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Molecular Therapy, ISSN 1525-0016, 10/2018, Volume 26, Issue 10, pp. 2327 - 2327
According to the proposed change, gene therapy would now become like other new therapies seeking regulatory approval for testing, which are subject to FDA... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Ethics | Reviews | Laboratories | Patient safety | FDA approval | Gene therapy | Deoxyribonucleic acid--DNA | Regulatory approval | Expression vectors
Journal Article
Genetics, ISSN 0016-6731, 04/2004, Volume 166, Issue 4, pp. 1775 - 1782
Journal Article
Obstetrical & Gynecological Survey, ISSN 0029-7828, 08/2016, Volume 71, Issue 8, pp. 458 - 460
(Abstracted from N Engl J Med 2016;374(17):1684–1686)CRISPR-Cas9, a recently developed genome-engineering method, has been used to treat mouse models of... 
Journal Article
Current Gene Therapy, ISSN 1566-5232, 12/2006, Volume 6, Issue 6, pp. 633 - 645
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 17, pp. 1684 - 1686
Duchenne's muscular dystrophy is caused by a loss-of-function mutation in DMD. Studies of the CRISPR–Cas9 method of excising the mutated region show efficacy... 
Proteins | CRISPR | Genes | Duchenne's muscular dystrophy | Stem cells | Genomes | Genetic engineering | Mutation | Dystrophy | Gene therapy | Muscular dystrophy | Deoxyribonucleic acid--DNA
Journal Article
Nature protocols, ISSN 1754-2189, 2007, Volume 2, Issue 10, pp. 2325 - 2331
We describe a microinjection-based phiC31 integrase mRNA-mediated method for creating transgenic Drosophila strains. This approach is more efficient than... 
Genetic Engineering - methods | Animals | RNA, Messenger - genetics | Plasmids - genetics | Bacteriophages - genetics | Streptomyces - virology | Viral Proteins - genetics | Drosophila - embryology | Transgenes | Integrases - genetics | Drosophila - genetics
Journal Article
Human gene therapy, ISSN 1043-0342, 2012, Volume 23, Issue 4, pp. 390 - 398
We generated a mouse model for hemophilia A that combines a homozygous knockout for murine factor VIII (FVIII) and a homozygous addition of a mutant human... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | INTRON | GENOMIC INTEGRATION | MAMMALIAN-CELLS | SITE-SPECIFIC INTEGRATION | IN-VITRO | HEMOPHILIA-A PATIENTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FACTOR-IX | GENETICS & HEREDITY | GENE-THERAPY | INHIBITORS
Journal Article
GENETICS, ISSN 0016-6731, 04/2004, Volume 166, Issue 4, pp. 1775 - 1782
The phiC31 integrase functions efficiently in vitro and in Escherichia coli, yeast, and mammalian cells, mediating unidirectional site-specific recombination... 
CRE/LOXP | COPLACEMENT | HUMAN-CELLS | DNA | GENETICS & HEREDITY | NONVIRAL GENETIC CORRECTION | GENOMIC INTEGRATION | HOMOLOGOUS RECOMBINATION | EPIDERMOLYSIS-BULLOSA | MELANOGASTER | EXPRESSION | Insects | Genetics | Cell cycle
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1239, pp. 29 - 38
ΦC31 integrase, a site-specific large serine recombinase, is a useful tool for genome engineering in a variety of eukaryotic species and cell types. ΦC31... 
Phic31 integrase | Bxb1 integrase | Cassette exchange | Phage integrase | Homologous recombination | TALEN | PhiC31 integrase | Genetic Engineering - methods | Attachment Sites, Microbiological | Cell Line | Polymerase Chain Reaction | Bacteriophages - enzymology | Homologous Recombination | Integrases - metabolism | Genetic Loci | Index Medicus
Journal Article
Human Gene Therapy, ISSN 1043-0342, 10/2010, Volume 21, Issue 10, pp. 1287 - 1297
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2001, Volume 21, Issue 12, pp. 3926 - 3934
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
DNA Dynamics and Chromosome Structure
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2016, Volume 44, Issue 8, pp. e76 - e76
Journal Article
Cold Spring Harbor Protocols, ISSN 1940-3402, 2012, Volume 7, Issue 5, pp. 609 - 614
Few nonviral techniques exist for efficient and stable eukaryotic gene transfer and fewer still are broadly useful in both cell culture and whole-organism... 
Genetic Engineering - methods | Attachment Sites, Microbiological | Cell Line | Humans | Molecular Biology - methods | Viral Proteins - metabolism | Animals | Plasmids | Recombination, Genetic | Bacteriophages - genetics | Bacteriophages - enzymology | Integrases - metabolism | Mutagenesis, Insertional
Journal Article
Human Gene Therapy, ISSN 1043-0342, 08/2006, Volume 17, Issue 8, pp. 871 - 876
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2006, Volume 357, Issue 1, pp. 28 - 48
The site-specific integrase from bacteriophage ϕC31 functions in mammalian cells and is being applied for genetic engineering, including gene therapy. The ϕC31... 
gene therapy | site-specific integration | ϕC31 integrase | pseudo site | genome engineering | Site-specific integration | Pseudo site | Genome engineering | φC31 integrase | Gene therapy
Journal Article
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