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Arteriosclerosis thrombosis and vascular biology, ISSN 1079-5642, 07/2010, Volume 30, Issue 7, pp. 1407 - U356
Objective-Endothelial cell senescence is an important contributor to vascular aging and is increased under diabetic conditions. Here we investigated whether... 
endothelium | APOPTOSIS | TRANSCRIPTION | glucagon-like peptide 1 | ATHEROSCLEROSIS | diabetes mellitus | ZUCKER RAT | NEPHROPATHY | UMCG Approved | senescence | reactive oxygen species | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | DYSFUNCTION | GLP-1 RECEPTOR | DIABETIC FATTY RATS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Diabetes Mellitus - enzymology | Diabetes Mellitus - pathology | Heme Oxygenase-1 - metabolism | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Cellular Senescence - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Adamantane - analogs & derivatives | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Adamantane - pharmacology | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Cells, Cultured | Diabetes Mellitus - drug therapy | Hydrogen Peroxide - pharmacology | Rats | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Rats, Zucker | Animals | Glucagon-Like Peptide-1 Receptor | Cyclic AMP Response Element-Binding Protein - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Venoms - pharmacology | DNA Damage | Enzyme Activation | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - enzymology | Endothelial Cells - drug effects
Journal Article
Diabetes Care, ISSN 0149-5992, 06/2017, Volume 40, Issue 6, pp. 784 - 792
OBJECTIVE Although patients with type 2 diabetes (T2D) with nephropathy are at high risk for renal and cardiovascular complications, relevant biomarkers have... 
CARDIOVASCULAR EVENTS | GROWTH-DIFFERENTIATION FACTOR-15 | MACROPHAGE INHIBITORY CYTOKINE-1 | SENSITIVITY TROPONIN-T | KIDNEY-FUNCTION | HEPARAN-SULFATE PROTEOGLYCAN | NESTED CASE-CONTROL | NATRIURETIC PEPTIDE | INDEPENDENT MARKER | NT-PROBNP
Journal Article
American journal of physiology-Renal physiology, ISSN 1931-857X, 05/2016, Volume 310, Issue 10, pp. F1047 - F1053
In healthy rats, the physiological variation of baseline endothelial function of intrarenal arteries correlates with the severity of renal damage in response... 
endothelial function | chronic kidney disease | proteinuria | SUSCEPTIBILITY | INJURY | FUNCTION PREDICTS | UREMIC RATS | DAMAGE | ACEi treatment | THERAPY | DISEASE | HYPERTENSION | KIDNEY | response variability
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 1522-1539, 12/2016, Volume 311, Issue 6, pp. H1459 - H1469
Vitamin D deficiency is one of the most common nutritional deficiencies worldwide. Maternal vitamin D deficiency is associated with increased susceptibility to... 
Blood Pressure | Receptor, Angiotensin, Type 1 | Prenatal Exposure Delayed Effects | ABNORMALITIES | Epigenesis, Genetic | Pregnancy Complications | Vitamin D Deficiency | Male | Paternal Exposure | Parathyroid Hormone | Maternal Exposure | Vasodilation | Journal Article | DUTCH FAMINE | Video-Audio Media | DNA Methylation | Renin | Vitamin D | PANNEXIN 1 | Atrial Natriuretic Factor | PLASMA-RENIN ACTIVITY | Female | Real-Time Polymerase Chain Reaction | Hypertension | HEART-FAILURE | Rats | Nerve Tissue Proteins | Rats, Sprague-Dawley | ENDOTHELIAL FUNCTION | Blotting, Western | DNA-METHYLATION | Pregnancy | Animals | Receptors, Calcitriol | Connexins | Endothelium, Vascular | RNA, Messenger | CARDIOVASCULAR RISK | RENAL-INSUFFICIENCY | Endothelial dysfunction | Epigenetics | Pannexin-1 | Blood pressure | blood pressure | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | vitamin D | endothelial dysfunction | epigenetics | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | Blood Pressure - genetics | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Vasodilation - genetics | Receptor, Angiotensin, Type 1 - genetics | Renin - genetics | Parathyroid Hormone - metabolism | Atrial Natriuretic Factor - genetics | Hypertension - genetics | Vitamin D Deficiency - genetics | Endothelium, Vascular - physiopathology | Connexins - genetics | Nerve Tissue Proteins - genetics | Hypertension - physiopathology | Prenatal Exposure Delayed Effects - genetics | Pregnancy Complications - genetics | Vitamin D - analogs & derivatives | Vitamin D - metabolism | Vitamin D Deficiency - metabolism | Physiological aspects | Vitamin D deficiency | Methylation | Pregnancy, Complications of | Health aspects
Journal Article
Expert Review of Cardiovascular Therapy, ISSN 1477-9072, 2006, Volume 4, Issue 5, pp. 631 - 647
Zofenopril, an inhibitor of the angiotensin-converting enzyme (ACE), has recently been widely introduced into the pharmaceutical market. Its clinical safety... 
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0162029
The sphingosine-1-phosphate (S1P) analog FTY720 exerts pleiotropic effects on the cardiovascular system and causes down-regulation of S1P receptors. Myogenic... 
HEART | SPHINGOSINE 1-PHOSPHATE RECEPTORS | COX-2 EXPRESSION | CONSTRICTION | INHIBITION | VASCULATURE | RESISTANCE | SPHINGOSINE-1-PHOSPHATE RECEPTOR-2 | MODULATOR | VASOCONSTRICTION | Mesenteric Arteries - cytology | Fingolimod Hydrochloride - pharmacology | Lysophospholipids - metabolism | Mesenteric Arteries - physiology | Rats, Wistar | Humans | Body Weight - drug effects | Rats | Male | Pressure | Vasoconstriction - drug effects | Gene Expression Regulation - drug effects | Sphingosine - analogs & derivatives | Animals | Muscle Development - drug effects | Signal Transduction - drug effects | Time Factors | Endothelial Cells - cytology | Hemodynamics - drug effects | Sphingosine - metabolism | Myocytes, Smooth Muscle - drug effects | Receptors, Lysosphingolipid - metabolism | Myocytes, Smooth Muscle - cytology | Endothelial Cells - drug effects | Smooth muscle | Dosage and administration | Research | Fingolimod | Sphingosine | Endothelium | Phosphates | Cardiac arrhythmia | Nephrology | Kinases | Arteries | Prostaglandin endoperoxide synthase | Sphingosine 1-phosphate | Angiogenesis | Receptors | Prostaglandins | Rodents | Denudation | Down-regulation | Constrictions | Blood pressure | Cardiovascular system | Kidneys | Contractility | Muscles | Pharmacology | Permeability | Muscle contraction | Endothelial cells | Medicine | Studies | Signaling | Perfusion | FTY720 | Pharmacy | Coronary vessels | Receptor mechanisms | Laboratory animals | Kidney transplantation | Veins & arteries
Journal Article
American journal of physiology-Renal physiology, ISSN 1931-857X, 11/2013, Volume 305, Issue 9, pp. F1249 - F1264
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2016, Volume 67, Issue 13, pp. 2292 - 2292
  Panx1 encodes a hemi channel known to be involved in endothelial-dependent relaxation, and we demonstrated that in F1-depl-rats the increase in blood... 
Cardiovascular | Internal Medicine | Hypertension | DNA methylation | Vitamin deficiency | Blood pressure | Vitamin D | Rodents
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46781
Background: Dipeptidyl peptidase 4 (DPP4) and angiotensin-converting enzyme (ACE) are important target enzymes in glycemic control and renovascular protection.... 
METABOLIC SYNDROME | CYCLOOXYGENASE-2 | GENE-EXPRESSION | INJURY | ANGIOTENSIN-II | INHIBITORS | KIDNEY | UP-REGULATION | NEPHROPATHY | UMCG Approved | DIPEPTIDYL PEPTIDASE-IV | MULTIDISCIPLINARY SCIENCES | DYSFUNCTION | Immunohistochemistry | Dipeptidyl Peptidase 4 - metabolism | Nitriles - pharmacology | Diabetes Mellitus, Type 2 - genetics | Dipeptidyl Peptidase 4 - blood | Endothelium, Vascular - drug effects | Aorta - metabolism | Diabetes Mellitus, Type 2 - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Endothelium, Vascular - physiology | Pyrrolidines - pharmacology | Kidney - metabolism | Peptidyl-Dipeptidase A - blood | E-Selectin - genetics | Peptidyl-Dipeptidase A - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Adamantane - analogs & derivatives | Rats, Inbred SHR | Adamantane - pharmacology | Egg Proteins - pharmacology | Kidney - drug effects | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Aorta - drug effects | Diabetes Mellitus, Type 2 - prevention & control | Rats | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion Molecules - metabolism | Protein Hydrolysates - pharmacology | Blotting, Western | Rats, Zucker | Animals | Prostaglandin-Endoperoxide Synthases - metabolism | Vasodilation - drug effects | In Vitro Techniques | Aorta - physiology | Type 2 diabetes | Glucagon | RNA | Protein hydrolysates | Angiotensin | Indomethacin | Diabetes therapy | Drinking water | Peptides | Syngeneic grafts | Interleukin | Western blotting | Prostaglandin endoperoxide synthase | Proteins | Prostaglandins | Metabolites | Peptidyl-dipeptidase A | Rodents | Aorta | Supplementation | Damage | Food | Formulations | Hypertension | Enzymes | Departments | Peptidase | Kidneys | Diabetes mellitus | Dietary supplements | Contractility | Pharmacology | Interleukin 13 | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Insulin | Hydrolysates | Endothelium | Studies | Polymerase chain reaction | p22phox Protein | Cyclooxygenase-1 | Coronary vessels | Fibrosis | Diabetes | Laboratory animals | Endocrinology | metabolic syndrome | up-regulation | angiotensin-ii | kidney | inhibitors | dipeptidyl peptidase-iv | cyclooxygenase-2 | nephropathy | gene-expression | injury
Journal Article
International Journal of Science Education, ISSN 0950-0693, 08/2012, Volume 34, Issue 12, pp. 1795 - 1821
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79884
Objective: We investigated endothelial dysfunction and the role of angiotensin (Ang)-II type I (AT1-R) and type II (AT2-R) receptor in the changes in the... 
Receptor, Angiotensin, Type 1 | Pyridines | Receptor, Angiotensin, Type 2 | Endothelial Cells | Cyclooxygenase 2 | Cyclooxygenase 1 | Rats | Nitric Oxide Synthase Type II | Lipopolysaccharides | Pregnancy | Angiotensin II Type 1 Receptor Blockers | Vasodilator Agents | Prostaglandins | Animals | Imidazoles | Losartan | Pre-Eclampsia | Aorta | Female | Angiotensin II | Disease Models, Animal | LOW-DOSE-ENDOTOXIN | HYPERPOLARIZING FACTOR | MESENTERIC-ARTERIES | MULTIDISCIPLINARY SCIENCES | URINARY-EXCRETION | NITRIC-OXIDE | PREGNANT RATS | RECEPTOR | VASCULAR REACTIVITY | ANIMAL-MODEL | ACETYLCHOLINE-INDUCED RELAXATION | Aorta - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Receptor, Angiotensin, Type 1 - genetics | Cyclooxygenase 2 - genetics | Pre-Eclampsia - metabolism | Receptor, Angiotensin, Type 2 - genetics | Cyclooxygenase 1 - genetics | Vasodilator Agents - pharmacology | Angiotensin II - metabolism | Endothelial Cells - metabolism | Aorta - drug effects | Losartan - pharmacology | Imidazoles - pharmacology | Receptor, Angiotensin, Type 2 - metabolism | Nitric Oxide Synthase Type II - genetics | Receptor, Angiotensin, Type 1 - metabolism | Lipopolysaccharides - pharmacology | Pyridines - pharmacology | Endothelial Cells - drug effects | Prostaglandins - metabolism | RNA | Vasodilators | Blood vessels | Endothelium | Arginine | Dilatation | Pregnant women | Preeclampsia | Angiotensin | Acetylcholine | Indomethacin | Endothelium-derived relaxing factors | Mitogens | Adaptations | Biology | Experiments | Rodents | Phenylephrine | Hypertension | Sensitivity analysis | Gynecology | Pharmacology | Pre-eclampsia | Gene expression | Obstetrics | Nitric-oxide synthase | NG-Nitroarginine methyl ester | Polymerase chain reaction | Sensitivity | Nitric oxide | Cyclooxygenase-2 | Laboratory animals | Veins & arteries
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2013, Volume 304, Issue 5, pp. 709 - 718
Growth differentiation factor 15 (GDF15) is an independent predictor of cardiovascular disease, and increased GDF15 levels have been associated with... 
endothelium | DB/DB MICE | MYOCARDIAL-INFARCTION | MACROPHAGE INHIBITORY CYTOKINE-1 | HEART-FAILURE | INJURY | BETA SUPERFAMILY | INDUCTION | growth differentiation factor 15 | mice | caveolin-1 | NITRIC-OXIDE | CARDIOVASCULAR-DISEASE | aorta | HYPERTENSION | caveolae | Caveolin-1 | Aorta | Mice | Caveolae | Growth differentiation factor 15 | Endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PERIPHERAL VASCULAR DISEASE | Human Umbilical Vein Endothelial Cells | Reactive Oxygen Species - metabolism | Receptors, Leptin - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Caveolae - physiology | Growth Differentiation Factor 15 - genetics | Aorta, Thoracic - physiology | Aorta, Thoracic - drug effects | Nitric Oxide Synthase Type III - metabolism | Vasodilation - physiology | Endothelial Cells - physiology | Disease Models, Animal | Endothelial Cells - metabolism | Mice, Inbred C57BL | Aorta, Thoracic - metabolism | Mice, Knockout | Caveolin 1 - metabolism | Animals | Diabetes Mellitus, Type 2 - physiopathology | Signal Transduction - drug effects | Signal Transduction - physiology | Growth Differentiation Factor 15 - pharmacology | Vasodilation - drug effects | Growth Differentiation Factor 15 - metabolism | Nitric Oxide - metabolism | Endothelial Cells - drug effects | Aortic coarctation | Research | Growth factors
Journal Article