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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 21, pp. 9551 - 9567
Oral PI3Kδ inhibitors such as Idelalisib and Duvelisib have shown efficacy as anticancer agents and Idelalisib has been approved for the treatment of three... 
PHOSPHOINOSITIDE 3-KINASE DELTA | P110-DELTA | CHEMISTRY, MEDICINAL | POTENCY
Journal Article
09/2009, ISBN 9780387764788, 574
This volume brings together an international group of leading researchers to discuss past, present and future research on the Paleolithic transitions. The... 
Stone age | Paleolithic period | Archaeology | Anthropology | Social Sciences
eBook
Biomarker Research, ISSN 2050-7771, 04/2018, Volume 6, Issue 1, pp. 14 - 8
Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma... 
Bronchoscopy | Immunohistochemistry | P38 mitogen-activated protein kinase | Allergens | Phosphoinositide 3-kinase | JAK-STAT signalling | Kinase | Asthma | Care and treatment | Analysis | Clinical trials | Research | Protein kinases | STAT proteins
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 08/2019, Volume 370, Issue 2, pp. 137 - 147
The Janus-activated kinase (JAK) family together with signal transducer and activator of transcription (STAT) signaling pathway has a key role in regulating... 
SIGNALING PATHWAYS | POTENT | JANUS KINASE INHIBITOR | DISEASE | EXACERBATIONS | PHARMACOLOGY & PHARMACY | TOFACITINIB | MODEL
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2014, Volume 24, Issue 21, pp. 5127 - 5133
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2014, Volume 24, Issue 21, pp. 5118 - 5122
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2016, Volume 111, pp. 208 - 216
The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTh2) is a G protein-coupled receptor expressed on the leukocytes most... 
Blood eosinophilia | Long receptor residence time | CRTh2 receptor | Long duration of action | Asthma | POTENT ANTAGONIST | ALLERGIC INFLAMMATION | NASAL CHALLENGE | KINETIC RELATIONSHIPS SKR | HOMOLOGOUS MOLECULE | ACTIVITY-RELATIONSHIPS SAR | PHARMACOLOGY & PHARMACY | HUMAN TH2 CELLS | HELPER TYPE-2 CELLS | ASTHMATIC-PATIENTS | PROSTAGLANDIN D-2 | Anti-Asthmatic Agents - blood | Eosinophils - metabolism | Pyrroles - pharmacokinetics | Cricetulus | Eosinophils - drug effects | Rats, Wistar | Pyridines - chemistry | Half-Life | Pyridines - pharmacokinetics | Male | Receptors, Immunologic - antagonists & inhibitors | Dose-Response Relationship, Drug | Anti-Asthmatic Agents - pharmacokinetics | Receptors, Prostaglandin - genetics | Transfection | Chemotaxis, Leukocyte - drug effects | Drug Design | Prostaglandin Antagonists - pharmacology | Receptors, Prostaglandin - blood | Prostaglandin Antagonists - chemistry | Receptors, Prostaglandin - antagonists & inhibitors | Receptors, Immunologic - blood | Anti-Asthmatic Agents - chemistry | CHO Cells | Anti-Asthmatic Agents - pharmacology | Prostaglandin Antagonists - pharmacokinetics | Guinea Pigs | Pyrroles - blood | Cell Shape - drug effects | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Pyridines - blood | Pyrroles - pharmacology | Animals | Dogs | Protein Binding | Pyrroles - chemistry | Mice | Pyridines - pharmacology | Kinetics | Receptors, Immunologic - genetics | Prostaglandin Antagonists - blood
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2019, Volume 62, Issue 20, pp. 9045 - 9060
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive... 
IMMUNE | CHEMISTRY, MEDICINAL | STAT PATHWAY | CP-690550 | INFLAMMATION | DISCOVERY
Journal Article
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2011, Volume 11, Issue 11, pp. 1773 - 1779
Journal Article
The Journal of pharmacology and experimental therapeutics, 05/2019
The Janus-activated kinase family (JAK) together with Signal transducer and activator of transcription (STAT) signaling pathway have a key role in regulating... 
Journal Article
Progress in Oceanography, ISSN 0079-6611, 2007, Volume 74, Issue 2, pp. 294 - 312
The study of the response of planktonic systems to environmental variability, and particularly to differences in the intensity and frequency of mechanical... 
Community structure | NW Mediterranean | Rate processes | Zooplankton | Physical forcing | ACARTIA-GRANI COPEPODA | zooplankton | SMALL-SCALE TURBULENCE | EXCRETION | rate processes | RATES | community structure | CENTROPAGES-TYPICUS | VERTICAL-DISTRIBUTION | RESPIRATION | OCEANOGRAPHY | GROWTH | physical forcing | EGG-PRODUCTION | SPATIAL-DISTRIBUTION | Ecosystems
Journal Article