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2001, 1, ISBN 9786610079773, 550
Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and... 
Bioreactors | Design and construction | Biochemical Engineering | Industrial Chemistry
eBook
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.... 
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | ACTIVATION | LIGAND EXPRESSION | CAR | EFFECTOR FUNCTION | GENE-EXPRESSION | FAS | DEATH | ANTITUMOR-ACTIVITY | NF-KAPPA-B | SIGNALING COMPLEX | CELL BIOLOGY | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Chimeric antigen receptor
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 14388 - 16
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 2002, pp. 101 - 119
The development of cellular therapies to treat hematological malignancies has motivated researchers to investigate ex vivo culture systems capable of expanding... 
Microwells | Hematopoietic stem/progenitor cells (HSPC) | Mesenchymal stem/stromal cells (MSC) | Co-culture | Hematopoietic niche | Spheroids
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1771, pp. 69 - 81
Cell-based microarrays are valuable platforms for the study of cytotoxicity and cellular microenvironment because they enable high-throughput screening of... 
High-content screening | 3D cell microarray | Cytotoxicity | Pluripotent stem cells | Cellular microenvironment | Pluripotent Stem Cells - cytology | Cell Culture Techniques | Printing, Three-Dimensional | Spheroids, Cellular | Tissue Array Analysis - methods
Journal Article