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Chemical Research in Toxicology, ISSN 0893-228X, 12/2004, Volume 17, Issue 12, pp. 1607 - 1613
Furan is an environmental chemical that induces liver toxicity and tumor formation in rodents, leading to its classification as a probable human carcinogen.... 
Deoxyadenosines - chemistry | Furans - metabolism | DNA Adducts - toxicity | DNA Adducts - chemistry | Deoxyadenosines - metabolism | Aldehydes - metabolism | Furans - toxicity | DNA Adducts - metabolism | Aldehydes - chemistry | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2008, Volume 75, Issue 2, pp. 484 - 493
Aldo-keto reductase (AKR) 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase) regulates ligand access to steroid hormone and prostaglandin... 
Prostaglandin metabolism | Inhibitor design | Steroid hormone metabolism | Cancer treatment | NSAIDs | Chemoprevention | cancer treatment | ANDROGEN RECEPTOR | SIGNALING PATHWAYS | INCREASED EXPRESSION | CRYSTAL-STRUCTURE | prostaglandin metabolism | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROLIFERATOR-ACTIVATED RECEPTOR | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | chemoprevention | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ACID-BINDING PROTEIN | CYCLOOXYGENASE-2 INHIBITORS | inhibitor design | PHARMACOLOGY & PHARMACY | steroid hormone metabolism | Indomethacin - analogs & derivatives | Oxidation-Reduction | Humans | Enzyme Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Melatonin - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | 3-Hydroxysteroid Dehydrogenases - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Catalysis | Neoplasms, Hormone-Dependent - drug therapy | Melatonin - pharmacology | Phenanthrenes - metabolism | Dihydrotestosterone - metabolism | Enzymes | Care and treatment | Synthetic prostaglandins F | Crystals | Hormones | Organic acids | Heterocyclic compounds | Physiological aspects | Glycols | Hormones, Sex | Indomethacin | Structure | Cancer | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 05/2012, Volume 130, Issue 1-2, p. 7
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 05/2011, Volume 125, Issue 1-2, p. 95
a* AKR1C3 produces steroids and prostaglandins for receptor mediated growth. a* AKR1C3 inhibition is desirable for hormone dependent and independent cancers.... 
Prostaglandins | Crystals | Medroxyprogesterone | Hormones, Sex | Structure | Benzodiazepines | Isoflavones
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2009, Volume 178, Issue 1, pp. 221 - 227
Aldo-keto reductase (AKR) 1C3 catalyzes the NADPH-dependent reduction of Δ -androstene-3,17-dione to yield testosterone, reduction of estrone to yield... 
Indomethacin | Prostaglandin metabolism | Steroid hormone metabolism | N-Phenylanthranilic acids | Aldo-keto reductase | CELLS | SIGNALING PATHWAYS | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEHYDROGENASE | SELECTIVE COX-2 INHIBITORS | STEROID-PRODUCING ENZYMES | PROGNOSTIC MARKER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2012, Volume 3, pp. 92 - 92
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 03/2009, Volume 178, Issue 1-3, p. 221
Aldo-keto reductase (AKR) 1C3 catalyzes the NADPH-dependent reduction of [DELTA].sup.4-androstene-3,17-dione to yield testosterone, reduction of estrone to... 
Immunohistochemistry | Enzymes | Care and treatment | Wind-pressure | Synthetic prostaglandins F | Crystals | Flexible response (Strategy) | Breast cancer | Deterrence (Strategy) | Estradiol | Prevention | Testosterone | Physiological aspects | Indomethacin | Progesterone | Drug therapy | Structure | Mass spectrometry | Cancer
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2311 - 2323
Aldo-keto reductase 1C3 (AKR1C3; type 5 17 beta-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated... 
TARGET | CHEMISTRY, MEDICINAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PURIFICATION | BIOLOGICAL EVALUATION | AKR1C3 | ABIRATERONE ACETATE | 17-BETA-HSD1 | RESISTANT PROSTATE-CANCER | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Antineoplastic Agents - chemical synthesis | Humans | Male | Structure-Activity Relationship | Hydroxyprostaglandin Dehydrogenases - metabolism | Fenamates - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 3-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Fenamates - chemistry | Testosterone - biosynthesis | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Cyclooxygenase Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Testosterone - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Fenamates - chemical synthesis | Cyclooxygenase 1 - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2010, Volume 118, Issue 3, pp. 177 - 187
Aldo-keto reductase (AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase), may stimulate proliferation via steroid hormone and... 
Estrogen receptor | Peroxisome proliferator activated receptor γ | Prostaglandin F synthase | Prostaglandin D 2 | 17β-Hydroxysteroid dehydrogenase | Prostaglandin D | SIGNALING PATHWAYS | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKR1C3 | PROLIFERATOR-ACTIVATED RECEPTOR | RISK | Prostaglandin D-2 | CELECOXIB | ENDOCRINOLOGY & METABOLISM | PROGNOSTIC MARKER | F SYNTHASE | INHIBITORS | 17 beta-Hydroxysteroid dehydrogenase | AROMATASE | Peroxisome proliferator activated receptor | gamma | Up-Regulation | Prostaglandins - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Dinoprost - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Breast Neoplasms - metabolism | Testosterone - metabolism | Breast Neoplasms - enzymology | Transfection | Prostaglandin D2 - metabolism | Prostaglandin D2 - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | 5-alpha-Dihydroprogesterone - metabolism | Dinoprost - pharmacology | Etiocholanolone - metabolism | Estradiol - pharmacology | Dihydrotestosterone - metabolism | Recombinant Proteins - metabolism | Estradiol - metabolism | Estrone - pharmacology | Gonadal Steroid Hormones - metabolism | Biocatalysis | Etiocholanolone - analogs & derivatives | Gonadal Steroid Hormones - pharmacology | Progesterone - analogs & derivatives | Recombinant Proteins - genetics | 20-alpha-Dihydroprogesterone - metabolism | Androsterone - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Breast Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Progesterone - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Prostaglandin D2 - pharmacology | Ketosteroids - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Prostaglandins - metabolism | Physiological aspects | Testosterone | Breast cancer | Progesterone | Estradiol | Synthetic prostaglandins F | Index Medicus
Journal Article
by Goodman, Louis S. 1906-2000. (Louis Sanford) and Brunton, Laurence L and Chabner, Bruce A and Knollmann, Bj orn C and Acosta, Edward P and Barnes, Peter J and Barnes, Jeffrey A and Benet, Leslie Z and Bennett, John E and Bennett, William and Bersot, Thomas P and Bertino, Joseph R and Blumenthal, Donald K and Bounkeua, Viengngeun and Brent, Gregory A and Brown, Joan Heller and Burkhart, Craig N and Buxton, Iain L. O and Byrns, Michael C and Catterall, William A and Chambers, Henry F and Clain, J er ome and Cleary James M and Coughtrie, Michael W. H and D'Alessio, David and Eastman, Richard T and Erd os, Ervin G and Fidock, David A and FitzGerald, Garret A and Flexner, Charles W and Friedman, Peter A and Funder, John W and Garrison, James C and Giacomini, Kathleen M and Gilman, Alfred G and Goldsmith, Lowell A and Gonzalez, Frank J and Grosser, Tilo and Gumbo, Tawanda and Hammes, Stephen R and Harris, R. Adron and Hazelwood, Lisa A and Henderer, Jeffrey D and Hibbs, Ryan E and Hilal-Dandan, Randa and Hoffman, Brian B and Hotez, Peter J and Isoherranen, Nina and Jackson, Edwin K and Kaplan, Allen P and Kass, Robert S and Kaushansky, Kenneth and Kipps, Thomas J and Koenig, Ronald J and Krensky, Alan M and Laiken, Nora and Lane, Andrew A and Lee, Richard J and Levin, Ellis R and Longo, Dan L and Loukas, Alex and MacDougall, Conan and Mackie, Kenneth P and Maron, Bradley A and McCarthy, James and McNamara, James O and Meyer, Jonathan M and Michel, Thomas and Mihic, S. John and Mitsiades, Constantine S and Molinoff, Perry and Morrell, Dean S and Moy, Beverly and Mujagic, Hamza and Neal, Joel W and O'Brien, Charles P and O'Donnell, James and Olson, Erin M and Ortiz, Taylor M and Osterhoudt, Kevin and Parker, Keith L and Patel, Hemal H and Patel, Piyush M and Penning, Trevor M and Petri, William A and Phillips, Margaret A and Powers, Alvin C and Rapuano, Christopher and Reilly, Robert F., M.D and Relling, Mary V and Richardson, Paul G and Rivera, Suzanne M and Roberson, Erik and Rocco, Thomas P and Roth, David M and Ryan, David P and Sampson, Kevin J and Sanders-Bush, Elaine and Schimmer, Bernard P and Schuckit, Marc A and ...
2011, 12th edition, McGraw-Hill's AccessMedicine. Clinical library, ISBN 0071624422
Web Resource
Journal Article
Chemico-biological interactions, ISSN 0009-2797, 3/2009, Volume 178, Issue 1-3, pp. 221 - 227
Aldo-keto reductase (AKR) 1C3 catalyzes the NADPH dependent reduction of Δ 4 -androstene-3,17-dione to yield testosterone, reduction of estrone to yield... 
N-phenylanthranilic acids | Aldo-keto reductase | prostaglandin metabolism | steroid hormone metabolism | indomethacin
Journal Article
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 2/2010, Volume 118, Issue 3, p. 177
Aldo-keto reductase (AKR) 1C3 (type 5 17β-hydroxysteroid dehydrogenase and prostaglandin F synthase), may stimulate proliferation via steroid hormone and... 
peroxisome proliferator activated receptor γ | estrogen receptor | 17β-Hydroxysteroid dehydrogenase | prostaglandin D2 | prostaglandin F synthase
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 08/2006, Volume 19, Issue 8, pp. 982 - 985
Journal Article
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