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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2004, Volume 101, Issue 32, pp. 11707 - 11712
We have determined the full protein kinase (PK) complement (kinome) of mouse. This set of 540 genes includes many novel kinases and corrections or extensions... 
Biological Sciences | Pseudogenes | Databases | Humans | Genomics | Genes | Rats | Evolution | Genetic loci | Genomes | Genetic mutation | MULTIDISCIPLINARY SCIENCES | Mice - genetics | Protein Kinases - genetics | Species Specificity | Retroelements | Chromosome Mapping | Phenotype | Animals | Base Sequence | Conserved Sequence | Mutation | Databases, Nucleic Acid | Evolution, Molecular | Protein kinases | Mice | Research
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-241 - LB-241
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 11/2019, Volume 62, Issue 22, pp. 10258 - 10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive... 
APOPTOSIS | POTENT | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | VENETOCLAX | PROTEINS | CANCER | DERIVATIVES | ABT-199 | STRUCTURE-BASED DESIGN
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2027 - 2027
Journal Article
Cold Spring Harbor Perspectives in Medicine, ISSN 2157-1422, 06/2016, Volume 6, Issue 6, p. a026336
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 2017, Volume 15, Issue 11, pp. 1587 - 1597
The receptor tyrosine kinase (RTK) MET represents a promising tumor target in a subset of glioblastomas. Most RTK inhibitors available in the clinic today,... 
CELL LUNG-CANCER | GLIOBLASTOMA | ONCOGENE | ONCOLOGY | THYROID-CANCER | C-MET | RESISTANCE | RECEPTOR | FACTOR/HEPATOCYTE GROWTH-FACTOR | HIGH-GRADE GLIOMA | BRAIN-TUMORS | CELL BIOLOGY | Aminopyridines - administration & dosage | Cell Survival - drug effects | Small Molecule Libraries - pharmacology | Small Molecule Libraries - administration & dosage | Humans | Brain Neoplasms - genetics | Gene Expression Profiling - methods | Brain Neoplasms - drug therapy | Glioma - genetics | HT29 Cells | Sequence Analysis, RNA - methods | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | Aminopyridines - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Glioma - drug therapy | Pyrazoles - pharmacology | Brain | Phosphorylation | Animal models | Brain tumors | Glioblastoma | Paracrine signalling | AKT protein | Kinases | Blood | Gene sequencing | c-Met protein | Ret protein | Plasticity | Xenografts | Protein-tyrosine kinase receptors | Inhibition | Protein-tyrosine kinase | Tyrosine | Compound A | Gene expression | Ribonucleic acid--RNA | Survival | Inhibitors | Glioma | Cell lines | Plastic properties | In vivo methods and tests | Tumors
Journal Article
Journal Article
Cancer discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1598 - 1613
BH3 mimetic drugs, which inhibit pro-survival BCL-2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics... 
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 3405 - 3405
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1267 - 1267
Bcl-2 and Mcl-1 play critical roles in AML stem/progenitor cell survival. Venetoclax (VEN), a highly selective Bcl-2 inhibitor, showed limited clinical... 
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 01/2020, Volume 19, Issue 1, pp. 147 - 156
Receptor tyrosine kinase inhibitors have shown clinical benefit in clear cell renal cell carcinoma (ccRCC), but novel therapeutic strategies are needed. The... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2163 - 2163
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2077 - 2077
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1598 - 1613
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for... 
DRUG-COMBINATIONS | MEK INHIBITION | ONCOLOGY | BIM | RESISTANCE | REGULATORS | BH3 MIMETIC ABT-737 | PROTEINS | EXPRESSION | DOCETAXEL | TRAMETINIB GSK1120212 | Lung Neoplasms - drug therapy | Diphenylamine - pharmacology | Apoptosis - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Antineoplastic Agents - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Aniline Compounds - administration & dosage | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | A549 Cells | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mice, SCID | Sulfonamides - pharmacology | Xenograft Model Antitumor Assays - methods | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Protein Kinase Inhibitors - administration & dosage | Animals | Tumor Burden - drug effects | Mice, Nude | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Sulfonamides - administration & dosage
Journal Article
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