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European Journal of Immunology, ISSN 0014-2980, 10/2010, Volume 40, Issue 10, pp. 2932 - 2941
Journal Article
Journal Article
Journal Article
Protein Engineering, Design & Selection, ISSN 1741-0126, 10/2011, Volume 24, Issue 10, pp. 791 - 799
Mice carrying human immunoglobulin transloci were immunised with HIV-1 gp140 antigen to gain insight into the range and nature of human monoclonal antibodies... 
antibody engineering | transgenic mice | somatic mutation | humanised mice | affinity maturation | BIOCHEMISTRY & MOLECULAR BIOLOGY | FULLY HUMAN-ANTIBODIES | GP120 | REGION | B-CELLS | HEAVY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FOLLICULAR DENDRITIC CELLS | GENERATION | DIVERSITY | EXPRESSION | Hybridomas - metabolism | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | B-Lymphocyte Subsets - cytology | env Gene Products, Human Immunodeficiency Virus - metabolism | Immunoglobulin M - immunology | Acquired Immunodeficiency Syndrome - genetics | Chromosomes, Artificial, Yeast - genetics | Immunoglobulin M - metabolism | env Gene Products, Human Immunodeficiency Virus - genetics | B-Lymphocyte Subsets - immunology | Antibodies, Monoclonal - immunology | Immunoglobulin M - genetics | Acquired Immunodeficiency Syndrome - metabolism | Mice, Transgenic | Genes, Immunoglobulin | Antibodies, Monoclonal - genetics | Animals | B-Lymphocyte Subsets - metabolism | Acquired Immunodeficiency Syndrome - pathology | Hybridomas - immunology | Immunoglobulin Variable Region - genetics | Mice | Antibodies, Monoclonal - metabolism | Hybridomas - cytology | Translocation, Genetic - genetics | Immunoglobulin M | Immunization | Immunoglobulins | somatic hypermutation | Lymphocytes B | Immunoglobulin G | Heavy chains | Hybridoma | Monoclonal antibodies | Epitopes
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2013, Volume 190, Issue 4, pp. 1481 - 1490
Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively... 
Journal Article
Molecular Immunology, ISSN 0161-5890, 08/2008, Volume 45, Issue 13, pp. 3573 - 3579
Nascent, full length, immunoglobulin (Ig) heavy (H)-chains are post- translationally associated with H-chain-binding protein (BiP or GRP78) in the endoplasmic... 
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2005, Volume 175, Issue 6, pp. 3769 - 3779
In mature B cells of mice and most mammals, cellular release of single H chain Abs without L chains is prevented by H chain association with Ig-specific... 
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2007, Volume 204, Issue 13, pp. 3271 - 3283
In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H... 
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/1997, Volume 386, Issue 6620, pp. 25 - 26
Researchers have described the creation of mice in which large sections of the human immunoglobulin gene loci have been integrated into the germ line. This... 
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 11/1999, Volume 294, Issue 2, pp. 457 - 465
The expressed human immunoglobulin V sub( lambda ) repertoire demonstrates a strong bias in the use of individual V sub( lambda ) segments. Mechanisms that... 
Repertoire | Transgenic mouse | Immunoglobulin | Lambda | Rearrangement | Immunoglobulin V
Journal Article
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