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Journal of the American Chemical Society, ISSN 0002-7863, 05/2015, Volume 137, Issue 20, pp. 6418 - 6427
Journal Article
ISSN 1367-5931, 2018
Hyperpolarization of 13C-labeled substrates can increase their 13C NMR signal by more than 10,000-fold, which has allowed magnetic resonance imaging (MRI) of... 
magnetic resonance | metabolism | carbon-13 | imaging
Journal Article
Cancer Research, ISSN 0008-5472, 01/2017, Volume 77, Issue 2 Supplement, pp. IA14 - IA14
Journal Article
Journal Article
ISSN 1078-0432, 2016
Changes in tumor metabolism may accompany disease progression and can occur following treatment, often before there are changes in tumor size. We focus here on... 
metabolism | imaging | tumor | PET | DNP
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 1900, Volume 137, Issue 20, pp. 6418 - 6427
Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and subsequent metabolism of 13C-labeled substrates is a powerful method for... 
Nuclear magnetic resonance spectroscopy | Usage | Research | Metabolism
Journal Article
British Journal of Radiology, ISSN 0007-1285, 06/2012, Volume 85, Issue 1014, pp. 697 - 708
A better understanding of tumour biology has led to the development of "targeted therapies", in which a drug is designed to disrupt a specific biochemical... 
Magnetic Resonance Imaging | Neoplasms - therapy | Animals | Magnetic Resonance Spectroscopy - methods | Humans | Cell Death | Carbon Isotopes | Magnetic Resonance Spectroscopy - instrumentation | Neoplasms - pathology | Equipment Design | Review
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 08/2018, Volume 45, pp. 187 - 194
Hyperpolarization of C-labeled substrates can increase their C NMR signal by more than 10 000-fold, which has allowed magnetic resonance imaging (MRI) of... 
Neoplasms - metabolism | Isotope Labeling - methods | Animals | Metabolic Networks and Pathways | Humans | Magnetic Resonance Imaging - methods | Tumor Microenvironment | Carbon Isotopes - metabolism | Carbon Isotopes - analysis | Neoplasms - diagnostic imaging
Journal Article
Magnetic resonance in medicine, ISSN 0740-3194, 02/2018, Volume 79, Issue 2, p. 741
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4116 - 4116
Journal Article
NMR in Biomedicine, ISSN 0952-3480, 04/2016, Volume 29, Issue 4, pp. 387 - 399
Dissolution dynamic nuclear polarization (DNP) enables the metabolism of hyperpolarized 13C‐labelled molecules, such as the conversion of [1‐13C]pyruvate to... 
kinetic modelling | spectroscopic imaging | dynamic nuclear polarization | hyperpolarized carbon‐13 | quantitative analysis | cancer imaging | Dynamic nuclear polarization | Spectroscopic imaging | Cancer imaging | Hyperpolarized carbon-13 | Kinetic modelling | Quantitative analysis | Comparative analysis | Diagnostic imaging | Methods
Journal Article
ISSN 0952-3480, 2018
Hyperpolarized MRI with 13C-labeled metabolites has enabled metabolic imaging of tumors in vivo. The heterogeneous nature of tumors and the limited lifetime of... 
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 08/2018, Volume 45, pp. 187 - 194
Hyperpolarization of C-labeled substrates can increase their C NMR signal by more than 10 000-fold, which has allowed magnetic resonance imaging (MRI) of... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24572 - 24580
Measurements of the kinetics of hyperpolarized (13)C label exchange between [1-(13)C]pyruvate and lactate in suspensions of intact and lysed murine lymphoma... 
Neoplasms - metabolism | Models, Biological | Humans | Lactic Acid - metabolism | Cell Line, Tumor | Pyruvic Acid - metabolism | Kinetics | Carbon Isotopes - chemistry | Tumor Metabolism | NMR | Lactic Acid | PI 3-Kinase | MRI | Pyruvate | Carbon-13 | Enzyme Kinetics | Metabolism | Isotope Exchange
Journal Article
Journal Article