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1. Full Text Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
by Hunt, Karen A and Mistry, Vanisha and Bockett, Nicholas A and Ahmad, Tariq and Ban, Maria and Barker, Jonathan N and Barrett, Jeffrey C and Blackburn, Hannah and Brand, Oliver and Burren, Oliver and Capon, Francesca and Compston, Alastair and Gough, Stephen C. L and Jostins, Luke and Kong, Yong and Lee, James C and Lek, Monkol and MacArthur, Daniel G and Mansfield, John C and Mathew, Christopher G and Mein, Charles A and Mirza, Muddassar and Nutland, Sarah and Onengut-Gumuscu, Suna and Papouli, Efterpi and Parkes, Miles and Rich, Stephen S and Sawcer, Steven and Satsangi, Jack and Simmonds, Matthew J and Trembath, Richard C and Walker, Neil M and Wozniak, Eva and Todd, John A and Simpson, Michael A and Plagnol, Vincent and Van Heel, David A
Nature (London), ISSN 0028-0836, 2013, Volume 498, Issue 7453, pp. 232 - 235
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Gene Frequency | Humans | Exons - genetics | United Kingdom | Mutation - genetics | Open Reading Frames - genetics | Autoimmune Diseases - genetics | Phenotype | Sample Size | Genetic Variation - genetics | Models, Genetic | Genetic aspects | Heritability | Nucleotide sequencing | Research | Autoimmune diseases | DNA sequencing | Testing | Studies | Genotype & phenotype | Statistical analysis | Diabetes | Index Medicus
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2. Full Text Widespread seasonal gene expression reveals annual differences in human immunity and physiology
by Dopico, Xaquin Castro and Evangelou, Marina and Ferreira, Ricardo C and Guo, Hui and Pekalski, Marcin L and Smyth, Deborah J and Cooper, Nicholas and Burren, Oliver S and Fulford, Anthony J and Hennig, Branwen J and Prentice, Andrew M and Ziegler, Anette-G and Bonifacio, Ezio and Wallace, Chris and Todd, John A
Nature communications, ISSN 2041-1723, 05/2015, Volume 6, Issue 1, pp. 7000 - 7000
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adaptation, Physiological | Genes, MHC Class II - physiology | ARNTL Transcription Factors - genetics | Europe | Humans | Middle Aged | RNA, Messenger - genetics | Transcriptome | ARNTL Transcription Factors - metabolism | Child, Preschool | Gene Expression Regulation - physiology | Infant | RNA, Messenger - metabolism | Oceania | Young Adult | Adipose Tissue - metabolism | Gambia | Adolescent | Adult | Aged | Seasons | Child | Leukocytes - metabolism | Infant, Newborn | Index Medicus
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3. Full Text Risedronate in children with osteogenesis imperfecta: a randomised, double-blind, placebo-controlled trial
by Bishop, Nick, Prof and Adami, Silvano, MD and Ahmed, S Faisal, MD and Antón, Jordi, MD and Arundel, Paul, MD and Burren, Christine P, MD and Devogelaer, Jean-Pierre, MD and Hangartner, Thomas, PhD and Hosszú, Eva, MD and Lane, Joseph M, MD and Lorenc, Roman, MD and Mäkitie, Outi, MD and Munns, Craig F, MD and Paredes, Ana, MD and Pavlov, Helene, MD and Plotkin, Horacio, MD and Raggio, Cathleen L, MD and Reyes, Maria Loreto, MD and Schoenau, Eckhard, MD and Semler, Oliver, MD and Sillence, David O, MD and Steiner, Robert D, MD
The Lancet (British edition), ISSN 0140-6736, 2013, Volume 382, Issue 9902, pp. 1424 - 1432
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Diseases of the osteoarticular system | Malformations and congenital and or hereditary diseases involving bones. Joint deformations | Etidronic Acid - administration & dosage | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Humans | Alkaline Phosphatase - metabolism | Osteogenesis Imperfecta - drug therapy | Child, Preschool | Male | Treatment Outcome | Bone Density Conservation Agents - administration & dosage | Collagen - metabolism | Bone Density - drug effects | Analysis of Variance | Etidronic Acid - adverse effects | Adolescent | Osteogenesis Imperfecta - physiopathology | Female | Risedronate Sodium | Child | Etidronic Acid - analogs & derivatives | Risedronate | Osteogenesis imperfecta | Children | Research | Drug therapy | Health aspects | Osteoporosis | Bone density | Fractures | Pain | Bone diseases | Older people | Index Medicus | Abridged Index Medicus | Age | Medicin och hälsovetenskap
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4. Full Text Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
by Javierre, Biola M and Burren, Oliver S and Wilder, Steven P and Kreuzhuber, Roman and Hill, Steven M and Sewitz, Sven and Cairns, Jonathan and Wingett, Steven W and Várnai, Csilla and Thiecke, Michiel J and Burden, Frances and Farrow, Samantha and Cutler, Antony J and Rehnström, Karola and Downes, Kate and Grassi, Luigi and Kostadima, Myrto and Freire-Pritchett, Paula and Wang, Fan and Martens, Joost H and Kim, Bowon and Sharifi, Nilofar and Janssen-Megens, Eva M and Yaspo, Marie-Laure and Linser, Matthias and Kovacsovics, Alexander and Clarke, Laura and Richardson, David and Datta, Avik and Flicek, Paul and Stunnenberg, Hendrik G and Todd, John A and Zerbino, Daniel R and Stegle, Oliver and Ouwehand, Willem H and Frontini, Mattia and Wallace, Chris and Spivakov, Mikhail and Fraser, Peter and The BLUEPRINT Consortium and BLUEPRINT Consortium
Cell (Cambridge), ISSN 0092-8674, 11/2016, Volume 167, Issue 5, pp. 1369 - 1384.e19
promoter capture Hi-C | non-coding genetic variation | disease gene prioritization | gene regulation | chromosome conformation | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Promoter Regions, Genetic | Chromatin | Genetic Predisposition to Disease | Genome-Wide Association Study | Epigenomics | Disease - genetics | Cell Separation | Humans | Cell Lineage | Blood Cells - cytology | Enhancer Elements, Genetic | Hematopoiesis | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genes | Genomics | Genetic aspects | Medical research | Medical genetics | Medicine, Experimental | Index Medicus | Resource
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5. Full Text VSEAMS: A pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes
by Burren, Oliver S and Guo, Hui and Wallace, Chris
Bioinformatics, ISSN 1367-4803, 2014, Volume 30, Issue 23, pp. 3342 - 3348
Statistics & Probability | Biochemistry & Molecular Biology | Physical Sciences | Computer Science, Interdisciplinary Applications | Life Sciences & Biomedicine | Technology | Biochemical Research Methods | Computer Science | Mathematics | Biotechnology & Applied Microbiology | Science & Technology | Mathematical & Computational Biology | Ikaros Transcription Factor - genetics | Genome-Wide Association Study | Sample Size | Receptors, Estrogen - genetics | Humans | Diabetes Mellitus, Type 1 - genetics | Polymorphism, Single Nucleotide | Software | Basic-Leucine Zipper Transcription Factors - genetics | Transcription Factors - genetics | Index Medicus | Enrichment | Pipelines | Genes | Summaries | Diabetes | Statistical tests | Bioinformatics | Loci | Original Papers
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6. Full Text Chromosome contacts in activated T cells identify autoimmune disease candidate genes
by Burren, Oliver S and Rubio García, Arcadio and Javierre, Biola-Maria and Rainbow, Daniel B and Cairns, Jonathan and Cooper, Nicholas J and Lambourne, John J and Schofield, Ellen and Castro Dopico, Xaquin and Ferreira, Ricardo C and Coulson, Richard and Burden, Frances and Rowlston, Sophia P and Downes, Kate and Wingett, Steven W and Frontini, Mattia and Ouwehand, Willem H and Fraser, Peter and Spivakov, Mikhail and Todd, John A and Wicker, Linda S and Cutler, Antony J and Wallace, Chris
Genome Biology, ISSN 1474-7596, 09/2017, Volume 18, Issue 1, pp. 165 - 165
CD4 | Genome-wide association studies | T cell activation | Chromatin conformation | Genomics | Autoimmune disease | Genetics | T cells | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Interleukin 2 receptors | Disease | Transcription | Lymphocytes T | Genomes | Regulatory sequences | Gene expression | Ribonucleic acid--RNA | CD4 antigen | Cell activation | Lymphocytes | Rheumatoid arthritis | Transcription activation | DNA methylation | Autoimmune diseases | Bioinformatics | Chromosomes | Index Medicus | CD4+ T cells | CD4+ T cell activation
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7. Full Text Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
by Fortune, Mary D and Guo, Hui and Burren, Oliver and Schofield, Ellen and Walker, Neil M and Ban, Maria and Sawcer, Stephen J and Bowes, John and Worthington, Jane and Barton, Anne and Eyre, Steve and Todd, John A and Wallace, Chris
Nature genetics, ISSN 1061-4036, 06/2015, Volume 47, Issue 7, pp. 839 - 846
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease | Genome-Wide Association Study | Celiac Disease - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 1 - genetics | Multiple Sclerosis - genetics | Risk | Case-Control Studies | Linkage Disequilibrium | Arthritis, Rheumatoid - genetics | Bayes Theorem | Models, Genetic | Polymorphism, Single Nucleotide | Genetic susceptibility | Genetic variation | Genetic research | Genetic aspects | Research | Autoimmune diseases | Identification and classification | Health aspects | Risk factors | Multiple sclerosis | Biomedical research | Disease | Funding | Experiments | Studies | Consortia | Celiac disease | Hypotheses | Councils | Rheumatoid arthritis | Methods | Index Medicus
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8. Full Text Fine mapping chromatin contacts in capture Hi-C data
by Eijsbouts, Christiaan Q and Burren, Oliver S and Newcombe, Paul J and Wallace, Chris
BMC genomics, 01/2019, Volume 20, Issue 1, p. 77
Promoter Regions, Genetic | CD4-Positive T-Lymphocytes | Models, Statistical | High-Throughput Nucleotide Sequencing - methods | Macrophages | Sequence Analysis, DNA - methods | Chromatin - chemistry
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9. Full Text A type I Interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes
by Ferreira, Ricardo C and Guo, Hui and Coulson, Richard M. R and Smyth, Deborah J and Pekalski, Marcin L and Burren, Oliver S and Cutler, Antony J and Doecke, James D and Flint, Shaun and McKinney, Eoin F and Lyons, Paul A and Smith, Kenneth G. C and Achenbach, Peter and Beyerlein, Andreas and Dunger, David B and Clayton, David G and Wicker, Linda S and Todd, John A and Bonifacio, Ezio and Wallace, Chris and Ziegler, Anette-G
Diabetes (New York, N.Y.), ISSN 0012-1797, 2014, Volume 63, Issue 7, pp. 2538 - 2550
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetic Predisposition to Disease | Humans | Middle Aged | Autoimmunity - genetics | Diabetes Mellitus, Type 1 - genetics | Male | Risk | Transcriptome - drug effects | Transcriptome - immunology | Interferon Type I - immunology | Gene Expression Regulation - drug effects | Young Adult | Interferon Type I - pharmacology | Adolescent | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Child | Cohort Studies | Type 1 diabetes | Analysis | Islands of Langerhans | Influence | Interferon | Diagnosis | Research | Gene expression | Risk factors | Diabetes | Epidemiology | Children & youth | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes | Proteomics
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