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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2004, Volume 279, Issue 48, pp. 50110 - 50119
Turnover of cyclin E is controlled by SCF Fbw7 . Three isoforms of Fbw7 are produced by alternative splicing. Whereas Fbw7α and -γ are nuclear and the... 
COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | MULTISITE PHOSPHORYLATION | C-MYC | KAPPA-B-ALPHA | CELL-CYCLE | PROTEOLYSIS | BETA-CATENIN | F-BOX PROTEIN | DEPENDENT DEGRADATION
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2341 - 2341
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2019, Volume 15, Issue 1, pp. e1007543 - e1007543
Merkel cell polyomavirus (MCPyV) accounts for 80% of all Merkel cell carcinoma (MCC) cases through expression of two viral oncoproteins: the truncated large T... 
Ubiquitin | Phosphates | Transformation | Phosphorylation | Immunoprecipitation | Stabilization | Lysergic acid diethylamide | c-Myc protein | Amino acids | Biology | Lysergide | Myc protein | Kinases | Skin cancer | Proteins | Cell cycle | Tumorigenesis | Cyclin E | Research centers | Antigens | Medical research | Latency | Transformations (mathematics) | Antigen (tumor-associated) | Binding sites | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2004, Volume 101, Issue 24, pp. 9085 - 9090
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 22, pp. 8954 - 8959
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2005, Volume 4, Issue 10, pp. 1356 - 1359
SCF ubiquitin ligases regulate the degradation of many proteins involved in thecontrol of cell division and growth. F-box proteins are the SCF components that... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Ubiquitination | Ras | Cell cycle | SCF complex | Cyclin E | Tumorigenesis | Fbw7 | cell cycle | CYCLIN-E DEGRADATION | C-MYC | MULTISITE PHOSPHORYLATION | CHROMOSOMAL INSTABILITY | ENDOMETRIAL CANCER | CELL BIOLOGY | cyclin E | ubiquitination | tumorigenesis | MUTATIONS | PHOSPHORYLATION-DEPENDENT DEGRADATION | F-BOX PROTEIN | FBW7 UBIQUITIN LIGASE | TRANSGENIC MICE
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 308 - 308
Journal Article
Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 11, pp. 2425 - 2439
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells... 
WEE1 | CRISPR-Cas9 | Glioblastoma | cancer therapeutics | functional genomics | PKMYT1 | gene editing | Myt1 | Cancer therapeutics | Gene editing | Functional genomics | ACTIVATION | PROTEIN | GENE-EXPRESSION | GOLGI | PHOSPHORYLATES CDC2 | HUMAN MYT1 | INHIBITORY KINASE | BRAIN | RNAI SCREEN | REQUIREMENT | CELL BIOLOGY | Neoplastic Stem Cells - cytology | Phosphorylation | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Microscopy, Video | Time-Lapse Imaging | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Gene Library | CDC2 Protein Kinase - antagonists & inhibitors | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | CRISPR-Cas Systems - genetics | Membrane Proteins - antagonists & inhibitors | Glioblastoma - pathology | Nuclear Proteins - antagonists & inhibitors | Cyclin B - metabolism | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2014, Volume 26, Issue 4, pp. 455 - 464
Tumor suppressors with widespread impact on carcinogenesis control broad spectra of oncogenic pathways. Protein degradation is an emerging mechanism by which... 
Journal Article
Journal Article
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