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1. Full Text Abstract 4560: Induced Sprouty4 expression in breast invasive ductal carcinoma cells downregulates ERK/MAPK activity and restores an epithelial-like phenotype
by Brock, Ethan J and Jackson, Ryan and Shah, Seema and Li, Quanwen and Sameni, Mansoureh and Krawetz, Stephen A and Mao, Shihong and Sloane, Bonnie F and Mattingly, Raymond R
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4560 - 4560
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2. How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization
by Brock, Ethan J and Ji, Kyungmin and Reiners, John J and Mattingly, Raymond R
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 03/2016, Volume 16, Issue 5, pp. 358 - 369
Oncogenic Ras proteins are a driving force in a significant set of human cancers and wildtype, unmutated Ras proteins likely contribute to the malignant... 
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3. Full Text Ras and Rap1: A tale of two GTPases
by Shah, Seema and Brock, Ethan J and Ji, Kyungmin and Mattingly, Raymond R
Seminars in Cancer Biology, ISSN 1044-579X, 02/2019, Volume 54, pp. 29 - 39
Ras oncoproteins play pivotal roles in both the development and maintenance of many tumor types. Unfortunately, these proteins are difficult to directly target... 
Rap1Gap | Ras | ERK/MAPK | Rap1 | FTI | Metabolism | Cell-adhesion | EMT | Integrins | BLADDER-CARCINOMA ONCOGENE | BINDING-PROTEIN | GUANINE-NUCLEOTIDE EXCHANGE | ENDOTHELIAL BARRIER FUNCTION | FARNESYL-PROTEIN TRANSFERASE | SIGNAL-REGULATED KINASES | IN-VITRO | H-RAS | ONCOLOGY | HUMAN TUMOR-CELLS | AMINO-ACID 12 | Neoplasms - metabolism | rap1 GTP-Binding Proteins - metabolism | ras Proteins - genetics | Cell Adhesion - genetics | rap1 GTP-Binding Proteins - antagonists & inhibitors | Humans | ras Proteins - antagonists & inhibitors | Integrins - genetics | ras Proteins - metabolism | Molecular Targeted Therapy | Biomarkers, Tumor | Integrins - metabolism | Neoplasms - drug therapy | Animals | Energy Metabolism | Neoplasms - genetics | Signal Transduction - drug effects | Epithelial-Mesenchymal Transition | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Neoplasms - pathology | rap1 GTP-Binding Proteins - genetics | Medical colleges | Therapeutics | Stem cells | Physiological aspects | Metastasis | G proteins | Mitogens | Protein kinases | Homeopathy | Materia medica and therapeutics
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4. Full Text Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation
by Shah, Seema and Brock, Ethan J and Jackson, Ryan M and Ji, Kyungmin and Boerner, Julie L and Sloane, Bonnie F and Mattingly, Raymond R
Neoplasia, ISSN 1476-5586, 09/2018, Volume 20, Issue 9, pp. 951 - 963
Diagnosis of breast ductal carcinoma (DCIS) presents a challenge since we cannot yet distinguish those cases that would remain indolent and not require... 
Immunohistochemistry | Phenotypes | Mesenchyme | Invasiveness | Extracellular signal-regulated kinase | MAP kinase | Immunoblotting | Breast cancer | Kinases | Rap1 protein | Breast carcinoma | Genotype & phenotype | Reversion | Protein kinase | Cytoskeleton | Guanosinetriphosphatase | Structure-function relationships
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5. How to target activated ras proteins: Direct inhibition vs. induced mislocalization
by Brock, Ethan J and Ji, Kyungmin and Reiners, John J and Mattingly, Raymond R
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 03/2016, Volume 16, Issue 5, pp. 358 - 369
Oncogenic Ras proteins are a driving force in a significant set of human cancers and wildtype, unmutated Ras proteins likely contribute to the malignant... 
H-ras | Prenylation inhibitors | N-ras | K-ras | Subcellular localization | Lovastatin | Statins | ONCOGENIC K-RAS | CONTAINING BISPHOSPHONATES INHIBIT | FARNESYLTRANSFERASE INHIBITOR | CHEMISTRY, MEDICINAL | RAS-GRF/CDC25(MM) EXCHANGE FACTOR | N-Ras | subcellular localization | GERANYLGERANYL DIPHOSPHATE SYNTHASE | prenylation inhibitors | FARNESYL TRANSFERASE INHIBITOR | PHASE-II TRIAL | H-Ras | K-Ras | statins | lovastatin | SMALL-MOLECULE INHIBITION
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6. Full Text In Vitro Models for Studying Invasive Transitions of Ductal Carcinoma In Situ
by Brock, Ethan J and Ji, Kyungmin and Shah, Seema and Mattingly, Raymond R and Sloane, Bonnie F
Journal of Mammary Gland Biology and Neoplasia, ISSN 1083-3021, 2018, Volume 24, Issue 1, pp. 1 - 15
About one fourth of all newly identified cases of breast carcinoma are diagnoses of breast ductal carcinoma in situ (DCIS). Since we cannot yet distinguish... 
Tumor microenvironment | 3D cultures | Synthetic matrices | Natural matrices | Co-cultures | Preclinical screens | 2D cultures | Engineered microfluidic platforms | PHYSIOLOGY | TISSUE ARCHITECTURE | BREAST-CANCER PROGRESSION | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR RECEPTOR | LASER CAPTURE MICRODISSECTION | MYOEPITHELIAL CELLS | ONCOLOGY | PROTEIN EXPRESSION | ENDOCRINOLOGY & METABOLISM | TUMOR-ASSOCIATED MACROPHAGES | FOCAL ADHESION KINASE | MAMMARY-GLAND | Carcinoma, Ductal | Medical colleges | Analysis | Microfluidics
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7. How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization
by Brock, Ethan J and Ji, Kyungmin and Reiners, John J and Mattingly, Raymond R
Mini reviews in medicinal chemistry, 2016, Volume 16, Issue 5, p. 358
Oncogenic Ras proteins are a driving force in a significant set of human cancers and wildtype, unmutated Ras proteins likely contribute to the malignant... 
Neoplasms - metabolism | Protein Prenylation - drug effects | ras Proteins - genetics | Humans | Enzyme Inhibitors - pharmacology | ras Proteins - antagonists & inhibitors | ras Proteins - metabolism | Antineoplastic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Enzyme Inhibitors - therapeutic use | Farnesyltranstransferase - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Enzyme Inhibitors - chemistry | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Farnesyltranstransferase - antagonists & inhibitors | Neoplasms - pathology
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8. Full Text Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution
by Leung, Wilson and Shaffer, Christopher D and Reed, Laura K and Smith, Sheryl T and Barshop, William and Dirkes, William and Dothager, Matthew and Lee, Paul and Wong, Jeannette and Xiong, David and Yuan, Han and Bedard, James E.J and Machone, Joshua F and Patterson, Seantay D and Price, Amber L and Turner, Bryce A and Robic, Srebrenka and Luippold, Erin K and McCartha, Shannon R and Walji, Tezin A and Walker, Chelsea A and Saville, Kenneth and Abrams, Marita K and Armstrong, Andrew R and Armstrong, William and Bailey, Robert J and Barberi, Chelsea R and Beck, Lauren R and Blaker, Amanda L and Blunden, Christopher E and Brand, Jordan P and Brock, Ethan J and Brooks, Dana W and Brown, Marie and Butzler, Sarah C and Clark, Eric M and Clark, Nicole B and Collins, Ashley A and Cotteleer, Rebecca J and Cullimore, Peterson R and Dawson, Seth G and Docking, Carter T and Dorsett, Sasha L and Dougherty, Grace A and Downey, Kaitlyn A and Drake, Andrew P and Earl, Erica K and Floyd, Trevor G and Forsyth, Joshua D and Foust, Jonathan D and Franchi, Spencer L and Geary, James F and Hanson, Cynthia K and Harding, Taylor S and Harris, Cameron B and Heckman, Jonathan M and Holderness, Heather L and Howey, Nicole A and Jacobs, Dontae A and Jewell, Elizabeth S and Kaisler, Maria and Karaska, Elizabeth A and Kehoe, James L and Koaches, Hannah C and Koehler, Jessica and Koenig, Dana and Kujawski, Alexander J and Kus, Jordan E and Lammers, Jennifer A and Leads, Rachel R and Leatherman, Emily C and Lippert, Rachel N and Messenger, Gregory S and Morrow, Adam T and NewcombVictoria, Haley J and Plasman, Plasman and Potocny, Stephanie J and Powers, Michelle K and Reem, Rachel M and Rennhack, Jonathan P and Reynolds, Katherine R and Reynolds, Lyndsey A and Rhee, Dong K and Rivard, Allyson B and Ronk, Adam J and Rooney, Meghan B and Rubin, Lainey S and Salbert, Luke R and Saluja, Rasleen K and Schauder, Taylor and Schneiter, Allison R and Schulz, Robert W and Smith, Karl E and Spencer, Sarah and Swanson, Bryant R and Tache, Melissa A and Tewilliager, Ashley A and Tilot, Amanda K and VanEck, Eve and Villerot, Matthew M and ... and Participating Students Fac Genomic
G3: Genes, Genomes, Genetics, ISSN 2160-1836, 2015, Volume 5, Issue 5, pp. 719 - 740
The Muller F element (4.2 Mb, similar to 80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low... 
Melting characteristics | Evolution of heterochromatin | Transposons | Gene size | Codon bias | codon bias | RNA INTERFERENCE | DINE-1 TRANSPOSABLE ELEMENTS | melting characteristics | transposons | CODON USAGE BIAS | DOT CHROMOSOME | evolution of heterochromatin | gene size | TANDEM REPEATS | HIGHLY ABUNDANT | GENETICS & HEREDITY | SEQUENCED GENOMES | MELANOGASTER CHROMOSOME-4 | HETEROCHROMATIN FORMATION | ROLLING-CIRCLE TRANSPOSONS | Polytene Chromosomes | Species Specificity | Exons | Introns | Genomics | Molecular Sequence Annotation | Computational Biology | Selection, Genetic | Drosophila melanogaster - genetics | DNA Transposable Elements | Heterochromatin | Animals | Codon | Gene Rearrangement | Repetitive Sequences, Nucleic Acid | Drosophila Proteins - genetics | Genome | Drosophila - genetics | Evolution, Molecular
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9. Full Text DrosophilaMuller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
by Leung, Wilson and Shaffer, Christopher D and Reed, Laura K and Smith, Sheryl T and Barshop, William and Dirkes, William and Dothager, Matthew and Lee, Paul and Wong, Jeannette and Xiong, David and Yuan, Han and Bedard, James E. J and Machone, Joshua F and Patterson, Seantay D and Price, Amber L and Turner, Bryce A and Robic, Srebrenka and Luippold, Erin K and McCartha, Shannon R and Walji, Tezin A and Walker, Chelsea A and Saville, Kenneth and Abrams, Marita K and Armstrong, Andrew R and Armstrong, William and Bailey, Robert J and Barberi, Chelsea R and Beck, Lauren R and Blaker, Amanda L and Blunden, Christopher E and Brand, Jordan P and Brock, Ethan J and Brooks, Dana W and Brown, Marie and Butzler, Sarah C and Clark, Eric M and Clark, Nicole B and Collins, Ashley A and Cotteleer, Rebecca J and Cullimore, Peterson R and Dawson, Seth G and Docking, Carter T and Dorsett, Sasha L and Dougherty, Grace A and Downey, Kaitlyn A and Drake, Andrew P and Earl, Erica K and Floyd, Trevor G and Forsyth, Joshua D and Foust, Jonathan D and Franchi, Spencer L and Geary, James F and Hanson, Cynthia K and Harding, Taylor S and Harris, Cameron B and Heckman, Jonathan M and Holderness, Heather L and Howey, Nicole A and Jacobs, Dontae A and Jewell, Elizabeth S and Kaisler, Maria and Karaska, Elizabeth A and Kehoe, James L and Koaches, Hannah C and Koehler, Jessica and Koenig, Dana and Kujawski, Alexander J and Kus, Jordan E and Lammers, Jennifer A and Leads, Rachel R and Leatherman, Emily C and Lippert, Rachel N and Messenger, Gregory S and Morrow, Adam T and Newcomb, Victoria and Plasman, Haley J and Potocny, Stephanie J and Powers, Michelle K and Reem, Rachel M and Rennhack, Jonathan P and Reynolds, Katherine R and Reynolds, Lyndsey A and Rhee, Dong K and Rivard, Allyson B and Ronk, Adam J and Rooney, Meghan B and Rubin, Lainey S and Salbert, Luke R and Saluja, Rasleen K and Schauder, Taylor and Schneiter, Allison R and Schulz, Robert W and Smith, Karl E and Spencer, Sarah and Swanson, Bryant R and Tache, Melissa A and Tewilliager, Ashley A and Tilot, Amanda K and VanEck, Eve and Villerot, Matthew M and ...
G3: Genes|Genomes|Genetics, ISSN 2160-1836, 05/2015, Volume 5, Issue 5, pp. 719 - 740
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10. Guns and butter
: the economic causes and consequences of conflict
by Hess, Gregory D and Blomberg, S. Brock and Davis, Steven J and Garfinkel, Michelle R and Glaeser, Edward L and Mesquita, Bruce Bueno de and Mesquita, Ethan Bueno de and Murphy, Kevin M and Rosendorff, B. Peter and Sheppard, Stephen Charles
2009, 1, CESifo seminar series, ISBN 9780262012812, Volume 1, vi, 323
Guns and Butter examines the causes and consequences of war from a political economy perspective, taking as its premise that a consideration of the incentives... 
Economics | War | Economic aspects | war; conflict; political economy
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11. Full Text Optimized Mie Potentials for Phase Equilibria: Application to Branched Alkanes
by Mick, Jason R and Soroush Barhaghi, Mohammad and Jackman, Brock and Schwiebert, Loren and Potoff, Jeffrey J
Journal of Chemical and Engineering Data, ISSN 0021-9568, 06/2017, Volume 62, Issue 6, pp. 1806 - 1818
A transferable united-atom (UA) force field based on Mie potentials is presented for branched alkanes. The performance of the optimized Mie potential... 
UNITED-ATOM DESCRIPTION | X-RAY-DIFFRACTION | VAPOR-LIQUID-EQUILIBRIA | THERMAL-DECOMPOSITION | CHEMISTRY, MULTIDISCIPLINARY | N-ALKANES | ENGINEERING, CHEMICAL | EQUATION-OF-STATE | THERMODYNAMICS | TRANSFERABLE POTENTIALS | NEOPENTANE | FORCE-FIELD | MONTE-CARLO-SIMULATION
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12. Full Text Comprehensive genomic characterization of squamous cell lung cancers
by Hammerman, Peter S and Voet, Doug and Lawrence, Michael S and Voet, Doug and Jing, Rui and Cibulskis, Kristian and Sivachenko, Andrey and Stojanov, Petar and McKenna, Aaron and Lander, Eric S and Gabriel, Stacey and Getz, Gad and Imielinski, Marcin and Helman, Elena and Hernandez, Bryan and Pho, Nam H and Meyerson, Matthew and Chu, Andy and Hye-Chun, Jung E and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Sipahimalani, Payal and Stoll, Dominik and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron S.N and Chuah, Eric and Coope, Robin J.N and Corbett, Richard and Dhalla, Noreen and Guin, Ranabir and He, An and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Karen and Nip, Ka Ming and Olshen, Adam and Schein, Jacqueline E and Slobodan, Jared R and Tam, Angela and Thiessen, Nina and Varhol, Richard and Zeng, Thomas and Zhao, Yongjun and Jones, Steven J.M and Marra, Marco A and Saksena, Gordon and Cherniack, Andrew D and Schumacher, Stephen E and Tabak, Barbara and Carter, Scott L and Nguyen, Huy and Onofrio, Robert C and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Protopopov, Alexei and Zhang, Jianhua and Hadjipanayis, Angela and Lee, Semin and Xi, Ruibin and Yang, Lixing and Ren, Xiaojia and Zhang, Hailei and Shukla, Sachet and Chen, Peng-Chieh and Haseley, Psalm and Lee, Eunjung and Chin, Lynda and Park, Peter J and Kucherlapati, Raju and Socci, Nicholas D and Liang, Yupu and Schultz, Nikolaus and Borsu, Laetitia and Lash, Alex E and Viale, Agnes and Sander, Chris and Ladanyi, Marc and Auman, J. Todd and Hoadley, Katherine A and Wilkerson, Matthew D and Shi, Yan and Liquori, Christina and Meng, Shaowu and Li, Ling and Turman, Yidi J and Topal, Michael D and Tan, Donghui and Waring, Scot and Buda, Elizabeth and Walsh, Jesse and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7417, pp. 519 - 525
Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell... 
GEFITINIB | ONCOGENE | AMPLIFICATION | GENE | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | SENSITIVITY | MUTATIONS | COPY-NUMBER ALTERATION | CARCINOMA | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Adenocarcinoma of Lung | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Mutation Rate | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Signal Transduction - genetics | Genes, p53 - genetics | Molecular Targeted Therapy | Mutation - genetics | Adenocarcinoma - drug therapy | Genes, p16 | Genome, Human - genetics | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - drug therapy | DNA Mutational Analysis | Gene Deletion | Adenocarcinoma - genetics | Squamous cell carcinoma | Lung cancer | Genetic research | Genetic aspects | Research | Observations | Genetic screening | Mortality | Cell cycle | DNA methylation | Genetics | Genomes | Mutation | Kinases | Chromosomes | Ovarian cancer
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