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by Ricketts, Christopher J and De Cubas, Aguirre A and Fan, Huihui and Lang, Martin and Reznik, Ed and Gibb, Ewan A and Akbani, Rehan and Beroukhim, Rameen and Bottaro, Donald P and Choueiri, Toni K and Gibbs, Richard A and Godwin, Andrew K and Hakimi, A. Ari and Henske, Elizabeth P and Kanchi, Rupa S and Krishnan, Bhavani and Merino, Maria J and Myers, Jerome and Nickerson, Michael L and Reuter, Victor E and Schmidt, Laura S and Shelley, C. Simon and Shuch, Brian and Signoretti, Sabina and Srinivasan, Ramaprasad and Tamboli, Pheroze and Thomas, George and Wheeler, David A and Yang, Lixing and Robertson, A. Gordon and Demchok, John A and Felau, Ina and Hutter, Carolyn M and Yang, Liming and Zhang, Jiashan (Julia) and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and Gehlenborg, Nils and Kim, Jaegil and Lin, Pei and Meier, Sam and Saksena, Gordon and Voet, Doug and Bernard, Brady and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Kanchi, Rupa S and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Wang, Jing and Weinstein, John N and Zhang, Jiexin and Abeshouse, Adam and Armenia, Joshua and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Gross, Benjamin E and Heins, Zachary J and Kundra, Ritika and La, Konnor and Ladanyi, Marc and Nissan, Moriah G and Phillips, Sarah M and Reznik, Ed and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sheridan, Robert and Sumer, S. Onur and Sun, Yichao and Zhang, Hongxin and Peto, Myron and Spellman, Paul and Benz, Christopher and Stuart, Joshua M and Wong, Christopher K and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 313 - 326.e5
Journal Article
by Saltz, Joel and Gupta, Rajarsi and Kurc, Tahsin and Singh, Pankaj and Nguyen, Vu and Shroyer, Kenneth R and Zhao, Tianhao and Batiste, Rebecca and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Yang, Liming and Zenklusen, Jean C and Chudamani, Sudha and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Heiman, David I and Lawrence, Michael S and Lin, Pei and Meier, Sam and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Leinonen, Kalle and Miller, Michael and Shmulevich, Ilya and Thorsson, Vesteinn and Zhang, Wei and Hegde, Apurva M and Ju, Zhenlin and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Abeshouse, Adam and Chakravarty, Debyani and Chatila, Walid K and de Bruijn, Ino and Gao, Jianjiong and Heins, Zachary J and Kundra, Ritika and Ladanyi, Marc and Luna, Augustin and Ochoa, Angelica and Phillips, Sarah M and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sumer, S. Onur and Taylor, Barry S and Wang, Jioajiao and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and Stuart, Joshua M and Wong, Christopher K and Yau, Christina and Hayes, D. Neil and Wilkerson, Matthew D and Ally, Adrian and Brooks, Denise and Carlsen, Rebecca and Dhalla, Noreen and Holt, Robert and Jones, Steven J.M and Kasaian, Katayoon and Lee, Darlene and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Mungall, Andrew J and Robertson, A. Gordon and Schein, Jacqueline E and Sipahimalani, Payal and Tse, Kane and Wong, Tina and Berger, Ashton C and Beroukhim, Rameen and Gabriel, Stacey B and Meyerson, Matthew and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 181 - 193.e7
Journal Article
Science Translational Medicine, ISSN 1946-6234, 2018, Volume 10, Issue 454, p. eaan1230
Journal Article
by Beard, David J and Davies, Loretta J and Cook, Jonathan A and MacLennan, Graeme and Price, Andrew and Kent, Seamus and Hudson, Jemma and Carr, Andrew and Leal, Jose and Campbell, Helen and Fitzpatrick, Ray and Arden, Nigel and Murray, David and Campbell, Marion K and Barker, Karen and Murray, Gordon and Simpson, Hamish and Dodwell, Donna and Donell, Simon and Waite, Jonathan and Arden, Nigel and Beard, David and Campbell, Helen and Carr, Andrew and Cooper, Cushla and Davies, Loretta and Doll, Helen and Kent, Seamus and Leal, Jose and Fitzpatrick, Ray and Murray, David and Price, Andrew and Cook, Jonathan and Campbell, Marion and Fernie, Gordon and McDonald, Alison and Duncan, Anne and Castillo, Mayret and Fusco, Francesco and Greshon, Akiko and Holland, Kay and Li, Jiyang and Rabaiotti, Elena and Regan, Sandra and Stalker, Victoria and Forrest, Mark and MacLennan, Graeme and McPherson, Gladys and Boachie, Charles and Collins, Diana and Cruden, Janice and Halpin, Sophie and Smith, Beverley and Torgerson, David and Maher, Chris and Brownson, Peter and Mullins, Mark Mullins and Blazeby, Jane and Jenkins, Ruth and Lewis, Mark and Mintowt-Czyz, Witek and Beverland, Beverland and Bryce, Leeann and Catney, Julie and Dobie, Ian and Doran, Emer and O'Brien, Seamus and Ali, Fazal and Cripps, Heather and Whileman, Amanda and Williams, Phil and Toms, Julie and Brown, Ellen and Horner, Gillian and Jennings, Andrew and Rose, Glynis and Bamford, Frances and Goddard, Wendy and Marynissen, Hans and Peel, Haleh and Richards, Lyndsey and Bell, Amanda and Deo, Sunny and Grayland, Sarah and Hollinghurst, David and Pegler, Suzannah and Satish, Venkat and Woodruffe, Claire and London, Nick and Duffy, David and Bennett, Caroline and Featherstone, James and Cook, Joss and Dearnley, Kim and Muthukumar, Nagarajan and Onuoha, Laura and Wilson, Sarah and Banher, Sandhu and Emeakaroha, Eunice and Horohan, Jamie and ... and TOPKAT Study Group and TOPKAT Study Grp
The Lancet, ISSN 0140-6736, 08/2019, Volume 394, Issue 10200, pp. 746 - 756
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers
Journal Article
by Seiler, Michael and Palacino, James and Teng, Teng and Smith, Peter G and Felau, Ina and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Zhang, Jiashan (Julia) and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Sun, Qiang and Wu, Ye and Cho, Juok and Gehlenborg, Nils and Getz, Gad and Heiman, David I and Kim, Jaegil and Meier, Sam and Zhang, Hailei and Bernard, Brady and Leinonen, Kalle and Liu, Yuexin and Reynolds, Sheila and Shmulevich, Ilya and Zhang, Wei and Akbani, Rehan and Broom, Bradley M and Hegde, Apurva M and Ju, Zhenlin and Kanchi, Rupa S and Li, Jun and Liu, Wenbin and Lu, Yiling and Mills, Gordon B and Ng, Kwok-Shing and Rao, Arvind and Ryan, Michael and Weinstein, John N and Zhang, Jiexin and Armenia, Joshua and Gao, Jianjiong and Heins, Zachary J and La, Konnor and Luna, Augustin and Phillips, Sarah M and Reznik, Ed and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sun, Yichao and Taylor, Barry S and Wang, Jioajiao and Anur, Pavana and Peto, Myron and Spellman, Paul and Stuart, Joshua M and Wong, Christopher K and Yau, Christina and Hayes, D. Neil and Parker, Joel S and Ally, Adrian and Balasundaram, Miruna and Bowlby, Reanne and Brooks, Denise and Carlsen, Rebecca and Chuah, Eric and Holt, Robert and Jones, Steven J.M and Kasaian, Katayoon and Ma, Yussanne and Moore, Richard A and Mungall, Andrew J and Mungall, Karen and Sadeghi, Sara and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Berger, Ashton C and Cherniack, Andrew D and Cibulskis, Carrie and Gabriel, Stacey B and Gao, Galen F and Ha, Gavin and Schumacher, Steven E and Shih, Juliann and Kucherlapati, Melanie H and Kucherlapati, Raju S and Baylin, Stephen and Maglinte, Dennis T and Auman, J. Todd and Bodenheimer, Tom and Fan, Cheng and Hoadley, Katherine A and Hoyle, Alan P and Jones, Corbin D and Meng, Shaowu and Mieczkowski, Piotr A and Mose, Lisle E and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 282 - 296.e4
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA... 
mutation | FUBP1 | SRSF2 | U2AF1 | cancer | splicing | SF3B1 | RBM10 | Biochemistry, Genetics and Molecular Biology(all) | U2AF1 MUTATIONS | RNA-BINDING | PATHWAY | SPLICEOSOME | C-MYC | FAR UPSTREAM ELEMENT | EXPRESSION | GENOME | CELL BIOLOGY
Journal Article
by Knijnenburg, Theo A and Zimmermann, Michael T and Gao, Galen F and Shen, Hui and Way, Gregory P and Liu, Yuexin and Akbani, Rehan and Feng, Bin and Donehower, Lawrence A and Miller, Chase and Karimi, Mostafa and Chen, Haoran and Kim, Pora and Shinbrot, Eve and Zhang, Shaojun and Liu, Jianfang and Yau, Christina and Wolf, Denise and Zhao, Zhongming and Weinstein, John N and Li, Lei and Laird, Peter W and Wheeler, David A and Shmulevich, Ilya and Demchok, John A and Kasapi, Melpomeni and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Chudamani, Sudha and Liu, Jia and Naresh, Rashi and Pihl, Todd and Sun, Qiang and Wan, Yunhu and Wu, Ye and DeFreitas, Timothy and Frazer, Scott and Getz, Gad and Heiman, David I and Lawrence, Michael S and Lin, Pei and Noble, Michael S and Saksena, Gordon and Voet, Doug and Zhang, Hailei and Bernard, Brady and Chambwe, Nyasha and Dhankani, Varsha and Knijnenburg, Theo and Kramer, Roger and Liu, Yuexin and Miller, Michael and Reynolds, Sheila and Thorsson, Vesteinn and Zhang, Wei and Ju, Zhenlin and Korkut, Anil and Li, Jun and Liang, Han and Ling, Shiyun and Ng, Kwok-Shing and Wang, Jing and Weinstein, John N and Armenia, Joshua and Chatila, Walid K and Gao, Jianjiong and Kundra, Ritika and Ladanyi, Marc and Luna, Augustin and Nissan, Moriah G and Ochoa, Angelica and Sanchez-Vega, Francisco and Sander, Chris and Schultz, Nikolaus and Sheridan, Robert and Sun, Yichao and Taylor, Barry S and Zhang, Hongxin and Anur, Pavana and Peto, Myron and Spellman, Paul and Benz, Christopher and Stuart, Joshua M and Yau, Christina and Parker, Joel S and Wilkerson, Matthew D and Ally, Adrian and Balasundaram, Miruna and Bowlby, Reanne and Brooks, Denise and Dhalla, Noreen and Kasaian, Katayoon and Lee, Darlene and Ma, Yussanne and Marra, Marco A and Mayo, Michael and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 1, pp. 239 - 254.e6
Journal Article