Journal of Thoracic Oncology, ISSN 1556-0864, 08/2017, Volume 12, Issue 8, pp. 1323 - 1324
Journal Article
2003, Seminars in oncology, Volume 30, no. 1, suppl. 1., 55
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Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10048, pp. 1012 - 1024
Summary Targeted therapies are substantially changing the management of lung cancers. These treatments include drugs that target driver mutations, those that...
Internal Medicine | 1ST-LINE TREATMENT | MEDICINE, GENERAL & INTERNAL | CISPLATIN PLUS GEMCITABINE | MULTICENTER PHASE-II | ADULT PATIENTS PTS | ACQUIRED-RESISTANCE | OPEN-LABEL | EGFR MUTATIONS | GROWTH-FACTOR | SINGLE-ARM | CLINICAL ACTIVITY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Translocation, Genetic | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Receptor Protein-Tyrosine Kinases - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung cancer, Non-small cell | Medical research | Chemotherapy | Lung cancer | Cytotoxicity | Kinases | Vascular endothelial growth factor | Cancer therapies | Patients
Internal Medicine | 1ST-LINE TREATMENT | MEDICINE, GENERAL & INTERNAL | CISPLATIN PLUS GEMCITABINE | MULTICENTER PHASE-II | ADULT PATIENTS PTS | ACQUIRED-RESISTANCE | OPEN-LABEL | EGFR MUTATIONS | GROWTH-FACTOR | SINGLE-ARM | CLINICAL ACTIVITY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Translocation, Genetic | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Molecular Targeted Therapy | Protein-Tyrosine Kinases - genetics | Receptor Protein-Tyrosine Kinases - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung cancer, Non-small cell | Medical research | Chemotherapy | Lung cancer | Cytotoxicity | Kinases | Vascular endothelial growth factor | Cancer therapies | Patients
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2014, Volume 32, Issue 10, pp. 973 - 982
Progress in lung cancer therapy has been slow but steady and has accelerated due to improvements in scientific basis for the disease and to technologic...
PHASE-III TRIAL | PROPHYLACTIC CRANIAL IRRADIATION | CISPLATIN PLUS GEMCITABINE | SOUTHWEST-ONCOLOGY-GROUP | ONCOLOGY | PLATINUM-BASED CHEMOTHERAPY | SMALL-CELL CARCINOMA | INTERNATIONAL-ASSOCIATION | QUALITY-OF-LIFE | RANDOMIZED CONTROLLED-TRIAL | PREDICTIVE GENE SIGNATURE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Early Detection of Cancer | Humans | Lung Neoplasms - pathology | Carcinoma, Non-Small-Cell Lung - diagnosis | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - therapy | Genes, erbB-1 | Small Cell Lung Carcinoma - pathology | Small Cell Lung Carcinoma - therapy | Lung Neoplasms - diagnosis | Neoplasm Staging
PHASE-III TRIAL | PROPHYLACTIC CRANIAL IRRADIATION | CISPLATIN PLUS GEMCITABINE | SOUTHWEST-ONCOLOGY-GROUP | ONCOLOGY | PLATINUM-BASED CHEMOTHERAPY | SMALL-CELL CARCINOMA | INTERNATIONAL-ASSOCIATION | QUALITY-OF-LIFE | RANDOMIZED CONTROLLED-TRIAL | PREDICTIVE GENE SIGNATURE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Early Detection of Cancer | Humans | Lung Neoplasms - pathology | Carcinoma, Non-Small-Cell Lung - diagnosis | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - therapy | Genes, erbB-1 | Small Cell Lung Carcinoma - pathology | Small Cell Lung Carcinoma - therapy | Lung Neoplasms - diagnosis | Neoplasm Staging
Journal Article
1993, Volume 17, no. 2., 71-141.
Book
1992, Oncology, ISBN 9783805556392, Volume 49/S1/92., iv, 80
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Nature Reviews Cancer, ISSN 1474-175X, 12/2017, Volume 17, Issue 12, pp. 725 - 737
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and...
BRONCHIAL EPITHELIUM | ENGINEERED MOUSE MODELS | STEM-CELLS | NEUROENDOCRINE TUMORS | DNA METHYLATION | ONCOLOGY | EPIGENETIC INACTIVATION | TUMOR-SUPPRESSOR GENES | POTENTIAL THERAPEUTIC TARGET | CARCINOMA | HISTONE METHYLTRANSFERASE | Signal Transduction | Humans | Receptors, Notch - genetics | Small Cell Lung Carcinoma - genetics | Molecular Targeted Therapy | Small Cell Lung Carcinoma - drug therapy | Tumor Suppressor Protein p53 - genetics | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Animals | Neurosecretory Systems - metabolism | Mice | Retinoblastoma Binding Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Care and treatment | Lung cancer, Small cell | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Health aspects | Oncogenes | Medical research | Animal models | Deactivation | Small cell lung carcinoma | p53 Protein | Lung cancer | Clinical trials | Cytotoxicity | Inactivation | Metastases | Signaling | Molecular modelling | Lungs | Xenografts | Genetic engineering | Notch protein | Tumors | Cancer
BRONCHIAL EPITHELIUM | ENGINEERED MOUSE MODELS | STEM-CELLS | NEUROENDOCRINE TUMORS | DNA METHYLATION | ONCOLOGY | EPIGENETIC INACTIVATION | TUMOR-SUPPRESSOR GENES | POTENTIAL THERAPEUTIC TARGET | CARCINOMA | HISTONE METHYLTRANSFERASE | Signal Transduction | Humans | Receptors, Notch - genetics | Small Cell Lung Carcinoma - genetics | Molecular Targeted Therapy | Small Cell Lung Carcinoma - drug therapy | Tumor Suppressor Protein p53 - genetics | Xenograft Model Antitumor Assays | Small Cell Lung Carcinoma - pathology | Animals | Neurosecretory Systems - metabolism | Mice | Retinoblastoma Binding Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Care and treatment | Lung cancer, Small cell | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Health aspects | Oncogenes | Medical research | Animal models | Deactivation | Small cell lung carcinoma | p53 Protein | Lung cancer | Clinical trials | Cytotoxicity | Inactivation | Metastases | Signaling | Molecular modelling | Lungs | Xenografts | Genetic engineering | Notch protein | Tumors | Cancer
Journal Article
Oncologist, ISSN 1083-7159, 2008, Volume 13, Issue 1, pp. 37 - 46
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 12/2012, Volume 7, Issue 12, pp. 1807 - 1814
Many patients with oncogene-driven non–small-cell lung cancer (NSCLC) treated with tyrosine kinase inhibitors experience limited sites of disease progression....
anaplastic lymphoma kinase gene arrangement non–small-cell lung cancer | EGFR-mutant non–small-cell lung cancer | Radiation therapy | Oligoprogressive disease | anaplastic lymphoma kinase gene arrangement non-small-cell lung cancer | EGFR-mutant non-small-cell lung cancer | PHASE-I/II TRIAL | ACQUIRED-RESISTANCE | BODY RADIATION-THERAPY | DOSE WEEKLY ERLOTINIB | BREAST-CANCER | LIVER METASTASES | SYNCHRONOUS BRAIN METASTASES | STEREOTACTIC RADIOSURGERY | ONCOLOGY | LEPTOMENINGEAL METASTASES | RESPIRATORY SYSTEM | RECURRENT MALIGNANT GLIOMAS | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - genetics | Pyrazoles - therapeutic use | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Catheter Ablation | Lung Neoplasms - pathology | Male | Young Adult | Brain Neoplasms - secondary | Aged, 80 and over | Adult | Female | Retrospective Studies | Brain Neoplasms - mortality | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Mutation - genetics | Carcinoma, Non-Small-Cell Lung - mortality | Disease Progression | Carcinoma, Non-Small-Cell Lung - therapy | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Gene Rearrangement | Brain Neoplasms - therapy | Aged | Neoplasm Staging
anaplastic lymphoma kinase gene arrangement non–small-cell lung cancer | EGFR-mutant non–small-cell lung cancer | Radiation therapy | Oligoprogressive disease | anaplastic lymphoma kinase gene arrangement non-small-cell lung cancer | EGFR-mutant non-small-cell lung cancer | PHASE-I/II TRIAL | ACQUIRED-RESISTANCE | BODY RADIATION-THERAPY | DOSE WEEKLY ERLOTINIB | BREAST-CANCER | LIVER METASTASES | SYNCHRONOUS BRAIN METASTASES | STEREOTACTIC RADIOSURGERY | ONCOLOGY | LEPTOMENINGEAL METASTASES | RESPIRATORY SYSTEM | RECURRENT MALIGNANT GLIOMAS | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - genetics | Pyrazoles - therapeutic use | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Catheter Ablation | Lung Neoplasms - pathology | Male | Young Adult | Brain Neoplasms - secondary | Aged, 80 and over | Adult | Female | Retrospective Studies | Brain Neoplasms - mortality | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Mutation - genetics | Carcinoma, Non-Small-Cell Lung - mortality | Disease Progression | Carcinoma, Non-Small-Cell Lung - therapy | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Gene Rearrangement | Brain Neoplasms - therapy | Aged | Neoplasm Staging
Journal Article
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 08/2017, Volume 12, Issue 8, p. 1323
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2018, Volume 36, Issue 25, pp. 2571 - 2574
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2004, Volume 22, Issue 9, pp. 1589 - 1597
Purpose To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously treated...
ONCOLOGY | QUALITY-OF-LIFE | Glutamates - therapeutic use | Lung Neoplasms - drug therapy | Glutamates - adverse effects | Guanine - analogs & derivatives | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Taxoids - therapeutic use | Antineoplastic Agents, Phytogenic - administration & dosage | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Guanine - adverse effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neutropenia - chemically induced | Guanine - therapeutic use | Taxoids - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Treatment Outcome | Pemetrexed | Taxoids - administration & dosage | Survival Analysis | Glutamates - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Guanine - administration & dosage
ONCOLOGY | QUALITY-OF-LIFE | Glutamates - therapeutic use | Lung Neoplasms - drug therapy | Glutamates - adverse effects | Guanine - analogs & derivatives | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Taxoids - therapeutic use | Antineoplastic Agents, Phytogenic - administration & dosage | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Guanine - adverse effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neutropenia - chemically induced | Guanine - therapeutic use | Taxoids - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Treatment Outcome | Pemetrexed | Taxoids - administration & dosage | Survival Analysis | Glutamates - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Guanine - administration & dosage
Journal Article
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 12/2012, Volume 136, Issue 12, pp. 1478 - 1481
Lung cancer is the leading worldwide cause of cancer deaths. Smoking is the dominant cause of lung cancer and smoking cessation is the established method to...
MEDICINE, RESEARCH & EXPERIMENTAL | 1ST-LINE TREATMENT | MULTICENTER | BEVACIZUMAB | ADENOCARCINOMA | PHASE-III | CLASSIFICATION | OPEN-LABEL | PATHOLOGY | CHEMOTHERAPY | GEMCITABINE | INTERNATIONAL ASSOCIATION | MEDICAL LABORATORY TECHNOLOGY | Smoking - adverse effects | Early Detection of Cancer - trends | Animals | Global Health | Lung Neoplasms - prevention & control | Humans | Smoking - trends | Lung Neoplasms - pathology | Lung Neoplasms - therapy | Neoplasm Staging - trends | Lung Neoplasms - diagnosis | Smoking Cessation | Care and treatment | Smokers | Lung cancer | Diagnostic imaging | Diagnosis | Comparative analysis | Health aspects | Cancer
MEDICINE, RESEARCH & EXPERIMENTAL | 1ST-LINE TREATMENT | MULTICENTER | BEVACIZUMAB | ADENOCARCINOMA | PHASE-III | CLASSIFICATION | OPEN-LABEL | PATHOLOGY | CHEMOTHERAPY | GEMCITABINE | INTERNATIONAL ASSOCIATION | MEDICAL LABORATORY TECHNOLOGY | Smoking - adverse effects | Early Detection of Cancer - trends | Animals | Global Health | Lung Neoplasms - prevention & control | Humans | Smoking - trends | Lung Neoplasms - pathology | Lung Neoplasms - therapy | Neoplasm Staging - trends | Lung Neoplasms - diagnosis | Smoking Cessation | Care and treatment | Smokers | Lung cancer | Diagnostic imaging | Diagnosis | Comparative analysis | Health aspects | Cancer
Journal Article
16.
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Erratum: Small-cell lung cancer: what we know, what we need to know and the path forward
Nature Reviews Cancer, ISSN 1474-175X, 12/2017, Volume 17, Issue 12, pp. 765 - 765
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2005, Volume 23, Issue 28, pp. 6838 - 6845
Purpose Bronchioloalveolar carcinoma (BAC) and adenocarcinomas with BAC features seem to be increasing in incidence, particularly in younger, never-smoking...
CELL LUNG-CANCER | BREAST-CANCER | PHASE-II TRIAL | AMPLIFICATION | EFFICACY | ONCOLOGY | SAFETY | TYROSINE KINASE | PROTEIN EXPRESSION | MUTATIONS | INHIBITOR | Lung Neoplasms - drug therapy | Predictive Value of Tests | Receptor, Epidermal Growth Factor - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Adenocarcinoma, Bronchiolo-Alveolar - genetics | Patient Selection | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Receptor, Epidermal Growth Factor - physiology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | In Situ Hybridization, Fluorescence | Treatment Outcome | Gene Dosage | Adenocarcinoma - drug therapy | Genes, erbB-2 | Quinazolines - therapeutic use | Survival Analysis | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Adenocarcinoma, Bronchiolo-Alveolar - drug therapy
CELL LUNG-CANCER | BREAST-CANCER | PHASE-II TRIAL | AMPLIFICATION | EFFICACY | ONCOLOGY | SAFETY | TYROSINE KINASE | PROTEIN EXPRESSION | MUTATIONS | INHIBITOR | Lung Neoplasms - drug therapy | Predictive Value of Tests | Receptor, Epidermal Growth Factor - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Adenocarcinoma, Bronchiolo-Alveolar - genetics | Patient Selection | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Receptor, Epidermal Growth Factor - physiology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | In Situ Hybridization, Fluorescence | Treatment Outcome | Gene Dosage | Adenocarcinoma - drug therapy | Genes, erbB-2 | Quinazolines - therapeutic use | Survival Analysis | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Adenocarcinoma, Bronchiolo-Alveolar - drug therapy
Journal Article
Cancer, ISSN 0008-543X, 09/2012, Volume 118, Issue 18, pp. 4502 - 4511
BACKGROUND: The discovery of distinct subsets of nonsmall cell lung cancer (NSCLC) characterized by activation of driver oncogenes has greatly affected...
anaplastic lymphoma kinase tyrosine kinase receptor | metastasis | nonsmall cell lung cancer | epidermal growth factor receptor | Kirsten rat sarcoma viral oncogene | CARBOPLATIN | GEFITINIB | PHASE-III | PACLITAXEL | GENE | ONCOLOGY | NEVER-SMOKERS | MUTATIONS | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Liver Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Male | Proto-Oncogene Proteins - genetics | Neoplasm Metastasis - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gene Rearrangement | Female | Genes, ras | Liver Neoplasms - secondary | Oncogenes | Lung cancer, Non-small cell | Care and treatment | Metastasis
anaplastic lymphoma kinase tyrosine kinase receptor | metastasis | nonsmall cell lung cancer | epidermal growth factor receptor | Kirsten rat sarcoma viral oncogene | CARBOPLATIN | GEFITINIB | PHASE-III | PACLITAXEL | GENE | ONCOLOGY | NEVER-SMOKERS | MUTATIONS | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Liver Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Male | Proto-Oncogene Proteins - genetics | Neoplasm Metastasis - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gene Rearrangement | Female | Genes, ras | Liver Neoplasms - secondary | Oncogenes | Lung cancer, Non-small cell | Care and treatment | Metastasis
Journal Article