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1. Full Text Response to "unexpected mutations after CRISPR-Cas9 editing in vivo"
by Nutter, Lauryl M.J and Heaney, Jason D and Kent Lloyd, K.C and Murray, Stephen A and Seavitt, John R and Skarnes, William C and Teboul, Lydia and Brown, Steve D.M and Moore, Mark
Nature Methods, ISSN 1548-7091, 04/2018, Volume 15, Issue 4, pp. 235 - 236
SYSTEM | MICE | BIOCHEMICAL RESEARCH METHODS | Mutation | Gene Editing | CRISPR-Cas Systems | Clustered Regularly Interspaced Short Palindromic Repeats | Restriction enzymes, DNA | Gene mutations | Nucleotide sequence | Causes of | Physiological aspects | Genetic engineering | Genetic aspects | Health aspects | Methods | CRISPR
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2. Full Text A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways
by Agnew, Thomas and Goldsworthy, Michelle and Aguilar, Carlos and Morgan, Anna and Simon, Michelle and Hilton, Helen and Esapa, Chris and Wu, Yixing and Cater, Heather and Bentley, Liz and Scudamore, Cheryl and Poulton, Joanna and Morten, Karl J and Thompson, Kyle and He, Langping and Brown, Steve D.M and Taylor, Robert W and Bowl, Michael R and Cox, Roger D
Cell Reports, ISSN 2211-1247, 12/2018, Volume 25, Issue 12, pp. 3315 - 3328.e6
Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic... 
adiposity | ISR | hypertrophic cardiomyopathy | mitochondrial dysfunction | deafness | pleiotropic | WARS2 | RESPIRATORY-CHAIN DEFICIENCY | HEARING-LOSS | HYPERTROPHIC CARDIOMYOPATHY | GENE | TRANSFER-RNA SYNTHETASE | LACTIC-ACIDOSIS | MUTATIONS | INDUCTION | MITOCHONDRIAL MYOPATHY | FGF21 | CELL BIOLOGY
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3. Full Text The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping
by Brown, Steve D. M and Moore, Mark W
Mammalian Genome, ISSN 0938-8990, 10/2012, Volume 23, Issue 9, pp. 632 - 640
Determining the function of all mammalian genes remains a major challenge for the biomedical science community in the 21st century. The goal of the... 
Life Sciences | Anatomy | Zoology | Cell Biology | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EUROPHENOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | FUNCTIONAL ANNOTATION | EMPRESS | MICROSCOPY | GENOME | MORPHOLOGY | RESOURCE | Phenotype | Mice | Animals | Internationality | Mice, Mutant Strains | Indexing in process
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4. Full Text Disease model discovery and translation. Introduction
by Brown, Steve D M
Mammalian genome : official journal of the International Mammalian Genome Society, 2011, Volume 22, Issue 7-8, p. 361
Animals | Disease - genetics | Humans | Translational Medical Research | Drug Therapy | Disease Models, Animal
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5. Full Text Genetic landscape of auditory dysfunction
by Bowl, Michael R and Brown, Steve D M
Human Molecular Genetics, ISSN 0964-6906, 08/2018, Volume 27, Issue R2, pp. R130 - R135
Abstract Over the past 25 years, human and mouse genetics research together has identified several hundred genes essential for mammalian hearing, leading to a... 
ENU MUTAGENESIS | HAIR-CELLS | SENSORINEURAL HEARING-LOSS | MUTAGENESIS SCREENS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GENETICS & HEREDITY | MICE | DEAFNESS | THRESHOLDS | GENOME-WIDE ASSOCIATION | IMPAIRMENT
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6. Full Text The Kir5.1 Potassium Channel is an Important Determinant of Neuronal PCO2/pH Sensitivity
by D'Adamo, M. Cristina and Shang, Lijun and Imbrici, Paola and Brown, Steve D.M and Pessia, Mauro and Tucker, Stephen J
Biophysical Journal, ISSN 0006-3495, 2011, Volume 100, Issue 3, pp. 430a - 430a
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7. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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8. Full Text Towards an encyclopaedia of mammalian gene function: The International Mouse Phenotyping Consortium
by Brown, Steve D. M and Moore, Mark W
DMM Disease Models and Mechanisms, ISSN 1754-8403, 05/2012, Volume 5, Issue 3, pp. 289 - 292
PATHOLOGY | RESOURCE | CELL BIOLOGY | Mammals - genetics | Phenotype | Pilot Projects | Animals | Alleles | International Cooperation | Mice | Encyclopedias as Topic | Mice, Knockout
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9. Full Text High-throughput mouse phenomics for characterizing mammalian gene function
by Brown, Steve D. M and Holmes, Chris C and Mallon, Ann-Marie and Meehan, Terrence F and Smedley, Damian and Wells, Sara
Nature Reviews Genetics, ISSN 1471-0056, 06/2018, Volume 19, Issue 6, pp. 357 - 370
We are entering a new era of mouse phenomics, driven by large-scale and economical generation of mouse mutants coupled with increasingly sophisticated and... 
ENU MUTAGENESIS | COLLABORATIVE CROSS | AUTISTIC-LIKE BEHAVIORS | HUMAN-DISEASE | GENETICS & HEREDITY | MENDELIAN DISORDERS | GENOME-WIDE | PHENOTYPING CONSORTIUM | KNOCKOUT MICE | RECOMBINANT INBRED LINES | COMPLEX TRAITS | Usage | Rats as laboratory animals | Genetic variation | Analysis | Machine learning | Genetic aspects | Research | High-throughput screening (Biochemical assaying) | Genotype & phenotype | Learning algorithms | Animal models | Phenotypes | Rodents | Phenotyping | Genetic diversity
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10. Full Text A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
by Simon, Michelle M and Greenaway, Simon and White, Jacqueline K and Fuchs, Helmut and Gailus-Durner, Valérie and Wells, Sara and Sorg, Tania and Wong, Kim and Bedu, Elodie and Cartwright, Elizabeth J and Dacquin, Romain and Djebali, Sophia and Estabel, Jeanne and Graw, Jochen and Ingham, Neil J and Jackson, Ian J and Lengeling, Andreas and Mandillo, Silvia and Marve, Jacqueline and Meziane, Hamid and Preitner, Frédéric and Puk, Oliver and Roux, Michel and Adams, David J and Atkins, Sarah and Ayadi, Abdel and Becker, Lore and Blake, Andrew and Brooker, Debra and Cater, Heather and Champy, Marie-France and Combe, Roy and Danecek, Petr and Di Fenza, Armida and Gates, Hilary and Gerdin, Anna-Karin and Golini, Elisabetta and Hancock, John M and Hans, Wolfgang and Hölter, Sabine M and Hough, Tertius and Jurdic, Pierre and Keane, Thomas M and Morgan, Hugh and Müller, Werner and Neff, Frauke and Nicholson, George and Pasche, Bastian and Roberson, Laura-Anne and Rozman, Jan and Sanderson, Mark and Santos, Luis and Selloum, Mohammed and Shannon, Carl and Southwel, Anne and Tocchini-Valentini, Glauco P and Vancollie, Valerie E and Westerberg, Henrik and Wurst, Wolfgang and Zi, Min and Yalcin, Binnaz and Ramirez-Solis, Ramiro and Steel, Karen P and Mallon, Ann-Marie and De Angelis, Martin Hrabe and Herault, Yann and Brown, Steve D.M
Genome Biology, ISSN 1474-7596, 2013, Volume 14, Issue 7, pp. R82 - R82
Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More... 
Mouse phenotyping | Sequence variation | Gene knockout | C57BL/6 | Mouse inbred lines | mouse phenotyping | VARIANTS | sequence variation | SUBSTRAINS | gene knockout | DATABASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | MICE | SEQUENCING DATA | COMPLEX TRAITS | GENE-FUNCTION | RESOURCE | Eye - pathology | Spleen - immunology | Mice, Inbred C57BL | Genome - genetics | Hypersensitivity - immunology | INDEL Mutation - genetics | Male | Disease Resistance - immunology | Femur - diagnostic imaging | X-Ray Microtomography | Behavior, Animal | Phenotype | Animals | Maze Learning | Listeriosis - immunology | Killer Cells, Natural - immunology | Polymorphism, Single Nucleotide - genetics | Female | Listeriosis - microbiology | Life Sciences | Genetics | Biochemistry, Molecular Biology | Genomics | Research | C57BL
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11. Full Text The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
by Koscielny, Gautier and Yaikhom, Gagarine and Iyer, Vivek and Meehan, Terrence F and Morgan, Hugh and Atienza-Herrero, Julian and Blake, Andrew and Chen, Chao-Kung and Easty, Richard and Di Fenza, Armida and Fiegel, Tanja and Grifiths, Mark and Horne, Alan and Karp, Natasha A and Kurbatova, Natalja and Mason, Jeremy C and Matthews, Peter and Oakley, Darren J and Qazi, Asfand and Regnart, Jack and Retha, Ahmad and Santos, Luis A and Sneddon, Duncan J and Warren, Jonathan and Westerberg, Henrik and Wilson, Robert J and Melvin, David G and Smedley, Damian and Brown, Steve D. M and Flicek, Paul and Skarnes, William C and Mallon, Ann-Marie and Parkinson, Helen
Nucleic Acids Research, ISSN 0305-1048, 01/2014, Volume 42, Issue 1, pp. D802 - D809
The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of... 
RESOURCES | GENOME-WIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-FUNCTION | Phenotype | Animals | Biological Ontologies | Databases, Genetic | Mice | Internet | Mice, Knockout | V. Human genome, model organisms, comparative genomics
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12. Full Text Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
by Tateossian, Hilda and Morse, Susan and Parker, Andrew and Mburu, Philomena and Warr, Nick and Acevedo-Arozena, Abraham and Cheeseman, Michael and Wells, Sara and Brown, Steve D.M
Human Molecular Genetics, ISSN 0964-6906, 07/2013, Volume 22, Issue 13, pp. 2553 - 2565
Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest... 
Hair Cells, Auditory - pathology | Epithelial Cells - metabolism | Male | Ear, Middle - metabolism | Female | Otitis Media - genetics | Ear, Middle - pathology | Craniofacial Abnormalities - genetics | Disease Models, Animal | Otitis Media - pathology | Signal Transduction | Otitis Media - metabolism | Repressor Proteins - genetics | Genotype | Homeodomain Proteins - genetics | Mice, Knockout | Hearing Loss - genetics | Placenta - metabolism | Pregnancy | Hair Cells, Auditory - ultrastructure | Homozygote | Phenotype | Animals | Mice | Mutation | Transforming Growth Factor beta - metabolism | Cytokines - biosynthesis
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13. Full Text Disease model discovery from 3,328 gene knockouts by the International Mouse Phenotyping Consortium
by Meehan, Terrence F and Conte, Nathalie and West, David B and Jacobsen, Julius O and Mason, Jeremy and Warren, Jonathan and Chen, Chao-Kung and Tudose, Ilinca and Relac, Mike and Matthews, Peter and Karp, Natasha and Santos, Luis and Fiegel, Tanja and Ring, Natalie and Westerberg, Henrik and Greenaway, Simon and Sneddon, Duncan and Morgan, Hugh and Codner, Gemma F and Stewart, Michelle E and Brown, James and Horner, Neil and Haendel, Melissa and Washington, Nicole and Mungall, Christopher J and Reynolds, Corey L and Gallegos, Juan and Gailus-Durner, Valerie and Sorg, Tania and Pavlovic, Guillaume and Bower, Lynette R and Moore, Mark and Morse, Iva and Gao, Xiang and Tocchini-Valentini, Glauco P and Obata, Yuichi and Cho, Soo Young and Seong, Je Kyung and Seavitt, John and Beaudet, Arthur L and Dickinson, Mary E and Herault, Yann and Wurst, Wolfgang and De Angelis, Martin Hrabe and Kent Lloyd, K.C and Flenniken, Ann M and Nutter, Lauryl M J and Newbigging, Susan and McKerlie, Colin and Justice, Monica J and Murray, Stephen A and Svenson, Karen L and Braun, Robert E and White, Jacqueline K and Bradley, Allan and Flicek, Paul and Wells, Sara and Skarnes, William C and Adams, David J and Parkinson, Helen and Mallon, Ann-Marie and Brown, Steve D.M and Smedley, Damian and Int Mouse Phenotyping Consortium and International Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1231 - 1238
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies... 
RESOURCES | DATABASE | GENETICS & HEREDITY | GENOME-WIDE | ONTOLOGY | MICE | GENERATION | EXPRESSION ATLAS | MUTATIONS | ASSOCIATION | ORGANISM | Genetic Predisposition to Disease | Phenotype | Animals | Humans | Female | Genetic Diseases, Inborn | Male | Mice | Gene Knockout Techniques | Disease Models, Animal | Mice, Knockout | Usage | Genetic aspects | Research | Animal models in research | Genomics | Heart | Animal models | Ontology | Disease | Genes | Disorders | Genomes | Statistical methods | Data bases | Gene sequencing | Consortia | Signal transduction | Annotations | Rodents | Right ventricular dysplasia | Dysplasia | Automation | Gene expression | Ventricular dysplasia | Diseases | Studies | Acids | Phenotyping | Diagnostic systems | Mutation | Ventricle
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