Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2018, Volume 506, Issue 2, p. 307
Actin cytoskeleton dynamics depend on a tight regulation of actin filament formation from an intracellular pool of monomers, followed by their linkage to each...
Hydrolysis | Medical colleges | Inositol | Actin | Analysis | Physiological aspects | Lipids | Binding proteins | Muscle proteins | Protein binding
Hydrolysis | Medical colleges | Inositol | Actin | Analysis | Physiological aspects | Lipids | Binding proteins | Muscle proteins | Protein binding
Journal Article
2.
Full Text
Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2011, Volume 108, Issue 16, pp. E77 - E81
Natural antimicrobial peptides (AMPs) provide prototypes for the design of unconventional antimicrobial agents. Existing bulk assays measure AMP activity but...
HOST-DEFENSE PEPTIDES | BACTERIA | PROTEIN | PERIPLASM | MULTIDISCIPLINARY SCIENCES | Pseudomonas aeruginosa - metabolism | Humans | Antimicrobial Cationic Peptides - pharmacology | Escherichia coli - metabolism | Escherichia coli - cytology | Antimicrobial Cationic Peptides - metabolism | Pseudomonas aeruginosa - cytology | PNAS Plus | Biological Sciences
HOST-DEFENSE PEPTIDES | BACTERIA | PROTEIN | PERIPLASM | MULTIDISCIPLINARY SCIENCES | Pseudomonas aeruginosa - metabolism | Humans | Antimicrobial Cationic Peptides - pharmacology | Escherichia coli - metabolism | Escherichia coli - cytology | Antimicrobial Cationic Peptides - metabolism | Pseudomonas aeruginosa - cytology | PNAS Plus | Biological Sciences
Journal Article
Complexity, ISSN 1076-2787, 2019, Volume 2019, pp. 1 - 36
The article focuses on one of the current problems of manufacturing systems which consist of individual machines equipped with dedicated tools that are...
MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | MULTIDISCIPLINARY SCIENCES | OPTIMIZATION | Robot arms | Model testing | Simulation | Computer simulation | Mathematical analysis | Feasibility studies | Storage containers | Containers | Mathematical models | Overfilling | Simulators | Logistics
MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | MULTIDISCIPLINARY SCIENCES | OPTIMIZATION | Robot arms | Model testing | Simulation | Computer simulation | Mathematical analysis | Feasibility studies | Storage containers | Containers | Mathematical models | Overfilling | Simulators | Logistics
Journal Article
Journal of Computing and Information Technology, ISSN 1330-1136, 05/2019, Volume 27, Issue 1, pp. 59 - 75
The paper highlights the problems of modelling the complex logistics manufacturing system which is to meet the needs of the contemporary lean approach to...
Case studies | Economic aspects | Algorithms | Synthetic training device industry | Artificial intelligence | Methods | logistics system, mathematical modelling, simulation, business process, manufacturing strategies, optimisation
Case studies | Economic aspects | Algorithms | Synthetic training device industry | Artificial intelligence | Methods | logistics system, mathematical modelling, simulation, business process, manufacturing strategies, optimisation
Journal Article
Journal of Nanobiotechnology, ISSN 1477-3155, 05/2016, Volume 14, Issue 1, p. 39
rapid development of nanotechnology provides alternative approaches to overcome several limitations of conventional anti-cancer therapy. Drug targeting using...
Drug delivery | Nanotechnology | Cancer | IRON-OXIDE NANOPARTICLES | GOLD NANOPARTICLES | PEGYLATED LIPOSOMAL DOXORUBICIN | PHOTODYNAMIC THERAPY | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | P-GLYCOPROTEIN | BREAST-CANCER CELLS | PHASE-II TRIAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALBUMIN-BOUND PACLITAXEL | IN-VIVO | Neoplasms - metabolism | Nanotechnology - methods | Humans | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Neoplasms - therapy | Animals | Nanomedicine - methods | Nanostructures - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Drug Delivery Systems - methods | Nanostructures - therapeutic use | Drugs | Usage | Drug delivery systems | Care and treatment | Research | Methods | Vehicles
Drug delivery | Nanotechnology | Cancer | IRON-OXIDE NANOPARTICLES | GOLD NANOPARTICLES | PEGYLATED LIPOSOMAL DOXORUBICIN | PHOTODYNAMIC THERAPY | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | P-GLYCOPROTEIN | BREAST-CANCER CELLS | PHASE-II TRIAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALBUMIN-BOUND PACLITAXEL | IN-VIVO | Neoplasms - metabolism | Nanotechnology - methods | Humans | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Neoplasms - drug therapy | Neoplasms - therapy | Animals | Nanomedicine - methods | Nanostructures - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neoplasms - pathology | Drug Delivery Systems - methods | Nanostructures - therapeutic use | Drugs | Usage | Drug delivery systems | Care and treatment | Research | Methods | Vehicles
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2018, Volume 506, Issue 2, pp. 307 - 314
Actin cytoskeleton dynamics depend on a tight regulation of actin filament formation from an intracellular pool of monomers, followed by their linkage to each...
Actin binding proteins | Actin assembly | PI(4,5)P2 | PROTEIN | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMERIZATION | CLUSTER FORMATION | PLASMA-MEMBRANE | ALPHA-ACTININ | BIOPHYSICS | EZRIN | CELL-MIGRATION | N-WASP | BINDING PEPTIDES | actin assembly | actin binding proteins
Actin binding proteins | Actin assembly | PI(4,5)P2 | PROTEIN | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMERIZATION | CLUSTER FORMATION | PLASMA-MEMBRANE | ALPHA-ACTININ | BIOPHYSICS | EZRIN | CELL-MIGRATION | N-WASP | BINDING PEPTIDES | actin assembly | actin binding proteins
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 40a - 41a
Journal Article
New Journal of Physics, ISSN 1367-2630, 2014, Volume 16, Issue 7, pp. 075002 - 15
Many cell types, including neurons, astrocytes and other cells of the central nervous system, respond to changes in the extracellular matrix or substrate...
glioma | mechanosensing | astrocyte | viscoelasticity | brain rheology | INTERSTITIAL FLUID PRESSURE | PHYSICS, MULTIDISCIPLINARY | TISSUE | SOFT | MECHANICS | HEPATIC STELLATE CELLS | STIFFNESS | MATRICES | INTRACRANIAL-PRESSURE | COLLAGENS | PROGRESSION | Extracellular matrix | Brain cancer | Brain | Central nervous system | Organs | Modulus of elasticity | Stiffness | Compressive strength | Stiffening | Tumors
glioma | mechanosensing | astrocyte | viscoelasticity | brain rheology | INTERSTITIAL FLUID PRESSURE | PHYSICS, MULTIDISCIPLINARY | TISSUE | SOFT | MECHANICS | HEPATIC STELLATE CELLS | STIFFNESS | MATRICES | INTRACRANIAL-PRESSURE | COLLAGENS | PROGRESSION | Extracellular matrix | Brain cancer | Brain | Central nervous system | Organs | Modulus of elasticity | Stiffness | Compressive strength | Stiffening | Tumors
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2018, Volume 19, Issue 9, p. 2516
Gelsolin, an actin-depolymerizing protein expressed both in extracellular fluids and in the cytoplasm of a majority of human cells, has been recently...
Biomarker | Inflammation | Extracellular recombinant gelsolin | Plasma gelsolin | Actin | MODULATES CELLULAR-RESPONSE | ACTIN-SCAVENGER SYSTEM | plasma gelsolin | PLATELET-AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DOWN-REGULATION | CIRCULATING ACTIN | biomarker | extracellular recombinant gelsolin | CEREBROSPINAL-FLUID | CHEMISTRY, MULTIDISCIPLINARY | actin | SERUM GELSOLIN | inflammation | SEPTIC SHOCK | SEVERE SEPSIS | Severity of Illness Index | Gelsolin - blood | Disease Susceptibility | Prognosis | Gelsolin - metabolism | Humans | Male | Treatment Outcome | Neoplasms - diagnosis | Inflammation - blood | Pregnancy | Inflammation - therapy | Animals | Neoplasms - blood | Biomarkers | Inflammation - genetics | Female | Gelsolin - genetics | Inflammation - diagnosis | Disease Models, Animal | Urine | Therapeutic applications | Cerebrospinal fluid | Proteins | Depolymerization | Diagnostic software | Diagnostic systems | Actin-depolymerizing protein | Gelsolin | Cytoplasm | Recombinant | Fluid | Gram-positive bacteria | Angiogenesis | Signal transduction | Blood platelets | Preeclampsia | Physiology | Cancer | Apoptosis
Biomarker | Inflammation | Extracellular recombinant gelsolin | Plasma gelsolin | Actin | MODULATES CELLULAR-RESPONSE | ACTIN-SCAVENGER SYSTEM | plasma gelsolin | PLATELET-AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DOWN-REGULATION | CIRCULATING ACTIN | biomarker | extracellular recombinant gelsolin | CEREBROSPINAL-FLUID | CHEMISTRY, MULTIDISCIPLINARY | actin | SERUM GELSOLIN | inflammation | SEPTIC SHOCK | SEVERE SEPSIS | Severity of Illness Index | Gelsolin - blood | Disease Susceptibility | Prognosis | Gelsolin - metabolism | Humans | Male | Treatment Outcome | Neoplasms - diagnosis | Inflammation - blood | Pregnancy | Inflammation - therapy | Animals | Neoplasms - blood | Biomarkers | Inflammation - genetics | Female | Gelsolin - genetics | Inflammation - diagnosis | Disease Models, Animal | Urine | Therapeutic applications | Cerebrospinal fluid | Proteins | Depolymerization | Diagnostic software | Diagnostic systems | Actin-depolymerizing protein | Gelsolin | Cytoplasm | Recombinant | Fluid | Gram-positive bacteria | Angiogenesis | Signal transduction | Blood platelets | Preeclampsia | Physiology | Cancer | Apoptosis
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 12/2010, Volume 299, Issue 6, pp. 1516 - 1523
Hypogelsolinemia is observed in patients with different states of acute or chronic inflammation such as sepsis, rheumatoid arthritis, and multiple sclerosis....
Binding | Inflammation | Astrocytes | FTY720 | Endothelial cells | endothelial cells | STEM-CELLS | PHYSIOLOGY | PROTEIN | ACTIN | binding | CEREBROSPINAL-FLUID | CELL BIOLOGY | LYSOPHOSPHATIDIC ACID | MULTIPLE-SCLEROSIS | inflammation | ROLES | astrocytes | PLATELET-ACTIVATING-FACTOR | PHOSPHOINOSITIDE-BINDING | LIPOPROTEINS | Organophosphates - metabolism | Astrocytes - drug effects | Cell Line | Lysophospholipids - metabolism | Gelsolin - blood | Meningitis - metabolism | Phosphorylation | Gelsolin - metabolism | Aorta - drug effects | Humans | Actins - metabolism | Gelsolin - cerebrospinal fluid | Rats | Aorta - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Sphingosine - cerebrospinal fluid | Extracellular Signal-Regulated MAP Kinases - analysis | Lymphatic Diseases - metabolism | Sphingosine - analogs & derivatives | Animals | Cattle | Sphingosine - metabolism | Lysophospholipids - cerebrospinal fluid | Astrocytes - metabolism | Sphingosine | Cell physiology | Research | Properties | Health aspects | Endothelium | Receptors and Signal Transduction
Binding | Inflammation | Astrocytes | FTY720 | Endothelial cells | endothelial cells | STEM-CELLS | PHYSIOLOGY | PROTEIN | ACTIN | binding | CEREBROSPINAL-FLUID | CELL BIOLOGY | LYSOPHOSPHATIDIC ACID | MULTIPLE-SCLEROSIS | inflammation | ROLES | astrocytes | PLATELET-ACTIVATING-FACTOR | PHOSPHOINOSITIDE-BINDING | LIPOPROTEINS | Organophosphates - metabolism | Astrocytes - drug effects | Cell Line | Lysophospholipids - metabolism | Gelsolin - blood | Meningitis - metabolism | Phosphorylation | Gelsolin - metabolism | Aorta - drug effects | Humans | Actins - metabolism | Gelsolin - cerebrospinal fluid | Rats | Aorta - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Sphingosine - cerebrospinal fluid | Extracellular Signal-Regulated MAP Kinases - analysis | Lymphatic Diseases - metabolism | Sphingosine - analogs & derivatives | Animals | Cattle | Sphingosine - metabolism | Lysophospholipids - cerebrospinal fluid | Astrocytes - metabolism | Sphingosine | Cell physiology | Research | Properties | Health aspects | Endothelium | Receptors and Signal Transduction
Journal Article
Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, 2/2010, Volume 58, Issue 1, pp. 15 - 25
The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense...
Infection | Biomedicine | Immunology | Bacteria | Pharmacology/Toxicology | Antibacterial agents | hCAP-18 | HCAP-18 | VITAMIN-D | F-ACTIN | LIPOPOLYSACCHARIDE NEUTRALIZATION | IMMUNOLOGY | SALIVARY-GLANDS | HOST-DEFENSE PEPTIDES | EPITHELIAL-CELLS | ANTIBIOTIC LL-37/HCAP-18 | PSEUDOMONAS-AERUGINOSA | CYSTIC-FIBROSIS SPUTUM | GROWTH-FACTOR | Bacterial Infections - drug therapy | Gene Expression Regulation - immunology | Humans | Neutrophils - drug effects | Antimicrobial Cationic Peptides - pharmacology | Neutrophils - immunology | Lipopolysaccharides - antagonists & inhibitors | Antimicrobial Cationic Peptides - therapeutic use | Gene Expression Regulation - drug effects | Bacterial Infections - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Antimicrobial Cationic Peptides - genetics | Interleukin-8 - immunology | Cytoprotection | Bacterial infections | Vitamin D | Peptides | Calcifediol | Alfacalcidol | Gene expression | Mitogens
Infection | Biomedicine | Immunology | Bacteria | Pharmacology/Toxicology | Antibacterial agents | hCAP-18 | HCAP-18 | VITAMIN-D | F-ACTIN | LIPOPOLYSACCHARIDE NEUTRALIZATION | IMMUNOLOGY | SALIVARY-GLANDS | HOST-DEFENSE PEPTIDES | EPITHELIAL-CELLS | ANTIBIOTIC LL-37/HCAP-18 | PSEUDOMONAS-AERUGINOSA | CYSTIC-FIBROSIS SPUTUM | GROWTH-FACTOR | Bacterial Infections - drug therapy | Gene Expression Regulation - immunology | Humans | Neutrophils - drug effects | Antimicrobial Cationic Peptides - pharmacology | Neutrophils - immunology | Lipopolysaccharides - antagonists & inhibitors | Antimicrobial Cationic Peptides - therapeutic use | Gene Expression Regulation - drug effects | Bacterial Infections - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Antimicrobial Cationic Peptides - genetics | Interleukin-8 - immunology | Cytoprotection | Bacterial infections | Vitamin D | Peptides | Calcifediol | Alfacalcidol | Gene expression | Mitogens
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 07/2019, Volume 20, Issue 13, p. 3199
The chronic sensation of a dry mouth is a disease condition called xerostomia and affects a large part of the population. Xerostomia is associated with...
HEAD | ORAL MANIFESTATIONS | FUNGICIDAL ACTIVITY | rheology | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-DELIVERY SYSTEM | PROSPECTIVE TRIAL | MODIFIED SCHIRMER TEST | MAGNETIC NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | FLOW-RATE | artificial saliva | xerostomia | POSTIRRADIATION XEROSTOMIA | ELDERLY-PATIENTS
HEAD | ORAL MANIFESTATIONS | FUNGICIDAL ACTIVITY | rheology | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-DELIVERY SYSTEM | PROSPECTIVE TRIAL | MODIFIED SCHIRMER TEST | MAGNETIC NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | FLOW-RATE | artificial saliva | xerostomia | POSTIRRADIATION XEROSTOMIA | ELDERLY-PATIENTS
Journal Article
Complexity, ISSN 1076-2787, 2017, Volume 2017, pp. 1 - 15
This paper highlights the problems of mathematical modelling for a specific element of the logistic supply chain, that is, the manufacturing system. The...
SYSTEM | DISCRETE-EVENT SIMULATION | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | OPTIMIZATION | MULTIDISCIPLINARY SCIENCES | Decision-making | Usage | Mathematical models | Models | Analysis | Logistics | Automation | Computer simulation | Decision making | Supply chains | Equations of state | Algorithms | Simulation | International conferences | Manufacturing | Assembly lines | Heuristic
SYSTEM | DISCRETE-EVENT SIMULATION | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | OPTIMIZATION | MULTIDISCIPLINARY SCIENCES | Decision-making | Usage | Mathematical models | Models | Analysis | Logistics | Automation | Computer simulation | Decision making | Supply chains | Equations of state | Algorithms | Simulation | International conferences | Manufacturing | Assembly lines | Heuristic
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 9/2019, Volume 97, Issue 9, pp. 1263 - 1271
Fingolimod (FTY) is known to have multiple effects on the immune system and the central nervous system (CNS) in patients with multiple sclerosis (MS). In this...
Human Genetics | Multiple sclerosis | Biomedicine | S1P | Fingolimod | CSF | Internal Medicine | CNS | Neurofilament light chain | Molecular Medicine | Immune cell | Monitoring | MEDICINE, RESEARCH & EXPERIMENTAL | ORAL FINGOLIMOD | FTY720 | GENETICS & HEREDITY | NEUROFILAMENT LIGHT-CHAIN | IMMUNOASSAY | SAMPLES | BLOOD | Phosphates | Neurosciences | Analysis | Therapy | Level (quantity) | CD19 antigen | CD8 antigen | Neurobiology | Markers | Central nervous system | CD3 antigen | Inflammation | Cerebrospinal fluid | CD14 antigen | Blood | Sphingosine 1-phosphate | CD4 antigen | Immunology | Correlation analysis | Phosphopyruvate hydratase | Immune system
Human Genetics | Multiple sclerosis | Biomedicine | S1P | Fingolimod | CSF | Internal Medicine | CNS | Neurofilament light chain | Molecular Medicine | Immune cell | Monitoring | MEDICINE, RESEARCH & EXPERIMENTAL | ORAL FINGOLIMOD | FTY720 | GENETICS & HEREDITY | NEUROFILAMENT LIGHT-CHAIN | IMMUNOASSAY | SAMPLES | BLOOD | Phosphates | Neurosciences | Analysis | Therapy | Level (quantity) | CD19 antigen | CD8 antigen | Neurobiology | Markers | Central nervous system | CD3 antigen | Inflammation | Cerebrospinal fluid | CD14 antigen | Blood | Sphingosine 1-phosphate | CD4 antigen | Immunology | Correlation analysis | Phosphopyruvate hydratase | Immune system
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4610 - 12
Fungal infections caused by Candida spp. represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious...
IRON-OXIDE NANOPARTICLES | ALBICANS BIOFILMS | CATIONIC LIPIDS | BACTERICIDAL ACTIVITY | ANTIBACTERIAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | STAPHYLOCOCCUS-AUREUS | INVASIVE FUNGAL-INFECTIONS | ANTIMICROBIAL PEPTIDES | SILVER NANOPARTICLES | Nanoparticles | Body fluids | Biofilms | Immunomodulation | Immobilization | Biocompatibility | Drug delivery | Immunocompromised hosts | Drug resistance | Osteoblasts | Nanotechnology
IRON-OXIDE NANOPARTICLES | ALBICANS BIOFILMS | CATIONIC LIPIDS | BACTERICIDAL ACTIVITY | ANTIBACTERIAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | STAPHYLOCOCCUS-AUREUS | INVASIVE FUNGAL-INFECTIONS | ANTIMICROBIAL PEPTIDES | SILVER NANOPARTICLES | Nanoparticles | Body fluids | Biofilms | Immunomodulation | Immobilization | Biocompatibility | Drug delivery | Immunocompromised hosts | Drug resistance | Osteoblasts | Nanotechnology
Journal Article