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Developmental Cell, ISSN 1534-5807, 10/2019, Volume 51, Issue 1, pp. 35 - 48.e7
Centromeres provide a robust model for epigenetic inheritance as they are specified by sequence-independent mechanisms involving the histone H3-variant... 
centromere | oocyte | meiosis | cell division | kinetochore | quiescence | terminal differentiation | mitosis | epigenetics | KINETOCHORE | STABILITY | TRANSCRIPTION | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | G1 PHASE | REVEALS | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2002, Volume 45, Issue 4, pp. 789 - 804
Synthesis and structure−activity relationships of tricyclic α-ethoxy-phenylpropionic acid derivatives guided by in vitro PPARα and PPARγ transactivation data... 
HEART-DISEASE | CHEMISTRY, MEDICINAL | ACTIVATED RECEPTOR-GAMMA | BETA-PHENYLPROPANOIC ACIDS | MMFF94 | CRYSTALLOGRAPHY | THIAZOLIDINEDIONE ANTIHYPERGLYCEMIC AGENTS | MOLECULAR-FORCE FIELD | GLUCOSE-TOLERANCE | BEZAFIBRATE | FAVORABLE BINDING-SITES
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 11, pp. 3198 - 3202
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARα agonists. Optimum PPARα... 
PPARα | Docking | Agonist | docking | CHEMISTRY, MEDICINAL | ACCURATE DOCKING | CHEMISTRY, ORGANIC | PPAR alpha | GLIDE | agonist
Journal Article
Neuroendocrinology, ISSN 0028-3835, 01/2002, Volume 75, Issue 1, pp. 24 - 33
The effects in the brain of selective estrogen receptor modulators (SERMs) such as tamoxifen and raloxifene have not yet been fully elucidated. Based upon the... 
Regulation of Reproductive Functions | Amygdala | Serotonin | Midbrain | Gonadal steroid receptors | Estrogen receptor modulators | Serotonin reuptake transporter | Gonadal steroids | gonadal steroid receptors | DEPRESSION | amygdala | midbrain | MESSENGER-RNA EXPRESSION | gonadal steroids | HORMONE REPLACEMENT THERAPY | OVARIECTOMIZED RATS | NEUROSCIENCES | estrogen receptor modulators | OVARIAN-STEROIDS | serotonin reuptake transporter | serotonin | ESTRADIOL | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | BONE TURNOVER | HYPOTHALAMUS | Raloxifene Hydrochloride - pharmacology | Serotonin - physiology | Body Weight | Gene Expression - drug effects | RNA, Messenger - analysis | Estrogen Antagonists - pharmacology | Serotonin Plasma Membrane Transport Proteins | Receptors, Serotonin - genetics | Brain - physiology | Pyrrolidines - pharmacology | Estrogen Receptor alpha | Gene Expression - physiology | Tamoxifen - chemistry | Estrogen Antagonists - chemistry | Female | Mesencephalon - physiology | Estradiol - pharmacology | Receptors, Estrogen - genetics | Ovariectomy | Hypothalamus - physiology | Rats | Nerve Tissue Proteins | Pyrrolidines - chemistry | Rats, Sprague-Dawley | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Estradiol - chemistry | Animals | Receptors, Serotonin, 5-HT1 | Membrane Transport Proteins | Tamoxifen - pharmacology | Raloxifene Hydrochloride - chemistry | Amygdala - physiology | Estrogen Receptor beta
Journal Article
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2007, Volume 17, Issue 11, p. 3198
Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARalpha agonists. Optimum... 
Computers | Phenylpropionates - pharmacology | Animals | Phenylpropionates - chemistry | Drug Design | Phenylpropionates - chemical synthesis | Ligands | PPAR alpha - agonists | Crystallography | PPAR alpha - chemistry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2003, Volume 13, Issue 2, pp. 257 - 260
Using a known dual PPARα/γ activator (5) as a structural template, SAR evaluations led to the identification of triple PPARα/γ/δ activators (18-20) with equal... 
CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | RECEPTORS | PROTEIN-LIGAND DOCKING | INCREMENTAL CONSTRUCTION ALGORITHM | AGONIST
Journal Article
03/2013
A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II)... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
08/2012
Process for the preparation of a compound of formula (I) as defined herein by (i) triflating a ketone of formula (II) as defined herein to form a triflate of... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
11/2011
A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II)... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
Journal of medicinal chemistry, ISSN 0022-2623, 02/2002, Volume 45, Issue 4, p. 789
Journal Article
2014, RSC metallobiology series, ISBN 1849735999, Volume no. 2., xxv, 911 pages
A comprehensive overview of the molecular nature of metal ions in nutrition, toxicology and pharmacology.. 
Bioinorganic chemistry | Metals | Metal ions | Life Sciences | Science | Biochemistry | Metals in the body | Cells
Book
12/2007
A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II)... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
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