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1. Full Text Identification of common variants associated with human hippocampal and intracranial volumes
by Stein, J.L and Medland, S.E and Arias Vasquez, A and Hibar, D.P and Senstad, R.E and Winkler, A.M and Toro, R and Appel, K and Bartecek, R and Bergmann, O and Bernard, M and Brown, A.A and Cannon, D.M and Chakravarty, M.M and Christoforou, A and Domin, M and Grimm, O and Hollinshead, M and Holmes, A.J and Homuth, G and Hottenga, J.J and Langan, C and Lopez, L.M and Hansell, N.K and Hwang, K.S and Kim, S and Laje, G and Lee, P.H and Liu, X and Loth, E and Lourdusamy, A and Mattingsdal, M and Mohnke, S and Maniega, S.M and Nho, K and Nugent, A.C and O'Brien, C and Papmeyer, M and Putz, B and Ramasamy, A and Rasmussen, J and Rijpkema, M.J.P and Risacher, S.L and Roddey, J.C and Rose, E.J and Ryten, M and Shen, L and Sprooten, E and Strengman, E and Teumer, A and Trabzuni, D and Turner, J and Eijk, K. van and Erp, T.G. van and Tol, M.J. van and Wittfeld, K and Wolf, C. de and Woudstra, S and Aleman, A and Alhusaini, S and Almasy, L and Binder, E.B and Brohawn, D.G and Cantor, R.M and Carless, M.A and Corvin, A and Czisch, M and Curran, J.E and Davies, G and Almeida, M.A. de and Delanty, N and Depondt, C and Duggirala, R and Dyer, T.D and Erk, S and Fagerness, J and Fox, P.T and Freimer, N.B and Gill, M and Goring, H.H and Hagler, D.J and Hoehn, D and Holsboer, F and Hoogman, M and Hosten, N and Jahanshad, N and Johnson, M.P and Kasperaviciute, D and Kent Jr., J.W and Kochunov, P and Lancaster, J.L and Lawrie, S.M and Liewald, D.C and Mandl, R.C.W and Matarin, M and Mattheisen, M and Meisenzahl, E and Melle, I and Moses, E.K and Muhleisen, T.W and ... and Cohorts Heart Aging Res Genomic Ep and EPIGEN Consortium and ADNI and Saguenay Youth Study Grp SYS and IMAGEN Consortium and Enhancing Neuro Imaging Genetics M and Alzheimer's Disease Neuroimaging Initiative and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium and Saguenay Youth Study Group and Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium and the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and Saguenay Youth Study Group (SYS) and for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium
Nature Genetics, ISSN 1061-4036, 2012, Volume 44, Issue 5, pp. 552 - 561
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The... 
AUTOMATED SEGMENTATION | HUMAN HEIGHT | FUNCTIONAL IMPLICATIONS | TEMPORAL-LOBE EPILEPSY | UNIFIED APPROACH | GENOTYPE IMPUTATION | ALZHEIMERS-DISEASE | GENETICS & HEREDITY | BRAIN VOLUME | NA+/H+ EXCHANGER | GENOME-WIDE ASSOCIATION | Neuroimaging | Genome-Wide Association Study | Meta-Analysis as Topic | Brain - physiopathology | Humans | Polymorphism, Single Nucleotide - genetics | Genetic Loci | Genetic Markers | Chromosomes, Human, Pair 12 - genetics | Hippocampus - physiopathology | Head | Genetic aspects | Hippocampus (Brain) | Genetic variation | Identification and classification | Body size | Studies | Haplotypes | Neurology | Brain | Genealogy | Statistical analysis | Quality control | Genetics | Genomes | Meta-analysis | Life Sciences | Neurons and Cognition
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2. Full Text The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
by Thompson, Paul M and Stein, Jason L and Medland, Sarah E and Hibar, Derrek P and Vasquez, Alejano Arias and Renteria, Miguel E and Toro, Roberto and Jahanshad, Neda and Schumann, Gunter and Franke, Barbara and Wright, Margaret J and Martin, Nicholas G and Agartz, Ingrid and Alda, Martin and Alhusaini, Saud and Almasy, Laura and Almeida, Jorge and Alpert, Kathryn and Aneasen, Nancy C and Aneassen, Ole A and Apostolova, Liana G and Appel, Katja and Armstrong, Nicola J and Aribisala, Benjamin and Bastin, Mark E and Bauer, Michael and Bearden, Carrie E and Bergmann, Orjan and Binder, Elisabeth B and Blangero, John and Bockholt, Henry J and Bøen, Erlend and Bois, Catherine and Boomsma, Dorret I and Booth, Tom and Bowman, Ian J and Bralten, Janita and Brouwer, Rachel M and Brunner, Han G and Brohawn, David G and Buckner, Randy L and Buitelaar, Jan and Bulayeva, Kazima and Bustillo, Juan R and Calhoun, Vince D and Cannon, Dara M and Cantor, Rita M and Carless, Melanie A and Caseras, Xavier and Cavalleri, Gianpiero L and Chakravarty, M. Mallar and Chang, Kiki D and Ching, Christopher R. K and Christoforou, Anea and Cichon, Sven and Clark, Vincent P and Conrod, Patricia and Coppola, Giovanni and Crespo-Facorro, Benedicto and Curran, Joanne E and Czisch, Michael and Deary, Ian J and de Geus, Eco J. C and den Braber, Anouk and Delvecchio, Giuseppe and Depondt, Chantal and de Haan, Lieuwe and de Zubicaray, Greig I and Dima, Danai and Dimitrova, Rali and Djurovic, Srdjan and Dong, Hongwei and Donohoe, Gary and Duggirala, Ravinanath and Dyer, Thomas D and Ehrlich, Stefan and Ekman, Carl Johan and Elvsåshagen, Torbjørn and Emsell, Louise and Erk, Susanne and Espeseth, Thomas and Fagerness, Jesen and Fears, Scott and Fedko, Iryna and Fernández, Guillén and Fisher, Simon E and Foroud, Tatiana and Fox, Peter T and Francks, Clyde and Frangou, Sophia and Frey, Eva Maria and Frodl, Thomas and Frouin, Vincent and Garavan, Hugh and Giddaluru, Sudheer and Glahn, David C and Godlewska, Beata and Goldstein, Rita Z and Gollub, Randy L and Grabe, Hans J and ... and EPIGEN Consortium and Saguenay Youth Study SYS Grp and Alzheimer's Dis Neuroimaging and IMAGEN Consortium and Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group and the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group and Stockholms universitet and Samhällsvetenskapliga fakulteten and Psykologiska institutionen
Brain imaging and behavior, ISSN 1931-7557, 2014, Volume 8, Issue 2, pp. 153 - 182
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of... 
Neurosciences | Biomedicine | GWAS | MRI | Multi-site | Consortium | Genetics | Neuropsychology | Psychiatry | Neuroradiology | Meta-analysis | COMMON VARIANTS | ALZHEIMERS-DISEASE | HIPPOCAMPAL ATROPHY | NEUROIMAGING | APOLIPOPROTEIN-E | QUANTITATIVE TRAIT LOCI | HUMAN BRAIN STRUCTURE | CORTICAL SURFACE-AREA | MULTIVARIATE PARALLEL ICA | WHITE-MATTER MICROSTRUCTURE | GENOME-WIDE ASSOCIATION | Neuroimaging - methods | Cooperative Behavior | Meta-Analysis as Topic | Brain Mapping - methods | Genome-Wide Association Study - methods | Humans | Medicine | Consortia | Neuroimaging | Usage | Conferences, meetings and seminars | Analysis | Life Sciences | Neurons and Cognition | Genetic Neuroimaging in Aging and Age-Related Diseases | Basic Medicine | Social Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Psychology | Samhällsvetenskap | Medicinska och farmaceutiska grundvetenskaper | Psykologi | Neurovetenskaper
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3. Full Text RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer’s Disease and Parkinson’s Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia
by Bennett, James P and Keeney, Paula M and Brohawn, David G
Frontiers in Neuroscience, ISSN 1662-453X, 03/2019, Volume 13
Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models of human NDD, such as rare monogenic causes of... 
Vector-borne diseases | Animal models | Parkinson's disease | Disease | Neurodegenerative diseases | Pathogenesis | Genes | Cytotoxicity | Amyotrophic lateral sclerosis | Genomes | Lymphocytes T | Ribonucleic acid--RNA | Gene expression | Gingivitis | Microglia | Neurotoxicity | Neurodegeneration | Autopsy | Aging | Tumor necrosis factor-TNF | Alzheimer's disease | Movement disorders | neurodegeneration | ALS | Alzheimer’s disease | microglia | Parkinson’s disease | gene expression
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4. Full Text RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia
by Bennett, JP and Keeney, PM and Brohawn, DG
FRONTIERS IN NEUROSCIENCE, ISSN 1662-453X, 03/2019, Volume 13, p. 235
Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models of human NDD, such as rare monogenic causes of... 
CELLS | Parkinson's disease | neurodegeneration | ALS | MECHANISMS | NEUROSCIENCES | MOLECULES | NEUROINFLAMMATION | PATHWAY | ROLES | HEALTH | STRESS | microglia | Alzheimer's disease | gene expression | PROGRESSION | RNA sequencing | Amyotrophic lateral sclerosis | RNA | T cells | Genes
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5. Full Text RNAseq analyses identify tumor necrosis factor-mediated inflammation as a major abnormality in ALS spinal cord
by Brohawn, David G and O'Brien, Laura C and Bennett, James P
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0160520
ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and... 
Inflammation - pathology | Genome-Wide Association Study | Spinal Cord - metabolism | Amyotrophic Lateral Sclerosis - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Signal Transduction - genetics | Gene Regulatory Networks | Case-Control Studies | Motor Neurons - pathology | Amyotrophic Lateral Sclerosis - complications | Motor Neurons - metabolism | Spinal Cord - immunology | Amyotrophic Lateral Sclerosis - pathology | Sequence Analysis, RNA | Autopsy | Spinal Cord - pathology | Tumor Necrosis Factor-alpha - physiology | Inflammation - genetics | High-Throughput Nucleotide Sequencing | RNA sequencing | RNA | Neurons | Genes | Genomics | Development and progression | Genomes | Inflammation | DNA binding proteins | Genetic transcription | Necrosis | Algorithms | Tumor necrosis factor | Cell death | Analysis | Tumors | Spinal cord | Transcription factors | Pathogenesis | Cytotoxicity | Lymphocytes T | Retinoid X receptor α | Activation | Macrophages | Caspase-3 | Gene sequencing | Proteins | Network analysis | Tumor necrosis factor-TNF | Physiology | Bioinformatics | Motor neurons | NF-κB protein | rRNA | Abnormalities | Spasticity | Caspase | Amyotrophic lateral sclerosis | Biophysics | Tumor necrosis factor-α | Gene expression | Ribonucleic acid--RNA | Studies | Pathology | Signaling | Adults | Mutation | Molecular biology | Viability | Chemokines | Ribonucleic acid
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6. Full Text Pharmacological properties of microneurotrophin drugs developed for treatment of amyotrophic lateral sclerosis
by Bennett, James P and O’Brien, Laura C and Brohawn, David G
Biochemical Pharmacology, ISSN 0006-2952, 10/2016, Volume 117, pp. 68 - 77
Microneurotrophins (MNT’s) are small molecule derivatives of dehydroepiandrosterone (DHEA) and do not have significant interactions with sex steroid receptors.... 
RNA-sequencing | Gene ontology | ALS | Microneurotrophin | iPSC-derived motor neuron | MOTOR-NEURONS | STEM-CELLS | NEUROSTEROIDS | DEHYDROEPIANDROSTERONE | P-GLYCOPROTEIN | STRATEGIES | ALIGNMENT | PHARMACOLOGY & PHARMACY | GENERATION | RECEPTORS | CANCER RESISTANCE PROTEIN | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - pharmacokinetics | Hepatocytes - pathology | Drugs, Investigational - metabolism | Hepatocytes - metabolism | Neural Stem Cells - cytology | Dehydroepiandrosterone - analogs & derivatives | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neurons - pathology | Neuroprotective Agents - metabolism | Tissue Distribution | Hepatocytes - cytology | Neuroprotective Agents - pharmacology | Neuroprotective Agents - pharmacokinetics | Biotransformation | Dehydroepiandrosterone - pharmacokinetics | Membrane Transport Modulators - pharmacology | Motor Neurons - cytology | Madin Darby Canine Kidney Cells | Dehydroepiandrosterone - metabolism | Induced Pluripotent Stem Cells - cytology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Hepatocytes - drug effects | Motor Neurons - drug effects | Caco-2 Cells | Recombinant Proteins - metabolism | Absorption, Physiological - drug effects | Cell Line | Induced Pluripotent Stem Cells - drug effects | Dehydroepiandrosterone - pharmacology | Cells, Cultured | Neural Stem Cells - drug effects | Recombinant Proteins - chemistry | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Motor Neurons - metabolism | Nerve Tissue Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Amyotrophic Lateral Sclerosis - metabolism | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Blood-Brain Barrier | Amyotrophic lateral sclerosis | Drug therapy | Real estate development | Analysis
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7. Full Text Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia
by Roffman, Joshua L and Brohawn, David G and Nitenson, Adam Z and MacKlin, Eric A and Smoller, Jordan W and Goff, Donald C
Schizophrenia Bulletin, ISSN 0586-7614, 03/2013, Volume 39, Issue 2, pp. 330 - 338
Low serum folate levels previously have been associated with negative symptom risk in schizophrenia, as has the hypofunctional 677C>T variant of the MTHFR... 
genetic risk score | methylation | epigenetics | gene-environment interaction | BLADDER-CANCER | DEPRESSION | PSYCHIATRY | COMMON MUTATION | DNA-METHYLATION | METHYLENETETRAHYDROFOLATE REDUCTASE | HOMOCYSTEINE LEVELS | CATECHOL-O-METHYLTRANSFERASE | POLYMORPHISMS | RISK-FACTOR | ONE-CARBON METABOLISM | Severity of Illness Index | Genetic Predisposition to Disease | Schizophrenia - metabolism | Gene Frequency | Humans | Reduced Folate Carrier Protein - genetics | Linear Models | Male | Mutation, Missense | Catechol O-Methyltransferase - genetics | Schizophrenic Psychology | Metabolic Networks and Pathways - genetics | Glutamate Carboxypeptidase II - genetics | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Ferredoxin-NADP Reductase - genetics | Folic Acid - blood | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics | Folic Acid - metabolism | Adult | Female | Polymorphism, Single Nucleotide | Cohort Studies | Regular
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8. Full Text RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency
by Ladd, Amy C and Brohawn, David G and Thomas, Ravindar R and Keeney, Paula M and Berr, Stuart S and Khan, Shaharyar M and Portell, Francisco R and Shakenov, Meiram Zh and Antkowiak, Patrick F and Kundu, Bijoy and Tustison, Nicholas and Bennett, James P
Brain Research, ISSN 0006-8993, 2017, Volume 1667, pp. 74 - 83
Highlights • Mitochondria are the organelles responsible for most energy production in the nervous system. • Amyotrophic lateral sclerosis (ALS) is a typically... 
Neurology | RNA expression | ALS | TFAM | Mitochondria | Genomics | OXIDATIVE-PHOSPHORYLATION | STEM-CELLS | TOXICITY | CEREBROSPINAL-FLUID | C9ORF72 | NEUROSCIENCES | SPORADIC ALS | BIOGENESIS | EXPANSION | DYSFUNCTION | BRAIN | Recombinant Proteins - metabolism | Transcription Factors - administration & dosage | Brain - diagnostic imaging | Gene Expression | Mitochondrial Proteins - administration & dosage | Humans | Cells, Cultured | Laser Capture Microdissection | DNA, Mitochondrial | Male | Rats, Sprague-Dawley | Recombinant Proteins - administration & dosage | Brain - metabolism | DNA-Binding Proteins - metabolism | Motor Neurons - metabolism | Transcription Factors - metabolism | Animals | Sequence Analysis, RNA | Mitochondrial Proteins - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Cervical Cord - metabolism | DNA-Binding Proteins - administration & dosage | Glucose - metabolism | Neural Stem Cells - metabolism | Amyotrophic lateral sclerosis | Mitochondrial DNA | RNA | Neurons | Analysis | Genes | Nervous system diseases | Genetic research | Genetic transcription
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9. Full Text A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals
by Roffman, Joshua L and Nitenson, Adam Z and Agam, Yigal and Isom, Marlisa and Friedman, Jesse S and Dyckman, Kara A and Brohawn, David G and Smoller, Jordan W and Goff, Donald C and Manoach, Dara S
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25253
Background: Responding to errors is a critical first step in learning from mistakes, a process that is abnormal in schizophrenia. To gain insight into the... 
METHYLENETETRAHYDROFOLATE REDUCTASE | EXECUTIVE FUNCTION | HUMAN CEREBRAL-CORTEX | POLYMORPHISMS | PERFORMANCE | ANTERIOR CINGULATE | BIOLOGY | NEURONS | DISORDERS | COMMON MUTATION | DNA-METHYLATION | Magnetic Resonance Imaging | Genetic Predisposition to Disease | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Humans | Alleles | Adult | Female | Male | DNA Methylation - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Schizophrenia | Methylation | Epigenetic inheritance | Mental disorders | Pathogenesis | Genes | Colorectal cancer | Cognitive ability | Activation | Methylenetetrahydrofolate reductase | Medical schools | Psychosis | Human error | Vitamin B | DNA methylation | Functional magnetic resonance imaging | Deoxyribonucleic acid--DNA | Cortex (cingulate) | Dopamine | Metabolism | Patients | Carbon | Genetic variance | Errors | Saccadic eye movements | Molecular modelling | Epigenetics | Protein expression | Homocysteine | Psychiatry | Deoxyribonucleic acid | DNA
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