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1. Full Text Antiresorptives: Safety Concerns—Clinical Perspective
by Brown, Jacques P
Toxicologic Pathology, ISSN 0192-6233, 10/2017, Volume 45, Issue 7, pp. 859 - 863
Antiresorptive drugs, such as amino-bisphosphonates and denosumab (Dmab), have dominated osteoporosis therapies for over 20 years. Since osteoporosis is a... 
bisphosphonates | osteonecrosis of the jaw | denosumab | atypical femur fracture | JAW | RISK-FACTORS | BISPHOSPHONATE USE | PATHOLOGY | OSTEONECROSIS | ALENDRONATE | ZOLEDRONIC ACID | POSTMENOPAUSAL OSTEOPOROSIS | TOXICOLOGY | ATYPICAL FEMORAL FRACTURES | BONE | OSTEOCLAST DIFFERENTIATION | Antibodies, Monoclonal, Humanized - adverse effects | Bone Density Conservation Agents - adverse effects | Humans | Risk Factors | Osteoporosis - drug therapy | Denosumab - adverse effects | Bone Remodeling - drug effects | Incidence | Clinical Trials, Phase III as Topic | Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology | Observational Studies as Topic | Female | Diphosphonates - adverse effects | Femoral Fractures - chemically induced
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2. Full Text Response to Dr Lamy and Dr Gonzalez‐Rodriguez
by Cummings, Steven R and Ferrari, Serge and Brown, Jacques P and Wang, Andrea T
Journal of Bone and Mineral Research, ISSN 0884-0431, 03/2018, Volume 33, Issue 3, pp. 548 - 548
Denosumab | Freedom | Humans | Spinal Fractures
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3. Full Text Response to letter to the editor by Leder et al. regarding commentary “Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics”
by Eriksen, Erik Fink and Brown, Jacques P
Bone, ISSN 8756-3282, 2016, Volume 89, pp. 75 - 76
Orthopedics | Osteoporosis | Denosumab | Parathyroid hormone | Teriparatide | Concurrent therapy
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4. Full Text Response to Dr Lamy and Dr Gonzalez-Rodriguez
: REPLY LETTER TO THE EDITOR
by Cummings, Steven R and Ferrari, Serge and Brown, Jacques P and Wang, Andrea T
Journal of Bone and Mineral Research, ISSN 0884-0431, 03/2018, Volume 33, Issue 3, pp. 548 - 548
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5. Full Text Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study
: SEQUENTIAL THERAPY AFTER ROMOSOZUMAB
by McClung, Michael R and Brown, Jacques P and Diez-Perez, Adolfo and Resch, Heinrich and Caminis, John and Meisner, Paul and Bolognese, Michael A and Goemaere, Stefan and Bone, Henry G and Zanchetta, Jose R and Maddox, Judy and Bray, Sarah and Grauer, Andreas
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2018, Volume 33, Issue 8, pp. 1397 - 1406
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6. Full Text Retraction Notice to “Kidney Function and Rate of Bone Loss at the Hip and Spine: The Canadian Multicentre Osteoporosis Study” [ Am J Kidney Dis. 55(2):291-299]
by Jamal, Sophie A., MD, PhD and Swan, Victoria J.D., BSc, BPHE and Brown, Jacques P., MD and Hanley, David A., MD and Prior, Jerilynn C., BA, MD and Papaioannou, Alexandra, MD, MSc and Langsetmo, Lisa, PhD and Josse, Robert G., MD and Canadian Multicentre Osteoporosis Study Research Group
American Journal of Kidney Diseases, ISSN 0272-6386, 2016, Volume 68, Issue 2, pp. 333 - 333
Nephrology
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7. Full Text 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada
by Brown, Jacques P and Josse, Robert G and Sci Advisory Council Osteoporosis and Scientific Advisory Council of the Osteoporosis Society of Canada
Canadian Medical Association Journal, ISSN 0008-4409, 11/2002, Volume 167, Issue 90100, pp. S1 - S34
All recommendations were graded according to the strength of the evidence; where the evidence was insufficient and recommendations were based on consensus... 
VITAMIN-D SUPPLEMENTATION | MEDICINE, GENERAL & INTERNAL | BONE-MINERAL DENSITY | EARLY POSTMENOPAUSAL WOMEN | VERTEBRAL FRACTURE RATE | PARATHYROID-HORMONE 1-34 | INTERMITTENT CYCLICAL ETIDRONATE | X-RAY ABSORPTIOMETRY | RANDOMIZED CONTROLLED-TRIAL | CORTICOSTEROID-INDUCED OSTEOPOROSIS | INTRANASAL SALMON-CALCITONIN | Phytoestrogens | Bone Density | Prognosis | Osteoporosis - prevention & control | Estrogens, Non-Steroidal | Humans | Middle Aged | Osteoporosis - diagnosis | Risk Factors | Male | Osteoporosis - drug therapy | Randomized Controlled Trials as Topic | Canada | Diet | Plant Preparations | Diphosphonates - therapeutic use | Adult | Female | Aged | Child | Isoflavones | Practice Guidelines as Topic | Osteoporosis | Management | Medical diagnosis | Standards | Supplement
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8. Full Text Paget’s disease of bone: An osteoimmunological disorder?
by Numan, Mohamed S and Amiable, Nathalie and Brown, Jacques P and Michou, Laëtitia
Drug Design, Development and Therapy, ISSN 1177-8881, 08/2015, Volume 9, pp. 4695 - 4707
Osteoimmunology represents a large area of research resulting from the cross talk between bone and immune systems. Many cytokines and signaling cascades are... 
Osteoimmunology | RANKL | SQSTM1/p62 | Osteoclast | Paget’s disease of bone | Crosstalk | Interleukin | Disorders | Cytotoxicity | Viruses | Arthritis | Osteoprotegerin | Interleukin 6 | Bone resorption | Osteoporosis | Bone growth | Immunology | Granulocytes | Measles | Cascades | Interleukin 1 | Bone marrow | Tumor necrosis factor-TNF | Biocompatibility | Bones | TRANCE protein | Immune system | Psoriasis | Cytokines | Medical treatment | Rheumatology | Monographs | Inflammation | Tumor necrosis factor-α | Interleukin 17 | Signaling | Periodontitis | Rheumatoid arthritis | γ-Interferon | Pharmacy | Stem cells | Biomarkers | Ligands | Interferon | Bone | Osteogenesis
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9. Full Text Romosozumab in Postmenopausal Women with Low Bone Mineral Density
by McClung, Michael R and Grauer, Andreas and Boonen, Steven and Bolognese, Michael A and Brown, Jacques P and Diez-Perez, Adolfo and Langdahl, Bente L and Reginster, Jean-Yves and Zanchetta, Jose R and Wasserman, Scott M and Katz, Leonid and Maddox, Judy and Yang, Yu-Ching and Libanati, Cesar and Bone, Henry G
The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 5, pp. 412 - 420
This study shows that in postmenopausal women with low bone mineral density, the monoclonal antibody romosozumab, which binds to sclerostin, an... 
MEDICINE, GENERAL & INTERNAL | SCLEROSTIN ANTIBODY | PROTEIN | GENE | DISEASE | STRENGTH | WNT | CARRIERS | OSTEOPOROSIS | DELETION | Biomarkers - metabolism | Teriparatide - pharmacology | Teriparatide - therapeutic use | Bone Density Conservation Agents - adverse effects | Drug Administration Schedule | Antibodies, Monoclonal - pharmacology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Lumbar Vertebrae - drug effects | Bone Density Conservation Agents - administration & dosage | Bone Remodeling - drug effects | Osteoporosis, Postmenopausal - drug therapy | Alendronate - therapeutic use | Bone Density Conservation Agents - pharmacology | Calcium - blood | Bone Density - drug effects | Antibodies, Monoclonal - administration & dosage | Injections, Subcutaneous | Alendronate - pharmacology | Aged, 80 and over | Least-Squares Analysis | Female | Aged | Osteoporosis | Care and treatment | Analysis | Monoclonal antibodies | Bones | Dosage and administration | Postmenopausal women | Research | Drug therapy | Density | Femur | Spine (lumbar) | SOST protein | Bone turnover | Bisphosphonates | Hip | Post-menopause | Bone resorption | Alendronic acid | Bone growth | Bone mass | Parathyroid hormone | Older people | Bone mineral density | Bone density | Osteogenesis
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10. Full Text Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo‐Controlled FREEDOM Trial and Its Extension
by Cummings, Steven R and Ferrari, Serge and Eastell, Richard and Gilchrist, Nigel and Jensen, Jens‐Erik Beck and McClung, Michael and Roux, Christian and Törring, Ove and Valter, Ivo and Wang, Andrea T and Brown, Jacques P
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2018, Volume 33, Issue 2, pp. 190 - 198
ABSTRACT Denosumab reduces bone resorption and vertebral and nonvertebral fracture risk. Denosumab discontinuation increases bone turnover markers 3 months... 
VERTEBRAL FRACTURES | BONE RESORPTION | DENOSUMAB | MULTIPLE VERTEBRAL FRACTURES | DISCONTINUATION | DENSITY | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | EXPOSURE | Clinical trials | Bones | Fractures | Density | Analysis | Bone resorption | Vertebrae | Bone mineral density | Bone turnover | Hip
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11. Full Text Bone turnover markers: Defining a therapeutic target
by Brown, Jacques P
Clinical Biochemistry, ISSN 0009-9120, 05/2016, Volume 49, Issue 7-8, pp. 527 - 528
WOMEN | POSTMENOPAUSAL OSTEOPOROSIS | RESORPTION | REDUCTION | SERUM ASSAY | I COLLAGEN | VERTEBRAL FRACTURE | TERIPARATIDE | MEDICAL LABORATORY TECHNOLOGY | TELOPEPTIDES | ALENDRONATE | Biomarkers - metabolism | Osteoporosis - drug therapy | Osteoporosis - metabolism | Bone Remodeling | Bone and Bones - metabolism | Humans
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12. Full Text 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: Summary
by Papaioannou, Alexandra and Morin, Suzanne and Cheung, Angela M and Atkinson, Stephanie and Brown, Jacques P and Feldman, Sidney and Hanley, David A and Hodsman, Anthony and Jamal, Sophie A and Kaiser, Stephanie M and Kvern, Brent and Siminoski, Kerry and Leslie, William D and Sci Advisory Council Osteoporosis and Scientific Advisory Council of Osteoporosis Canada and for the Scientific Advisory Council of Osteoporosis Canada
CMAJ, ISSN 0820-3946, 11/2010, Volume 182, Issue 17, pp. 1864 - 1873
Competing interests: All authors received consulting fees and travel support from Osteoporosis Canada during the preparation of this article. In addition,... 
ZOLEDRONIC ACID | HIP FRACTURE | MEDICINE, GENERAL & INTERNAL | ORAL BISPHOSPHONATES | LOW BONE-DENSITY | CARE GAP | VERTEBRAL FRACTURE | QUALITY-OF-LIFE | ESOPHAGEAL CANCER | POSTMENOPAUSAL WOMEN | PREVENT FRACTURES | Bone Density | Age Factors | Bone Density Conservation Agents - adverse effects | Osteoporosis - therapy | Humans | Middle Aged | Osteoporosis - diagnosis | Osteoporotic Fractures - prevention & control | Risk Factors | Bone Density Conservation Agents - therapeutic use | Male | Exercise Therapy | Canada | Accidental Falls - prevention & control | Calcium - therapeutic use | Female | Vitamin D - therapeutic use | Dietary Supplements | Osteoporosis | Care and treatment | Fractures | Diagnosis | Pharmaceutical industry | Risk factors | Cancer | Bone density | Clinical medicine | Review
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13. Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
by Numan, Mohamed Saber and Brown, Jacques P and Michou, Laeetitia
International Journal of Environmental Research and Public Health, ISSN 1661-7827, 02/2015, Volume 12, Issue 2, pp. 2289 - 2289
Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging... 
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14. Full Text Comparative Analysis of the Radiology of Osteoporotic Vertebral Fractures in Women and Men: Cross‐Sectional and Longitudinal Observations from the Canadian Multicentre Osteoporosis Study (CaMos)
by Lentle, Brian C and Berger, Claudie and Probyn, Linda and Brown, Jacques P and Langsetmo, Lisa and Fine, Ben and Lian, Kevin and Shergill, Arvind K and Trollip, Jacques and Jackson, Stuart and Leslie, William D and Prior, Jerilynn C and Kaiser, Stephanie M and Hanley, David A and Adachi, Jonathan D and Towheed, Tanveer and Davison, K Shawn and Cheung, Angela M and Goltzman, David and CaMos Res Grp and CaMos Research Group
Journal of Bone and Mineral Research, ISSN 0884-0431, 04/2018, Volume 33, Issue 4, pp. 569 - 579
ABSTRACT We compared two methods for osteoporotic vertebral fracture (VF) assessment on lateral spine radiographs, the Genant semiquantitative (GSQ) technique... 
OSTEOPOROSIS | RADIOLOGY | FRACTURE RISK | NON‐VERTEBRAL FRACTURES | VERTEBRAL FRACTURE PREVALENCE AND INCIDENCE | NON-VERTEBRAL FRACTURES | RISK-FACTORS | PREVALENT | DEFORMITIES | VICE-VERSA | AGREEMENT | DENSITY | ENDOCRINOLOGY & METABOLISM | OLDER MEN | POSTMENOPAUSAL WOMEN | BONE MASS | PROPORTION | Women | Osteoporosis | Fractures | Comparative analysis | Radiography | Vertebrae | Femur | Spine (lumbar) | Spine (thoracic) | Hormone replacement therapy | Bone mineral density | Hip
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15. Full Text Metabolic bone diseases Treating Paget disease: when matters more than how
by Brown, Jacques P
Nature Reviews Rheumatology, ISSN 1759-4790, 12/2009, Volume 5, Issue 12, pp. 663 - 665
DOUBLE-BLIND | RISEDRONATE | ETIDRONATE | RHEUMATOLOGY | Bone Density Conservation Agents - therapeutic use | Diphosphonates - therapeutic use | Osteitis Deformans - drug therapy | Humans | Treatment Failure | Randomized Controlled Trials as Topic
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16. Full Text Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
by Kendler, David L and Roux, Christian and Benhamou, Claude Laurent and Brown, Jacques P and Lillestol, Michael and Siddhanti, Suresh and Man, Hoi‐Shen and Martin, Javier San and Bone, Henry G
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2010, Volume 25, Issue 1, pp. 72 - 81
Patients treated with bisphosphonates for osteoporosis may discontinue or require a switch to other therapies. Denosumab binds to RANKL and is a potent... 
clinical trial | bone mineral density | RANKL | alendronate | denosumab | postmenopausal osteoporosis | Clinical trial | Bone mineral density | Alendronate | Denosumab | Postmenopausal osteoporosis | CLINICAL TRIAL | DRUG-THERAPY | NONVERTEBRAL FRACTURES | DENOSUMAB | PHASE-2 | ALENDRONATE | OSTEOPOROSIS | RATES | POSTMENOPAUSAL OSTEOPOROSIS | BONE MINERAL DENSITY | VERTEBRAL FRACTURE RISK | OSTEOPROTEGERIN LIGAND | LUMBAR SPINE | MASS | ENDOCRINOLOGY & METABOLISM | OSTEOCLAST DIFFERENTIATION | Collagen Type I - blood | Peptides - blood | Postmenopause - blood | Postmenopause - drug effects | Demography | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Bone Remodeling - drug effects | Alendronate - therapeutic use | Antibodies, Monoclonal, Humanized | RANK Ligand - pharmacology | Peptide Fragments - blood | Female | RANK Ligand - adverse effects | Bone Density Conservation Agents - adverse effects | Antibodies, Monoclonal - pharmacology | Lumbar Vertebrae - drug effects | Procollagen - blood | Biomarkers - blood | Hip | Bone Density Conservation Agents - pharmacology | Alendronate - adverse effects | Bone Density - drug effects | Alendronate - pharmacology | Aged | Femur Neck - drug effects | Osteoporosis | Bone density | Hormone replacement therapy
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