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by Turcot, Valérie and Lu, Yingchang and Highland, Heather M and Schurmann, Claudia and Justice, Anne E and Fine, Rebecca S and Bradfield, Jonathan P and Esko, Tõnu and Giri, Ayush and Graff, Mariaelisa and Guo, Xiuqing and Hendricks, Audrey E and Karaderi, Tugce and Lempradl, Adelheid and Locke, Adam E and Mahajan, Anubha and Marouli, Eirini and Sivapalaratnam, Suthesh and Young, Kristin L and Alfred, Tamuno and Feitosa, Mary F and Masca, Nicholas G. D and Manning, Alisa K and Medina-Gomez, Carolina and Mudgal, Poorva and Ng, Maggie C. Y and Reiner, Alex P and Vedantam, Sailaja and Willems, Sara M and Winkler, Thomas W and Abecasis, Gonçalo and Aben, Katja K and Alam, Dewan S and Alharthi, Sameer E and Allison, Matthew and Amouyel, Philippe and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Bang, Lia E and Barroso, Inês and Bastarache, Lisa and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boehnke, Michael and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Brumat, Marco and Burt, Amber A and Butterworth, Adam S and Campbell, Peter T and Cappellani, Stefania and Carey, David J and Catamo, Eulalia and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der I and Chowdhury, Rajiv and Christensen, Cramer and Chu, Audrey Y and Cocca, Massimiliano and Cook, James P and Corley, Janie and Corominas Galbany, Jordi and Cox, Amanda J and Crosslin, David S and Cuellar-Partida, Gabriel and D'Eustacchio, Angela and Danesh, John and Davies, Gail and Bakker, Paul I. W and Groot, Mark C. H and Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and Heijer, Martin and Hollander, Anneke I and Ruijter, Hester M and Dennis, Joe G and Denny, Josh C and Angelantonio, Emanuele and Drenos, Fotios and Du, Mengmeng and Dubé, Marie-Pierre and Dunning, Alison M and Easton, Douglas F and Edwards, Todd L and ... and Chd Exome Consortium and EPIC InterAct Consortium and Global Lipids Genetic Consortium and GoT2D Genes Consortium and MAGIC Investigators and Understanding Soc Sci Grp and ReproGen Consortium and Interval Study and Epic-Cvd Consortium and ExomeBP Consortium and T2D-Genes Consortium and INTERVAL Study and EPIC-CVD Consortium and EPIC InterAct Consortium and CHD Exome+ Consortium and Understanding Society Scientific Group and The MAGIC Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Allmänmedicin and Umeå universitet and Medicin
Nature Genetics, ISSN 1061-4036, 01/2018, Volume 50, Issue 1, pp. 26 - 35
Journal Article
by Evangelou, Evangelos and Warren, Helen R and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia P and Karaman, Ibrahim and Ng, Fu Liang and Evangelou, Marina and Witkowska, Katarzyna and Tzanis, Evan and Hellwege, Jacklyn N and Giri, Ayush and Velez Edwards, Digna R and Sun, Yan V and Cho, Kelly and Gaziano, J. Michael and Wilson, Peter W. F and Tsao, Philip S and Kovesdy, Csaba P and Esko, Tonu and Mägi, Reedik and Milani, Lili and Almgren, Peter and Boutin, Thibaud and Debette, Stéphanie and Ding, Jun and Giulianini, Franco and Holliday, Elizabeth G and Jackson, Anne U and Li-Gao, Ruifang and Lin, Wei-Yu and Luan, Jian’an and Mangino, Massimo and Oldmeadow, Christopher and Prins, Bram Peter and Qian, Yong and Sargurupremraj, Muralidharan and Shah, Nabi and Surendran, Praveen and Thériault, Sébastien and Verweij, Niek and Willems, Sara M and Zhao, Jing-Hua and Amouyel, Philippe and Connell, John and de Mutsert, Renée and Doney, Alex S. F and Farrall, Martin and Menni, Cristina and Morris, Andrew D and Noordam, Raymond and Paré, Guillaume and Poulter, Neil R and Shields, Denis C and Stanton, Alice and Thom, Simon and Abecasis, Gonçalo and Amin, Najaf and Arking, Dan E and Ayers, Kristin L and Barbieri, Caterina M and Batini, Chiara and Bis, Joshua C and Blake, Tineka and Bochud, Murielle and Boehnke, Michael and Boerwinkle, Eric and Boomsma, Dorret I and Bottinger, Erwin P and Braund, Peter S and Brumat, Marco and Campbell, Archie and Campbell, Harry and Chakravarti, Aravinda and Chambers, John C and Chauhan, Ganesh and Ciullo, Marina and Cocca, Massimiliano and Collins, Francis and Cordell, Heather J and Davies, Gail and Borst, Martin H. de and Geus, Eco J. de and Deary, Ian J and Deelen, Joris and Del Greco M, Fabiola and Demirkale, Cumhur Yusuf and Dörr, Marcus and Ehret, Georg B and Elosua, Roberto and Enroth, Stefan and Erzurumluoglu, A. Mesut and Ferreira, Teresa and Frånberg, Mattias and Franco, Oscar H and Gandin, Ilaria and ... and Million Vet Program and Million Veteran Program and the Million Veteran Program and Stockholms universitet and Matematiska institutionen and Naturvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 10/2018, Volume 50, Issue 10, pp. 1412 - 1425
Journal Article
by Day, Felix R and Thompson, Deborah J and Helgason, Hannes and Chasman, Daniel I and Finucane, Hilary and Sulem, Patrick and Ruth, Katherine S and Whalen, Sean and Sarkar, Abhishek K and Albrecht, Eva and Altmaier, Elisabeth and Amini, Marzyeh and Barbieri, Caterina M and Boutin, Thibaud and Campbell, Archie and Demerath, Ellen and Giri, Ayush and He, Chunyan and Hottenga, Jouke J and Karlsson, Robert and Kolcic, Ivana and Loh, Po-Ru and Lunetta, Kathryn L and Mangino, Massimo and Marco, Brumat and McMahon, George and Medland, Sarah E and Nolte, Ilja M and Noordam, Raymond and Nutile, Teresa and Paternoster, Lavinia and Perjakova, Natalia and Porcu, Eleonora and Rose, Lynda M and Schraut, Katharina E and Segre, Ayellet V and Smith, Albert V and Stolk, Lisette and Teumer, Alexander and Anulis, Irene L and Bandinelli, Stefania and Beckmann, Matthias W and Benitez, Javier and Bergmann, Sven and Bochud, Murielle and Boerwinkle, Eric and Bojesen, Stig E and Bolla, Manjeet K and Brand, Judith S and Brauch, Hiltrud and Brenner, Hermann and Broer, Linda and Bruning, Thomas and Buring, Julie E and Campbell, Harry and Catamo, Eulalia and Chanock, Stephen and Chenevix-Trench, Georgia and Corre, Tanguy and Couch, Fergus J and Cousminer, Diana L and Cox, Angela and Crisponi, Laura and Czene, Kamila and Smith, George Davey and de Geus, Eco J. C. N and de Mutsert, Renee and De Vivo, Immaculata and Dennis, Joe and Devilee, Peter and dos-Santos-Silva, Isabel and Dunning, Alison M and Eriksson, Johan G and Fasching, Peter A and Fernandez-Rhodes, Lindsay and Ferrucci, Luigi and Flesch-Janys, Dieter and Franke, Lude and Gabrielson, Marike and Gandin, Ilaria and Giles, Graham G and Grallert, Harald and Gudbjartsson, Daniel F and Guenel, Pascal and Hall, Per and Hallberg, Emily and Hamann, Ute and Harris, Tamara B and Hartman, Catharina A and Heiss, Gerardo and Hooning, Maartje J and Hopper, John L and Hu, Frank and Hunter, David J and Ikram, M. Arfan and Im, Hae Kyung and Jarvelin, Marjo-Riitta and Joshi, Peter K and Karasik, David and Kellis, Manolis and ... and Endometrial Canc Accoc Consortium and InterAct Consortium and PRACTICAl Consortium and kConFab AOCS Investigators and LifeLines Cohort Study and Ovarian Canc Accoc Consortium and kConFab/AOCS Investigators and Ovarian Cancer Association Consortium and PRACTICAL consortium and Endometrial Cancer Association Consortium and The InterAct Consortium and The LifeLines Cohort Study
Nature Genetics, ISSN 1061-4036, 06/2017, Volume 49, Issue 6, pp. 834 - 841
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes... 
REGRESSION | METAANALYSIS | METABOLISM | GROWTH | GENETICS & HEREDITY | BODY-MASS INDEX | LOCI | WIDE ASSOCIATION | MENDELIAN RANDOMIZATION | TRAITS | INHERITANCE | Body Mass Index | Genomic Imprinting | Genetic Predisposition to Disease | Genome-Wide Association Study | Age Factors | Membrane Proteins - genetics | Menarche - genetics | Humans | Risk Factors | Intercellular Signaling Peptides and Proteins - genetics | Databases, Genetic | Male | Puberty - genetics | Neoplasms - genetics | Adolescent | Female | Ribonucleoproteins - genetics | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genetic variation | Menarche | Genetic aspects | Gene expression | Health aspects | Carcinogenesis | Risk factors | Enrichment | Transcription | Laboratories | Genomics | Genes | Risk | Genomes | Tissues | Preadipocyte factor 1 | Epidemiology | Variance | Complexity | Body mass index | Mens health | Randomization | Coding | Genetics | Trends | Children | Endometrium | Public health | Age | Medical research | Puberty | Internal medicine | Gynecology | Health risks | Time measurement | Obstetrics | Diseases | Medicine | Studies | Hospitals | Body mass | Womens health | Men | Breast | Links | Heritability | Polygenic inheritance | Prostate cancer | Prostate | Endocrinology | Cancer | InterAct Consortium | AOCS Investigators | PRACTICAL consortium | Endometrial Cancer Association Consortium | Ovarian Cancer Association Consortium | LifeLines Cohort Study | kConFab
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2018, Volume 50, Issue 5, pp. 652 - 656
Journal Article
FRONTIERS IN GENETICS, ISSN 1664-8021, 02/2019, Volume 10, p. 142
Age-related hearing loss (ARHL) is the most common sensory impairment in the elderly affecting millions of people worldwide. To shed light on the genetics of... 
PDZ-DOMAIN | ZEBRAFISH | new gene discovery | next-generation sequencing | zebrafish model | HIGHLY EFFICIENT | OTIC VESICLE | INHIBITION | SCREEN | CRISPR-Cas9 | EAR | GENETICS & HEREDITY | hearing loss | MUTATIONS | EXPRESSION | GENOME-WIDE ASSOCIATION | Animal experimentation | Prevention | Usage | Care and treatment | Genetic aspects | Diagnosis | High-throughput screening (Biochemical assaying) | Hearing loss
Journal Article
by Noordam, Raymond and Young, William J and Salman, Reem and Kanters, Jørgen K and van den Berg, Marten E and van Heemst, Diana and Lin, Henry J and Barreto, Sandhi Maria and Biggs, Mary L and Biino, Ginevra and Catamo, Eulalia and Concas, Maria Pina and Ding, Jun and Evans, Daniel S and Foco, Luisa and Grarup, Niels and Lyytikäinen, Leo-Pekka and Mangino, Massimo and Mei, Hao and van der Most, Peter J and Müller-Nurasyid, Martina and Nelson, Christopher P and Qian, Yong and Repetto, Linda and Said, M. Abdullah and Shah, Nabi and Schramm, Katharina and Vidigal, Pedro G and Weiss, Stefan and Yao, Jie and Zilhao, Nuno R and Brody, Jennifer A and Braund, Peter S and Brumat, Marco and Campana, Eric and Christofidou, Paraskevi and Caulfield, Mark J and De Grandi, Alessandro and Dominiczak, Anna F and Doney, Alex S.F and Eiriksdottir, Gudny and Ellervik, Christina and Giatti, Luana and Gögele, Martin and Graff, Claus and Guo, Xiuqing and van der Harst, Pim and Joshi, Peter K and Kähönen, Mika and Kestenbaum, Bryan and Lima-Costa, Maria F and Linneberg, Allan and Maan, Arie C and Meitinger, Thomas and Padmanabhan, Sandosh and Pattaro, Cristian and Peters, Annette and Petersmann, Astrid and Sever, Peter and Sinner, Mortiz F and Shen, Xia and Stanton, Alice and Strauch, Konstantin and Soliman, Elsayed Z and Tarasov, Kirill V and Taylor, Kent D and Thio, Chris H.L and Uitterlinden, André G and Vaccargiu, Simona and Waldenberger, Melanie and Robino, Antonietta and Correa, Adolfo and Cucca, Francesco and Cummings, Steven R and Dörr, Marcus and Girotto, Giorgia and Gudnason, Vilmundur and Hansen, Torben and Heckbert, Susan R and Juhl, Christian R and Kääb, Stefan and Lehtimäki, Terho and Liu, Yongmei and Lotufo, Paulo A and Palmer, Colin N.A and Pirastu, Mario and Pramstaller, Peter P and Ribeiro, Antonio Luiz P and Rotter, Jerome I and Samani, Nilesh J and Snieder, Harold and Spector, Tim D and Stricker, Bruno H and Verweij, Niek and Wilson, James G and Wilson, James F and Jukema, J. Wouter and Tinker, Andrew and Newton-Cheh, Christopher H and Sotoodehnia, Nona and ...
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2019, Volume 73, Issue 24, pp. 3118 - 3131
Journal Article
by Kilpelainen, TO and Bentley, AR and Noordam, R and Sung, YJ and Schwander, K and Winkler, TW and Jakupovic, H and Chasman, DI and Manning, A and Ntalla, I and Aschard, H and Brown, MR and de las Fuentes, L and Franceschini, N and Guo, XQ and Vojinovic, D and Aslibekyan, S and Feitosa, MF and Kho, M and Musani, SK and Richard, M and Wang, HM and Wang, Z and Bartz, TM and Bielak, LF and Campbell, A and Dorajoo, R and Fisher, V and Hartwig, FP and Horimoto, ARVR and Li, CW and Lohman, KK and Marten, J and Sim, XL and Smith, AV and Tajuddin, SM and Alver, M and Amini, M and Boissel, M and Chai, JF and Chen, X and Divers, J and Evangelou, E and Gao, C and Graff, M and Harris, SE and He, MA and Hsu, FC and Jackson, AU and Zhao, JH and Kraja, AT and Kuhnel, B and Laguzzi, F and Lyytikainen, LP and Nolte, IM and Rauramaa, R and Riaz, M and Robino, A and Rueedi, R and Stringham, HM and Takeuchi, F and van der Most, PJ and Varga, TV and Verweij, N and Ware, EB and Wen, WQ and Li, XY and Yanek, LR and Amin, N and Arnett, DK and Boerwinkle, E and Brumat, M and Cade, B and Canouil, M and Chen, YDI and Concas, MP and Connell, J and de Mutsert, R and de Silva, HJ and de Vries, PS and Demirkan, A and Ding, JZ and Eaton, CB and Faul, JD and Friedlander, Y and Gabriel, KP and Ghanbari, M and Giulianini, F and Gu, CC and Gu, DF and Harris, TB and He, J and Heikkinen, S and Heng, CK and Hunt, SC and Ikram, MA and Jonas, JB and Koh, WP and Komulainen, P and Krieger, JE and ... and Lifelines Cohort Study
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 1 - 11
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects.... 
INDIVIDUALS | METAANALYSIS | CARBOXYLASE | SNP | MULTIDISCIPLINARY SCIENCES | WIDE ASSOCIATION | REVEAL | EXERCISE | Lipoproteins (low density) | Physical activity | Muscles | Lipids | Genomes | Metabolism | Loci | Low density lipoprotein | Blood | Cholesterol | Genetic effects | Gene loci | Lipid metabolism | Lipoproteins (high density)
Journal Article