | intravenous immunoglobulin | Intravenous immunoglobulin | Plasma exchange | Myasthenia gravis | Neuromuscular junction disease | Cost-minimization analysis | cost-minimization analysis | HEALTH-CARE | NEUROSCIENCES | CLINICAL NEUROLOGY | Costs and Cost Analysis | Immunoglobulins, Intravenous - economics | Humans | Middle Aged | Myasthenia Gravis - therapy | Male | Myasthenia Gravis - economics | Young Adult | Immunoglobulins, Intravenous - therapeutic use | Plasma Exchange - methods | Statistics, Nonparametric | Aged, 80 and over | Adult | Female | Aged | Plasma Exchange - economics | Immunoglobulins | Biological products | Analysis | Medical care, Cost of | Plasma | Index Medicus
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14. Full Text Validation of the Toronto Clinical Scoring System for Diabetic Polyneuropathy
by Vera Bril and Bruce A. Perkins
Diabetes Care, ISSN 0149-5992, 11/2002, Volume 25, Issue 11, pp. 2048 - 2052
Validation of the Toronto Clinical Scoring System for Diabetic Polyneuropathy Vera Bril , MD, FRCPC 1 and Bruce A. Perkins , MD, FRCPC 2 1 Toronto General... 
PERIPHERAL-NERVE FUNCTION | SENSORIMOTOR POLYNEUROPATHY | GLYCEMIC CONTROL | RISK-FACTORS | NEUROPATHY | SURAL NERVE | FOOT ULCERATION | ENDOCRINOLOGY & METABOLISM | CONDUCTION | COMPLICATIONS | SEVERITY | Reproducibility of Results | Diabetes Mellitus, Type 1 - physiopathology | Humans | Middle Aged | Diabetes Mellitus, Type 1 - pathology | Male | Ataxia - epidemiology | Diabetes Mellitus, Type 2 - physiopathology | Neurologic Examination | Sural Nerve - pathology | Analysis of Variance | Biopsy | Diabetic Foot - epidemiology | Diabetic Neuropathies - pathology | Diabetic Neuropathies - diagnosis | Female | Diabetes Mellitus, Type 2 - pathology | Diabetic Neuropathies - physiopathology | Diabetic neuropathies | Diabetes | Diagnosis | Polyneuropathies | Complications | Performance evaluation | Diagnostic tests | Neurological disorders | Index Medicus
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15. Full Text Safety of plasma exchange therapy in patients with myasthenia gravis
by Ebadi, Hamid and Barth, David and Bril, Vera
Muscle & Nerve, ISSN 0148-639X, 04/2013, Volume 47, Issue 4, pp. 510 - 514
Introduction : Plasma exchange (PLEX) is effective in myasthenia gravis (MG), but there are concerns about its safety. Methods : We collected data... 
immunomodulation | treatment | MG | PLEX | plasma exchange | plasmapheresis | Plasma exchange | Treatment | Immunomodulation | Plasmapheresis | MODERATE | IMMUNOGLOBULIN | DISORDERS | UPDATE | NEUROSCIENCES | CLINICAL NEUROLOGY | Prospective Studies | Humans | Middle Aged | Myasthenia Gravis - therapy | Male | Young Adult | Immunoglobulins, Intravenous - therapeutic use | Plasma Exchange - methods | Aged, 80 and over | Adult | Female | Aged | Plasma Exchange - adverse effects | Immunologic Factors - therapeutic use | Care and treatment | Myasthenia gravis | Safety and security measures | Plasma exchange (Therapeutics) | Drug therapy | Plasma | Medical research | Index Medicus
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16. Full Text Quantitative sonographic assessment of myotonia
by Abraham, Alon and Breiner, Ari and Barnett, Carolina and Bril, Vera and Katzberg, Hans D
Muscle & Nerve, ISSN 0148-639X, 01/2018, Volume 57, Issue 1, pp. 146 - 149
Introduction: This study explores ultrasound imaging for qualitative and quantitative assessment of myotonia. Methods: Sixteen patients with myotonia and 16... 
myotonic dystrophy | myotonia congenita | myotonia | hyperkalemic periodic paralysis | ultrasound | SURVIVAL | NATURAL-HISTORY | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROLOGICAL EXAMINATION | SPINAL MUSCULAR-ATROPHY | INFANTS | OPTIMALITY SCORE | Reproducibility of Results | Humans | Middle Aged | Male | Myotonia - diagnostic imaging | Muscle Relaxation | Myotonic Dystrophy - diagnostic imaging | Feasibility Studies | Young Adult | Muscle, Skeletal - diagnostic imaging | Sensitivity and Specificity | Adolescent | Ultrasonography | Adult | Female | Electromyography | Observer Variation | Cohort Studies | Ultrasound imaging | Paralysis | Evaluation | Myotonia | Muscles | Trinucleotide repeats | Feasibility analysis | Percussion | Patients | Muscle contraction | Relaxation time | Myotonic dystrophy | Reliability analysis | Dystrophy | Ultrasound | Trinucleotide repeat diseases | Index Medicus
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