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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 6, pp. 2070 - 2075
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase... 
Adenocarcinoma | Enzymes | Lungs | Molecular structure | Crystals | Growth factor receptors | Drug resistance | Genetic mutation | Lung neoplasms | Crystal structure | X-ray crystallography | Tyrosine kinase | Lung cancer | IRREVERSIBLE INHIBITORS | GEFITINIB | GROWTH-FACTOR-RECEPTOR | MULTIDISCIPLINARY SCIENCES | tyrosine kinase | BCR-ABL | ACQUIRED-RESISTANCE | SENSITIVITY | DOMAIN MUTATIONS | CHRONIC MYELOID-LEUKEMIA | lung cancer | CELL LUNG-CANCER | x-ray crystallography | ALLOSTERIC MECHANISM | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Insecta | Enzyme Inhibitors - pharmacology | ErbB Receptors - genetics | Crystallography, X-Ray | Drug Resistance - genetics | Animals | ErbB Receptors - chemistry | Adenosine Triphosphate - metabolism | Protein Conformation | Kinetics | Mutation | Gefitinib | Quinazolines - pharmacology | Causes of | Genetic aspects | Health aspects | Adenosine triphosphate | Cell growth | Inhibitor drugs | Kinases | Adenosine triphosphatase | Index Medicus | AUGMENTATION | NEOPLASMS | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | LUNGS | CHANNELING | MOLECULES | GROWTH FACTORS | MUTANTS | AFFINITY | TYROSINE | DRUGS | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | PHOSPHOTRANSFERASES | MUTATIONS | RECEPTORS | ATP | THREONINE | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7276, pp. 1070 - 1074
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 36, pp. 14476 - 14481
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2013, Volume 5, Issue 216, pp. 216ra177 - 216ra177
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 01/2016, Volume 30, Issue 1, pp. 173 - 181
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small... 
CELL LUNG-CANCER | EGFR KINASE | GROWTH-FACTOR RECEPTOR | TARGETED THERAPIES | GEFITINIB | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MUTATIONS | AZD9291 | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Drug Resistance, Multiple - drug effects | Protein Conformation - drug effects | Lung Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Allosteric Regulation - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Drug Resistance, Multiple - genetics | Lung Neoplasms - enzymology | Allosteric Site - drug effects | Mutant Proteins - genetics | Cetuximab - pharmacology | Mutant Proteins - metabolism | Receptor, Epidermal Growth Factor - chemistry | Drug Synergism | Drug Resistance, Neoplasm - genetics | Animals | Mutant Proteins - chemistry | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Studies | Phosphorylation | Nuclear magnetic resonance--NMR | Epidermal growth factor | Mutation | Kinases | Enzyme kinetics | Tumors | Index Medicus
Journal Article