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The EMBO Journal, ISSN 0261-4189, 07/2016, Volume 35, Issue 14, pp. 1486 - 1487
Despite its name, minor spliceosome alterations are often involved in human disease origin. Work by Reber et al ( ) in this issue of The EMBO Journal now... 
NEURODEGENERATION | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Proteins | Amyotrophic lateral sclerosis | Mutation | Index Medicus | RNA Biology | Neuroscience | Views
Journal Article
FEBS Journal, ISSN 1742-464X, 02/2010, Volume 277, Issue 4, pp. 841 - 855
Journal Article
2015, First edition., Advances in Genetics, ISBN 0128029218, Volume 91.
Web Resource
2015, First edition., Advances in Genetics, ISBN 0128029218, Volume 91.
Web Resource
Molecular Biotechnology, ISSN 1073-6085, 07/2012, Volume 51, Issue 3, p. 303
Journal Article
Molecular Biotechnology, ISSN 1073-6085, 06/2012, Volume 51, Issue 2, p. 200
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2009, Volume 111, Issue 4, pp. 1051 - 1061
Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic... 
Amyotrophic lateral sclerosis | RNA-binding protein | Transactive response DNA-binding protein 43 | Stress granules | GENE-MUTATIONS | INCLUSIONS | FUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING PROTEIN | amyotrophic lateral sclerosis | NEUROSCIENCES | PROCESSING BODIES | MESSENGER-RNA | DISEASE | stress granules | EXPRESSION | Arsenites - pharmacology | ELAV-Like Protein 1 | RNA, Small Interfering - genetics | Spinal Cord - metabolism | Emetine - pharmacology | Hybrid Cells | Oxidative Stress - physiology | Protein Transport - drug effects | ELAV Proteins | DNA-Binding Proteins - metabolism | Transfection - methods | Teratogens - pharmacology | Spinal Cord - pathology | Antigens, Surface - metabolism | Protein Synthesis Inhibitors - pharmacology | Motor Neurons - drug effects | Hot Temperature - adverse effects | Oxidative Stress - genetics | Ribonucleoproteins - metabolism | DNA-Binding Proteins - genetics | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Mice | Oxidative Stress - drug effects | RNA-Binding Proteins - metabolism | Protein Structure, Tertiary - drug effects | RNA, Small Interfering - metabolism | Neurosciences | Messenger RNA | Snow | Neurons | Analysis | Genetically modified organisms | Protein biosynthesis | Binding proteins | Proteins | Brain | Biochemistry | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2010, Volume 277, Issue 10, pp. 2268 - 2281
TDP‐43 has recently been described as the major component of the inclusions found in the brain of patients with a variety of neurodegenerative diseases, such... 
microRNAs | miR‐663 | amyotrophic lateral sclerosis | TDP‐43 | let‐7b | Let-7b | Amyotrophic lateral sclerosis | MiR-663 | MicroRNAs | TDP-43 | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | let-7b | STRUCTURAL DETERMINANTS | RNA-BINDING PROTEIN | CELLULAR TOXICITY | miR-663 | EXPRESSION PATTERNS | DOWN-SYNDROME | GENE-EXPRESSION | CFTR EXON-9 | HNRNP A1 | RNA, Small Interfering - genetics | Protein Binding - genetics | Luciferases - metabolism | Gene Expression - genetics | Humans | MicroRNAs - metabolism | RNA, Messenger - metabolism | Luciferases - genetics | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Qa-SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 3 - genetics | Recombinant Proteins - metabolism | Base Sequence - genetics | Ribonuclease III - metabolism | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Genes, Reporter - genetics | Up-Regulation - genetics | Recombinant Proteins - genetics | DNA-Binding Proteins - genetics | Down-Regulation - genetics | Epoxide Hydrolases - genetics | Laminin - genetics | Cell Line, Tumor | MicroRNAs - genetics | HeLa Cells | Messenger RNA | Genetically modified organisms | Proteins | Brain | Biochemistry | Ribonucleic acid--RNA | Neurological disorders | Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, pp. 33996 - 33996
Journal Article
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5870, pp. 1668 - 1672
Journal Article
Brain research, ISSN 0006-8993, 09/2016, Volume 1647, pp. 50 - 56
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 04/2016, Volume 283, Issue 7, pp. 1242 - 1260
TDP‐43 is an RNA processing protein which can form neuropathological aggregates. We report the high resolution structure of TDP‐43's N‐terminal domain. A novel... 
protein structure | TDP | TAR DNA | FTLD | protein dynamics | ALS | binding protein 43 | hydrogen/deuterium exchange | 43 | Hydrogen/deuterium exchange | ALS/FTLD | Protein dynamics | TAR DNA-binding protein 43 (TDP-43) | Protein structure | FIBRIL FORMATION | CHEMICAL-SHIFTS | NMR-SPECTROSCOPY | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXATION | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | DNA-BINDING PROTEIN | HYDROGEN-EXCHANGE | AGGREGATION | Protein Structure, Tertiary | Amino Acid Sequence | Peptide Fragments - metabolism | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Humans | Models, Molecular | Molecular Sequence Data | Spectrometry, Fluorescence | Binding Sites - genetics | Protein Folding | Deuterium Exchange Measurement | Peptide Fragments - chemistry | Animals | Hydrogen Bonding | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Hydrogen-Ion Concentration | Ubiquitin | Nervous system diseases | Binding proteins | Analysis | Protein binding | Proteins | Nuclear magnetic resonance--NMR | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA | Neurological disorders | Deuterium | Exchanging | Residues | High resolution | Hydrogen | Strands | Hydrophobicity | Monomers | Data bases | Recruitment | Databases | DNA-binding protein | Temporal variations | Protein transport | Transporting | RNA processing | Torsion | Translation | Stability | Neurodegenerative diseases | Aliphatic compounds | Diseases | Neurological diseases | Constraints | Aggregates | Aberration | Index Medicus
Journal Article
Journal Article