Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 39, p. E8224
Rab GTPases are switched from their GDP-bound inactive conformation to a GTP-bound active state by guanine nucleotide exchange factors (GEFs). The first...
CRISPR | Yeast | Stability | Homology | Genomes | Glucose | Adipocytes | Chaperones | Exocytosis | Insulin | Cells | Genetic screening | Defects | Molecules | Restoration | Guanine nucleotide exchange factor | Conformation | Guanosinetriphosphatase
CRISPR | Yeast | Stability | Homology | Genomes | Glucose | Adipocytes | Chaperones | Exocytosis | Insulin | Cells | Genetic screening | Defects | Molecules | Restoration | Guanine nucleotide exchange factor | Conformation | Guanosinetriphosphatase
Journal Article
BMC Genomics, ISSN 1471-2164, 08/2017, Volume 18, Issue 1, pp. 659 - 15
Background: The human oral microbiome is formed early in development. Its composition is influenced by environmental factors including diet, substance use,...
METAANALYSIS | HOST GENETICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CIGARETTE-SMOKE | HEALTH | COMMUNITIES | CARIES | HERITABILITY | GENOME-WIDE ASSOCIATION | ACTIVIN | TWIN | Heritability | Single nucleotide polymorphisms | Research | Microbiology | Mouth | Cohabitation | Nucleotide sequence | Genes | Correlation coefficients | Sex | Chromosome 7 | Genomes | Single-nucleotide polymorphism | Environmental factors | Loci | Substance use | Studies | Taxa | Microorganisms | Hypotheses | Ribonucleic acids | Influence | Chromosome 12 | Marijuana | Twins | Chromosomes | Non-coding RNA | Deoxyribonucleic acid--DNA
METAANALYSIS | HOST GENETICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CIGARETTE-SMOKE | HEALTH | COMMUNITIES | CARIES | HERITABILITY | GENOME-WIDE ASSOCIATION | ACTIVIN | TWIN | Heritability | Single nucleotide polymorphisms | Research | Microbiology | Mouth | Cohabitation | Nucleotide sequence | Genes | Correlation coefficients | Sex | Chromosome 7 | Genomes | Single-nucleotide polymorphism | Environmental factors | Loci | Substance use | Studies | Taxa | Microorganisms | Hypotheses | Ribonucleic acids | Influence | Chromosome 12 | Marijuana | Twins | Chromosomes | Non-coding RNA | Deoxyribonucleic acid--DNA
Journal Article
3.
Full Text
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample
Behavior Genetics, ISSN 0001-8244, 7/2015, Volume 45, Issue 4, pp. 375 - 381
Behavioral disinhibition (BD) is a quantitative measure designed to capture the heritable variation encompassing risky and impulsive behaviors. As a result, BD...
Pathway analysis | Public Health | GWAS | Psychology | Clinical Psychology | Health Psychology | Heritability | Behavioral disinhibition | IDENTIFY | METAANALYSIS | VARIANTS | QUANTITATIVE TRAIT LOCI | NICOTINE DEPENDENCE | PSYCHOLOGY, MULTIDISCIPLINARY | RISK LOCI | GENETICS & HEREDITY | BEHAVIORAL SCIENCES | SUBSTANCE DEPENDENCE | SMOKING-BEHAVIOR | ALCOHOL DEPENDENCE | GENETIC INFLUENCE | Impulsive Behavior | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Genotype | Male | Conduct Disorder - genetics | Substance-Related Disorders - genetics | Antisocial Personality Disorder - genetics | Likelihood Functions | Phenotype | Risk-Taking | Adolescent | Alleles | Alcoholism - genetics | Female | Polymorphism, Single Nucleotide | Genetic research | Single nucleotide polymorphisms | Alcoholism | Analysis | Genomics
Pathway analysis | Public Health | GWAS | Psychology | Clinical Psychology | Health Psychology | Heritability | Behavioral disinhibition | IDENTIFY | METAANALYSIS | VARIANTS | QUANTITATIVE TRAIT LOCI | NICOTINE DEPENDENCE | PSYCHOLOGY, MULTIDISCIPLINARY | RISK LOCI | GENETICS & HEREDITY | BEHAVIORAL SCIENCES | SUBSTANCE DEPENDENCE | SMOKING-BEHAVIOR | ALCOHOL DEPENDENCE | GENETIC INFLUENCE | Impulsive Behavior | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Genotype | Male | Conduct Disorder - genetics | Substance-Related Disorders - genetics | Antisocial Personality Disorder - genetics | Likelihood Functions | Phenotype | Risk-Taking | Adolescent | Alleles | Alcoholism - genetics | Female | Polymorphism, Single Nucleotide | Genetic research | Single nucleotide polymorphisms | Alcoholism | Analysis | Genomics
Journal Article
4.
The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study
Psychosomatic Medicine, ISSN 0033-3174, 10/2017, Volume 79, Issue 8, p. 936
Objective: Inadequate immunoregulation and elevated inflammation may be risk factors for posttraumatic stress disorder (PTSD), and microbial inputs are...
Community structure | rRNA 16S | Mental disorders | Immunoregulation | Abundance | Inflammation | Posttraumatic stress disorder | Diagnostic and Statistical Manual | Trauma | Risk factors | Microbiota | Post traumatic stress disorder | DNA | Post-traumatic stress disorder | Bacteria | Traumatic life events | Deoxyribonucleic acid--DNA | Immune system
Community structure | rRNA 16S | Mental disorders | Immunoregulation | Abundance | Inflammation | Posttraumatic stress disorder | Diagnostic and Statistical Manual | Trauma | Risk factors | Microbiota | Post traumatic stress disorder | DNA | Post-traumatic stress disorder | Bacteria | Traumatic life events | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Cell, ISSN 0092-8674, 03/2019, Volume 177, Issue 1, pp. 200 - 220
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is...
ALZHEIMER-DISEASE | STEM-CELLS | OXIDATIVE STRESS | ENERGY-EXPENDITURE | HUMAN LONGEVITY | REGULATES LIFE-SPAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENESCENT CELLS | NOTHOBRANCHIUS-FURZERI | DIETARY RESTRICTION | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
ALZHEIMER-DISEASE | STEM-CELLS | OXIDATIVE STRESS | ENERGY-EXPENDITURE | HUMAN LONGEVITY | REGULATES LIFE-SPAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENESCENT CELLS | NOTHOBRANCHIUS-FURZERI | DIETARY RESTRICTION | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2017, Volume 114, Issue 39, pp. E8224 - E8233
Rab GTPases are switched from their GDP-bound inactive conformation to a GTP-bound active state by guanine nucleotide exchange factors (GEFs). The first...
Rab GTPase | CRISPR screen | Exocytosis | GLUT4 | Vesicle transport | NUCLEOTIDE EXCHANGE | PROTEIN | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | vesicle transport | MEMBRANE-FUSION | INSULIN | HUMAN GENOME | GTPASES | GLUCOSE-TRANSPORTER | GENETIC SCREENS | exocytosis | WIDE CRISPR SCREEN | rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Molecular Chaperones - metabolism | Transport Vesicles - physiology | Glucose Transporter Type 4 - metabolism | Humans | Protein Transport - physiology | Exocytosis - physiology | Animals | Guanine Nucleotide Exchange Factors - metabolism | Adipocytes - metabolism | CRISPR-Cas Systems | HEK293 Cells | Cell Line, Tumor | Mice | HeLa Cells | Biological Sciences | PNAS Plus
Rab GTPase | CRISPR screen | Exocytosis | GLUT4 | Vesicle transport | NUCLEOTIDE EXCHANGE | PROTEIN | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | vesicle transport | MEMBRANE-FUSION | INSULIN | HUMAN GENOME | GTPASES | GLUCOSE-TRANSPORTER | GENETIC SCREENS | exocytosis | WIDE CRISPR SCREEN | rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Molecular Chaperones - metabolism | Transport Vesicles - physiology | Glucose Transporter Type 4 - metabolism | Humans | Protein Transport - physiology | Exocytosis - physiology | Animals | Guanine Nucleotide Exchange Factors - metabolism | Adipocytes - metabolism | CRISPR-Cas Systems | HEK293 Cells | Cell Line, Tumor | Mice | HeLa Cells | Biological Sciences | PNAS Plus
Journal Article
Developmental Cell, ISSN 1534-5807, 08/2019, Volume 50, Issue 4, pp. 436 - 446.e5
Multimeric adaptors are broadly involved in vesicle-mediated membrane trafficking. AP2 adaptor, in particular, plays a central role in clathrin-mediated...
CRISPR screen | AP2 adaptor | adaptor complex | membrane trafficking | AP1 adaptor | clathrin-mediated endocytosis | REQUIREMENTS | RECRUITMENT | PROTEIN | RECOGNITION | VESICLES | SIGNALS | AP-2 | MECHANISMS | DEVELOPMENTAL BIOLOGY | GLUT4 | BINDING | CELL BIOLOGY | Medical colleges | Clathrin | Behavior genetics | Developmental biology | Genomics | Skin diseases | Skin | Kidney diseases | Genetic screening | Protein binding
CRISPR screen | AP2 adaptor | adaptor complex | membrane trafficking | AP1 adaptor | clathrin-mediated endocytosis | REQUIREMENTS | RECRUITMENT | PROTEIN | RECOGNITION | VESICLES | SIGNALS | AP-2 | MECHANISMS | DEVELOPMENTAL BIOLOGY | GLUT4 | BINDING | CELL BIOLOGY | Medical colleges | Clathrin | Behavior genetics | Developmental biology | Genomics | Skin diseases | Skin | Kidney diseases | Genetic screening | Protein binding
Journal Article
Psychosomatic Medicine, ISSN 0033-3174, 10/2017, Volume 79, Issue 8, pp. 936 - 946
Objective: Inadequate immunoregulation and elevated inflammation may be risk factors for posttraumatic stress disorder (PTSD), and microbial inputs are...
childhood trauma | immunoregulation | C-reactive protein | inflammation | microbiome | posttraumatic stress disorder | INTERPERSONAL VIOLENCE | PSYCHIATRY | OLD FRIENDS | BEHAVIOR | SUSCEPTIBILITY | GUT MICROBIOTA | PSYCHOLOGY | PTSD | PSYCHOLOGY, MULTIDISCIPLINARY | QUALITY-OF-LIFE | BRAIN
childhood trauma | immunoregulation | C-reactive protein | inflammation | microbiome | posttraumatic stress disorder | INTERPERSONAL VIOLENCE | PSYCHIATRY | OLD FRIENDS | BEHAVIOR | SUSCEPTIBILITY | GUT MICROBIOTA | PSYCHOLOGY | PTSD | PSYCHOLOGY, MULTIDISCIPLINARY | QUALITY-OF-LIFE | BRAIN
Journal Article
01/2017, ISBN 9780355231014
The human oral microbiome is formed early in development. Its composition is influenced by environmental factors including diet, substance use, oral health,...
Genetics
Genetics
Dissertation
01/2018, ISBN 9780438321045
A lack of training around religious and spiritual issues in formalized mental health professional programs has placed the responsibility to ensure clinicians...
Spirituality | Counseling Psychology
Spirituality | Counseling Psychology
Dissertation
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