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animals (22) 22
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spindle position (3) 3
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1. Full Text Sleep-active neurons: Conserved motors of sleep
by Bringmann, Henrik
Genetics, ISSN 0016-6731, 04/2018, Volume 208, Issue 4, pp. 1279 - 1289
Sleep is crucial for survival and well-being. This behavioral and physiological state has been studied in all major genetically accessible model animals,... 
Caenorhabditis elegans | Mus musculus | Sleep | Danio rerio | Optogenetics | Model organisms | Drosophila melanogaster | Behavioral genetics | DROSOPHILA-MELANOGASTER | CIRCADIAN-RHYTHMS | optogenetics | DEPENDENT PLASTICITY | LOCOMOTOR-ACTIVITY | STRESS-INDUCED SLEEP | SLOW-WAVE-SLEEP | sleep | behavioral genetics | CAENORHABDITIS-ELEGANS | MEMORY CONSOLIDATION | model organisms | GENETICS & HEREDITY | C. ELEGANS | REM-SLEEP | Biological Evolution | Animals | Humans | Neurons - physiology | Models, Animal | Sleep - physiology | Mammals | Biological evolution | Science | Nervous system | Electroencephalography | Eye movements | Reptiles & amphibians | Depolarization | Pathways | Wakefulness | Rodents | Arousal | Physiology | Behavior | Species | Sleep and wakefulness | Cell survival | Neurons | Zebrafish | Birds | Insects | Nematodes | Respiration | FlyBook
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2. Full Text Genetic sleep deprivation: using sleep mutants to study sleep functions
by Bringmann, Henrik
EMBO reports, ISSN 1469-221X, 03/2019, Volume 20, Issue 3, p. n/a
Sleep is a fundamental conserved physiological state in animals and humans. It may serve multiple functions, ranging from energy conservation to higher brain... 
sleep | sleep deprivation | genetics | model organism | optogenetics | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLIN-A | SLOW-WAVE SLEEP | STRESS-INDUCED SLEEP | DROSOPHILA | CELL BIOLOGY | METABOLIC CONSEQUENCES | CEREBRAL PROTEIN-SYNTHESIS | REDUCED SLEEP | C-ELEGANS | GROUND-SQUIRRELS SLEEP | REM-SLEEP | Brain | Deprivation | Regulators | Phenotypes | Sleep loss | Zebrafish | Optics | Sleep deprivation | Mutants | Side effects | Sleep | Animals | Energy conservation | Rodents | Information processing | Sensory stimulation | Driver fatigue | Fruit flies | Genetics | Neuroscience | Chromatin, Epigenetics, Genomics & Functional Genomics | Review | Molecular Biology of Disease
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3. Full Text Motoren des Schlafs
by Bringmann, Henrik
Biologie in unserer Zeit, ISSN 0045-205X, 12/2017, Volume 47, Issue 6, p. 370
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4. Full Text Agarose hydrogel microcompartments for imaging sleep- and wake-like behavior and nervous system development in Caenorhabditis elegans larvae
by Bringmann, Henrik
Journal of Neuroscience Methods, ISSN 0165-0270, 09/2011, Volume 201, Issue 1, pp. 78 - 88
► Simultaneous culture and observation of several individual young larvae inside agarose hydrogel-based arrayed microcompartments. ► Observation of larval... 
C. elegans | Microfluidics | Sleep | ON-CHIP | BIOCHEMICAL RESEARCH METHODS | NEMATODE | NEUROSCIENCES | CARBON-DIOXIDE AVOIDANCE | CONNECTIVITY | GENETICS | NEURON | CIRCUIT | FOOD | Caenorhabditis elegans | Culture Techniques - methods | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Nervous System - growth & development | Larva - growth & development | Wakefulness - physiology | Organogenesis - physiology | Sleep - physiology | Sepharose - administration & dosage | Fluorescence
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5. Full Text Motoren des Schlafs
by Bringmann, Henrik
Biologie in unserer Zeit, ISSN 0045-205X, 12/2017, Volume 47, Issue 6, pp. 370 - 377
Zusammenfassung Schlaf‐aktive Nervenzellen sind Inhibitoren des Wachseins und somit die entscheidenden Regulatoren des Schlafs. Sie sind im Tierreich weit... 
Modellorganismen | REM‐Schlaf | Nicht‐REM‐Schlaf | Schlaf
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6. Full Text Motoren des Schlafs
: Was macht uns müde und was wieder munter?
by Bringmann, Henrik
Biologie in unserer Zeit, ISSN 0045-205X, 12/2017, Volume 47, Issue 6, pp. 370 - 377
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7. Full Text Automated detection and manipulation of sleep in C. Elegans reveals depolarization of a sleep-active neuron during mechanical stimulation-induced sleep deprivation
by Spies, Jan and Bringmann, Henrik
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 9732 - 10
Across species, sleep is characterized by a complex architecture. Sleep deprivation is a classic method to study the consequences of sleep loss, which include... 
NERVOUS-SYSTEM | LETHARGUS | GENETICS | MULTIDISCIPLINARY SCIENCES | STATE | NEMATODE CAENORHABDITIS-ELEGANS | STRESS | DROSOPHILA | NEUROPEPTIDES | BEHAVIORAL QUIESCENCE | Depolarization | Nematodes | Nervous system | Automation | Mechanical stimuli | Sleep deprivation
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8. Full Text G protein regulator 1 (GPR-1) localizes to cortical sites of artificial mechanical indentation inCaenorhabditis eleganszygotes
by Bringmann, Henrik
Cytoskeleton, ISSN 1949-3584, 10/2012, Volume 69, Issue 10, pp. 819 - 825
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9. Full Text Engineered non-Mendelian inheritance of entire parental genomes in C. elegans
by Besseling, Judith and Bringmann, Henrik
Nature Biotechnology, ISSN 1087-0156, 09/2016, Volume 34, Issue 9, pp. 982 - 986
The ability to rewrite the rules of genetic segregation would open new possibilities in diverse areas of biotechnology ranging from breeding to epigenetics.... 
CORTICAL FORCE GENERATORS | EMBRYO | DYNEIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NEMATODE CAENORHABDITIS-ELEGANS | EXPRESSION | LINEAGES | Genetic Engineering - methods | Mendelian Randomization Analysis - methods | Animals | Caenorhabditis elegans - genetics | Genome - genetics | Inheritance Patterns - genetics | Female | Male | Caenorhabditis elegans Proteins - genetics | Chromosome Segregation - genetics | Physiological aspects | Epigenetic inheritance | Caenorhabditis elegans | Genetic aspects | Observations | Chromosomes
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10. Full Text A cytokinesis furrow is positioned by two consecutive signals
by Bringmann, Henrik and Hyman, Anthony A
Nature, ISSN 0028-0836, 08/2005, Volume 436, Issue 7051, pp. 731 - 734
The position of the cytokinesis furrow in a cell determines the relative sizes of its two daughter cells as well as the distribution of their contents. In... 
ORGANIZATION | SPINDLE MIDZONE | CELL-DIVISION | RNAI | PROTEIN | SAND DOLLAR EGGS | MULTIDISCIPLINARY SCIENCES | MITOTIC APPARATUS | C-ELEGANS | CAENORHABDITIS-ELEGANS EMBRYO | EMBRYOGENESIS | Cell Compartmentation - physiology | Microtubules - metabolism | Animals | Caenorhabditis elegans - cytology | Ultraviolet Rays | Zygote - cytology | Cytokinesis - physiology | Lasers | Spindle Apparatus - physiology | Actomyosin - metabolism | Cellular biology | Cell division | Cell cycle
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11. Full Text Reduced Sleep-Like Quiescence in Both Hyperactive and Hypoactive Mutants of the Galphaq Gene egl-30 during lethargus in Caenorhabditis elegans
by Schwarz, Juliane and Bringmann, Henrik
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e75853
Sleep-like states are characterized by massively reduced behavioral activity. Little is known about genetic control of sleep-like behavior. It is also not... 
NERVOUS-SYSTEM | DOMAIN | PROTEIN | RIC-8 SYNEMBRYN | G(Q)ALPHA | MULTIDISCIPLINARY SCIENCES | SIGNALING NETWORK | ADAPTATION | C-ELEGANS | SEROTONIN | MUTATIONS | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Lethargy - physiopathology | Signal Transduction | Calcium - metabolism | Larva - metabolism | Gene Expression Regulation | Caenorhabditis elegans Proteins - metabolism | Behavior, Animal - physiology | Mutation - genetics | Larva - cytology | Caenorhabditis elegans - physiology | Mechanotransduction, Cellular | Animals | Wakefulness | Neurons - physiology | Animals, Genetically Modified - physiology | Sleep - physiology | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans | Sleep deprivation | Larvae | Genetic control | Genes | Nervous system | Circadian rhythm | Mammals | Kinases | Mutants | Sleep | Nematodes | Behavior | Mutation | Sleep and wakefulness | Worms
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12. Full Text Gene expression changes of Caenorhabditis elegans larvae during molting and sleep-like lethargus
by Turek, Michal and Bringmann, Henrik
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e113269
During their development, Caenorhabditis elegans larvae go through four developmental stages. At the end of each larval stage, nematodes molt. They synthesize... 
BEHAVIOR | MULTIDISCIPLINARY SCIENCES | QUIESCENCE | NEURON | BRAIN | CUT-1 | WAKEFULNESS | CIRCUIT | Dopamine Plasma Membrane Transport Proteins - metabolism | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | Caenorhabditis elegans Proteins - metabolism | Molting | Gene Expression Profiling | Dopamine Plasma Membrane Transport Proteins - genetics | Animals | Lethargy - genetics | Gene Expression Regulation, Developmental | Larva - genetics | Neurons - metabolism | Larva - physiology | Caenorhabditis elegans Proteins - genetics | Larvae | Dopamine | Transcription | Neurons | Genes | Genomics | Cuticle | Nervous system | Genomes | Gene expression | Studies | Sleep | Developmental stages | Nematodes | Dopamine transporter | Extracellular matrix | Behavior | Bioinformatics | Transporter | Sleep and wakefulness | Worms
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13. Full Text Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep
by Schwarz, Juliane and Bringmann, Henrik
eLife, ISSN 2050-084X, 02/2017, Volume 6
Sleep is a behavior that is found in all animals that have a nervous system and that have been studied carefully. In Caenorhabditis elegans larvae, sleep is... 
NERVOUS-SYSTEM | HOMEOSTASIS | PROTEIN | CONSERVATION | BIOLOGY | STATE | NEMATODE CAENORHABDITIS-ELEGANS | MODEL | C. ELEGANS | MODULATION | BEHAVIORAL QUIESCENCE | Caenorhabditis elegans - physiology | Motor Neurons - physiology | Animals | Sleep | Homeodomain Proteins - metabolism | Caenorhabditis elegans Proteins - metabolism | Larva - physiology | Motor Activity | Homeobox | Motor neurons | Turning behavior | Young adults | Neurons | Nervous system | Motor task performance
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14. Full Text G protein regulator 1 (GPR‐1) localizes to cortical sites of artificial mechanical indentation in Caenorhabditis elegans zygotes
by Bringmann, Henrik
Cytoskeleton, ISSN 1949-3584, 10/2012, Volume 69, Issue 10, pp. 819 - 825
Cytokinesis and spindle positioning require the cortical force regulator G Protein Regulator 1/2 (GPR‐1/2). GPR‐1/2 is thought to localize to sites of cortical... 
GPR‐1/2 | C. elegans | mechanosensation | cytokinesis | Mechanosensation | Cytokinesis | GPR-1/2 | COMPLEX | POLARITY | LIN-5 | SPINDLE | ASYMMETRIC CELL-DIVISION | MYOSIN-II | CELL BIOLOGY | LET-99 | EMBRYO | C.-ELEGANS | Biomechanical Phenomena | Animals | Caenorhabditis elegans - cytology | Caenorhabditis elegans - metabolism | Zygote - cytology | Zygote - metabolism | Caenorhabditis elegans Proteins - metabolism | Stress, Mechanical | Recombinant Fusion Proteins - metabolism | Protein Transport
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15. Full Text An AP2 Transcription Factor Is Required for a Sleep-Active Neuron to Induce Sleep-like Quiescence in C. elegans
by Turek, Michal and Lewandrowski, Ines and Bringmann, Henrik
Current Biology, ISSN 0960-9822, 11/2013, Volume 23, Issue 22, pp. 2215 - 2223
Sleep is an essential behavior that is found in all animals that have a nervous system. Neural activity is thought to control sleep, but little is known about... 
NERVOUS-SYSTEM | LETHARGUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | STATE | AP-2 | NEMATODE CAENORHABDITIS-ELEGANS | IDENTIFICATION | DROSOPHILA | BEHAVIORAL QUIESCENCE | CIRCUIT | CELL BIOLOGY | Signal Transduction | gamma-Aminobutyric Acid - metabolism | Gene Expression Regulation | Behavior, Animal - physiology | Neuropeptides - metabolism | Transcription Factor AP-2 - metabolism | Caenorhabditis elegans - physiology | Locomotion | Animals | Interneurons - metabolism | Larva | Neurons - physiology | Caenorhabditis elegans Proteins - physiology | Mutation | Sleep - physiology | Neurons | Animal behavior | Sleep | GABA | Neural circuitry
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16. Full Text Codon adaptation-based control of protein expression in C. elegans
by Ernst, Susanne and Redemann, Stefanie and Hyman, Antony A and Schloissnig, Siegfried and Bringmann, Henrik and Pozniakowsky, Andrey and Ayloo, Swathi
Nature Methods, ISSN 1548-7091, 03/2011, Volume 8, Issue 3, pp. 250 - 252
We present a method to control protein levels under native genetic regulation in Caenorhabditis elegans by using synthetic genes with adapted codons. We found... 
CAENORHABDITIS-ELEGANS | SPINDLE POSITION | MESSENGER-RNA | GENE | USAGE | ESCHERICHIA-COLI | SEQUENCE | BIOCHEMICAL RESEARCH METHODS | TRANSLATION | FORCE GENERATORS | PREDICTION | Cell Division - genetics | Animals | Caenorhabditis elegans - genetics | Gene Expression Regulation | Protein Biosynthesis - genetics | Codon - genetics | Genetic Techniques | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans | Protein research | Codon | Physiological aspects | Genetic aspects | Research | Genetic regulation | Proteins | Nematodes | Scientific method | Gene expression
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