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Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 12/2010, Volume 76, Issue 6, pp. 472 - 479
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2015, Volume 5, Issue 4, pp. 424 - 437
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2010, Volume 53, Issue 6, pp. 2636 - 2645
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose metabolism. It has been recognized... 
CHEMISTRY, MEDICINAL | ZSTK474 | 3-KINASE INHIBITOR | PATHWAY | 3-KINASE/MAMMALIAN TARGET | TUMOR-SUPPRESSOR | MUTATIONS | ANTITUMOR-ACTIVITY | IDENTIFICATION | CANCER | PTEN/MMAC1 | Neoplasms - metabolism | Models, Chemical | Area Under Curve | Humans | Neoplasms - prevention & control | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Structure-Activity Relationship | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Adenosine Triphosphate - pharmacology | Protein Kinase Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Inhibitory Concentration 50 | Female | Triazines - chemistry | Molecular Structure | Protein-Serine-Threonine Kinases - metabolism | Binding, Competitive | Protein Kinase Inhibitors - pharmacokinetics | Protein Structure, Tertiary | Cell Survival - drug effects | Triazines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Morpholines - pharmacology | Morpholines - chemistry | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Survival Analysis | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Morpholines - pharmacokinetics | Mutation | Adenosine Triphosphate - chemistry | Neoplasms - pathology | Triazines - pharmacokinetics
Journal Article
Science Translational Medicine, ISSN 1946-6234, 11/2017, Volume 9, Issue 414
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 7, pp. 2321 - 2325
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2009, Volume 52, Issue 16, pp. 5013 - 5016
The mammalian target of rapamycin (mTOR), a central regulator of growth, survival, and metabolism, is a validated target for cancer therapy. Rapamycin and its... 
CHEMISTRY, MEDICINAL | IDENTIFICATION | PATHWAY | MTOR | Microsomes - metabolism | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Crystallography, X-Ray | Isoenzymes - chemistry | Structure-Activity Relationship | Urea - chemical synthesis | Carbamates - chemistry | Pyrimidines - chemistry | Urea - chemistry | Pyrazoles - chemistry | Urea - analogs & derivatives | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Class Ib Phosphatidylinositol 3-Kinase | Antineoplastic Agents - pharmacology | Adenosine Triphosphate - physiology | Binding Sites | Carbamates - pharmacology | Pyrazoles - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Carbamates - chemical synthesis | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mice, Nude | Cell Line, Tumor | Mice | Protein-Serine-Threonine Kinases - chemistry | TOR Serine-Threonine Kinases | Urea - pharmacology | DESIGN | THERAPY | METABOLISM | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | SYNTHESIS | TARGETS | IN VIVO | PROTEINS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3169 - 3182
Journal Article
Journal Article