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predictive value of tests (15) 15
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1. Full Text Prof. Lukas Bubendorf: the pros and cons of using cytology specimens in molecular testing
by Li, B and Zhao, V and Bubendorf, L
TRANSLATIONAL LUNG CANCER RESEARCH, ISSN 2218-6751, 02/2018, Volume 7, Issue Suppl 1, pp. S62 - S63
ONCOLOGY | RESPIRATORY SYSTEM | Meet the Professor
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2. Full Text Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study
by Mamot, Christoph, Dr and Ritschard, Reto and Wicki, Andreas, MD and Stehle, Gregor and Dieterle, Thomas, MD and Bubendorf, Lukas, Prof and Hilker, Christoph, Dipl Chem and Deuster, Stefanie, PhD and Herrmann, Richard, Prof and Rochlitz, Christoph, Prof
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 12, pp. 1234 - 1241
Summary Background Results of preclinical studies have shown that EGFR immunoliposomes have substantial antitumour effects. We aimed to assess the... 
Hematology, Oncology and Palliative Medicine | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | CELLS | ONCOLOGY | DRUG-DELIVERY | RESISTANCE | MECHANISMS | TOXICITY | PEGYLATED-LIPOSOMAL DOXORUBICIN | CANCER-THERAPY | Receptor, Epidermal Growth Factor - immunology | Humans | Middle Aged | Antibiotics, Antineoplastic - adverse effects | Male | Doxorubicin - pharmacokinetics | Nanoconjugates | Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Antibodies, Monoclonal, Humanized | Maximum Tolerated Dose | Adult | Female | Aged | Immunoglobulin Fab Fragments - immunology | Liposomes | Antibiotics, Antineoplastic - pharmacokinetics | Cetuximab | Neoplasms - pathology | Antibodies, Monoclonal - immunology | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Anthracyclines | Tumors | Index Medicus
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3. Full Text Multiprobe Fluorescence in situ Hybridization (UroVysion) for the Detection of Urothelial Carcinoma – FISHing for the Right Catch
by Bubendorf, Lukas
Acta Cytologica, ISSN 0001-5547, 04/2011, Volume 55, Issue 2, pp. 113 - 119
Urinary cytology has a well-established role in the detection and monitoring of urothelial carcinoma. The main strength of cytology is the high specificity for... 
Review | Urine | UroVysion | Bladder cancer | Chromosomes | Cytology | Fluorescence in situ hybridization | ASSAY | UPPER URINARY-TRACT | INTRAVESICAL THERAPY | EAU GUIDELINES | FOLLOW-UP | CELL BIOLOGY | VOIDED URINE | CALMETTE-GUERIN THERAPY | TRANSITIONAL-CELL CARCINOMA | INVASIVE BLADDER-CANCER | Molecular Probes | Urinary Bladder Neoplasms - diagnosis | Urine - cytology | Humans | Chromosome Aberrations | Urinary Bladder Neoplasms - pathology | In Situ Hybridization, Fluorescence - methods
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4. Full Text Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells
by Müller, Philipp and Rothschild, Sacha I and Arnold, Walter and Hirschmann, Petra and Horvath, Lukas and Bubendorf, Lukas and Savic, Spasenija and Zippelius, Alfred
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 1/2016, Volume 65, Issue 1, pp. 1 - 11
Tumor-infiltrating lymphocytes play an important role in cell-mediated immune destruction of cancer cells and tumor growth control. We investigated the... 
Immunology | Medicine & Public Health | Non-small cell lung cancer | Oncology | Cancer Research | Primary tumor | Metastasis | Immune cells | Anti-tumor immunity | SURVIVAL | SYSTEM | PD-1 BLOCKADE | MACROPHAGES | ANTIBODY | IMMUNOSURVEILLANCE | IMMUNOLOGY | PROGNOSTIC-FACTOR | ONCOLOGY | COLORECTAL-CANCER | ANTITUMOR IMMUNITY | Carcinoma, Non-Small-Cell Lung - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Immunohistochemistry | Lung Neoplasms - immunology | Neoplasm Metastasis | Prognosis | Humans | Tumor Microenvironment | Female | Lung Neoplasms - pathology | Male | Lymphocytes, Tumor-Infiltrating - immunology | Care and treatment | Analysis | Lung cancer, Small cell | T cells | Lung cancer, Non-small cell | Formaldehyde
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5. Full Text Predictive potential and need for standardization of PD-L1 immunohistochemistry
by Savic Prince, Spasenija and Bubendorf, Lukas
Virchows Archiv, ISSN 0945-6317, 4/2019, Volume 474, Issue 4, pp. 475 - 484
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are a promising treatment option in several tumor types. PD-L1 expression detected by immunohistochemistry... 
Immunohistochemistry | PD-L1 | Pathology | Medicine & Public Health | Immunotherapy | Predictive biomarker | SQUAMOUS-CELL | IHC | OPEN-LABEL | PATHOLOGY | DOCETAXEL | CELL LUNG-CANCER | PEMBROLIZUMAB | ASSAYS | NIVOLUMAB | CARCINOMA | EXPRESSION | Lung cancer, Non-small cell | Medical research | PD-1 protein | Laboratories | Lung cancer | Standardization | Clinical trials | Non-small cell lung carcinoma | Pembrolizumab | Inhibitors | Immune checkpoint | PD-L1 protein | Biomarkers | Cutoffs | Tumors | Cancer
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6. Full Text Common fluorescence in situ hybridization applications in cytology
by Savic, Spasenija and Bubendorf, Lukas
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 12/2016, Volume 140, Issue 12, pp. 1323 - 1330
Context.-Fluorescence in situ hybridization ( FISH) is a well-established method for detection of genomic aberrations in diagnostic, prognostic, and predictive... 
ALK | MEDICINE, RESEARCH & EXPERIMENTAL | HOMOZYGOUS DELETION | BLADDER-CANCER | DIAGNOSIS | GENE REARRANGEMENTS | PATHOLOGY | CELL LUNG-CANCER | CRIZOTINIB | FISH | MEDICAL LABORATORY TECHNOLOGY | MALIGNANT MESOTHELIOMA | UTILITY | Neoplasms - metabolism | Cytogenetic Analysis - trends | Prognosis | Humans | Neoplasm Staging - trends | Neoplasms - diagnosis | Gene Amplification | Neoplasms - genetics | Gene Rearrangement | Chromosome Aberrations | Biomarkers, Tumor - metabolism | Neoplasm Grading - trends | In Situ Hybridization, Fluorescence - trends | Biomarkers, Tumor - genetics | Neoplasms - pathology | Molecular Diagnostic Techniques - trends | Tyrosine | Technology application | Epidermal growth factor | Lung cancer | Fluorescence | Genetic aspects | Non-Hodgkin's lymphomas | Cancer
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7. Full Text EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations
by Thunnissen, Erik and Bubendorf, Lukas and Dietel, Manfred and Elmberger, Göran and Kerr, Keith and Lopez-Rios, Fernando and Moch, Holger and Olszewski, Wlodzimierz and Pauwels, Patrick and Penault-Llorca, Frédérique and Rossi, Giulio
Virchows Archiv, ISSN 0945-6317, 9/2012, Volume 461, Issue 3, pp. 245 - 257
In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact... 
Crizotinib | Pathology | Medicine & Public Health | Non-small cell lung cancer | Anaplastic lymphoma kinase | Algorithm | Rearrangement | Guidelines | TRANSLOCATION | ALK GENE REARRANGEMENT | ADENOCARCINOMA | KINASE | IN-SITU-HYBRIDIZATION | ANAPLASTIC LYMPHOMA | FUSION GENE | PATHOLOGY | CANCER | C-MET | INHIBITOR | Oncogene Proteins, Fusion - metabolism | Pyrazoles - therapeutic use | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - diagnosis | Serine Endopeptidases - genetics | Cell Cycle Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Clinical Competence - standards | Pyridines - therapeutic use | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cell Cycle Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Algorithms | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Protein Kinase Inhibitors - therapeutic use | Gene Rearrangement | Serine Endopeptidases - metabolism | Lung Neoplasms - diagnosis | Quality Assurance, Health Care - standards | Quality of Health Care | Review and s
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8. Full Text Protocols for tissue microarrays in prostate cancer studies
by Vlajnic, Tatjana and Eppenberger-Castori, Serenella and Bubendorf, Lukas
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1786, pp. 103 - 116
Tissue microarray (TMA) technology is a method for high-throughput analysis of tissue biomarkers, commonly used in translational cancer research. TMAs allow... 
Immunohistochemistry | Tissue arrayer | Tumor heterogeneity | Tissue microarray | TMA | In situ hybridization | Prostate cancer | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | In Situ Hybridization | Prostatic Neoplasms - genetics | Prostatic Neoplasms - surgery | Humans | Male | Tissue Array Analysis - methods | Disease Progression
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9. Full Text Editorial Comment on: The Value of the UroVysion® Assay for Surveillance of Non–Muscle-Invasive Bladder Cancer
by Bubendorf, Lukas
European Urology, ISSN 0302-2838, 2007, Volume 54, Issue 2, pp. 407 - 408
Urology | In Situ Hybridization, Fluorescence | Neoplasm Invasiveness | Population Surveillance | Humans | Urinary Bladder Neoplasms - pathology | Bladder cancer
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10. Full Text The Paris System for reporting urinary cytology in daily practice with emphasis on ancillary testing by multiprobe FISH
by Vlajnic, Tatjana and Gut, André and Savic, Spasenija and Bubendorf, Lukas
Journal of clinical pathology, ISSN 0021-9746, 08/2019, p. jclinpath-2019-206109
The Paris System (TPS) was introduced in the diagnostic routine with the goal to simplify and standardise diagnostic reporting of urinary cytology. The... 
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11. Full Text Alveolar herniation in transbronchial lung biopsy: a newly recognised diagnostic pitfall
by Jain, Deepali and Tamm, Michael and Savic, Spasenija and Bubendorf, Lukas
Histopathology, ISSN 0309-0167, 03/2018, Volume 72, Issue 4, pp. 710 - 712
PATHOLOGY | CELL BIOLOGY | Alveoli | Biopsy
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12. Full Text MET overexpression and gene amplification: prevalence, clinico-pathological characteristics and prognostic significance in a large cohort of patients with surgically resected NSCLC
by Sterlacci, William and Fiegl, Michael and Gugger, Mathias and Bubendorf, Lukas and Savic, Spasenija and Tzankov, Alexandar
Virchows Archiv, ISSN 0945-6317, 07/2017, Volume 471, Issue 1, pp. 49 - 55
The prevalence of overexpression and amplification of the proto-oncogene mesenchymal epithelial transition (MET) in non-small cell lung cancer (NSCLC) varies... 
Immunohistochemistry | FISH | MET | Non-small cell lung cancer | CELL LUNG-CANCER | C-MET | PROTEIN EXPRESSION | COPY NUMBER | MUTATIONS | PATHOLOGY | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-met - biosynthesis | Area Under Curve | Carcinoma, Non-Small-Cell Lung - genetics | Lung Neoplasms - mortality | Tissue Array Analysis | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Carcinoma, Non-Small-Cell Lung - mortality | Proto-Oncogene Proteins c-met - genetics | Gene Amplification | Survival Analysis | Adult | Female | ROC Curve | Aged | Retrospective Studies | Medical colleges | Epidermal growth factor | Genes | Stem cells | Resveratrol | Genetic research | Lung cancer, Non-small cell | Therapy | Epidermal growth factor receptors | Mesenchyme | Therapeutic applications | Lung cancer | Non-small cell lung carcinoma | Gene expression | Patients | Amplification | c-Met protein | Gene amplification | DNA microarrays | Effectors | Tumors | Cancer
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13. Full Text Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis
by Ruiz, Christian and Martins, Joana Raquel and Rudin, Florian and Schneider, Sandra and Dietsche, Tanja and Fischer, Claude A and Tornillo, Luigi and Terracciano, Luigi M and Schreiber, Rainer and Bubendorf, Lukas and Kunzelmann, Karl
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e43265
Head and neck squamous cell carcinoma (HNSCC) has the potential for early metastasis and is associated with poor survival. Ano1 (Dog1) is an established and... 
AMPLIFICATION | GENE | MARKER | DOG1 | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | ION CHANNELS | TMEM16A | TISSUE MICROARRAY ANALYSIS | CANCER | TRANSCRIPTOME ANALYSIS | Anoctamin-1 | Prognosis | Calcium - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Cell Size | Chromosomes, Human, Pair 11 - genetics | Chloride Channels - genetics | Neoplasm Proteins - metabolism | Cell Movement - genetics | Cell Movement - physiology | Head and Neck Neoplasms - metabolism | Head and Neck Neoplasms - pathology | Chloride Channels - metabolism | Chlorides - metabolism | Calcium Signaling - genetics | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Squamous cell carcinoma | Metastasis | Analysis | Cell proliferation | Calcium currents | Correlation | Intracellular signalling | Malignancy | Tissues | Human tissues | Metastases | Cell adhesion & migration | Calcium signalling | Proteins | Cell growth | Chloride | Rodents | Chromosome 11 | Physiology | Head | Calcium (intracellular) | Cell survival | Wound healing | Breast cancer | Survival | Patients | Bladder cancer | Loci | Amplification | Pathology | Survival analysis | Medical prognosis | Cell lines | Head and neck cancer | Protein expression | Cell size | Cell migration | Tumors
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14. Full Text Re: Aberrant ERG Expression Cooperates with Loss of PTEN to Promote Cancer Progression in the Prostate
by Bubendorf, Lukas
European Urology, ISSN 0302-2838, 2009, Volume 56, Issue 5, pp. 882 - 883
Urology | UROLOGY & NEPHROLOGY
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15. Full Text Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression
by Leighton, Ximena and Bera, Alakesh and Bera, Alakesh and Eidelman, Ofer and Bubendorf, Lukas and Zellweger, Tobias and Banerjee, Jaideep and Banerjee, Jaideep and Gelmann, Edward P and Gelmann, Edward P and Pollard, Harvey B and Pollard, Harvey B and Srivastava, Meera and Srivastava, Meera
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0205837
Background Annexin A7 (ANXA7) is a member of the multifunctional calcium or phospholipid-binding annexin gene family. While low levels of ANXA7 are associated... 
SURVIVAL | PREDICTOR | KI67 LABELING INDEX | SYNDECAN-1 EXPRESSION | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | TUMOR-SUPPRESSOR GENE | MARKERS | RADICAL PROSTATECTOMY | REDUCED EXPRESSION | Immunohistochemistry | Cancer patients | Usage | DNA microarrays | Patient outcomes | Development and progression | Research | Tumor proteins | Health aspects | Prostate cancer | Neurosciences | Prognosis | Calcium | Bcl-2 protein | p53 Protein | Phospholipids | Tissue analysis | Neutral endopeptidase | Proteins | Fibroblasts | Genetics | Physiology | Growth factors | Medical research | Anatomy & physiology | Survival | Patients | Medicine | Androgens | Hospitals | Endopeptidase | Neprilysin | Alzheimers disease | Prostate | Syndecan | Cancer | Tumors | Apoptosis
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16. Full Text Targeted multiprobe fluorescence in situ hybridization analysis for elucidation of inconclusive pancreatobiliary cytology
by Vlajnic, Tatjana and Somaini, Gina and Savic, Spasenija and Barascud, Audrey and Grilli, Bruno and Herzog, Michelle and Obermann, Ellen C and Holmes, Brittany J and Ali, Syed Z and Degen, Lukas and Bubendorf, Lukas
Cancer Cytopathology, ISSN 1934-662X, 08/2014, Volume 122, Issue 8, pp. 627 - 634
BACKGROUND Endoscopic fine‐needle aspiration (FNA) and brush cytology are standard methods for the diagnosis of pancreatobiliary malignancies. Although the... 
fluorescence in situ hybridization | cytology | biliary tract | pancreatic cancer | atypia | FISH | fine‐needle aspiration | Biliary tract | Fine-needle aspiration | Atypia | Pancreatic cancer | Cytology | Fluorescence in situ hybridization | BLADDER-CANCER | DIAGNOSIS | BILE-DUCT | BILIARY STRICTURES | UROTHELIAL CARCINOMA | PATHOLOGY | ROUTINE CYTOLOGY | FINE-NEEDLE-ASPIRATION | K-RAS | ONCOLOGY | CHRONIC-PANCREATITIS | fine-needle aspiration | DUCT BRUSHING CYTOLOGY | Bile Duct Neoplasms - diagnosis | Predictive Value of Tests | In Situ Hybridization, Fluorescence | Adenocarcinoma - diagnosis | Pancreatic Neoplasms - diagnosis | Humans | Usage | Diagnosis | Research | Biopsy, Needle | Health aspects
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17. Full Text Urinary Calprotectin loses specificity as tumour marker due to sterile leukocyturia associated with bladder cancer
by Bausch, Kathrin and Roth, Elisa and Heinz, Stefan and Horst, David and Mathia, Susanne and Vlajnic, Tatjana and Bubendorf, Lukas and Westhoff, Timm and Wetterauer, Christian and Seifert, Hans Helge and Ebbing, Jan
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0213549
Background Urinary Calprotectin, a mediator of the innate immune system, has been identified as a biomarker in bladder cancer. Our aim was to investigate the... 
INFLAMMATORY BOWEL DISEASES | PROGNOSTIC VALUE | MULTIDISCIPLINARY SCIENCES | S100 PROTEINS | GRANULOCYTES | FECAL CALPROTECTIN | Usage | Diagnosis, Laboratory | Diagnosis | Leukocytes | Research | Bladder cancer | Observational studies | Risk factors | Immunohistochemistry | Analysis | Oncology, Experimental | BCG | BCG vaccines | Tumors | Cancer | Nephrology | Disease | Bladder | Systematic review | Multivariate analysis | Subgroups | Proteins | Urinary tract infections | Bioindicators | Urogenital system | Visual fields | Immune system | Urine | Antigens | Bacteriuria | Visual field | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Patients | Urinary tract diseases | White blood cells | Studies | Pathology | Hospitals | Medical prognosis | Biomarkers
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18. Full Text Advancing a clinically relevant perspective of the clonal nature of cancer
by Christian Ruiz and Elizabeth Lenkiewicz and Lisa Evers and Tara Holley and Alex Robeson and Jeffrey Kiefer and Michael J. Demeure and Michael A. Hollingsworth and Michael Shen and Donna Prunkard and Peter S. Rabinovitch and Tobias Zellweger and Spyro Mousses and Jeffrey M. Trent and John D. Carpten and Lukas Bubendorf and Daniel Von Hoff and Michael T. Barrett
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 29, pp. 12054 - 12059
Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of... 
Metagenomics | Diploidy | Genomics | Genes | Biopsies | Aneuploidy | Genomes | Chromosomes | Tumors | Cancer | Prostate cancer | Pancreatic cancer | Clonal genomics | HUMAN BREAST | METASTASIS | MULTIDISCIPLINARY SCIENCES | clonal genomics | AMPLIFICATIONS | GENE FUSIONS | pancreatic cancer | prostate cancer | EVOLUTION | COPY NUMBER | PROSTATE-CANCER | GENOMIC ALTERATIONS | EXPRESSION | PROGRESSION | Humans | In Situ Hybridization, Fluorescence | Male | Pancreatic Neoplasms - genetics | DNA Primers - genetics | Sequence Analysis, DNA | Genetic Variation | Neoplasm Metastasis - genetics | Flow Cytometry | Prostatic Neoplasms - genetics | Comparative Genomic Hybridization | Biopsy | Microarray Analysis | Polymerase Chain Reaction | Adenocarcinoma - genetics | Clone Cells | Genomics - methods | Precision Medicine - methods | Evolution, Molecular | Genetic aspects | Research | Biological Sciences
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