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[ sdv.bbm.gtp ] life sciences [q-bio]/biochemistry, molecular biology/genomics [q-bio.gn] (2) 2
[ sdv.mhep ] life sciences [q-bio]/human health and pathology (2) 2
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by Zheng, Hou-Feng and Forgetta, Vincenzo and Hsu, Yi-Hsiang and Estrada, Karol and Rosello-Diez, Alberto and Leo, Paul J and Dahia, Chitra L and Park-Min, Kyung Hyun and Tobias, Jonathan H and Kooperberg, Charles and Kleinman, Aaron and Styrkarsdottir, Unnur and Liu, Ching-Ti and Uggla, Charlotta and Evans, Daniel S and Nielson, Carrie M and Walter, Klaudia and Pettersson-Kymmer, Ulrika and Mccarthy, Shane and Eriksson, Joel and Kwan, Tony and Jhamai, Mila and Trajanoska, Katerina and Memari, Yasin and Min, Josine and Huang, Jie and Danecek, Petr and Wilmot, Beth and Li, Rui and Chou, Wen-Chi and Mokry, Lauren E and Moayyeri, Alireza and Claussnitzer, Melina and Cheng, Chia-Ho and Cheung, Warren and Medina-Gómez, Carolina and Ge, Bing and Chen, Shu-Huang and Choi, Kwangbom and Oei, Ling and Fraser, James and Kraaij, Robert and Hibbs, Matthew A and Gregson, Celia L and Paquette, Denis and Hofman, Albert and Wibom, Carl and Tranah, Gregory J and Marshall, Mhairi and Gardiner, Brooke B and Cremin, Katie and Auer, Paul and Hsu, Li and Ring, Sue and Tung, Joyce Y and Thorleifsson, Gudmar and Enneman, Anke W and van Schoor, Natasja M and de Groot, Lisette C. P. G. M and van der Velde, Nathalie and Melin, Beatrice and Kemp, John P and Christiansen, Claus and Sayers, Aian and Zhou, Yanhua and Calderari, Sophie and van Rooij, Jeroen and Carlson, Chris and Peters, Ulrike and Berlivet, Soizik and Dostie, Josée and Uitterlinden, Ane G and Williams, Stephen R and Farber, Charles and Grinberg, Daniel and LaCroix, Anea Z and Haessler, Jeff and Chasman, Daniel I and Giulianini, Franco and Rose, Lynda M and Ridker, Paul M and Eisman, John A and Nguyen, Tuan V and Center, Jacqueline R and Nogues, Xavier and Garcia-Giralt, Natalia and Launer, Lenore L and Gudnason, Vilmunder and Mellström, Dan and Vandenput, Liesbeth and Amin, Najaf and van Duijn, Cornelia M and Karlsson, Magnus K and Ljunggren, Östen and Svensson, Olle and Hallmans, Göran and Rousseau, François and Giroux, Sylvie and Bussière, Johanne and Arp, Pascal P and ... and AOGC Consortium and UK10K Consortium and Medicinska fakulteten and Institutionen för strålningsvetenskaper and Umeå universitet and Institutionen för folkhälsa och klinisk medicin and Institutionen för farmakologi och klinisk neurovetenskap and Farmakologi and Enheten för biobanksforskning and Näringsforskning and Institutionen för kirurgisk och perioperativ vetenskap
Nature, ISSN 0028-0836, 2015, Volume 526, Issue 7571, pp. 112 - +
The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF <= 1%) variants contribute to complex traits and disease in the... 
WIDE ASSOCIATION LOCI | MINERAL DENSITY | METAANALYSIS | VARIANTS | GENE | ENGRAILED-1 | MULTIDISCIPLINARY SCIENCES | MOUSE | HUMAN-DISEASES | COMPLEX TRAITS | OSTEOPOROSIS | European Continental Ancestry Group - genetics | Gene Frequency - genetics | Genetic Predisposition to Disease - genetics | Genomics | Humans | Genotype | Bone Density - genetics | Sequence Analysis, DNA | Europe - ethnology | Fractures, Bone - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Exome - genetics | Animals | Wnt Proteins - genetics | Bone and Bones - metabolism | Female | Genetic Variation - genetics | Mice | Disease Models, Animal | Quantitative trait loci | Fractures | Bones | Genetic aspects | Nucleotide sequencing | Identification and classification | Density | Methods | DNA sequencing | Proteins | Studies | Osteoporosis | Ethnicity | Population | Bone density | Genomes | Neck | Meta-analysis | Index Medicus | Malalties | Aspectes genètics | Ossos | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences | HNE Voeding en Gezondheid in de Levenscyclus | Wereldvoeding | VLAG | Chair Nutrition and Health over the Lifecourse | Global Nutrition | HNE Nutrition and Health over the Lifecourse
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e82825 - e82825
Nutritional factors play important roles in the etiology of obesity, type 2 diabetes mellitus and their complications through genotype x environment... 
METABOLIC SYNDROME | PATHWAY | STEATOSIS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | MOUSE | NONALCOHOLIC STEATOHEPATITIS | RECEPTOR-GAMMA ACTIVATION | HEPATIC GENE-EXPRESSION | INSULIN-RESISTANT MICE | Adaptation, Physiological | Liver - pathology | Reproducibility of Results | Disease Susceptibility | Fatty Liver - metabolism | Signal Transduction | Obesity - complications | Liver - metabolism | Gene Expression Regulation | Transcriptome | Lipid Metabolism | Male | Gene Expression Profiling | Animals | Diet, High-Fat | Non-alcoholic Fatty Liver Disease | Glucose - metabolism | Nutrigenomics | Obesity - etiology | Mice | Proteasome Endopeptidase Complex - metabolism | Fatty Liver - etiology | Type 2 diabetes | Ubiquitin | Obesity | Genes | Genomics | Dietary fat | Disease susceptibility | Genomes | Genetic transcription | Fatty liver | Diet | Insulin resistance | Genetic aspects | Adaptations | Regulations | Animal models | Transcription | Laboratories | Liver | Steroidogenic acute regulatory protein | Glucose | Kinases | High fat diet | Signal transduction | Pathways | Etiology | Proteolysis | Rodents | Genetics | Inbreeding | Physiology | Strains (organisms) | Age | Liver diseases | Complications | Diabetes mellitus | Histology | Metabolism | Gene expression | Insulin | Environmental impact | Nutrition research | Signaling | Molecular modelling | Physiological tests | Peroxisome proliferator-activated receptors | Metabolic disorders | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e94555 - e94555
Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation... 
LONGEVITY | LIVER-MITOCHONDRIA | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | STRESS | ACETYLOME | RODENT MODEL | SIRT3 | INSIGHTS | Species Specificity | Diabetes Mellitus, Type 2 - genetics | Diabetes Mellitus, Experimental - genetics | Male | Diabetes Mellitus, Type 2 - metabolism | Acetyltransferases - genetics | Pyrimidines - metabolism | Amino Acids - metabolism | Transcription, Genetic | Acetylation | Diabetes Mellitus, Experimental - metabolism | Fatty Acids - metabolism | Gluconeogenesis | Sirtuin 3 - genetics | Purines - metabolism | Liver - metabolism | Gene Expression Regulation | Rats | Citric Acid Cycle | Polymorphism, Genetic | Animals | Sequence Analysis, RNA | Proteomics | Glycolysis | Protein Processing, Post-Translational | Pentose Phosphate Pathway | Care and treatment | Analysis | Genetic aspects | Diabetes | Diagnosis | Research | Transcription | Liver | Homeostasis | Genomes | Single-nucleotide polymorphism | Kinases | Metabolic syndrome | Proteins | Spectrometry | Mitochondria | Pathways | Metabolites | Rodents | Post-translation | Genetics | Inbreeding | Chromosomes | Bioinformatics | Deoxyribonucleic acid--DNA | Enzymes | Nutrition | Genetic control | Nucleotide sequence | Diabetes mellitus | Genetic diversity | Gene expression | Studies | NAD | Musculoskeletal system | Lysine | Metabolic disorders | Index Medicus | Life Sciences | Human health and pathology | Deoxyribonucleic acid | DNA
Journal Article
Cell Reports, ISSN 2211-1247, 07/2017, Volume 20, Issue 1, pp. 136 - 148
Journal Article
Diabetes, ISSN 0012-1797, 06/2006, Volume 55, Issue 6, pp. 1625 - 1633
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e91375 - e91375
MicroRNAs are emerging as new mediators in the regulation of adipose tissue biology and the development of obesity. An important role of microRNA-125a has been... 
3T3-L1 ADIPOCYTES | CELLS | SPONTANEOUS RAT MODEL | ACTIVATION | PROFILES | INSULIN TARGET TISSUES | METABOLISM | GLUCOSE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | SENSITIVITY | Adaptation, Biological - genetics | Humans | Middle Aged | Transcriptome | Male | Gene Expression Profiling | Obesity - genetics | Adipose Tissue - metabolism | RNA Interference | Diet, High-Fat | Aged, 80 and over | Adult | Female | Obesity - diagnosis | Cell Differentiation | Bariatric Surgery | Obesity - surgery | Genome-Wide Association Study | Down-Regulation | Gene Expression Regulation | Insulin Resistance | 3T3-L1 Cells | Obesity - metabolism | Phenotype | Animals | Adipocytes - metabolism | Sex Factors | Biomarkers | Glucose - metabolism | Aged | Mice | MicroRNAs - genetics | Cluster Analysis | Ubiquitin | Adipose tissues | Type 2 diabetes | Obesity | Genes | Glucose | Dextrose | Glucose metabolism | MicroRNA | Analysis | Surgery | Insulin resistance | Enrichment | Adipose tissue | Pathogenesis | Genomics | Serine | Gastric bypass | Genomes | Adipocytes | Mannan | High fat diet | Proteins | Body mass index | Mannose-binding lectin | Physiology | Serine peptidase | Peptidase | Ubiquitin-conjugating enzyme | MiRNA | Triglycerides | Gene expression | Insulin | Patients | Embryos | Thyrotroph embryonic factor | Nutrition research | Ribonucleic acids | Biopsy | MicroRNAs | Gastrointestinal surgery | Diabetes | Index Medicus | Life Sciences | Human health and pathology
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2012, Volume 97, Issue 5, pp. E775 - E780
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e90045 - e90045
Regenerating (REG) proteins are associated with islet development, beta-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved... 
ISLET INFLAMMATION | STONE PROTEIN/REGENERATING PROTEIN | OXIDATIVE STRESS | REG3-BETA GENES | MULTIDISCIPLINARY SCIENCES | BETA-CELL | REG GENE | KNOCKOUT MICE | UP-REGULATION | SPONTANEOUS MODEL | FAMILY | Antigens, Neoplasm - genetics | Chemokines - blood | Chemokines - secretion | Rats, Wistar | Diabetes Mellitus, Type 2 - genetics | Gene Expression Regulation | Lithostathine - genetics | Rats | Male | Diabetes Mellitus, Type 2 - metabolism | Lectins, C-Type - genetics | Pancreatitis-Associated Proteins | Lectins, C-Type - metabolism | Lithostathine - metabolism | Diabetes Mellitus, Type 2 - blood | Macrophages - metabolism | Animals | Islets of Langerhans - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Diabetes Mellitus, Type 2 - pathology | Proteins | Immunohistochemistry | Type 2 diabetes | Interleukins | RNA | MHC antibodies | Genes | Pancreatitis | Inflammation | Gene expression | Cell culture | Interleukin | Antibodies | Homeostasis | Paraffin | Macrophages | Experiments | Interleukin 6 | Angiogenesis | Hyperglycemia | Cell growth | Rodents | Tumor necrosis factor-TNF | Pancreas | Localization | Vascular endothelial growth factor | Acinar cells | Medical research | Cell survival | Cytokines | Secretion | Diabetes mellitus | Insulin | Medicine | Polymerase chain reaction | Major histocompatibility complex | Ligands | Infiltration | Islets of Langerhans | Diabetes | Histocompatibility | Chemokines | Index Medicus | Life Sciences | Human health and pathology
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e29438 - e29438
Aims/hypothesis: Islet vascularization, by controlling beta-cell mass expansion in response to increased insulin demand, is implicated in the progression to... 
ISLET TRANSPLANTATION | INSULIN GENE-EXPRESSION | FACTOR-A | ANGIOGENESIS | VEGF | IN-VIVO | BIOLOGY | BLOOD-VESSELS | MICE | BETA-CELL PROLIFERATION | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Nestin | Angiopoietin-2 - genetics | Diabetes Mellitus, Experimental - genetics | Transplantation, Heterologous | Pancreas - blood supply | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Angiopoietin-2 - metabolism | Hyperglycemia - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | In Situ Hybridization | Islets of Langerhans - metabolism | Pancreas, Exocrine - blood supply | Intermediate Filament Proteins - genetics | Female | Diabetes Mellitus, Experimental - metabolism | Islets of Langerhans - blood supply | Endothelial Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Pancreas - metabolism | Mice, SCID | Chick Embryo | Nerve Tissue Proteins - genetics | Hyperglycemia - metabolism | Nerve Tissue Proteins - metabolism | Animals | Pancreas Transplantation - methods | Chickens | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Pancreas, Exocrine - metabolism | Angiopoietin-2 - antagonists & inhibitors | Blood Glucose - metabolism | Intermediate Filament Proteins - metabolism | Type 2 diabetes | Hyperglycemia | Kidneys | Streptozocin | Transplantation | Comparative analysis | Intermediate filament proteins | Vascular endothelial growth factor | Diabetes therapy | Endothelium | Syngeneic grafts | Angiopoietin | Hybridization | Kinases | Grafting | Cell density | Vascularization | Proteins | Cell growth | RNA probes | Allografts | Rodents | Xenografts | Pancreas | Cytokines | DNA probes | Diabetes mellitus | Cloning | Blood vessels | Gene expression | Microwave heating | Ribonucleic acid--RNA | Insulin | Embryos | Endothelial cells | Glucose tolerance | Beta cells | Intolerance | Overexpression | Insulin resistance | Islets of Langerhans | Diabetes | Differentiation | Kidney transplantation | Apoptosis | Index Medicus | RNA | Ribonucleic acid
Journal Article