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Experimental Cell Research, ISSN 0014-4827, 2009, Volume 315, Issue 9, pp. 1549 - 1555
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 5/2016, Volume 73, Issue 9, pp. 1895 - 1915
The metalloprotease ADAM10 mediates the shedding of the ectodomain of various cell membrane proteins, including APP, the precursor of the amyloid peptide Aβ,... 
Life Sciences | Biochemistry, general | Life Sciences, general | Microdomain | Membrane compartmentalization | Notch | ADAM10 | Biomedicine general | Cell Biology | Tetraspanin | Ectodomain shedding | ALPHA-SECRETASE | MAJOR CD9 | CD151 | CD81 | INTEGRIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEOLYTIC ACTIVATION | COMPLEXES | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | ENDOTHELIAL-CELLS | PROTEINS | Amyloid Precursor Protein Secretases - genetics | Immunoprecipitation | Cadherins - metabolism | Humans | Substrate Specificity | Chromatography, High Pressure Liquid | Membrane Proteins - analysis | Tandem Mass Spectrometry | RNA Interference | ADAM Proteins - analysis | Amyloid beta-Protein Precursor - metabolism | Hyaluronan Receptors - metabolism | Membrane Proteins - metabolism | Tetraspanins - genetics | Tetraspanins - metabolism | Membrane Proteins - genetics | ADAM10 Protein | Amyloid Precursor Protein Secretases - analysis | Receptor, Notch1 - metabolism | Microscopy, Confocal | Tetraspanins - antagonists & inhibitors | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Cell Line, Tumor | ADAM Proteins - genetics | Receptor, Notch1 - genetics | RNA, Small Interfering - metabolism | Peptides | Analysis | Resveratrol | Membrane proteins | Proteins | Cytokines | Mass spectrometry | Endoplasmic reticulum | Cellular Biology | Original
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 7, pp. 1359 - 1367
Journal Article
Journal Article
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2014, Volume 1187, pp. 87 - 100
The Notch receptor and its ligands are cell surface transmembrane proteins that are internalized. Endocytosis and vesicle trafficking play key roles in Notch... 
Degradation | Endocytosis | Biotinylation | Antibody uptake | Delta | Internalization | Trafficking | Notch | Jagged | Recycling | Immunohistochemistry - methods | Staining and Labeling - methods | Cell Line | Receptors, Notch - analysis | Animals | Antibodies - metabolism | Receptors, Notch - metabolism | Humans | Antibodies - analysis | Protein Transport
Conference Proceeding
Cell Reports, ISSN 2211-1247, 12/2018, Volume 25, Issue 13, pp. 3811 - 3827.e7
Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate into endocrine cells, they must escape Notch activation to... 
development | NFIA | Notch signaling | pancreas | cell fate | endocytosis | endocrine cell | Mib1 | REGULATING NOTCH | ACTIVATION | ENDOCRINE PROGENITORS | UBIQUITIN LIGASE | DELTA | DISTINCT | DIFFERENTIATION | ENDOCYTOSIS | LINEAGE | REVEALS | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/1998, Volume 95, Issue 14, pp. 8108 - 8112
The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300).... 
T lymphocytes | Proteins | Molecules | Receptors | Antiserum | Complementary DNA | Cell lines | HeLa cells | Amino acids | Ligands | SIGNAL-TRANSDUCTION | INHIBITION | PROTEIN | MULTIDISCIPLINARY SCIENCES | Extracellular matrix | Cell receptors | Research | Proteolysis
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2013, Volume 126, Issue 19, pp. 4457 - 4468
Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated,... 
Ubiquitin | Endocytosis | Itch | Arrestin | Notch | ACTIVATION | DOMAIN | NEDD4 FAMILY | DELTEX | TRAFFICKING | CELL BIOLOGY | UBIQUITINATION | PATHWAY | PROTEIN COMPLEXES | LIGAND | BETA-ADRENERGIC RECEPTOR | Signal Transduction | Receptors, Notch - metabolism | Humans | Arrestins - metabolism | Endocytosis - physiology | Ubiquitination | Animals | Transfection | beta-Arrestins | HEK293 Cells | Cell Line, Tumor | Mice | Fibroblasts - metabolism
Journal Article