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Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 7, pp. 1222 - 1232
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7591, pp. 485 - 489
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase... 
PROTEIN | CANDIDA-GLABRATA | PDR1 | MULTIDISCIPLINARY SCIENCES | Fluconazole - pharmacology | Mediator Complex - metabolism | Transcriptional Activation - drug effects | Thiourea - pharmacology | Candidiasis - microbiology | Trans-Activators - chemistry | Ketoconazole - pharmacology | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Fungal - drug effects | Mediator Complex - chemistry | Drug Resistance, Multiple, Fungal - drug effects | Candidiasis - drug therapy | Protein Binding - drug effects | Nuclear Magnetic Resonance, Biomolecular | Binding Sites - drug effects | Antifungal Agents - pharmacology | Protein Structure, Tertiary | Hydrazines - pharmacology | Drug Resistance, Fungal - drug effects | Hydrazines - pharmacokinetics | Models, Molecular | Thiourea - pharmacokinetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Candida glabrata - metabolism | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | Mice | Candida glabrata - genetics | Thiourea - analogs & derivatives | Candida glabrata - drug effects | Fungal Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Prevention | Drug resistance in microorganisms | Gene mutations | Yeast fungi | Physiological aspects | Genetic aspects | Research | Fungi | Transcription factors | Genes | Mutation | Fungal infections | RNA polymerase | Drug resistance | Urogenital system | Index Medicus
Journal Article
Tetrahedron, ISSN 0040-4020, 04/2009, Volume 65, Issue 16, p. 3305
The function and higher order structure of [beta]-proline oligomers have been relatively unexplored compared to other foldamer classes due in part to synthetic... 
Stereoisomers | Oligomers | Proline | Monomers
Journal Article
Blood, ISSN 0006-4971, 06/2016, Volume 127, Issue 25, pp. 3237 - 3252
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2013, Volume 12, Issue 12, pp. 2651 - 2662
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2017, Volume 13, Issue 12, pp. 1207 - 1215
Oncogenic forms of the kinase FLT3 are important therapeutic targets in acute myeloid leukemia (AML); however, clinical responses to small-molecule kinase... 
INTERNAL TANDEM DUPLICATION | CELLS | DUBS | C-CBL | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | DEATH | ACUTE MYELOID-LEUKEMIA | MUTATIONS | DISCOVERY | Small Molecule Libraries - pharmacology | Humans | Leukemia, Myeloid, Acute - metabolism | Ubiquitin - metabolism | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | fms-Like Tyrosine Kinase 3 - genetics | Protein Kinase Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Ubiquitin Thiolesterase - metabolism | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Ubiquitin Thiolesterase - antagonists & inhibitors | Cell Survival - drug effects | Leukemia, Myeloid, Acute - pathology | Thiophenes - pharmacology | Antineoplastic Agents - chemistry | Ubiquitin Thiolesterase - genetics | fms-Like Tyrosine Kinase 3 - metabolism | Small Molecule Libraries - chemistry | Animals | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Neoplasms, Experimental - metabolism | Thiophenes - chemistry | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Degradation | Ubiquitin | Animal models | Inhibitors | Myeloid leukemia | Leukemia | Rodents | Cell lines | Pharmacology | Kinases | Acute myeloid leukemia | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 01/2016, Volume 30, Issue 1, pp. 173 - 181
Journal Article
British Journal of Haematology, ISSN 0007-1048, 07/2019
Mutations in two type-3 receptor tyrosine kinases (RTKs), KIT and FLT3, are common in both acute myeloid leukaemia (AML) and systemic mastocytosis (SM) and... 
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2014, Volume 457, Issue 1, pp. 215 - 225
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1)... 
AMPK-related kinase 5 (ARK5) | AMP-activated protein kinase (AMPK) | Sucrose-non-fermenting protein kinase/AMPKrelated protein kinase (SNARK) | Liver kinase B1 (LKB1) | Kinase profiling | Kinase inhibitor | Myosin phosphate-targeting subunit 1(MYPT1) | CELLS | liver kinase B1 (LKB1) | PHOSPHORYLATION | ARK5 | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | sucrose-non-fermenting protein kinase/AMPK-related protein kinase (SNARK) | kinase inhibitor | INVASION | PATHWAY | ROLES | kinase profiling | AMPK | myosin phosphate-targeting subunit 1(MYPT1) | ASSOCIATION | EXPRESSION | Protein Kinases - genetics | Humans | Substrate Specificity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Repressor Proteins - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Protein-Serine-Threonine Kinases - physiology | Benzodiazepinones - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Repressor Proteins - agonists | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Cell Movement - drug effects | Tumor Suppressor Proteins - physiology | Animals | Anilides - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Index Medicus | ACC, acetyl-CoA carboxylase | AMPKrelated protein kinase (SNARK) | SIK, salt-induced kinase | NF-κB, nuclear factor κB | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HA, haemagglutinin | BRSK, brain-specific kinase | sucrose-non-fermenting protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | PP1, protein phosphatase 1 | MEF, mouse embryonic fibroblast | PEI, polyethylenimine | MARK, microtubule-affinity-regulating kinase | MYPT1, myosin phosphate-targeting subunit 1 | LKB1, liver kinase B1
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 12, pp. 4511 - 4519
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal... 
inactive conformation | kinase | innate immunity | inflammation | Toll-like receptor (TLR) | crystal structure | drug development | type II inhibition | structural biology | IRAK4 | ACTIVATION | INFECTIONS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | CRYSTAL-STRUCTURES | MODEL | DISCOVERY | MUTATION | OPTIMIZATION | MYD88
Journal Article
Blood, ISSN 0006-4971, 05/2018, Volume 131, Issue 18, pp. 2047 - 2059
Acquired ibrutinib resistance due to BTKCys481 mutations occurs in B-cell malignancies, including those with MYD88 mutations. BTKCys481 mutations are usually... 
SURVIVAL | CYTOKINES | BRUTON TYROSINE KINASE | IL-10 LEVELS | BONE-MARROW | MUTATION | RECEPTOR | EXTRACELLULAR-MATRIX | WALDENSTROM MACROGLOBULINEMIA | INHIBITOR | HEMATOLOGY | Index Medicus | Abridged Index Medicus
Journal Article