Neurobiology of Aging, ISSN 0197-4580, 2015, Volume 43, pp. 180.e1 - 180.e5
Abstract Recently, mutations in the TANK-binding kinase 1 ( TBK1 ) gene were identified as a cause amyotrophic lateral sclerosis (ALS) with or without comorbid...
Neurology | Internal Medicine | Amyotrophic lateral sclerosis | Genetics | TBK1 | Sporadic | AMYOTROPHIC-LATERAL-SCLEROSIS | SEQUENCING DATA | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Frontotemporal Dementia - genetics | Genetic Association Studies | Amyotrophic Lateral Sclerosis - genetics | Humans | Protein-Serine-Threonine Kinases | Female | Italy | Male | Aged | Mutation | Cohort Studies | Nucleotide sequencing | Analysis | Genomics | DNA sequencing
Neurology | Internal Medicine | Amyotrophic lateral sclerosis | Genetics | TBK1 | Sporadic | AMYOTROPHIC-LATERAL-SCLEROSIS | SEQUENCING DATA | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Frontotemporal Dementia - genetics | Genetic Association Studies | Amyotrophic Lateral Sclerosis - genetics | Humans | Protein-Serine-Threonine Kinases | Female | Italy | Male | Aged | Mutation | Cohort Studies | Nucleotide sequencing | Analysis | Genomics | DNA sequencing
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2012, Volume 11, Issue 4, pp. 323 - 330
Summary Background We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large...
Neurology | PREVALENCE | MUTATIONS | LOBAR DEGENERATION | GENETICS | TDP-43 | CLINICAL NEUROLOGY | Frontotemporal Dementia - genetics | Cross-Sectional Studies | DNA Repeat Expansion - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Child, Preschool | Genotype | Male | Genetic Loci | Open Reading Frames - genetics | Young Adult | Chromosomes, Human, Pair 9 - genetics | Adolescent | Age of Onset | Aged, 80 and over | Adult | Female | Aged | Child | Cohort Studies | Medical research | Medical colleges | Care and treatment | Nervous system diseases | Neurosciences | Molecular genetics | Oncology, Experimental | Questions and answers | Amyotrophic lateral sclerosis | Research | Medicine, Experimental | Agriculture | Physicians (General practice) | Alzheimer's disease | Dementia | Cancer | Biomedical engineering | Haplotypes | Polymerase chain reaction | Neurodegenerative diseases | Ethnic groups | Data processing | Mutation | Frontotemporal dementia | Genetic counselling | Islands | Age | Toll-Like Receptor 4 | Open Reading Frames | Adaptor Proteins, Vesicular Transport | Lipopolysaccharides | Life Sciences | DNA Repeat Expansion | Interferon Regulatory Factor-3 | Transfection | Amyotrophic Lateral Sclerosis | RNA Interference | HEK293 Cells | Membrane Glycoproteins | Vesicular Transport Proteins | Protein Structure, Tertiary | Cell Line | Chemokine CCL5 | Frontotemporal Dementia | Signal Transduction | Myeloid Differentiation Factor 88 | Chromosomes, Human, Pair 9 | Protein Transport | Adaptor Proteins, Signal Transducing | Santé publique et épidémiologie | RNA, Small Interfering | Endosomes | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Neurology | PREVALENCE | MUTATIONS | LOBAR DEGENERATION | GENETICS | TDP-43 | CLINICAL NEUROLOGY | Frontotemporal Dementia - genetics | Cross-Sectional Studies | DNA Repeat Expansion - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Child, Preschool | Genotype | Male | Genetic Loci | Open Reading Frames - genetics | Young Adult | Chromosomes, Human, Pair 9 - genetics | Adolescent | Age of Onset | Aged, 80 and over | Adult | Female | Aged | Child | Cohort Studies | Medical research | Medical colleges | Care and treatment | Nervous system diseases | Neurosciences | Molecular genetics | Oncology, Experimental | Questions and answers | Amyotrophic lateral sclerosis | Research | Medicine, Experimental | Agriculture | Physicians (General practice) | Alzheimer's disease | Dementia | Cancer | Biomedical engineering | Haplotypes | Polymerase chain reaction | Neurodegenerative diseases | Ethnic groups | Data processing | Mutation | Frontotemporal dementia | Genetic counselling | Islands | Age | Toll-Like Receptor 4 | Open Reading Frames | Adaptor Proteins, Vesicular Transport | Lipopolysaccharides | Life Sciences | DNA Repeat Expansion | Interferon Regulatory Factor-3 | Transfection | Amyotrophic Lateral Sclerosis | RNA Interference | HEK293 Cells | Membrane Glycoproteins | Vesicular Transport Proteins | Protein Structure, Tertiary | Cell Line | Chemokine CCL5 | Frontotemporal Dementia | Signal Transduction | Myeloid Differentiation Factor 88 | Chromosomes, Human, Pair 9 | Protein Transport | Adaptor Proteins, Signal Transducing | Santé publique et épidémiologie | RNA, Small Interfering | Endosomes | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2014, Volume 13, Issue 11, pp. 1108 - 1113
Summary Background Amyotrophic lateral sclerosis shares characteristics with some cancers, such as onset being more common in later life, progression usually...
Neurology | HETEROGENEITY | REGISTER | ALS | RISK | NEURODEGENERATION | MOTOR-NEURON DISEASE | MUTATIONS | SUPEROXIDE-DISMUTASE | CANCER | EPIDEMIOLOGY | CLINICAL NEUROLOGY | Models, Theoretical | Humans | Middle Aged | Amyotrophic Lateral Sclerosis - diagnosis | Ireland - epidemiology | Linear Models | Male | Scotland - epidemiology | Disease Progression | Registries - statistics & numerical data | England - epidemiology | Adult | Female | Italy - epidemiology | Aged | Finland - epidemiology | Population Surveillance - methods | Amyotrophic Lateral Sclerosis - epidemiology | Amyotrophic lateral sclerosis | Neurosciences | Models | Analysis | Medical research | Mutation | Neurodegeneration
Neurology | HETEROGENEITY | REGISTER | ALS | RISK | NEURODEGENERATION | MOTOR-NEURON DISEASE | MUTATIONS | SUPEROXIDE-DISMUTASE | CANCER | EPIDEMIOLOGY | CLINICAL NEUROLOGY | Models, Theoretical | Humans | Middle Aged | Amyotrophic Lateral Sclerosis - diagnosis | Ireland - epidemiology | Linear Models | Male | Scotland - epidemiology | Disease Progression | Registries - statistics & numerical data | England - epidemiology | Adult | Female | Italy - epidemiology | Aged | Finland - epidemiology | Population Surveillance - methods | Amyotrophic Lateral Sclerosis - epidemiology | Amyotrophic lateral sclerosis | Neurosciences | Models | Analysis | Medical research | Mutation | Neurodegeneration
Journal Article
Chest, ISSN 0012-3692, 2016, Volume 149, Issue 5, pp. 1155 - 1164
Objective Diffuse alveolar damage (DAD) is considered the histologic hallmark of ARDS although DAD is absent in approximately half of patients with ARDS. The...
Pulmonary/Respiratory | meta-analysis | open lung biopsy | diffuse alveolar damage | ARDS
Pulmonary/Respiratory | meta-analysis | open lung biopsy | diffuse alveolar damage | ARDS
Journal Article
Journal of Pediatrics, The, ISSN 0022-3476, 2016, Volume 171, pp. 111 - 115.e3
Objective To compare the incidence and epidemiology of bacteremic community-acquired pneumonia (CAP) in the setting of changes in 13-valent pneumococcal...
Pediatrics | PEDIATRICS | IMPACT | OUTCOMES | REQUIRING HOSPITALIZATION | COMMUNITY-ACQUIRED-PNEUMONIA | CHILDREN | Community-Acquired Infections - epidemiology | Humans | Pneumococcal Vaccines - therapeutic use | Child, Preschool | Male | Hospitalization | Case-Control Studies | Incidence | Spain | Streptococcus pneumoniae | Pneumococcal Infections - epidemiology | Immunization Programs | Pneumococcal Infections - prevention & control | Female | Community-Acquired Infections - prevention & control | Medicine, Experimental | Medical research | Pneumonia | Epidemiology | Bacterial pneumonia | Vaccination
Pediatrics | PEDIATRICS | IMPACT | OUTCOMES | REQUIRING HOSPITALIZATION | COMMUNITY-ACQUIRED-PNEUMONIA | CHILDREN | Community-Acquired Infections - epidemiology | Humans | Pneumococcal Vaccines - therapeutic use | Child, Preschool | Male | Hospitalization | Case-Control Studies | Incidence | Spain | Streptococcus pneumoniae | Pneumococcal Infections - epidemiology | Immunization Programs | Pneumococcal Infections - prevention & control | Female | Community-Acquired Infections - prevention & control | Medicine, Experimental | Medical research | Pneumonia | Epidemiology | Bacterial pneumonia | Vaccination
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2017, Volume 16, Issue 3, pp. 208 - 216
Summary Background Neurite outgrowth inhibitor A (Nogo-A) is thought to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). A monoclonal...
Neurology | Multicenter Study | Clinical Trial, Phase II | Randomized Controlled Trial | Journal Article | DIAGNOSIS | RILUZOLE SERUM CONCENTRATIONS | NEURITE OUTGROWTH INHIBITOR | MARKER | DISEASE | ALS | NOGO-A | DENERVATION | EXPRESSION | CLINICAL NEUROLOGY | Antibodies, Monoclonal, Humanized - therapeutic use | Nogo Proteins - immunology | Age Factors | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | International Cooperation | Amyotrophic Lateral Sclerosis - drug therapy | Amyotrophic Lateral Sclerosis - mortality | Young Adult | Adolescent | Survival Analysis | Aged, 80 and over | Electrocardiography | Adult | Female | Aged | Immunologic Factors - therapeutic use | Medical colleges | Neurosciences | Hospitals | Analysis | Clinical trials | Monoclonal antibodies | Amyotrophic lateral sclerosis | Musculoskeletal system | Rodents | Life Sciences | Human health and pathology | Neurons and Cognition
Neurology | Multicenter Study | Clinical Trial, Phase II | Randomized Controlled Trial | Journal Article | DIAGNOSIS | RILUZOLE SERUM CONCENTRATIONS | NEURITE OUTGROWTH INHIBITOR | MARKER | DISEASE | ALS | NOGO-A | DENERVATION | EXPRESSION | CLINICAL NEUROLOGY | Antibodies, Monoclonal, Humanized - therapeutic use | Nogo Proteins - immunology | Age Factors | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | International Cooperation | Amyotrophic Lateral Sclerosis - drug therapy | Amyotrophic Lateral Sclerosis - mortality | Young Adult | Adolescent | Survival Analysis | Aged, 80 and over | Electrocardiography | Adult | Female | Aged | Immunologic Factors - therapeutic use | Medical colleges | Neurosciences | Hospitals | Analysis | Clinical trials | Monoclonal antibodies | Amyotrophic lateral sclerosis | Musculoskeletal system | Rodents | Life Sciences | Human health and pathology | Neurons and Cognition
Journal Article
Journal of Instrumentation, ISSN 1748-0221, 2014, Volume 9, Issue 10, pp. P10009 - P10009
A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton...
Large detectorsystems performance | Performance of High Energy Physics Detectors | Pattern recognition, cluster finding, calibration and fitting methods | Large detector-systems performance | DESIGN | INSTRUMENTS & INSTRUMENTATION | PATTERN-RECOGNITION | SIMULATION | EVENT | Hadrons | Algorithms | Large Hadron Collider | Bremsstrahlung | Tracking (position) | Instrumentation | Software | Solenoids | Computer programs | Muons | Instrumentation and Detectors | Physics | High Energy Physics - Experiment | INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY | CERN LHC | ELECTRONS | TRANSVERSE MOMENTUM | CHARGED PARTICLES | PERFORMANCE | BREMSSTRAHLUNG | MUONS | PARTICLE RAPIDITY | ALGORITHMS | PROTON-PROTON INTERACTIONS
Large detectorsystems performance | Performance of High Energy Physics Detectors | Pattern recognition, cluster finding, calibration and fitting methods | Large detector-systems performance | DESIGN | INSTRUMENTS & INSTRUMENTATION | PATTERN-RECOGNITION | SIMULATION | EVENT | Hadrons | Algorithms | Large Hadron Collider | Bremsstrahlung | Tracking (position) | Instrumentation | Software | Solenoids | Computer programs | Muons | Instrumentation and Detectors | Physics | High Energy Physics - Experiment | INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY | CERN LHC | ELECTRONS | TRANSVERSE MOMENTUM | CHARGED PARTICLES | PERFORMANCE | BREMSSTRAHLUNG | MUONS | PARTICLE RAPIDITY | ALGORITHMS | PROTON-PROTON INTERACTIONS
Journal Article
The European Physical Journal C, ISSN 1434-6044, 10/2014, Volume 74, Issue 10, pp. 1 - 49
Observation of the diphoton decay mode of the recently discovered Higgs boson and measurement of some of its properties are reported. The analysis uses the...
Nuclear Physics, Heavy Ions, Hadrons | Measurement Science and Instrumentation | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | TRANSVERSE-MOMENTUM | BROKEN SYMMETRIES | SPECTRUM | MODEL | PHYSICS, PARTICLES & FIELDS | Measurement | Collisions (Nuclear physics) | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Regular - Experimental Physics
Nuclear Physics, Heavy Ions, Hadrons | Measurement Science and Instrumentation | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | TRANSVERSE-MOMENTUM | BROKEN SYMMETRIES | SPECTRUM | MODEL | PHYSICS, PARTICLES & FIELDS | Measurement | Collisions (Nuclear physics) | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Regular - Experimental Physics
Journal Article
Journal of Instrumentation, ISSN 1748-0221, 04/2013, Volume 8, Issue 4, pp. 1 - 65
At the Large Hadron Collider, the identification of jets originating from b quarks is important for searches for new physics and for measurements of standard...
Performance of High Energy Physics Detectors | Large detector-systems performance | Pattern recognition, cluster finding, calibration and fitting methods | INSTRUMENTS & INSTRUMENTATION | TO-LEADING ORDER | Algorithms | Large Hadron Collider | Decay | Luminosity | Instrumentation | Jets | Mathematical models | Marking | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
Performance of High Energy Physics Detectors | Large detector-systems performance | Pattern recognition, cluster finding, calibration and fitting methods | INSTRUMENTS & INSTRUMENTATION | TO-LEADING ORDER | Algorithms | Large Hadron Collider | Decay | Luminosity | Instrumentation | Jets | Mathematical models | Marking | Physics - High Energy Physics - Experiment | Physics | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
Journal Article
The European Physical Journal C, ISSN 1434-6044, 6/2013, Volume 73, Issue 6, pp. 1 - 27
A search for a standard-model-like Higgs boson in the H→WW and H→ZZ decay channels is reported, for Higgs boson masses in the range 145 Nuclear Physics, Heavy Ions, Hadrons | Measurement Science and Instrumentation | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | BROKEN SYMMETRIES | PARTON DISTRIBUTIONS | WEAK-INTERACTIONS | HIGH-ENERGIES | COLLIDERS | PHYSICS | PHYSICS, PARTICLES & FIELDS | Confidence intervals | Large Hadron Collider | Searching | Higgs bosons | Solenoids | Cross sections | Channels | Physics - High Energy Physics - Experiment | Regular - Experimental Physics
Journal Article