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1. Full Text Age‐ and Sex‐Related Changes in Bone Microarchitecture and Estimated Strength: A Three‐Year Prospective Study Using HRpQCT
by Shanbhogue, Vikram V and Brixen, Kim and Hansen, Stinus
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2016, Volume 31, Issue 8, pp. 1541 - 1549
Although projections from cross-sectional studies have shown that bone loss leading to osteoporosis begins around menopause in women and later in life in men,... 
ADULTS | CORTICAL POROSITY | BONE MICROARCHITECTURE | HIGH‐RESOLUTION PERIPHERAL QUANTITATIVE TOMOGRAPHY | Cortical porosity | Adults | High-resolution peripheral quantitative tomography | Bone microarchitecture | HIGH-RESOLUTION PERIPHERAL QUANTITATIVE TOMOGRAPHY | POROSITY | SKELETAL SITES | TIBIA | QUANTITATIVE COMPUTED-TOMOGRAPHY | DENSITY | SPINAL TRABECULAR BONE | DISTAL RADIUS | MEN | ENDOCRINOLOGY & METABOLISM | HR-PQCT | POSTMENOPAUSAL WOMEN | Prospective Studies | Age Factors | Humans | Middle Aged | Radius - physiology | Tibia - anatomy & histology | Tomography, X-Ray Computed - methods | Male | Radius - anatomy & histology | Young Adult | Bone and Bones - anatomy & histology | Cortical Bone - anatomy & histology | Cancellous Bone - diagnostic imaging | Bone and Bones - diagnostic imaging | Aged, 80 and over | Adult | Cortical Bone - physiology | Female | Cancellous Bone - physiology | Bone Density | Bone and Bones - physiology | Tibia - physiology | Tibia - diagnostic imaging | Sex Characteristics | Absorptiometry, Photon | Aging - physiology | Cancellous Bone - anatomy & histology | Aged | Porosity | Cortical Bone - diagnostic imaging | Radius - diagnostic imaging | Osteoporosis | Bones | Postmenopausal women | Density | Epidemiology | Menopause | Women | Radius | Population studies | Bone (trabecular) | Post-menopause | Fractures | Computed tomography | Tibia | Hormone replacement therapy | Bone mineral density | Bone loss | Bone (cortical) | Bone strength | Age | Index Medicus
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2. Full Text Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR‐pQCT in Adult Patients With Type 1 Diabetes Mellitus
by Shanbhogue, Vikram V and Hansen, Stinus and Frost, Morten and Jørgensen, Niklas Rye and Hermann, Anne Pernille and Henriksen, Jan Erik and Brixen, Kim
Journal of Bone and Mineral Research, ISSN 0884-0431, 12/2015, Volume 30, Issue 12, pp. 2188 - 2199
The primary goal of this cross-sectional in vivo study was to assess peripheral bone microarchitecture, bone strength, and bone remodeling in adult type 1... 
MICROVASCULAR DISEASE | TYPE 1 DIABETES MELLITUS | HIGH‐RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY | BONE MICROARCHITECTURE | HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY | TOMOGRAPHY | MARKERS | QUANTITATIVE COMPUTED-TOMOGRAPHY | FRACTURE RISK | OSTEOPOROSIS | TRABECULAR BONE | HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED | MINERAL DENSITY | DISTAL RADIUS | ADOLESCENTS | OSTEOPENIA | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | Bone and Bones - pathology | Radius - pathology | Vascular Diseases - complications | Anthropometry | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Case-Control Studies | Tibia - pathology | Young Adult | Microcirculation | Bone and Bones - diagnostic imaging | Adult | Female | Child | Body Mass Index | Bone Density | Cross-Sectional Studies | Diabetes Mellitus, Type 1 - physiopathology | Tibia - diagnostic imaging | Vascular Diseases - physiopathology | Absorptiometry, Photon | Adolescent | Bone Remodeling | Radius - diagnostic imaging | Medical research | Type 1 diabetes | Analysis | Medicine, Experimental | Hemoglobin | Bones | Density | Index Medicus
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3. Full Text KIT D816V mutation burden does not correlate to clinical manifestations of indolent systemic mastocytosis
by Broesby-Olsen, Sigurd, MD and Kristensen, Thomas, PhD and Vestergaard, Hanne, MD, PhD and Brixen, Kim, MD, PhD and Møller, Michael Boe, MD, DMSc and Bindslev-Jensen, Carsten, MD, PhD, DMSc and Mastocytosis Ctr Odense Univ Hosp and Mastocytosis Centre Odense University Hospital (MastOUH)
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 3, pp. 723 - 728
Background Clinical manifestations of indolent systemic mastocytosis (ISM) comprise mediator-related symptoms, anaphylaxis, and osteoporosis. A new sensitive... 
Allergy and Immunology | KIT D816V | Indolent systemic mastocytosis | mast cell | anaphylaxis | mutation burden | allele burden | osteoporosis | STANDARDIZATION | MAST-CELLS | C-KIT | PERIPHERAL-BLOOD | PREVALENCE | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | FEATURES | ALLERGY | FRACTURES | CLONALITY | Severity of Illness Index | Anaphylaxis - complications | Humans | Middle Aged | Male | Mastocytosis, Systemic - genetics | Anaphylaxis - genetics | Young Adult | Osteoporosis - complications | Adult | Female | Osteoporosis - genetics | Proto-Oncogene Proteins c-kit - genetics | Aged | Mutation | Bone Marrow Cells - metabolism | Mastocytosis, Systemic - complications | Osteoporosis | Mast cell disease | Genetic aspects | Variables | Hospitals | Pain | Disease | Biopsy | Older people | Medical records | Bone density | Hospitalization | Patients | Age | Index Medicus | Abridged Index Medicus
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4. Full Text Differing effects of PTH 1–34, PTH 1–84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: An 18‐month open‐labeled observational study using HR‐pQCT
by Hansen, Stinus and Hauge, Ellen M and Beck Jensen, Jens‐Erik and Brixen, Kim
Journal of Bone and Mineral Research, ISSN 0884-0431, 04/2013, Volume 28, Issue 4, pp. 736 - 745
Whereas the beneficial effects of intermittent treatment with parathyroid hormone (PTH) (intact PTH 1–84 or fragment PTH 1–34, teriparatide) on vertebral... 
ZOLEDRONIC ACID | PTH 1–84 | HR‐PQCT | ANTI‐OSTEOPOROTIC TREATMENT | OSTEOPOROSIS | PTH 1–34 | HR-PQCT | PTH 1-34 | PTH 1-84 | osteoporosis | anti-osteoporotic treatment | zoledronic acid | CORTICAL BONE | OVARIECTOMIZED RHESUS-MONKEYS | PARATHYROID-HORMONE 1-34 | TERIPARATIDE | QUANTITATIVE COMPUTED-TOMOGRAPHY | ALENDRONATE | ANTI-OSTEOPOROTIC TREATMENT | TRABECULAR BONE | MINERAL DENSITY | DISTAL RADIUS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | Bone and Bones - pathology | Radius - pathology | Humans | Middle Aged | Parathyroid Hormone - therapeutic use | Osteoporosis - drug therapy | Parathyroid Hormone - pharmacology | Tomography, X-Ray Computed | Bone Remodeling - drug effects | Tibia - pathology | Bone and Bones - drug effects | Time Factors | Bone and Bones - diagnostic imaging | Osteoporosis - diagnostic imaging | Biomechanical Phenomena - drug effects | Radius - drug effects | Aged, 80 and over | Diphosphonates - therapeutic use | Postmenopause | Female | Finite Element Analysis | Imidazoles - therapeutic use | Osteoporosis - physiopathology | Tibia - physiopathology | Biomarkers - metabolism | Radius - physiopathology | Imidazoles - pharmacology | Tibia - drug effects | Absorptiometry, Photon | Bone and Bones - physiopathology | Aged | Diphosphonates - pharmacology | Index Medicus
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5. Full Text Fracture Risk and Zoledronic Acid Therapy in Men with Osteoporosis
by Boonen, Steven and Reginster, Jean-Yves and Kaufman, Jean-Marc and Lippuner, Kurt and Zanchetta, Jose and Langdahl, Bente and Rizzoli, Rene and Lipschitz, Stanley and Dimai, Hans Peter and Witvrouw, Richard and Eriksen, Erik and Brixen, Kim and Russo, Luis and Claessens, Frank and Papanastasiou, Philemon and Antunez, Oscar and Su, Guoqin and Bucci-Rechtweg, Christina and Hruska, Josef and Incera, Elodie and Vanderschueren, Dirk and Orwoll, Eric
The New England Journal of Medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 18, pp. 1714 - 1723
This multicenter trial evaluated zoledronic acid versus placebo in men with osteoporosis for a primary end point of new morphometric vertebral fracture over 24... 
BONE-DENSITY | MORTALITY | HIP FRACTURE | WOMEN | MEDICINE, GENERAL & INTERNAL | MULTICENTER | POSTMENOPAUSAL OSTEOPOROSIS | VERTEBRAL FRACTURES | DOUBLE-BLIND | ORAL ALENDRONATE | RISEDRONATE | Humans | Middle Aged | Male | Osteoporosis - drug therapy | Risk | Osteoporosis - etiology | Spinal Fractures - prevention & control | Aged, 80 and over | Diphosphonates - therapeutic use | Imidazoles - therapeutic use | Testosterone - blood | Diphosphonates - adverse effects | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Imidazoles - adverse effects | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Logistic Models | Imidazoles - pharmacology | Bone Density Conservation Agents - pharmacology | Bone Density - drug effects | Analysis of Variance | Hypogonadism - complications | Aged | Diphosphonates - pharmacology | Drugs | Dose-response relationship (Biochemistry) | Osteoporosis | Men | Zoledronic acid | Dosage and administration | Product/Service Evaluations | Drug therapy | Health aspects | Risk factors | Vertebrae | Intravenous administration | Calcium | Clinical trials | Bone turnover | Hypogonadism | Serum levels | Testosterone | Fractures | Vitamin D | Older people | Bone mineral density | Bone density | Supplementation | Index Medicus | Abridged Index Medicus
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6. Full Text Bone Microarchitecture and Estimated Strength in 499 Adult Danish Women and Men: A Cross-Sectional, Population-Based High-Resolution Peripheral Quantitative Computed Tomographic Study on Peak Bone Structure
by Hansen, Stinus and Shanbhogue, Vikram and Folkestad, Lars and Nielsen, Morten Munk Frost and Brixen, Kim
Calcified Tissue International, ISSN 0171-967X, 3/2014, Volume 94, Issue 3, pp. 269 - 281
High-resolution peripheral quantitative computed tomography (HR-pQCT) allows in vivo assessment of cortical and trabecular bone mineral density (BMD),... 
Life Sciences | Biochemistry, general | Orthopedics | Bone microarchitecture | Adult | High-resolution pQCT | Bone strength | Endocrinology | Cell Biology | SKELETAL SITES | QUALITY-CONTROL | GENDER-RELATED DIFFERENCES | TRABECULAR BONE | MINERAL DENSITY | IN-VIVO ASSESSMENT | DISTAL RADIUS | ENDOCRINOLOGY & METABOLISM | HR-PQCT | POSTMENOPAUSAL WOMEN | ULTRADISTAL RADIUS | Age Factors | Bone Density - physiology | Cross-Sectional Studies | Humans | Middle Aged | Tomography, X-Ray Computed - methods | Male | Sex Characteristics | Tibia - cytology | Young Adult | Biomechanical Phenomena | Aged, 80 and over | Denmark | Radius - cytology | Female | Aged | Tibia - metabolism | Radius - metabolism | Bones | Adults | Porosity | Density | Analysis | Tomography | Bone density | Medical imaging | Microstructure | Index Medicus | Age
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7. Full Text Age- and Sex-Related Changes in Bone Microarchitecture and Estimated Strength: A Three-Year Prospective Study Using HRpQCT
: AGE-RELATED CHANGES IN BONE MICROARCHITECTURE BY HRpQCT
by Shanbhogue, Vikram V and Brixen, Kim and Hansen, Stinus
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2016, Volume 31, Issue 8, pp. 1541 - 1549
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8. Full Text Mortality and Causes of Death in Patients With Osteogenesis Imperfecta: A Register‐Based Nationwide Cohort Study
by Folkestad, Lars and Hald, Jannie Dahl and Canudas‐Romo, Vladimir and Gram, Jeppe and Hermann, Anne Pernille and Langdahl, Bente and Abrahamsen, Bo and Brixen, Kim
Journal of Bone and Mineral Research, ISSN 0884-0431, 12/2016, Volume 31, Issue 12, pp. 2159 - 2166
Osteogenesis imperfecta (OI) is a hereditary connective tissue disease that causes frequent fractures. Little is known about causes of death and length of... 
COLLAGEN DEFECTS | CAUSES OF DEATH | OSTEOGENESIS IMPERFECTA | RARE BONE DISORDERS | REGISTER‐BASED RESEARCH | REGISTER-BASED RESEARCH | ENDOCRINOLOGY & METABOLISM | MODEL | Comorbidity | Humans | Middle Aged | Kaplan-Meier Estimate | Child, Preschool | Infant | Male | Osteogenesis Imperfecta - mortality | Cause of Death | Young Adult | Adolescent | Adult | Female | Registries | Aged | Child | Infant, Newborn | Cohort Studies | Medicine, Experimental | Medical research | Analysis | Mortality | Index Medicus
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9. Full Text Compromised trabecular microarchitecture and lower finite element estimates of radius and tibia bone strength in adults with turner syndrome: A cross‐sectional study using high‐resolution–pQCT
by Hansen, Stinus and Brixen, Kim and Gravholt, Claus H
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2012, Volume 27, Issue 8, pp. 1794 - 1803
Although bone mass appear ample for bone size in Turner syndrome (TS), epidemiological studies have reported an increased risk of fracture in TS. We used... 
BONE STRENGTH | TURNER SYNDROME | FINITE ELEMENT ANALYSIS | BONE MICROARCHITECTURE | HR‐PQCT | HR-PQCT | CORTICAL POROSITY | QUANTITATIVE COMPUTED-TOMOGRAPHY | SHORT STATURE | MINERAL DENSITY | ESTROGEN REPLACEMENT | GROWTH-HORMONE | DISTAL RADIUS | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | YOUNG-WOMEN | Radius - pathology | Bone Density | Cross-Sectional Studies | Anthropometry | Humans | Middle Aged | Tibia - diagnostic imaging | Radius - physiopathology | Tomography, X-Ray Computed | Absorptiometry, Photon | Case-Control Studies | Tibia - pathology | Young Adult | Regression Analysis | Turner Syndrome - diagnostic imaging | Turner Syndrome - physiopathology | Adolescent | Adult | Female | Finite Element Analysis | Radius - diagnostic imaging | Tibia - physiopathology | Turner Syndrome - pathology | Index Medicus
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10. Full Text Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study
by Thue Kvorning and Marianne Andersen and Kim Brixen and Klavs Madsen
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/2006, Volume 291, Issue 6, pp. 1325 - 1332
We hypothesized that suppression of endogenous testosterone would inhibit the adaptations to strength training in otherwise healthy men. Twenty-two young men... 
Lean body mass | Isometric strength | Exercise | Gonadotropin-releasing hormone analog | Fat mass | lean body mass | ACTIVATION | PHYSIOLOGY | YOUNG MEN | fat mass | exercise | TIME-COURSE | HUMAN SKELETAL-MUSCLE | gonadotropin-releasing hormone analog | HORMONAL ADAPTATIONS | HYPERTROPHY | MUSCLE PROTEIN-SYNTHESIS | METABOLISM | RESISTANCE EXERCISE | ENDOCRINOLOGY & METABOLISM | isometric strength | SERUM TESTOSTERONE | Leg - anatomy & histology | Double-Blind Method | Muscle, Skeletal - growth & development | Humans | Androgen Antagonists - pharmacology | Testosterone - biosynthesis | Male | Organ Size - physiology | Muscle, Skeletal - physiology | Absorptiometry, Photon | Estrogens - blood | Goserelin - pharmacology | Diet | Testosterone - antagonists & inhibitors | Adult | Isometric Contraction | Exercise - physiology | Testosterone - blood | Hormones - blood | Weight Lifting - physiology | Body Composition - physiology | Studies | Testosterone | Mens health | Placebo effect | Index Medicus
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11. Full Text Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: A two-year longitudinal study
by Shanbhogue, Vikram V and Støving, René Klinkby and Frederiksen, Katrine Hartmund and Hanson, Stine and Brixen, Kim and Gram, Jeppe and Jørgensen, Niklas Rye and Hansen, Stinus
European Journal of Endocrinology, ISSN 0804-4643, 06/2017, Volume 176, Issue 6, pp. 685 - 693
Objective, design and methods: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease.... 
MINERAL DENSITY | METABOLISM | DISTAL RADIUS | MICROARCHITECTURE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | BARIATRIC SURGERY | MORBID-OBESITY | QUANTITATIVE COMPUTED-TOMOGRAPHY | POSTMENOPAUSAL WOMEN | FRACTURE RISK | Postoperative Complications - etiology | Obesity, Morbid - surgery | Humans | Leptin - metabolism | Middle Aged | Postoperative Complications - metabolism | Male | Tomography, X-Ray Computed | Luteinizing Hormone - metabolism | Osteoporosis - etiology | Peptides - metabolism | Osteoporosis - metabolism | Parathyroid Hormone - metabolism | Osteoporosis - diagnostic imaging | Adiponectin - metabolism | Adult | Female | Follicle Stimulating Hormone - metabolism | Peptide Fragments - metabolism | Bone Density | Bone Diseases, Metabolic - diagnostic imaging | Collagen Type I - metabolism | Lumbar Vertebrae - diagnostic imaging | Bone Diseases, Metabolic - etiology | Tibia - diagnostic imaging | Gastric Bypass - adverse effects | Procollagen - metabolism | Absorptiometry, Photon | Bone Diseases, Metabolic - metabolism | Hip Joint - diagnostic imaging | Insulin - metabolism | Weight Loss | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Bone Remodeling | Longitudinal Studies | Postoperative Complications - diagnostic imaging | Radius - diagnostic imaging | Dual energy X-ray absorptiometry | Radius | Spine | Body weight | Gastric bypass | Body weight loss | Bone turnover | Metabolism | Bone surgery | Insulin | Hip | Osteoporosis | Bone mass | Fractures | Computed tomography | Tibia | Leptin | Bone mineral density | Gastrointestinal surgery | Bone loss | Bone strength | Index Medicus
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12. Full Text Fracture Rates and Fracture Sites in Patients With Osteogenesis Imperfecta: A Nationwide Register‐Based Cohort Study
by Folkestad, Lars and Hald, Jannie Dahl and Ersbøll, Annette Kjær and Gram, Jeppe and Hermann, Anne Pernille and Langdahl, Bente and Abrahamsen, Bo and Brixen, Kim
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2017, Volume 32, Issue 1, pp. 125 - 134
Osteogenesis imperfecta (OI) is a hereditary, clinically heterogeneous, connective tissue disorder. The population prevalence of OI in Denmark is 10.6 in... 
REGISTER‐BASED STUDIES | RARE BONE DISEASES | OSTEOGENESIS IMPERFECTA | COLLAGEN | FRACTURE RATES | EPIDEMIOLOGY | REGISTER-BASED STUDIES | POPULATION | ENDOCRINOLOGY & METABOLISM | ADULTS | BONE | Humans | Middle Aged | Osteogenesis Imperfecta - complications | Child, Preschool | Fractures, Bone - epidemiology | Infant | Male | Reference Values | Young Adult | Osteogenesis Imperfecta - epidemiology | Adolescent | Fractures, Bone - complications | Denmark - epidemiology | Adult | Female | Registries | Child | Infant, Newborn | Cohort Studies | Medicine, Experimental | Medical research | Epidemiology | Analysis | Index Medicus
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13. Full Text Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture, and Estimated Bone Strength
by Cheung, Angela M and Majumdar, Sharmila and Brixen, Kim and Chapurlat, Roland and Fuerst, Thomas and Engelke, Klaus and Dardzinski, Bernard and Cabal, Antonio and Verbruggen, Nadia and Ather, Shabana and Rosenberg, Elizabeth and de Papp, Anne E
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2014, Volume 29, Issue 8, pp. 1786 - 1794
The cathepsin K inhibitor odanacatib (ODN), currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone... 
VOLUMETRIC BMD | OSTEOPOROSIS | ODANACATIB | Osteoporosis | Volumetric BMD | Odanacatib | CORTICAL BONE | TURNOVER | QUANTITATIVE COMPUTED-TOMOGRAPHY | PREDICTION | FRACTURE | DISTAL RADIUS | ENDOCRINOLOGY & METABOLISM | HR-PQCT | MICROSTRUCTURE | FINITE-ELEMENT-ANALYSIS | Compressive Strength | Reference Standards | Biphenyl Compounds - pharmacology | Humans | Middle Aged | Radius - drug effects | Bone and Bones - ultrastructure | Female | Aged | Tibia - drug effects | Bone Remodeling - drug effects | Bone and Bones - drug effects | Bones | Postmenopausal women | Density | Analysis | Index Medicus
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