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Journal Article
Science, ISSN 0036-8075, 11/2006, Volume 314, Issue 5801, pp. 994 - 997
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2017, Volume 127, Issue 11, pp. 4179 - 4192
Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EIF4E PHOSPHORYLATION | ACQUIRED-RESISTANCE | PHASE-II | TRANSLATION INITIATION | CANCER | MAP | INTERACTING KINASE 1 | IMATINIB MESYLATE | INDUCED HEPATOTOXICITY | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Signal Transduction | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Melanoma - enzymology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Mice, SCID | Melanoma - secondary | Dasatinib - pharmacology | Xenograft Model Antitumor Assays | Animals | Skin Neoplasms - enzymology | Melanoma - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Female | Mice, Inbred NOD | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Care and treatment | Phosphorylation | Gene mutations | Melanoma | Diagnosis | Research | Cell migration | Tyrosine | Translation | Transcription | Threonine | Leukocyte migration | Leukemia | Mucosa | Translation initiation | MAP kinase | Metastasis | Kinases | c-Kit protein | Metastases | Skin cancer | Cell growth | Cell cycle | Protein-tyrosine kinase receptors | Tumorigenesis | Mutation | Initiation factor eIF-4E | Protein-tyrosine kinase
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 08/2017, Volume 24, Issue 28, pp. 3025 - 3053
MAP kinase-interacting kinases (MNK1 and MNK2) are often activated downstream of ERK and p38 MAPK in the MAP kinase family. The role of MNKs in the development... 
Protein kinase | MNK1 MNK2 | Drug discovery | Small molecule | Kinase inhibitors | EIF4E phosphorylation | Cancer | C-TERMINI | small molecule | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | INITIATION-FACTOR 4E | ACUTE MYELOID-LEUKEMIA | eIF4E phosphorylation | CELL-CYCLE PROGRESSION | kinase inhibitors | drug discovery | PROSTATE-CANCER | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | cancer | Signal Transduction | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Protein Kinase Inhibitors - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Protein Kinase Inhibitors - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Phosphorylation | Transformation | Deregulation | Myc protein | Cyclin D1 | Kinases | Anticancer properties | Proteins | β-catenin | Angiogenesis | Smad2 protein | Cell cycle | Vascular endothelial growth factor | Translation | Hematology | DNA probes | RNA-mediated interference | Extracellular signal-regulated kinase | MAP kinase | Pharmacology | Ribonucleic acid--RNA | Mcl-1 protein | Inhibitors | Antitumor activity | Solid tumors | Initiation factor eIF-4E | Tumors
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2019, Volume 14, Issue 1, pp. 169 - 181
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 10/2015, Volume 1854, Issue 10, pp. 1617 - 1629
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 29, Issue 2, pp. 169 - 179
The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by... 
RNA | MOLIMMUNO | RESPONSES | HELICASE LGP2 | VIRUS | ACID | REPLICATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIVIRAL INNATE IMMUNITY | HOST | IDENTIFICATION | ADAPTER PROTEIN | CELL BIOLOGY | RNA Caps - immunology | RNA Helicases - metabolism | Zinc - metabolism | Humans | rab GTP-Binding Proteins - genetics | Structure-Activity Relationship | RNA Helicases - chemistry | Interferons - immunology | RNA Caps - metabolism | Zinc - chemistry | Adenosine Triphosphatases - immunology | Interferon-Induced Helicase, IFIH1 | RNA, Viral - genetics | Immunity, Innate - physiology | RNA Caps - chemistry | Zinc - immunology | RNA Helicases - genetics | RNA, Viral - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Dimerization | RNA Caps - genetics | rab GTP-Binding Proteins - metabolism | Cell Line | DEAD Box Protein 58 | Adenosine Triphosphatases - metabolism | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Substrate Specificity - genetics | Polyphosphates - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Viral - chemistry | Polyphosphates - immunology | rab GTP-Binding Proteins - immunology | DEAD-box RNA Helicases - immunology | Interferons - metabolism | Adenosine Triphosphatases - chemistry | RNA, Viral - immunology | rab GTP-Binding Proteins - chemistry | Adenosine Triphosphatases - genetics | Structural Homology, Protein | RNA Helicases - immunology | Polyphosphates - chemistry | Sensors | G proteins | Biological response modifiers | Adenosine triphosphatase | Index Medicus
Journal Article
Journal Article
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 08/2019, Volume 671, pp. 130 - 142
Heme oxygenase-1 (HO-1, ) degrades pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe ) and biliverdin. The enzyme exerts multiple cytoprotective... 
Angiogenesis | HO-1 | Tumorigenesis | Prostate cancer | Pancreatic cancer | Migration | Care and treatment | Heme | Drug therapy | Cells | Cancer
Journal Article
Journal of Molecular Modeling, ISSN 1610-2940, 02/2019, Volume 25, Issue 2, p. 1
Journal Article