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Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 96 - 100
Pyruvate constitutes a critical branch point in cellular carbon metabolism. We have identified two proteins, Mpc1 and Mpc2, as essential for mitochondrial... 
Yeasts | Mitochondria | Diet | Plasmids | Drosophila | REPORTS | Amino acids | Oxidation | Respiration | Sugars | Medical schools | RAT-LIVER | TRANSPORT | COMPLEX | MECHANISM | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | Metabolomics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Amino Acids - metabolism | Biological Transport | Mitochondrial Proteins - metabolism | Pyruvic Acid - metabolism | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Carbohydrate Metabolism | Mitochondria - metabolism | Drosophila Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Citric Acid Cycle | Mitochondrial Membranes - metabolism | Point Mutation | Animals | Drosophila melanogaster - chemistry | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Cell metabolism | Pyruvates | Chemical properties | Research | Molecular biology | Proteins | Yeast | Metabolism | Carriers | Human | Bacteria | Transport | Transporter
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2016, Volume 113, Issue 39, p. 10998
  The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic... 
Genotype & phenotype | Mitochondria | Oxidation | Pharmacology | Mutation | Metabolic syndrome
Journal Article
Human mutation, ISSN 1059-7794, 2010, Volume 31, Issue 7, pp. E1564 - E1573
Journal Article
Mitochondrion, ISSN 1567-7249, 11/2013, Volume 13, Issue 6, pp. 916 - 916
Journal Article
Annals of Clinical and Translational Neurology, ISSN 2328-9503, 2014, Volume 1, Issue 7, pp. 462 - 470
OBJECTIVE: Deficiency of pyruvate dehydrogenase complex (PDHC) is the most common genetic disorder leading to lactic acidosis. PDHC deficiency is genetically... 
NEUROSCIENCES | CLINICAL NEUROLOGY | Proteins | Enzymes | Immunoglobulins | Phosphorylation | Dehydrogenases | Genes | Fibroblasts | Mutation | Kinases | Males | Patients | Defects
Journal Article
Orphanet journal of rare diseases, ISSN 1750-1172, 2010, Volume 5, Issue 1, pp. 26 - 26
Journal Article
Neuromuscular Disorders, ISSN 0960-8966, 2009, Volume 19, Issue 5, pp. 324 - 329
Abstract Very Long-Chain Acyl-CoA dehydrogenase (VLCAD) deficiency is an inborn error of mitochondrial long-chain fatty acid oxidation (FAO) most often... 
Neurology | Fatty acid oxidation | Muscle lipidosis | Very Long-Chain Acyl-Coenzyme A dehydrogenase | Metabolic myopathy | DEFECTS | COA DEHYDROGENASE | CARDIOMYOPATHY | MOLECULAR HETEROGENEITY | RHABDOMYOLYSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | FATTY-ACID OXIDATION | HYPOGLYCEMIA | MUTATIONS | A DEHYDROGENASE | MYOGLOBINURIA | Rhabdomyolysis - enzymology | Genetic Testing | Muscular Diseases - enzymology | Humans | Middle Aged | Male | Metabolism, Inborn Errors - enzymology | Muscle Weakness - genetics | Young Adult | Muscle Weakness - enzymology | DNA Mutational Analysis | Adult | Female | Carnitine - analogs & derivatives | Child | Exercise Tolerance - genetics | Mitochondrial Diseases - genetics | Carnitine - analysis | Acyl-CoA Dehydrogenase, Long-Chain - genetics | Biomarkers - analysis | Carnitine - blood | Cells, Cultured | Rhabdomyolysis - physiopathology | Genotype | Biomarkers - blood | Mutation - genetics | Metabolism, Inborn Errors - genetics | Mitochondrial Diseases - enzymology | Muscular Diseases - diagnosis | Homozygote | Metabolism, Inborn Errors - diagnosis | Rhabdomyolysis - genetics | Adolescent | Heterozygote | Muscle Weakness - physiopathology | Muscular Diseases - genetics | Mitochondrial Diseases - diagnosis | Enzymes | Analysis | Adults | Diagnosis | Mass spectrometry | Fatty acids | Hyperthermia | Fever
Journal Article
Molecular Genetics and Metabolism, ISSN 1096-7192, 11/2012, Volume 107, Issue 3, pp. 438 - 447
Journal Article
Journal of Inherited Metabolic Disease, ISSN 1573-2665, 12/2010, Volume 33, Issue S3, pp. 443 - 453
Journal Article
Journal Article