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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 05/2015, Volume 137, Issue 20, pp. 6418 - 6427
Non-invasive C-13 magnetic resonance spectroscopy measurements of the uptake and subsequent metabolism of C-13-labeled substrates is a powerful method for... 
BREAST-CANCER | C-13 MAGNETIC-RESONANCE | NMR | DYNAMIC NUCLEAR-POLARIZATION | PYRUVATE | INTERMEDIARY METABOLISM | SPECTROSCOPY | IN-VIVO | LACTATE | TUMOR RESPONSE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
MAGNETIC RESONANCE IN MEDICINE, ISSN 0740-3194, 08/2011, Volume 66, Issue 2, pp. 505 - 519
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of magnetic resonance imaging and spectroscopy, particularly for low-gamma... 
SELECTIVE EXCITATION | INTERMEDIARY METABOLISM | NMR-SPECTROSCOPY | PULSE DESIGN ALGORITHM | KINETIC-PROPERTIES | dynamic nuclear polarization | imaging | pyruvate | hyperpolarized carbon-13 | SINGLET-STATE | PARAMETER RELATIONS | tumor | IN-VIVO | TREATMENT RESPONSE | metabolism | MR SPECTROSCOPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
CURRENT OPINION IN CHEMICAL BIOLOGY, ISSN 1367-5931, 08/2018, Volume 45, pp. 187 - 194
Hyperpolarization of C-13-labeled substrates can increase their C-13 NMR signal by more than 10 000-fold, which has allowed magnetic resonance imaging (MRI) of... 
GLUTAMINE TRANSPORT | DYNAMIC NUCLEAR-POLARIZATION | IN-VIVO ASSESSMENT | THERAPY | BIOPHYSICS | F-18-FDG PET/CT | HYPERPET | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVERDIAGNOSIS | EMISSION-TOMOGRAPHY | C-13-PYRUVATE MRI | DETECTING TUMOR RESPONSE
Journal Article
NATURE, ISSN 0028-0836, 06/2008, Volume 453, Issue 7197, pp. 940 - U73
As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and... 
TUMOR PH | NMR | C-13 | SPECTROSCOPY | INVIVO | MULTIDISCIPLINARY SCIENCES | EXTRACELLULAR PH | CONTRAST AGENT | BRAIN | MRS
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 11/2007, Volume 13, Issue 11, pp. 1382 - 1387
Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | CELLS | BIOMARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | MRS | CELL BIOLOGY | THERAPY | INHIBITION | IN-VIVO | EMISSION-TOMOGRAPHY | P-31
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 01/2014, Volume 20, Issue 1, pp. 93 - 93
In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-H-2, U-C-13]glucose to lactate using... 
MEDICINE, RESEARCH & EXPERIMENTAL | PENTOSE-PHOSPHATE PATHWAY | PYRUVATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATIO | CELL BIOLOGY | BREAST-CANCER | RATES | METABOLISM | IN-VIVO | LACTATE | EXCHANGE | BRAIN
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 02/2012, Volume 72, Issue 4, pp. 854 - 864
No clinically validated biomarkers exist to image tumor responses to antiangiogenic therapy. Here, we report the utility of hyperpolarized C-13 magnetic... 
CONTRAST-ENHANCED MRI | MAGNETIC-RESONANCE-SPECTROSCOPY | ANGIOGENESIS | PERMEABILITY | ONCOLOGY | BEVACIZUMAB | SUSCEPTIBILITY | BLOOD-FLOW | CANCER | ENDOTHELIAL GROWTH-FACTOR | XENOGRAFTS
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2015, Volume 6
Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability,... 
TIME UPTAKE DATA | HUMAN CORONARY-ARTERIES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | BRAIN TRANSFER CONSTANTS | CALCIFICATION | MECHANISMS | ATHEROSCLEROTIC PLAQUE | GRAPHICAL EVALUATION | F-18-FLUORIDE PET
Journal Article
Biological Reviews, ISSN 1464-7931, 2015, Volume 90, Issue 3, pp. 927 - 963
Journal Article
NMR IN BIOMEDICINE, ISSN 0952-3480, 10/2011, Volume 24, Issue 8, pp. 1006 - 1015
pH is a fundamental physiological parameter that is tightly controlled by endogenous buffers. The acid-base balance is altered in many disease states, such as... 
SATURATION-TRANSFER CEST | CARBONIC-ANHYDRASE | BRAIN PH | MRI | hyperpolarized carbon | INTRACELLULAR PH | dynamic nuclear polarization | pyruvate | CONTRAST AGENT | TUMOR PH | C-13 | POSITRON-EMISSION-TOMOGRAPHY | MAGNETIC-RESONANCE-SPECTROSCOPY | BIOPHYSICS | SPECTROSCOPY | tumor | IN-VIVO | bicarbonate | EXTRACELLULAR PH | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article