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chemistry (17) 17
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Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 7, pp. 5166 - 5171
The development of constrained peptides for inhibition of protein-protein interactions is an emerging strategy in chemical biology and drug discovery. This... 
CLOSING OLEFIN METATHESIS | CONSTRAINED PEPTIDES | CONJUGATION | MODULATORS | BINDING-AFFINITY | CROSS-LINKING | PROTEIN-PROTEIN INTERACTIONS | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | IN-SITU | MACROCYCLIZATION | Cycloaddition | Constraints | Peptides | Methodology | Molecular dynamics | Amino acids | Inhibition | Alkynes
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 08/2019, Volume 30, Issue 17, pp. 2296 - 2308
In eukaryotic cells, organelle-specific protein quality control (PQC) is critical for maintaining cellular homeostasis. Despite the Golgi apparatus being the... 
FUSION | PATHWAY | RETROGRADE TRANSPORT | MEMBRANE GLYCOPROTEIN | DEGRADATION | ENDOPLASMIC-RETICULUM | QUALITY-CONTROL | MISFOLDED PROTEINS | INHIBITOR | CELL BIOLOGY | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2019, p. canres.1236.2019
While the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leukemia... 
Journal Article
Synlett, ISSN 0936-5214, 02/2014, Volume 25, Issue 3, pp. 324 - 335
Abstract The development of inhibitors of protein–protein interactions (PPIs) represents a major challenge in chemical biology. α-Helix-mediated PPIs represent... 
account | amides | peptidomimetics | oligomerization | solid-phase synthesis | BLOCK-COPOLYMERS | CHEMISTRY, ORGANIC | LARGE-SCALE | DESIGNED MOLECULES | AMINO-ACIDS | FOLDAMERS | PROTEIN-PROTEIN INTERACTIONS | AMIDE BOND FORMATION | AROMATIC OLIGOAMIDES | HYBRID PEPTIDES
Journal Article
Chemical science, ISSN 2041-6520, 2/2018, Volume 9, Issue 7, pp. 21 - 211
Correction for 'Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions' by George M. Burslem et al. ,... 
Proteins | Hypoxia | Inhibition
Journal Article
Chemical Science, ISSN 2041-6520, 2/2018, Volume 9, Issue 7, pp. 28 - 29
Correction for 'Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions' by George M. Burslem et al. , Chem. Sci. ,... 
Proteins | Hypoxia | Inhibition
Journal Article
Chemical Science, ISSN 2041-6520, 5/2017, Volume 8, Issue 6, pp. 4188 - 422
The modulation of protein-protein interactions (PPIs) represents a major challenge in modern chemical biology. Current approaches ( e.g. high-throughput... 
SIGNAL-TRANSDUCTION | PAS-B DOMAIN | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | FACTOR-I | PEPTIDE LIBRARIES | TUMOR-GROWTH | CHEMISTRY, MULTIDISCIPLINARY | RENAL-CELL CARCINOMA | E3 UBIQUITIN LIGASE | TRANSCRIPTIONAL RESPONSE | Modulation | Topography | Hypoxia | Ligands | Mathematical models | Biology | Computer aided design | Modulators | Chemistry
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 04/2014, Volume 12, Issue 16, pp. 2584 - 2591
Piperazines are found widely in commercially-available compounds and bioactive molecules (including many drugs). However, in the vast majority of these... 
CHEMISTRY | CHEMISTRY, ORGANIC | STRATEGY | Azepines - chemistry | Heterocyclic Compounds, 1-Ring - chemistry | Azepines - chemical synthesis | Piperazines - chemical synthesis | Molecular Structure | Piperazines - chemistry | Heterocyclic Compounds, 1-Ring - chemical synthesis | Index Medicus
Journal Article
Chemical Science, ISSN 2041-6520, 02/2018, Volume 9, Issue 7, pp. 2010 - 2011
Journal Article
Chemical science, ISSN 2041-6520, 02/2018, Volume 9, Issue 7, pp. 2008 - 2009
[This corrects the article DOI: 10.1039/C7SC00388A.]. 
Journal Article
Chemical Science, ISSN 2041-6520, 04/2015, Volume 6, Issue 4, pp. 2382 - 2388
In this work we describe the solvent free synthesis of supramolecular polyurethanes held together by heterocomplementary triple hydrogen bonding. We perform a... 
ALCOHOLS | CATALYSIS | DESIGN | MECHANISM | HIGH-MOLECULAR-WEIGHT | MECHANOCHEMISTRY | COPOLYMERS | PHENYL ISOCYANATE | CHEMISTRY, MULTIDISCIPLINARY | ELASTOMERS | Polyurethane resins | Solvents | Solid state | Synthesis | Amines | Ball milling | Ureas | Hydrogen bonding
Journal Article
ISSN 2041-6520, 6/2017, Volume 8, Issue 7, pp. 5166 - 5171
The development of constrained peptides for inhibition of protein-protein interactions is an emerging strategy in chemical biology and drug discovery. This... 
Journal Article
Chemical Science, ISSN 2041-6520, 7/2017, Volume 8, Issue 7, pp. 5166 - 5171
A versatile, rapid and reversible approach to constrain peptides in a bioactive helical conformation and bearing a functional handle for inhibition of... 
Chemistry
Journal Article
Chemical Communications (Cambridge, England), ISSN 1359-7345, 4/2016, Volume 52, Issue 31, pp. 5421 - 5424
An extended sequence of α-amino acids in HIF-1α is replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide to... 
Chemistry
Journal Article
Molecular biology of the cell, 06/2019, p. mbcE19010069
In eukaryotic cells, organelle-specific protein quality control is critical for maintaining cellular homeostasis. Despite the Golgi apparatus being the major... 
Journal Article
ISSN 1477-0520, 12/2014, Volume 13, Issue 1, pp. 258 - 264
The exploitation of multivalent ligands for the inhibition of protein-protein interactions has not yet been explored as a supramolecular design strategy. This... 
Journal Article
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