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Journal of cellular physiology, ISSN 0021-9541, 10/2017, Volume 232, Issue 10, pp. 2674 - 2678
Cancer stem cells (CSCs), also called Tumor Initiating Cells (TICs), can be defined as cancer cells that are present within solid tumors or hematological... 
tumor initiating cells | humanized mice | innate and adaptive immunity | phenotypic plasticity
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 10/2017, Volume 232, Issue 10, pp. 2674 - 2678
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3
Journal Article
Matrix Biology, ISSN 0945-053X, 10/2015, Volume 48, p. 66
Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction... 
Collagen | Melanoma | Development and progression | Cellular signal transduction | Transforming growth factors | Gene expression
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 12/2009, Volume 11, Issue 6, pp. 136 - 136
The shared characteristics of rheumatoid arthritis (RA) and cancer, particularly their unchecked growth and invasive behaviors, have been apparent for some... 
RHEUMATOID-ARTHRITIS | GENE-EXPRESSION | RHEUMATOLOGY | METALLOPROTEINASES | TIMELINE | Arthritis, Rheumatoid - metabolism | Matrix Metalloproteinase 3 - metabolism | Humans | ras-GRF1 - metabolism | Arthritis, Rheumatoid - pathology | Index Medicus
Journal Article
Cancer Biology and Therapy, ISSN 1538-4047, 07/2009, Volume 8, Issue 14, pp. 77 - 89
Journal Article
Cancer biology & therapy, ISSN 1538-4047, 7/2009, Volume 8, Issue 14, pp. 1389 - 1401
Despite recent advances in cancer therapies, metastatic renal cell carcinoma (RCC) remains difficult to treat. Most RCCs result from inactivation of the von... 
YY1 | renal cell carcinoma | MT1-MMP | HIF-2α | PTEN | VHL
Journal Article
Oncogene, ISSN 0950-9232, 02/2005, Volume 24, Issue 6, pp. 1043 - 1052
Metastatic renal cell carcinoma (RCC) resulting from the hereditary loss of the von Hippel - Lindau (VHL) tumor suppressor gene is the leading cause of death... 
Von Hippel-Lindau | MT1-MMP | HIF-2α | Renal cell carcinoma | HIF-2 alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CANCER | PAS DOMAIN PROTEIN-1 | CELL BIOLOGY | MESSENGER-RNAS | renal cell carcinoma | INVASION | von Hippel-Lindau | GENE | ONCOLOGY | ENDOTHELIAL-CELLS | GROWTH | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | EXPRESSION | Metalloendopeptidases - genetics | Up-Regulation | Kidney Neoplasms - genetics | Humans | Carcinoma, Renal Cell - genetics | Molecular Sequence Data | von Hippel-Lindau Disease - complications | Neoplasm Metastasis | Matrix Metalloproteinases, Membrane-Associated | Base Sequence | Kidney Neoplasms - etiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Transcription, Genetic | Trans-Activators - biosynthesis | Trans-Activators - pharmacology | Tumor Cells, Cultured | Carcinoma, Renal Cell - etiology | Genes, Tumor Suppressor | Basic Helix-Loop-Helix Transcription Factors | Enzyme-Linked Immunosorbent Assay | Carcinoma, Renal Cell - pathology | von Hippel-Lindau Disease - genetics | Reverse Transcriptase Polymerase Chain Reaction | Ubiquitin-Protein Ligases - biosynthesis | Metalloendopeptidases - biosynthesis | Metalloendopeptidases - pharmacology | Kidney Neoplasms - pathology | Von Hippel-Lindau Tumor Suppressor Protein | Tumor Suppressor Proteins - biosynthesis | Ubiquitin-Protein Ligases - genetics | Index Medicus | von Hippel Lindau
Journal Article
Matrix Biology, ISSN 0945-053X, 10/2015, Volume 48, pp. 66 - 77
Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction... 
Human melanoma | Vemurafenib | MMP-1 | Murine melanoma | TGFβ | IL-8 | pERK | PERK
Journal Article
Cancer Research, ISSN 0008-5472, 11/2007, Volume 67, Issue 22, pp. 10849 - 10858
Melanoma incidence is increasing worldwide, and metastatic melanoma is almost completely resistant to every known therapy. New approaches to treating melanoma... 
Lung - pathology | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Humans | Neovascularization, Pathologic | Melanoma - pathology | Neoplasm Metastasis | Animals | RNA Interference | Mice, Nude | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Female | Mice | Collagenases - metabolism | Matrix Metalloproteinase 1 - metabolism | Index Medicus
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 07/2009, Volume 8, Issue 14, pp. 1389 - 1401
We are grateful to the following for their generous gifts:  Dr. William G. Kaelin, Jr. for use of the WT8 and pRc-9 cells and the VHL expression construct; Dr.... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | YY1 | PTEN | HIF-2 | MT1-MMP | VHL | Renal cell carcinoma | MAMMALIAN TARGET | HOMOZYGOUS DELETION | AKT ACTIVATION | TUMOR SUPPRESSION | MATRIX-METALLOPROTEINASE | HYPOXIA-INDUCIBLE-FACTOR | 3-KINASE/AKT PATHWAY | renal cell carcinoma | GENE | ONCOLOGY | TRANSCRIPTION FACTOR YY1 | KIDNEY CANCER | Kidney Neoplasms - genetics | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | Matrix Metalloproteinase 14 - biosynthesis | Cell Transformation, Neoplastic - genetics | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | YY1 Transcription Factor - antagonists & inhibitors | YY1 Transcription Factor - physiology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Neoplasm Proteins - biosynthesis | Protein-Serine-Threonine Kinases - physiology | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Proto-Oncogene Proteins c-akt - physiology | Signal Transduction - genetics | Carcinoma, Renal Cell - metabolism | Matrix Metalloproteinase 14 - genetics | Phosphatidylinositol 3-Kinases - physiology | Kidney Neoplasms - pathology | TOR Serine-Threonine Kinases | Intracellular Signaling Peptides and Proteins - physiology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/1999, Volume 274, Issue 36, pp. 25371 - 25378
Journal Article
Oncogene, ISSN 0950-9232, 12/2009, Volume 28, Issue 48, pp. 4237 - 4248
Journal Article
MATRIX BIOLOGY, ISSN 0945-053X, 10/2015, Volume 48, pp. 66 - 77
Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction... 
Human melanoma | SURVIVAL | TGF-BETA | Murine melanoma | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRAF | IL-8 | CELL BIOLOGY | Vemurafenib | INVASION | MMP-1 | MATRIX METALLOPROTEINASE-1 | GROWTH | STROMAL FIBROBLASTS | TGF beta | pERK | EXPRESSION | PROGRESSION | ras Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Collagen Type I - genetics | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Collagen Type I - metabolism | Melanoma - pathology | Sulfonamides - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Collagen Type I - agonists | Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Mice | Mutation | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 05/2014, Volume 27, Issue 3, pp. 495 - 501
The BRAF V600E mutation, which approaches 50% in human melanomas, constitutively activates pERK and contributes to disease progression. The BRAF V600E... 
Cells | Melanoma | Vemurafenib | PLX4032 | cell culture | melanoma | Murine BRafV600E | pERK | B6 syngeneic mouse model
Journal Article
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