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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2805 - 2814
Unbound intrahepatic drug concentrations determine the interaction potential with intracellular targets related to toxicity, pharmacokinetics, or... 
passive diffusion/transport | human liver microsomes | disposition | biliary excretion | active transport | tissue partition | distribution | protein binding | hepatocytes | hepatic metabolism | Index Medicus
Journal Article
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2805 - 2814
Unbound intrahepatic drug concentrations determine the interaction potential with intracellular targets related to toxicity, pharmacokinetics, or... 
Pharmaceutical Preparations - blood | Pharmaceutical Preparations - metabolism | Temperature | Lysosomes - metabolism | Models, Biological | Humans | Liver - metabolism | Cells, Cultured | Metabolic Clearance Rate | Hepatocytes - metabolism
Journal Article
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 11/2018, Volume 46, Issue 11, pp. 1670 - 1683
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2007, Volume 102, Issue 6, pp. 1749 - 1757
Imatinib, a protein tyrosine kinase inhibitor, may prevent the growth of glioblastoma cells. Unfortunately, its brain distribution is restricted by... 
CGP74588 | mouse | p‐glycoprotein | imatinib | blood–brain barrier | breast cancer resistance protein | Imatinib | Blood-brain barrier | Mouse | Breast cancer resistance protein | p-glycoproteinz | blood-brain barrier | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | p-glycoprotein | C-KIT | DRUG-RESISTANCE | DEFICIENT MICE | GF120918 | NEUROSCIENCES | REVERSAL | IN-VITRO | PHARMACOKINETICS | TYROSINE KINASE INHIBITOR | MULTIDRUG-RESISTANCE | Male | Piperazines - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | ATP Binding Cassette Transporter, Subfamily B, Member 1 | ATP-Binding Cassette Transporters - genetics | Biological Transport, Active - physiology | ATP-Binding Cassette Transporters - metabolism | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Subfamily B - genetics | Piperazines - pharmacokinetics | Immunosuppressive Agents - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Tetrahydroisoquinolines - pharmacology | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Blood-Brain Barrier - drug effects | Imatinib Mesylate | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Mice | Benzamides | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Breast cancer | Proteins | Neurosciences | Inhibitor drugs | Rodents | Biochemistry | Glycoproteins
Journal Article
Drug Metabolism Letters, ISSN 1872-3128, 01/2019, Volume 13, Issue 1, p. 53
Background: Although the liver is the primary organ of drug metabolism, the lungs also contain drug-metabolizing enzymes and may, therefore, contribute to the... 
Cytochrome | Enzyme activity | Incubation | Cytochrome P450 | Standardization | Tissues | Metabolism | Substrates | Dissolved organic carbon | Lungs | Enzymatic activity | Organ culture | Drug metabolism | Cytochromes P450
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2007, Volume 24, Issue 9, pp. 1720 - 1728
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2017, Volume 45, Issue 8, pp. 900 - 907
Journal Article
Physical Chemistry Chemical Physics : PCCP, ISSN 1463-9076, 01/2019, Volume 21, Issue 35, pp. 18850 - 18865
Proton detected solid-state NMR under fast magic-angle-spinning (MAS) conditions is currently redefining the applications of solid-state NMR, in particular in... 
Proteins | Protons | Organic chemistry | Solid state | Nuclear magnetic resonance--NMR | Simulation | Molecular structure | Computer simulation | Coherence | Deuteration
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2017, Volume 45, Issue 8, p. 900
The human mass balance study is the definitive study for the assessment of absorption, distribution, metabolism, and excretion (ADME) properties of a new... 
Excretion | Nuclear magnetic resonance--NMR | Profiling | Oral administration | Mass spectroscopy | Liquid chromatography | Metabolism | Developmental stages | DRM protein | Solid tumors | Fluorination | Mass spectrometry | Isotopes | Carbon 14
Journal Article