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British Journal of Haematology, ISSN 0007-1048, 10/2016, Volume 175, Issue 1, pp. 141 - 153
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2017, Volume 8, Issue 3, pp. 321 - 326
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and... 
sickle cell hemoglobin | oxygen affinity | red blood cell partitioning | Schiff-base formation | aldehyde | Sickle cell disease | allosteric modulator | CHEMISTRY, MEDICINAL | PYRIDYL DERIVATIVES | ANTISICKLING AGENT | POTENT | STRUCTURAL BASIS | DISEASE | ANEMIA | BINDING
Journal Article
07/2018
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
01/2020
Provided are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, and R3 are as defined herein. Also provided is a... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
05/2018
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their... 
HYGIENE | METALLURGY | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HETEROCYCLIC COMPOUNDS | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
04/2019
본원에는 헤모글로빈의 조정제로서 적당한 화합물 및 약학 조성물, 이것들의 제조 방법과 제조를 위한 중간체, 그리고 조직 및/또는 세포 산소화(oxygenation)로부터 이익을 얻을 질환들과 헤모글로빈에 의해 매개되는 질환들을 치료함에 있어서 이것들의 사용 방법이 제공되어 있다.... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
Patent
12/2018
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
07/2018
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
01/2020
Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, Y1, Y2, L1, and G1 are as defined herein. Also provided... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
06/2017
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
06/2017
본원에는 헤모글로빈의 조정제로서 적당한 화합물 및 약학 조성물, 이것들의 제조 방법과 제조를 위한 중간체, 그리고 조직 및/또는 세포 산소화(oxygenation)로부터 이익을 얻을 질환들과 헤모글로빈에 의해 매개되는 질환들을 치료함에 있어서 이것들의 사용 방법이 제공되어 있다.... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
Patent
10/2018
Provided are cycloalkyl- and cycloalkenyl-substituted benzaldehydes and heteroaldehydes of formula (I) that act as allosteric modulators of hemoglobin, methods... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC OR CARBOCYCLIC COMPOUNDS
Patent
04/2015
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
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