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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, pp. 3502 - 3513
(+)-Cyclazosin is one of most selective antagonists of the α -adrenoceptor subtype (selectivity ratios, α /α  = 13, α /α  = 38–39). To improve the selectivity,... 
(+)-Cyclazosin analogues | α1-Adrenoceptor subtypes | α1-Adrenoceptor antagonists | α1B-Adrenoceptor selective antagonists | Adrenoceptor selective antagonists | α | Adrenoceptor antagonists | Adrenoceptor subtypes | (+)-cyclazosin analogues | α1-adrenoceptor subtypes | α1-adrenoceptor antagonists | α1B-adrenoceptor selective antagonists
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, p. 3502
(+)-Cyclazosin [(+)-1] is one of most selective antagonists of the [alpha].sub.1B-adrenoceptor subtype (selectivity ratios, [alpha].sub.1B/[alpha].sub.1A = 13,... 
Analysis | Drug discovery | Enantiomers
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 12/2019, Volume 29, Issue 12, pp. 943 - 963
Introduction: Purinergic P2X3-P2X2/3 receptors are placed in nociceptive neurons' strategic location and show unique desensitization properties; hence, they... 
AF-219 | patents on P2X3 receptor antagonists | P2X3 and P2X2/3 receptors | P2X3 receptor antagonists
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5772 - 5790
In this work, we describe the identification of the 1,2,4-triazolo­[4,3-a]­pyrazin-3-one as a new versatile scaffold for the development of adenosine human (h)... 
Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 2019, Volume 149, Issue 2, pp. 211 - 230
Cerebral ischemia is the second most common cause of death and a major cause of disability worldwide. Available therapies are based only on anticoagulants or... 
neuroblastoma cells | receptor | adenosine A | hippocampus | cerebral ischemia | partial agonists
Journal Article
Life Sciences, ISSN 0024-3205, 07/2018, Volume 205, p. 155
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.lfs.2018.05.028 A.sub.3... 
Prevention | Care and treatment | Cell death | Colorectal cancer | Development and progression | Prostate cancer | Cancer
Journal Article
Life Sciences, ISSN 0024-3205, 07/2018, Volume 205, p. 155
Aims A3 adenosine receptor (A3AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification... 
Toxicity | Mortality | Colorectal carcinoma | Cytotoxicity | Hepatocellular carcinoma | T cell receptors | Activation | Drug development | Assaying | Autophagy | Anticancer properties | Time dependence | Antagonist drugs | Cell death | Antitumor activity | Drug therapy | ACE inhibitors | Prostate cancer | Prostate | Cell migration | Phagocytosis | Cancer | Apoptosis
Journal Article
Life Sciences, ISSN 0024-3205, 07/2018, Volume 205, pp. 155 - 163
A adenosine receptor (A AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of... 
Reactive oxygen species | Migration | Cancer cells | A3 adenosine receptor ligands | Signal activation | Autophagy | A3 adenosine receptor | Adenosine derivatives | Apoptosis | adenosine receptor | adenosine receptor ligands | Index Medicus
Journal Article
Life sciences, ISSN 0024-3205, 05/2018, Volume 205, pp. 155 - 163
A adenosine receptor (A AR) signalling activation seems to mediate anticancer effect, and it has been targeted for drug development. The identification of... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2018, Volume 151, pp. 199 - 213
The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and -position, respectively, is reported. The... 
Adenosine receptor antagonists | Adenosine | Adenosine receptors | Purinergic receptors | A1 adenosine receptor | Mouse ileum | adenosine receptor
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2018, Volume 151, p. 199
The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N.sup.6-position, respectively, is reported.... 
Gastrointestinal diseases | Crystals | Cyclic adenylic acid | G proteins | Structure | Acetic acid | Membrane proteins
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2019, Volume 176, p. 310
A series of compounds generated by ring expansion/opening and molecular elongation/simplification of the 1,3-dioxolane scaffold were prepared and tested for... 
Dioxane | Oxalic acid | Antidepressants | Hydrogen | Oxalates | Antianxiety agents | Formaldehyde
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2018, Volume 26, Issue 12, pp. 3502 - 3513
Journal Article
Molecular Informatics, ISSN 1868-1743, 09/2016, Volume 35, Issue 8-9, pp. 403 - 413
Non‐nucleoside agonists of adenosine receptors were analysed at the A2A adenosine receptor to simulate and compare their possible binding modes. The docking... 
Docking | Agonist | Adenosine | A2A Adenosine Receptor | Adenosine Receptor | Binding, Competitive - physiology | Adenosine A2 Receptor Agonists - pharmacology | Humans | Binding Sites - physiology | Adenosine - metabolism | Ligands | Receptor, Adenosine A2A - metabolism | Adenosine A2 Receptor Agonists - chemistry | Mutagenesis | Rodents | Index Medicus
Journal Article
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