Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi219 - vi220
Abstract In 2016 there were 5250 brain cancer deaths in the UK. Standard treatment is surgical resection followed by chemo-radiotherapy. In most cases of...
Journal Article
European Urology, ISSN 0302-2838, 2011, Volume 61, Issue 3, pp. e19 - e20
Journal Article
European Urology, ISSN 0302-2838, 03/2012, Volume 61, Issue 3, pp. e19 - e20
Journal Article
Nanotechnology, ISSN 0957-4484, 12/2010, Volume 21, Issue 48, pp. 482001 - 482001
One clinical precedent for the use of nanosized imaging agents is the localization of the tumor draining sentinel lymph nodes. In this application,...
Drainage | Nanoparticles | Dyes | Nanocomposites | Imaging | Nanomaterials | Nanostructure | Lymph
Drainage | Nanoparticles | Dyes | Nanocomposites | Imaging | Nanomaterials | Nanostructure | Lymph
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2007, Volume 13, Issue 21, pp. 6440 - 6449
Purpose: The brain is a pharmacologic sanctuary site, due to the presence of the blood-brain barrier (BBB). Whereas the effect of P-glycoprotein (P-gp) at the...
drug transporters | knockout mice | Blood-brain barrier | elacridar | topotecan | PHARMACOKINETICS | ONCOLOGY | IN-VIVO | BARRIER | DRUGS | PHASE-II | MICE | MULTIDRUG-RESISTANCE | INHIBITOR GF120918 | BLOOD | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Topotecan - pharmacology | Area Under Curve | Liver - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Male | ATP Binding Cassette Transporter, Sub-Family B - chemistry | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Topotecan - chemistry | Mice, Knockout | Brain - drug effects | Brain - metabolism | ATP-Binding Cassette Transporters - chemistry | Animals | Biological Transport | Brain - pathology | Female | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Blood-Brain Barrier
drug transporters | knockout mice | Blood-brain barrier | elacridar | topotecan | PHARMACOKINETICS | ONCOLOGY | IN-VIVO | BARRIER | DRUGS | PHASE-II | MICE | MULTIDRUG-RESISTANCE | INHIBITOR GF120918 | BLOOD | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Topotecan - pharmacology | Area Under Curve | Liver - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Male | ATP Binding Cassette Transporter, Sub-Family B - chemistry | ATP-Binding Cassette Transporters - physiology | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Topotecan - chemistry | Mice, Knockout | Brain - drug effects | Brain - metabolism | ATP-Binding Cassette Transporters - chemistry | Animals | Biological Transport | Brain - pathology | Female | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Mice | Blood-Brain Barrier
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2015, Volume 21, Issue 8, pp. 955 - 961
Colon cancer prevention currently relies on colonoscopy using white light to detect and remove polyps, but small and flat polyps are difficult to detect and...
COLONOSCOPY | MEDICINE, RESEARCH & EXPERIMENTAL | ENDOSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOMA | COLONIC DYSPLASIA | CANCER | CELL BIOLOGY | Amino Acid Sequence | Humans | Fluorescence | Macaca fascicularis | Molecular Sequence Data | Male | Peptides, Cyclic - drug effects | Colorectal Neoplasms - diagnosis | Animals | Proto-Oncogene Proteins c-met - analysis | Cell Line, Tumor | Female | Intestinal Polyps - diagnosis | Mice | Mice, Inbred BALB C | Prevention | Usage | Polyps (Pathology) | Colon cancer | Diagnosis | Colonoscopy | Biomarkers | Peptides | Medical diagnosis | Colorectal cancer
COLONOSCOPY | MEDICINE, RESEARCH & EXPERIMENTAL | ENDOSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADENOMA | COLONIC DYSPLASIA | CANCER | CELL BIOLOGY | Amino Acid Sequence | Humans | Fluorescence | Macaca fascicularis | Molecular Sequence Data | Male | Peptides, Cyclic - drug effects | Colorectal Neoplasms - diagnosis | Animals | Proto-Oncogene Proteins c-met - analysis | Cell Line, Tumor | Female | Intestinal Polyps - diagnosis | Mice | Mice, Inbred BALB C | Prevention | Usage | Polyps (Pathology) | Colon cancer | Diagnosis | Colonoscopy | Biomarkers | Peptides | Medical diagnosis | Colorectal cancer
Journal Article
Analytica Chimica Acta, ISSN 0003-2670, 10/2019, Volume 1074, pp. 43 - 53
This work evaluates the possibility of placement of high-resolution imaging and single-cell analysis laser ablation-inductively coupled plasma-mass...
Receptor-mediated imaging | Hybrid tracers | Breast cancer | Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) | Precision medicine | Fluorescence confocal microscopy | Fluoresceins - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Cetuximab - chemistry | Humans | Laser Therapy | Chelating Agents - chemistry | Fluorescence | Calibration | Pentetic Acid - analogs & derivatives | Microscopy, Confocal - methods | Peptides, Cyclic - chemistry | Receptors, CXCR4 - analysis | Flow Cytometry | Lanthanoid Series Elements - chemistry | Microscopy, Fluorescence - methods | Single-Cell Analysis - methods | Cell Line, Tumor | Mass Spectrometry - methods | ErbB Receptors - analysis | Biotechnology | Atomic force microscopy | Flow cytometry | High resolution | Instrumentation | Confocal microscopy | Pixels | Glass substrates | Receptors | Epidermal growth factor | Gelatin | Localization | Growth factors | Binding | Spectroscopy | Image resolution | Gels | Epidermal growth factor receptors | Mass spectroscopy | Cell membranes | Laser ablation | Tumor cell lines | Ablation | CXCR4 protein | Inductively coupled plasma | Microscopy | Cell lines | Green fluorescent protein | Scientific imaging | Mass spectrometry | Chelates | Tracers
Receptor-mediated imaging | Hybrid tracers | Breast cancer | Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) | Precision medicine | Fluorescence confocal microscopy | Fluoresceins - chemistry | Fluorescent Dyes - chemistry | Limit of Detection | Cetuximab - chemistry | Humans | Laser Therapy | Chelating Agents - chemistry | Fluorescence | Calibration | Pentetic Acid - analogs & derivatives | Microscopy, Confocal - methods | Peptides, Cyclic - chemistry | Receptors, CXCR4 - analysis | Flow Cytometry | Lanthanoid Series Elements - chemistry | Microscopy, Fluorescence - methods | Single-Cell Analysis - methods | Cell Line, Tumor | Mass Spectrometry - methods | ErbB Receptors - analysis | Biotechnology | Atomic force microscopy | Flow cytometry | High resolution | Instrumentation | Confocal microscopy | Pixels | Glass substrates | Receptors | Epidermal growth factor | Gelatin | Localization | Growth factors | Binding | Spectroscopy | Image resolution | Gels | Epidermal growth factor receptors | Mass spectroscopy | Cell membranes | Laser ablation | Tumor cell lines | Ablation | CXCR4 protein | Inductively coupled plasma | Microscopy | Cell lines | Green fluorescent protein | Scientific imaging | Mass spectrometry | Chelates | Tracers
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2008, Volume 7, Issue 8, pp. 2280 - 2287
We tested whether erlotinib hydrochloride (Tarceva, OSI-774), an orally active epidermal growth factor receptor tyrosine kinase inhibitor, is a substrate for...
BCRP | pharmacokinetics | P-gp | MRP2 | bioavailability | erlotinib | CELL LUNG-CANCER | MULTIDRUG TRANSPORTER | GEFITINIB | METABOLISM | ONCOLOGY | MDR1A P-GLYCOPROTEIN | ORAL BIOAVAILABILITY | TOPOTECAN | TYROSINE KINASE INHIBITOR | DIETARY CARCINOGEN | CANCER RESISTANCE PROTEIN | Erlotinib Hydrochloride | Protein Kinase Inhibitors - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | ATP Binding Cassette Transporter, Subfamily B - physiology | Quinazolines - pharmacokinetics | ATP-Binding Cassette Transporters - physiology | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 1 | Animals | ATP-Binding Cassette Transporters - genetics | Multidrug Resistance-Associated Proteins - physiology | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | Mice
BCRP | pharmacokinetics | P-gp | MRP2 | bioavailability | erlotinib | CELL LUNG-CANCER | MULTIDRUG TRANSPORTER | GEFITINIB | METABOLISM | ONCOLOGY | MDR1A P-GLYCOPROTEIN | ORAL BIOAVAILABILITY | TOPOTECAN | TYROSINE KINASE INHIBITOR | DIETARY CARCINOGEN | CANCER RESISTANCE PROTEIN | Erlotinib Hydrochloride | Protein Kinase Inhibitors - pharmacokinetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 | ATP Binding Cassette Transporter, Subfamily B - physiology | Quinazolines - pharmacokinetics | ATP-Binding Cassette Transporters - physiology | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 1 | Animals | ATP-Binding Cassette Transporters - genetics | Multidrug Resistance-Associated Proteins - physiology | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | Mice
Journal Article
Investigational New Drugs, ISSN 0167-6997, 4/2012, Volume 30, Issue 2, pp. 443 - 449
Purpose Erlotinib (Tarceva®, OSI-774) is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. As high-grade gliomas...
Brain tumor | Medicine & Public Health | Blood-brain barrier | Erlotinib | Oncology | ABC transporters | Pharmacology/Toxicology | MULTIDRUG TRANSPORTER | GEFITINIB | GROWTH-FACTOR-RECEPTOR | GLIOBLASTOMA-MULTIFORME | RECURRENT GLIOBLASTOMA | CELL LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | IN-VIVO | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Erlotinib Hydrochloride | Capillary Permeability | Area Under Curve | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Quinazolines - pharmacokinetics | Metabolic Clearance Rate | Antineoplastic Agents - administration & dosage | Chromatography, High Pressure Liquid | Tissue Distribution | Chromatography, Reverse-Phase | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Female | Quinazolines - administration & dosage | Antineoplastic Agents - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Injections, Intraperitoneal | Protein Kinase Inhibitors - blood | Quinazolines - blood | Blood-Brain Barrier - metabolism | Mice, Knockout | Protein Kinase Inhibitors - administration & dosage | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Antineoplastic Agents - blood | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Physiological aspects | Glycoproteins | Research | Membrane proteins | Studies | Pharmacology | Inhibitor drugs | Testing laboratories | Brain cancer
Brain tumor | Medicine & Public Health | Blood-brain barrier | Erlotinib | Oncology | ABC transporters | Pharmacology/Toxicology | MULTIDRUG TRANSPORTER | GEFITINIB | GROWTH-FACTOR-RECEPTOR | GLIOBLASTOMA-MULTIFORME | RECURRENT GLIOBLASTOMA | CELL LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | IN-VIVO | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Erlotinib Hydrochloride | Capillary Permeability | Area Under Curve | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Quinazolines - pharmacokinetics | Metabolic Clearance Rate | Antineoplastic Agents - administration & dosage | Chromatography, High Pressure Liquid | Tissue Distribution | Chromatography, Reverse-Phase | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Female | Quinazolines - administration & dosage | Antineoplastic Agents - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Injections, Intraperitoneal | Protein Kinase Inhibitors - blood | Quinazolines - blood | Blood-Brain Barrier - metabolism | Mice, Knockout | Protein Kinase Inhibitors - administration & dosage | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Antineoplastic Agents - blood | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Physiological aspects | Glycoproteins | Research | Membrane proteins | Studies | Pharmacology | Inhibitor drugs | Testing laboratories | Brain cancer
Journal Article
Neoplasia, ISSN 1476-5586, 07/2018, Volume 20, Issue 7, pp. 710 - 720
The anticancer drug temozolomide is the only drug with proven activity against high-grade gliomas and has therefore become a part of the standard treatment of...
Antineoplastic Agents, Alkylating/pharmacokinetics | Cell Line | Brain Neoplasms/diagnostic imaging | Neoplasm Proteins/antagonists & inhibitors | Dacarbazine/analogs & derivatives | Humans | Blood-Brain Barrier/metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors | Magnetic Resonance Imaging | Animals | Swine | Mice | Temozolomide | ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors | Disease Models, Animal | DRUG | PHASE-II TRIAL | EFFLUX TRANSPORTERS | ONCOLOGY | GLIOBLASTOMA-MULTIFORME | 1ST RELAPSE | BARRIER | TYROSINE KINASE INHIBITOR | MICE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Pharmacodynamics | Blood-brain barrier | Clonal deletion | Brain cancer | Antitumor activity | Breast cancer | Pharmacokinetics | P-Glycoprotein | Protein transport | Tumors
Antineoplastic Agents, Alkylating/pharmacokinetics | Cell Line | Brain Neoplasms/diagnostic imaging | Neoplasm Proteins/antagonists & inhibitors | Dacarbazine/analogs & derivatives | Humans | Blood-Brain Barrier/metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors | Magnetic Resonance Imaging | Animals | Swine | Mice | Temozolomide | ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors | Disease Models, Animal | DRUG | PHASE-II TRIAL | EFFLUX TRANSPORTERS | ONCOLOGY | GLIOBLASTOMA-MULTIFORME | 1ST RELAPSE | BARRIER | TYROSINE KINASE INHIBITOR | MICE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Pharmacodynamics | Blood-brain barrier | Clonal deletion | Brain cancer | Antitumor activity | Breast cancer | Pharmacokinetics | P-Glycoprotein | Protein transport | Tumors
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2019, p. jnumed.119.235234
Journal Article
Annals of surgical oncology, ISSN 1068-9265, 2012, Volume 19, Issue 6, pp. 1988 - 1994
This study was designed to examine the feasibility of combining lymphoscintigraphy and intraoperative sentinel node identification in patients with head and...
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | SURGERY | ONCOLOGY | BLUE | Melanoma - diagnostic imaging | Lymph Nodes - pathology | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Feasibility Studies | Adult | Female | Radiopharmaceuticals | Technetium Tc 99m Aggregated Albumin | Head and Neck Neoplasms - diagnostic imaging | Indocyanine Green | Melanoma - pathology | Head and Neck Neoplasms - pathology | Aged | Sentinel Lymph Node Biopsy | Melanoma - surgery | Neoplasm Staging | Fluorescent Dyes | Head and Neck Neoplasms - surgery | Lymph Nodes - diagnostic imaging | Preoperative Period | Gamma rays | Fluorescence | Tracers (Chemistry) | SPECT imaging | Tracers (Biology) | Melanoma | Head and Neck Oncology
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | SURGERY | ONCOLOGY | BLUE | Melanoma - diagnostic imaging | Lymph Nodes - pathology | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Feasibility Studies | Adult | Female | Radiopharmaceuticals | Technetium Tc 99m Aggregated Albumin | Head and Neck Neoplasms - diagnostic imaging | Indocyanine Green | Melanoma - pathology | Head and Neck Neoplasms - pathology | Aged | Sentinel Lymph Node Biopsy | Melanoma - surgery | Neoplasm Staging | Fluorescent Dyes | Head and Neck Neoplasms - surgery | Lymph Nodes - diagnostic imaging | Preoperative Period | Gamma rays | Fluorescence | Tracers (Chemistry) | SPECT imaging | Tracers (Biology) | Melanoma | Head and Neck Oncology
Journal Article
European Urology, ISSN 0302-2838, 2011, Volume 60, Issue 4, pp. 826 - 833
Abstract Background Integration of molecular imaging and in particular intraoperative image guidance is expected to improve the surgical accuracy of...
Urology | Fluorescence | Image-guided surgery | Sentinel lymph node | Prostate cancer | SPECT/CT | BREAST-CANCER | LYMPHADENECTOMY | DISSECTION | METASTASES | UROLOGY & NEPHROLOGY | CARCINOMA | Prostatectomy - methods | Radioactive Tracers | Lymph Nodes - surgery | Prostatic Neoplasms - surgery | Technetium Tc 99m Aggregated Albumin | Carcinoma - surgery | Humans | Middle Aged | Sentinel Lymph Node Biopsy - methods | Indocyanine Green | Male | Tomography, X-Ray Computed | Lymphatic Metastasis | Positron-Emission Tomography | Carcinoma - diagnostic imaging | Laparoscopy - methods | Pilot Projects | Multimodal Imaging - methods | Monitoring, Intraoperative - methods | Prostatic Neoplasms - diagnostic imaging | Aged | Fluorescent Dyes | Lymph Nodes - diagnostic imaging | Care and treatment | Tracers (Biology) | Surgery | Laparoscopic surgery | SPECT imaging | Laparoscopy
Urology | Fluorescence | Image-guided surgery | Sentinel lymph node | Prostate cancer | SPECT/CT | BREAST-CANCER | LYMPHADENECTOMY | DISSECTION | METASTASES | UROLOGY & NEPHROLOGY | CARCINOMA | Prostatectomy - methods | Radioactive Tracers | Lymph Nodes - surgery | Prostatic Neoplasms - surgery | Technetium Tc 99m Aggregated Albumin | Carcinoma - surgery | Humans | Middle Aged | Sentinel Lymph Node Biopsy - methods | Indocyanine Green | Male | Tomography, X-Ray Computed | Lymphatic Metastasis | Positron-Emission Tomography | Carcinoma - diagnostic imaging | Laparoscopy - methods | Pilot Projects | Multimodal Imaging - methods | Monitoring, Intraoperative - methods | Prostatic Neoplasms - diagnostic imaging | Aged | Fluorescent Dyes | Lymph Nodes - diagnostic imaging | Care and treatment | Tracers (Biology) | Surgery | Laparoscopic surgery | SPECT imaging | Laparoscopy
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 07/2012, Volume 53, Issue 7, pp. 1026 - 1033
Intraprostatic injection of the hybrid tracer indocyanine green (ICG)-Tc-99m-nanocolloid enables both preoperative sentinel node (SN) identification and...
Fluorescence | Hybrid | Sentinel node | Surgical guidance | Prostate | hybrid | fluorescence | DISSECTION | sentinel node | surgical guidance | prostate | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prostatic Neoplasms - pathology | Prostatic Neoplasms - surgery | Coloring Agents | Humans | Sentinel Lymph Node Biopsy - methods | Indocyanine Green | Tomography, Emission-Computed, Single-Photon | Male | Laparoscopy | Radiopharmaceuticals - chemical synthesis | Preoperative Care | Paraffin Embedding | Prostate - pathology | Technetium Tc 99m Aggregated Albumin - chemical synthesis | Image Processing, Computer-Assisted | Prostate - diagnostic imaging | Prostatic Neoplasms - diagnostic imaging | Prostatectomy | Fluorescent Dyes | Lymph Nodes - diagnostic imaging
Fluorescence | Hybrid | Sentinel node | Surgical guidance | Prostate | hybrid | fluorescence | DISSECTION | sentinel node | surgical guidance | prostate | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prostatic Neoplasms - pathology | Prostatic Neoplasms - surgery | Coloring Agents | Humans | Sentinel Lymph Node Biopsy - methods | Indocyanine Green | Tomography, Emission-Computed, Single-Photon | Male | Laparoscopy | Radiopharmaceuticals - chemical synthesis | Preoperative Care | Paraffin Embedding | Prostate - pathology | Technetium Tc 99m Aggregated Albumin - chemical synthesis | Image Processing, Computer-Assisted | Prostate - diagnostic imaging | Prostatic Neoplasms - diagnostic imaging | Prostatectomy | Fluorescent Dyes | Lymph Nodes - diagnostic imaging
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 605
Objectives: The success of (receptor-mediated) fluorescence-based image guided surgery is directly linked to the specific (in vivo) characteristics of the...
Slopes | Dyes | Liver | Fluorescence | Emission | Fluorescent dyes | Fluorescent indicators | Serum proteins | Composition effects | Optimization | Proteins | Endoscopes | Surgery | Imaging | Chemical composition | Binding | Cyanine dyes | Medical imaging | Kidneys | I.R. radiation | Derivatives | Physical properties | Single photon emission computed tomography | Cells | Emissions | Near infrared radiation | Organic chemistry | Wavelengths | Penetration | Affinity | In vivo methods and tests | Visibility | Kinetics | Chelates | Tracers | Tumors
Slopes | Dyes | Liver | Fluorescence | Emission | Fluorescent dyes | Fluorescent indicators | Serum proteins | Composition effects | Optimization | Proteins | Endoscopes | Surgery | Imaging | Chemical composition | Binding | Cyanine dyes | Medical imaging | Kidneys | I.R. radiation | Derivatives | Physical properties | Single photon emission computed tomography | Cells | Emissions | Near infrared radiation | Organic chemistry | Wavelengths | Penetration | Affinity | In vivo methods and tests | Visibility | Kinetics | Chelates | Tracers | Tumors
Journal Article
Investigational New Drugs, ISSN 0167-6997, 2/2009, Volume 27, Issue 1, pp. 31 - 40
Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption,...
BCRP | Elacridar | Imatinib | P-gp | Medicine & Public Health | Pantoprazole | ADME | Oncology | Pharmacology/Toxicology | DRUG-INTERACTIONS | TYROSINE KINASE | PHASE-II | BLOOD-BRAIN-BARRIER | CHRONIC MYELOID-LEUKEMIA | MESYLATE | LIQUID-CHROMATOGRAPHY | ONCOLOGY | PHARMACOLOGY & PHARMACY | ABC TRANSPORTERS | GASTROINTESTINAL STROMAL TUMORS | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Pyrimidines - blood | Bile - chemistry | 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology | Kidney - metabolism | Absorption | ATP-Binding Cassette Transporters - genetics | Female | Antineoplastic Agents - pharmacokinetics | Piperazines - pharmacokinetics | Piperazines - blood | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Liver - metabolism | Imatinib Mesylate | Mice, Knockout | Brain - drug effects | Animals | Feces - chemistry | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Metabolic Clearance Rate - drug effects | Mice | Benzamides | ATP Binding Cassette Transporter, Sub-Family B - genetics | Drug Combinations | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Proteins | Prescription drugs | Chemotherapy | Cellular biology | Rodents | Pharmacology | Pharmaceutical sciences
BCRP | Elacridar | Imatinib | P-gp | Medicine & Public Health | Pantoprazole | ADME | Oncology | Pharmacology/Toxicology | DRUG-INTERACTIONS | TYROSINE KINASE | PHASE-II | BLOOD-BRAIN-BARRIER | CHRONIC MYELOID-LEUKEMIA | MESYLATE | LIQUID-CHROMATOGRAPHY | ONCOLOGY | PHARMACOLOGY & PHARMACY | ABC TRANSPORTERS | GASTROINTESTINAL STROMAL TUMORS | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Pyrimidines - blood | Bile - chemistry | 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology | Kidney - metabolism | Absorption | ATP-Binding Cassette Transporters - genetics | Female | Antineoplastic Agents - pharmacokinetics | Piperazines - pharmacokinetics | Piperazines - blood | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Liver - metabolism | Imatinib Mesylate | Mice, Knockout | Brain - drug effects | Animals | Feces - chemistry | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Metabolic Clearance Rate - drug effects | Mice | Benzamides | ATP Binding Cassette Transporter, Sub-Family B - genetics | Drug Combinations | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Proteins | Prescription drugs | Chemotherapy | Cellular biology | Rodents | Pharmacology | Pharmaceutical sciences
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, p. 39908
The use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or "training" of cells to make them...
POLYMERS | ADHESION | CLICK CHEMISTRY | MULTIDISCIPLINARY SCIENCES | MEMBRANES | AGENTS | RECEPTOR 4 | CYBORG CELLS | BINDING | DELIVERY | BETA | Fluorescent Dyes - chemistry | Humans | Peptides, Cyclic - pharmacology | Peptides, Cyclic - chemistry | Receptors, CXCR4 - metabolism | beta-Cyclodextrins - chemistry | Cell Line, Tumor | Protein Binding | Polymers - chemistry | Cell Membrane - metabolism | Cell Membrane - drug effects | Adamantane - analogs & derivatives | Maleic Anhydrides - chemistry | Cyclodextrin | Cell interactions | Therapeutic applications | Cell surface | CXCR4 protein | Mammalian cells
POLYMERS | ADHESION | CLICK CHEMISTRY | MULTIDISCIPLINARY SCIENCES | MEMBRANES | AGENTS | RECEPTOR 4 | CYBORG CELLS | BINDING | DELIVERY | BETA | Fluorescent Dyes - chemistry | Humans | Peptides, Cyclic - pharmacology | Peptides, Cyclic - chemistry | Receptors, CXCR4 - metabolism | beta-Cyclodextrins - chemistry | Cell Line, Tumor | Protein Binding | Polymers - chemistry | Cell Membrane - metabolism | Cell Membrane - drug effects | Adamantane - analogs & derivatives | Maleic Anhydrides - chemistry | Cyclodextrin | Cell interactions | Therapeutic applications | Cell surface | CXCR4 protein | Mammalian cells
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 7/2012, Volume 41, Issue 15, pp. 5239 - 5261
The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL12) is a natural regulatory process in the...
CELL LUNG-CANCER | HIGH SELECTIVITY INDEXES | POSITRON-EMISSION-TOMOGRAPHY | ANTI-HIV ACTIVITY | LYMPH-NODE METASTASIS | BREAST-CANCER METASTASIS | WEAK PARTIAL AGONISTS | HUMAN-IMMUNODEFICIENCY-VIRUS | CHEMISTRY, MULTIDISCIPLINARY | FIREFLY LUCIFERASE COMPLEMENTATION | SMALL-MOLECULE INHIBITOR | Neoplasms - metabolism | Animals | Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Cell Line, Tumor | Molecular Imaging - methods | Neoplasms - pathology | Luminescent Agents - metabolism | Receptors, CXCR4 - chemistry | Receptors, CXCR4 - metabolism
CELL LUNG-CANCER | HIGH SELECTIVITY INDEXES | POSITRON-EMISSION-TOMOGRAPHY | ANTI-HIV ACTIVITY | LYMPH-NODE METASTASIS | BREAST-CANCER METASTASIS | WEAK PARTIAL AGONISTS | HUMAN-IMMUNODEFICIENCY-VIRUS | CHEMISTRY, MULTIDISCIPLINARY | FIREFLY LUCIFERASE COMPLEMENTATION | SMALL-MOLECULE INHIBITOR | Neoplasms - metabolism | Animals | Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Cell Line, Tumor | Molecular Imaging - methods | Neoplasms - pathology | Luminescent Agents - metabolism | Receptors, CXCR4 - chemistry | Receptors, CXCR4 - metabolism
Journal Article