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Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 244 - 13
FLT3 mutations are prevalent in AML patients and confer poor prognosis. Crenolanib, a potent type I pan-FLT3 inhibitor, is effective against both internal... 
TARGETED THERAPY | AML | INTERNAL TANDEM DUPLICATION | ACTIVATION | FLT3 INHIBITORS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | PROGNOSTIC RELEVANCE | MUTATIONS | SORAFENIB | CHEMOTHERAPY | Humans | Middle Aged | Male | Antineoplastic Combined Chemotherapy Protocols - pharmacology | fms-Like Tyrosine Kinase 3 - genetics | Piperidines - pharmacology | HEK293 Cells | Aged, 80 and over | Inhibitory Concentration 50 | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Pyrimidinones - pharmacology | Epigenesis, Genetic - drug effects | Tandem Repeat Sequences - genetics | Benzimidazoles - therapeutic use | Leukemia, Myeloid, Acute - pathology | Membrane Proteins - genetics | Pyrimidinones - therapeutic use | Isocitrate Dehydrogenase - genetics | Treatment Outcome | Mutation - genetics | Whole Exome Sequencing | Drug Resistance, Neoplasm - genetics | Animals | Mutation - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Benzimidazoles - pharmacology | Aged | Mice | Protein Kinase Inhibitors - pharmacology | Pyridones - therapeutic use | Pyridones - pharmacology | Drug Screening Assays, Antitumor | Leukemia, Myeloid, Acute - genetics | Tyrosine | Regulators | Transcription factors | Myeloid leukemia | Leukemia | Genetic diversity | Kinases | Patients | Molecular modelling | Epigenetics | Mutation | Acute myeloid leukemia | Protein-tyrosine kinase
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2189 - 16
Improvement in survival has been achieved for children and adolescents with AML but is largely attributed to enhanced supportive care as opposed to the... 
NUCLEOSIDE | ONCOLOGY | VOLASERTIB | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOGENOUS LEUKEMIA | ACUTE MEGAKARYOBLASTIC LEUKEMIA | LOW-DOSE CYTARABINE | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | CANCER | CHILDREN | Cytarabine - pharmacology | Taxoids - pharmacology | Cytarabine - therapeutic use | Humans | Child, Preschool | Deoxycytidine - pharmacology | Infant | Male | Bone Marrow - radiation effects | Leukemia, Experimental - etiology | Whole-Body Irradiation - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Young Adult | Taxoids - therapeutic use | Deoxycytidine - therapeutic use | Janus Kinase Inhibitors - pharmacology | Leukemia, Experimental - mortality | Bone Marrow Transplantation | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Child | High-Throughput Screening Assays - methods | Leukemia, Experimental - pathology | Leukemia, Experimental - drug therapy | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Mice, Transgenic | Leukemia, Myeloid, Acute - mortality | Xenograft Model Antitumor Assays | Disease-Free Survival | Animals | Janus Kinase Inhibitors - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Bone Marrow - pathology | Cell Line, Tumor | Mice | Deoxycytidine - analogs & derivatives | Pediatrics | Gemcitabine | Leukemia | High-throughput screening | Survival | Hematopoietic stem cells | Hemopoiesis | Chemotherapy | Cytarabine | Inhibitors | Stem cells | In vivo methods and tests | Children | Adolescents | Acute myeloid leukemia
Journal Article
Journal Article
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 11/2014, Volume 138, Issue 11, pp. 1474 - 1480
Journal Article
Clinical and Translational Science, ISSN 1752-8054, 11/2019, Volume 12, Issue 6, pp. 641 - 647
Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse... 
Journal Article
Clinical and Translational Science, ISSN 1752-8054, 11/2019, Volume 12, Issue 6, pp. 641 - 647
Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse... 
Pediatrics | Tyk2 protein | Pathogenesis | Leukemia | Genes | Clinical trials | Kinases | Cancer therapies | Gene sequencing | Complexity | Heterogeneity | Diagnosis | Localization | Protein-tyrosine kinase | Tyrosine | Myeloid leukemia | Cloning | Ribonucleic acid--RNA | Patients | Mutants | Children & youth | Gene frequency | Leukemogenesis | Lymphomas | Mutation | Acute myeloid leukemia | Research
Journal Article
Journal Article