Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9683, pp. 56 - 64
Summary Background Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | 10-DAY MELARSOPROL SCHEDULE | CLINICAL-TRIAL | METABOLISM | EFFICACY | I TRIAL | SLEEPING SICKNESS | DIFLUOROMETHYLORNITHINE | FAILURE | ANGOLA | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - adverse effects | Follow-Up Studies | Humans | Eflornithine - adverse effects | Male | Eflornithine - therapeutic use | Fever - chemically induced | Infection - chemically induced | Seizures - chemically induced | Trypanosomiasis, African - diagnosis | Trypanosomiasis, African - epidemiology | Congo - epidemiology | Adult | Female | Trypanocidal Agents - therapeutic use | Safety | Drug Therapy, Combination | Drug Administration Schedule | Administration, Oral | Kaplan-Meier Estimate | Treatment Outcome | Trypanosoma brucei gambiense | Democratic Republic of the Congo - epidemiology | Animals | Nifurtimox - adverse effects | Infusions, Intravenous | Nifurtimox - therapeutic use | Evaluation | Drug therapy, Combination | Drug therapy | African trypanosomiasis | Drugs | Data analysis | Disease | Research methodology | Clinical trials | Clinical medicine | Tropical diseases | Index Medicus | Abridged Index Medicus
Internal Medicine | MEDICINE, GENERAL & INTERNAL | 10-DAY MELARSOPROL SCHEDULE | CLINICAL-TRIAL | METABOLISM | EFFICACY | I TRIAL | SLEEPING SICKNESS | DIFLUOROMETHYLORNITHINE | FAILURE | ANGOLA | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - adverse effects | Follow-Up Studies | Humans | Eflornithine - adverse effects | Male | Eflornithine - therapeutic use | Fever - chemically induced | Infection - chemically induced | Seizures - chemically induced | Trypanosomiasis, African - diagnosis | Trypanosomiasis, African - epidemiology | Congo - epidemiology | Adult | Female | Trypanocidal Agents - therapeutic use | Safety | Drug Therapy, Combination | Drug Administration Schedule | Administration, Oral | Kaplan-Meier Estimate | Treatment Outcome | Trypanosoma brucei gambiense | Democratic Republic of the Congo - epidemiology | Animals | Nifurtimox - adverse effects | Infusions, Intravenous | Nifurtimox - therapeutic use | Evaluation | Drug therapy, Combination | Drug therapy | African trypanosomiasis | Drugs | Data analysis | Disease | Research methodology | Clinical trials | Clinical medicine | Tropical diseases | Index Medicus | Abridged Index Medicus
Journal Article
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Radiation-induced changes in the glycome of endothelial cells with functional consequences
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 5290 - 16
As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in...
ACTIVATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | NORMAL TISSUE | MONOCYTE ADHESION | FACTOR-KAPPA-B | LEUKOCYTE ADHESION | SIALYL-LEX | RADIOTHERAPY | PROTEIN GLYCOSYLATION | GLYCAN STRUCTURES | Cesium Radioisotopes | Humans | Mice, Inbred C57BL | Monocytes - radiation effects | Cells, Cultured | Male | Monocytes - metabolism | Gene Expression Profiling | Glycosylation | Cell Adhesion | Polysaccharides - metabolism | Animals | Endothelium, Vascular - metabolism | Monocytes - pathology | Gene Expression Regulation - radiation effects | Endothelium, Vascular - pathology | Mice | Endothelium, Vascular - radiation effects | Radiation, Ionizing | Glycosaminoglycans | Mannose | Inflammation | N-glycans | Radiation therapy | Endothelial cells | Cell adhesion molecules | Endothelium | Cell adhesion & migration | Monocytes | Polysaccharides | Ionizing radiation | Rodents | α Radiation
ACTIVATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | NORMAL TISSUE | MONOCYTE ADHESION | FACTOR-KAPPA-B | LEUKOCYTE ADHESION | SIALYL-LEX | RADIOTHERAPY | PROTEIN GLYCOSYLATION | GLYCAN STRUCTURES | Cesium Radioisotopes | Humans | Mice, Inbred C57BL | Monocytes - radiation effects | Cells, Cultured | Male | Monocytes - metabolism | Gene Expression Profiling | Glycosylation | Cell Adhesion | Polysaccharides - metabolism | Animals | Endothelium, Vascular - metabolism | Monocytes - pathology | Gene Expression Regulation - radiation effects | Endothelium, Vascular - pathology | Mice | Endothelium, Vascular - radiation effects | Radiation, Ionizing | Glycosaminoglycans | Mannose | Inflammation | N-glycans | Radiation therapy | Endothelial cells | Cell adhesion molecules | Endothelium | Cell adhesion & migration | Monocytes | Polysaccharides | Ionizing radiation | Rodents | α Radiation
Journal Article
Epigenetics and Chromatin, ISSN 1756-8935, 07/2016, Volume 9, Issue 1, p. 27
Background: Adaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in...
Adaptive evolution | Epigenetics | Compatibility polymorphism | Schistosoma mansoni | INFECTIVITY | MODEL | VARIABILITY | SEX-RATIO | GENETICS & HEREDITY | GENE-EXPRESSION | BIOMPHALARIA-GLABRATA | PARASITE | INHERITANCE | RECEPTORS | Evolutionary biology | Epigenetic inheritance | Research | Life Sciences | Populations and Evolution | Microbiology and Parasitology | Parasitology | Biodiversity
Adaptive evolution | Epigenetics | Compatibility polymorphism | Schistosoma mansoni | INFECTIVITY | MODEL | VARIABILITY | SEX-RATIO | GENETICS & HEREDITY | GENE-EXPRESSION | BIOMPHALARIA-GLABRATA | PARASITE | INHERITANCE | RECEPTORS | Evolutionary biology | Epigenetic inheritance | Research | Life Sciences | Populations and Evolution | Microbiology and Parasitology | Parasitology | Biodiversity
Journal Article
1990, Garland reference library of the social sciences, ISBN 0824037138, Volume 502, xxxix, 928
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