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Nature Cell Biology, ISSN 1465-7392, 10/2014, Volume 16, Issue 11, pp. 1069 - 1079
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169855
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 9385 - 8
Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds... 
RNA-SYNTHESIS | VIRUS | CAP | VX-787 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PRIMERS | BINDING | CONFORMATIONAL SELECTION | Proteins | Transcription | Influenza | Cap-binding protein | Antiviral activity | RNA polymerase | Protein structure | DNA-directed RNA polymerase | Crystal structure
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2017, Volume 139, Issue 49, pp. 17824 - 17833
Structure-based drug design is an integral part of modern day drug discovery and requires detailed structural characterization of protein–ligand interactions,... 
SITE | 3D STRUCTURE | DESIGN | AFFINITY | RECONSTRUCTION | DRUG DISCOVERY | METHYL | RESOLUTION | SURFACE | EFFICIENCY | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2019, Volume 15, Issue 7, pp. 747 - 755
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide... 
Cell proliferation | Ubiquitin | Pathogens | Platforms | Profiling | Substrate inhibition | Breast cancer | Substrates | Suppressors | Proteins | Degradation | Pathogenicity | Ubiquitination | Natural products | Neem | Disruption | Recognition | Ubiquitin-protein ligase | Cancer | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 20, pp. 7066 - 7083
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 07/2019, Volume 93, Issue 13
Hepatitis E virus (HEV) is a 7.2-kb positive-sense, single-stranded RNA virus containing three partially overlapping reading frames, ORF1 to ORF3. All... 
DENSITY MODIFICATION | RECONSTRUCTION | RESOLUTION | E VIRUS HEV | nuclear magnetic resonance | FEATURES | protease | REPLICATION | VIROLOGY | GENOMES | MOLECULAR VIROLOGY | crystal structure | INFECTION | biophysics | fatty-acid binding | EXPRESSION
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0174706
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2017, Volume 429, Issue 11, p. 1684
ATR, a protein kinase in the PIKK family, plays a critical role in the cell DNA-damage response and is an attractive anticancer drug target. Several potent and... 
Proteins | Structure | Protein kinases | Analysis | Crystals
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2011, Volume 2, Issue 10, pp. 774 - 779
Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein... 
NVP-BKM120 | phosphoinositide-3-kinase | PI3K/AKT3 pathway | TARGET | RAPAMYCIN | 3-KINASES | CHEMISTRY, MEDICINAL | PATHWAY
Journal Article
Journal Article