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Journal of Clinical Investigation, ISSN 0021-9738, 07/2006, Volume 116, Issue 7, pp. 2022 - 2032
CD4(+)CD25(+) Tregs regulate immunity, but little is known about their own regulation. We now report that the human 60-kDa heat shock protein (HSP60) acts as a... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEAT-SHOCK PROTEINS | ACTIVATION | DISCRIMINATION | INFLAMMATION | SUPPRESSOR FUNCTION | IL-10 PRODUCTION | LIPOPOLYSACCHARIDE | TRANSCRIPTION FACTOR | IMMUNOLOGICAL-TOLERANCE | BETA
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2013, Volume 110, Issue 6, pp. 2264 - 2269
The adaptive arm of the immune system has been suggested as an important factor in brain function. However, given the fact that interactions of neurons or... 
Brain senescence | Neuroinflammation | Blood-cerebrospinal fluid barrier | LUNG | DENDRITIC CELLS | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | CENTRAL MEMORY | IL-4 | CD4(+) T-CELLS | CEREBROSPINAL-FLUID | blood-cerebrospinal fluid barrier | neuroinflammation | NEUROGENESIS | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | brain senescence | Biological Sciences
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 06/2018, Volume 128, Issue 6, pp. 2651 - 2651
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 10/2010, Volume 14, Issue 10, pp. 2470 - 2482
Amyotrophic lateral sclerosis (ALS) is a devastating disease, characterized by extremely rapid loss of motor neurons. Our studies over the last decade have... 
immunomodulation | immune deficiency | neuroprotection | neurodegeneration | thymus involution | protective autoimmunity | T cells | amyotrophic lateral sclerosis | Neuroprotection | Immunomodulation | Neurodegeneration | Thymus involution | Amyotrophic lateral sclerosis | Protective autoimmunity | Immune deficiency | MEDICINE, RESEARCH & EXPERIMENTAL | RECEPTOR EXCISION CIRCLES | ALZHEIMERS-DISEASE | SPINAL-CORD | T-CELL LYMPHOMA | CELL BIOLOGY | IMMUNE-SYSTEM | MOUSE MODEL | GENE REARRANGEMENT | CENTRAL-NERVOUS-SYSTEM | GLATIRAMER ACETATE | HIV-1 INFECTION | Amyotrophic Lateral Sclerosis - immunology | Thymus Gland - physiopathology | Gene Rearrangement, T-Lymphocyte | Humans | Middle Aged | Male | Mice, Transgenic | Gene Expression Profiling | CD4-Positive T-Lymphocytes - immunology | Amyotrophic Lateral Sclerosis - pathology | Animals | Adult | Female | Thymus Gland - immunology | Mice | Disease Models, Animal | Cell culture | Animal models | Disease | Bax protein | CD86 antigen | Genes | Central nervous system | Superoxide dismutase | Leukocytes (mononuclear) | Lymphocytes T | Blood | Thymus | Reduction | Lymphocytes | Human immunodeficiency virus--HIV | Interleukin 1 | Peripheral blood mononuclear cells | Thymic involution | Deoxyribonucleic acid--DNA | Immune system | Motor neurons | Antigens | Life expectancy | CD80 antigen | Superoxide | Histology | Gene expression | Morbidity | Interleukin 18 | Blood levels | CD4 antigen | Autoimmune diseases | Apoptosis
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2000, Volume 191, Issue 7, pp. 1167 - 1176
Elevated extracellular K + ([K + ] o ), in the absence of “classical” immunological stimulatory signals, was found to itself be a sufficient stimulus to... 
Potassium channels | Extracellular K | T cells | Neuroimmunomodulation | Integrins | integrins | extracellular K | neuroimmunomodulation | Original | potassium channels
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 547 - 549
Chondroitin sulfate proteoglycan (CSPG), a matrix protein that occurs naturally in the central nervous system (CNS), is considered to be a major inhibitor of... 
encephalomyelitis | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | experimental autoimmune uveitis | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | immunosuppression | CELL BIOLOGY | HIGH-DOSE METHYLPREDNISOLONE | MULTIPLE-SCLEROSIS | BIOLOGY | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | TNF-ALPHA | THERAPEUTIC VACCINATION | NF-KAPPA-B | T-CELLS | Apoptosis - drug effects | Chondroitin Sulfate Proteoglycans - chemistry | Humans | NF-kappa B - metabolism | Hypersensitivity, Delayed - prevention & control | Disaccharides - isolation & purification | Retinal Ganglion Cells - pathology | Disaccharides - pharmacology | Chondroitin Sulfate Proteoglycans - pharmacology | Microglia - pathology | Disaccharides - therapeutic use | Autoimmune Diseases - pathology | Cells, Cultured - immunology | Autoimmune Diseases - drug therapy | Amino Acid Sequence | Cells, Cultured - drug effects | T-Lymphocytes - secretion | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Rats | Suppressor of Cytokine Signaling Proteins - genetics | Chemotaxis - drug effects | Cell Adhesion | Chondroitin Sulfate Proteoglycans - therapeutic use | Encephalomyelitis, Autoimmune, Experimental - complications | T-Lymphocytes - immunology | Cells, Cultured - metabolism | Mice | Mice, Inbred BALB C | Nerve Degeneration - etiology | Suppressor of Cytokine Signaling Proteins - biosynthesis | Uveitis - complications | Immunologic Factors - pharmacology | Immunologic Factors - isolation & purification | Rats, Inbred Lew | Molecular Sequence Data | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Nerve Degeneration - prevention & control | Chondroitin Sulfate Proteoglycans - isolation & purification | Female | Drug Evaluation, Preclinical | Hypersensitivity, Delayed - drug therapy | Encephalomyelitis, Autoimmune, Experimental - pathology | Microglia - drug effects | Uveitis - drug therapy | Interferon-gamma - secretion | Mice, Inbred C57BL | Autoimmune Diseases - complications | Cytokines - secretion | Suppressor of Cytokine Signaling 3 Protein | Animals | T-Lymphocytes - cytology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Retinal Ganglion Cells - drug effects | Uveitis - pathology | Immunologic Factors - therapeutic use
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2001, Volume 69, Issue 6, pp. 885 - 892
On their extravasation from the vascular system into inflamed tissues, leukocytes must maneuver through a complex insoluble network of molecules termed the... 
T lymphocytes | cytokines | chemokines | cytoskeleton | metalloproteinase | Cytoskeleton | Metalloproteinase | Cytokines | Chemokines | PEPTIDE CHEMOATTRACTANTS | CROSS-DESENSITIZATION | IMMUNOLOGY | HUMAN MONOCYTES | DIFFERENTIAL REGULATION | CELL BIOLOGY | CD4+ T-LYMPHOCYTES | GROWTH-FACTOR-BETA | TIMP-1 PRODUCTION | FOCAL ADHESION KINASE | TNF-ALPHA | HEMATOLOGY | CELL ADHERENCE | Humans | Extracellular Matrix - metabolism | Microscopy, Video | Cytokines - physiology | Chemotaxis, Leukocyte - physiology | Chemotactic Factors - pharmacology | Chemotaxis, Leukocyte - drug effects | Chemokines, CXC - pharmacology | Matrix Metalloproteinase 9 - secretion | Chemokines - pharmacology | Interleukins - pharmacology | Leukocytes - cytology | Chemokine CXCL12 | Cells, Cultured - drug effects | Chemokine CCL4 | Chemokines - physiology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Cell Adhesion - drug effects | Cells, Cultured - secretion | Fibronectins - metabolism | Drug Synergism | Transforming Growth Factor beta - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Chemokine CCL5 - pharmacology | Signal Transduction - drug effects | Cell Adhesion - physiology | Leukocytes - drug effects | Leukocytes - secretion | Laminin - metabolism | Cytokines - pharmacology | Interferon-gamma - pharmacology | Macrophage Inflammatory Proteins - pharmacology
Journal Article
European Journal of Immunology, ISSN 0014-2980, 11/2006, Volume 36, Issue 11, pp. 2971 - 2980
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2013, Volume 110, Issue 6, p. 2264
  The adaptive arm of the immune system has been suggested as an important factor in brain function. However, given the fact that interactions of neurons or... 
Brain | Cytokines | Memory | Cognitive ability | Aging | Homeostasis | Immune system
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2004, Volume 172, Issue 9, pp. 5185 - 5193
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2004, Volume 75, Issue 6, pp. 1139 - 1146
We previously reported that disaccharides (DS), generated by enzymatic degradation of heparin or heparan sulfate, inhibit T cell‐mediated immune reactions in... 
CXCL12 | chemokines | TNF‐α | IFN‐γ | extracellular matrix | Extracellular matrix | IFN-γ | TNF-α | Chemokines | TNF-alpha | REL PROTEINS | NECROSIS-FACTOR-ALPHA | FACTOR-I | IMMUNOLOGY | PROTEIN-KINASES | CELL BIOLOGY | ADHESION | RESPONSES | IFN-gamma | CHEMOATTRACTANT RECEPTORS | EXTRACELLULAR-MATRIX | HETEROLOGOUS DESENSITIZATION | HEMATOLOGY
Journal Article