X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry (88) 88
chemistry, medicinal (85) 85
humans (85) 85
index medicus (84) 84
metallurgy (83) 83
organic chemistry (83) 83
heterocyclic compounds (80) 80
human necessities (78) 78
hygiene (78) 78
medical or veterinary science (78) 78
animals (72) 72
preparations for medical, dental, or toilet purposes (70) 70
structure-activity relationship (67) 67
specific therapeutic activity of chemical compounds ormedicinal preparations (66) 66
models, molecular (56) 56
pyrroles - pharmacology (38) 38
mice (37) 37
chemistry, organic (32) 32
ligands (32) 32
pharmacology & pharmacy (31) 31
rats (30) 30
molecular structure (29) 29
oxazepines - pharmacology (29) 29
drug design (26) 26
apoptosis (25) 25
apoptosis - drug effects (25) 25
derivatives (25) 25
inhibitors (25) 25
cell line, tumor (24) 24
male (23) 23
analysis (22) 22
cell line (20) 20
antineoplastic agents - pharmacology (19) 19
stereoisomerism (19) 19
binding sites (18) 18
biochemistry & molecular biology (18) 18
in-vitro (17) 17
malaria (16) 16
alzheimers-disease (15) 15
dose-response relationship, drug (15) 15
drug discovery (15) 15
oncology (15) 15
antimalarials - pharmacology (14) 14
binding (14) 14
identification (14) 14
molecular conformation (14) 14
potent (14) 14
pyrroles - chemistry (14) 14
drug resistance (13) 13
female (13) 13
in vitro techniques (13) 13
inhibition (13) 13
plasmodium falciparum - drug effects (13) 13
protein binding (13) 13
pyrroles - chemical synthesis (13) 13
crystallography, x-ray (12) 12
design (12) 12
drug synergism (12) 12
acetylcholinesterase (11) 11
force-field (11) 11
resistance (11) 11
antimalarials - chemical synthesis (10) 10
brain (10) 10
plasmodium-falciparum (10) 10
proteins (10) 10
reverse transcriptase inhibitors - pharmacology (10) 10
analogs (9) 9
antimalarials - chemistry (9) 9
discovery (9) 9
enzymes (9) 9
microtubules - drug effects (9) 9
piperazines - pharmacology (9) 9
plasmodium falciparum (9) 9
radioligand assay (9) 9
rats, sprague-dawley (9) 9
thiazepines - pharmacology (9) 9
tubulin (9) 9
alzheimer's disease (8) 8
antagonists (8) 8
binding, competitive (8) 8
cell cycle - drug effects (8) 8
cell proliferation - drug effects (8) 8
docking (8) 8
drugs (8) 8
hiv-1 - drug effects (8) 8
in-vivo (8) 8
induce apoptosis (8) 8
kinetics (8) 8
leukemia (8) 8
mechanism (8) 8
peptides (8) 8
phosphorylation (8) 8
pyrroles - metabolism (8) 8
research (8) 8
thiazepines - chemical synthesis (8) 8
activation (7) 7
anti-hiv agents - chemistry (7) 7
antineoplastic agents - chemistry (7) 7
antipsychotic agents - pharmacology (7) 7
blotting, western (7) 7
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (326) 326
French (36) 36
German (19) 19
Portuguese (5) 5
Chinese (4) 4
Italian (4) 4
Danish (2) 2
Polish (2) 2
Slovenian (2) 2
Hungarian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


FRONTIERS IN CHEMISTRY, ISSN 2296-2646, 08/2019, Volume 7, p. 574
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives as HIV... 
3-hydroxy-pyran-4-one | in silico combinatorial library design | ASSAY | side chain hopping | DOCKING | HIV-1 integrase inhibitors (HIV-1 INIs) | hit compounds optimization | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | ZINC | REDUCTION | DYNAMICS | FORCE-FIELD | BINDING | Molecular dynamics | Usage | Care and treatment | Integrase inhibitors | HIV infection | HIV (Viruses) | Methods | Raltegravir
Journal Article
Cancer Research, ISSN 0008-5472, 09/2009, Volume 69, Issue 17, pp. 6906 - 6914
Journal Article
RSC Advances, ISSN 0306-0012, 2015, Volume 5, Issue 29, pp. 22431 - 22448
Currently available drugs to treat malaria are often ineffective due to the acquisition of drug resistance. In this context, drugs with innovative modes of... 
ALCOHOLS | PFSUB1 | ALZHEIMERS GAMMA-SECRETASE | HYDROGENATION | DOCKING | MALARIA PARASITE | FORCE-FIELD | ALDEHYDES | CHEMISTRY, MULTIDISCIPLINARY | GENETIC ALGORITHM | PREDICTION
Journal Article
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2002, Volume 8, Issue 8, pp. 615 - 657
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 51, pp. 4466 - 4470
We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a... 
Jocic reaction | Antitumor agents | Pyrrolonaphthoxazepines | Aryl-alkyl ethers | SUBSTITUTION | ALPHA-AMINO | ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | PYRROLOBENZOXAZEPINE | PYRROLO-1,5-BENZOXAZEPINE | TRICHLOROMETHYL KETONES | PRIMER GRIP REGION | BIOLOGICAL-ACTIVITY | INHIBITORS | DERIVATIVES | Organic acids | Apoptosis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 15, pp. 6687 - 6688
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 5, pp. 1401 - 1420
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 6, pp. 2612 - 2632
Journal Article
Journal of Natural Products, ISSN 0163-3864, 05/2016, Volume 79, Issue 5, pp. 1459 - 1463
Journal Article
International Journal of Oncology, ISSN 1019-6439, 07/2016, Volume 49, Issue 1, pp. 74 - 88
Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel... 
Caspase | Acute lymphoblastic leukaemia | Akt | Tumour necrosis factor-related apoptosis-inducing ligand | Apoptosis | Inhibitor of apoptosis protein | CANCER-CELLS | DEATH RECEPTORS | MICROTUBULE-TARGETING AGENT | apoptosis | COMBINATION | tumour necrosis factor-related apoptosis-inducing ligand | caspase | PACLITAXEL | FAMILY | inhibitor of apoptosis protein | INHIBITION | ONCOLOGY | PATHWAY | acute lymphoblastic leukaemia | C-FLIP | RESISTANCE | Oxazepines - administration & dosage | TNF-Related Apoptosis-Inducing Ligand - administration & dosage | Apoptosis - drug effects | Humans | Gene Expression Regulation, Leukemic - drug effects | Caspase 8 - biosynthesis | CASP8 and FADD-Like Apoptosis Regulating Protein - biosynthesis | Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Pyrroles - administration & dosage | Myeloid Cell Leukemia Sequence 1 Protein - biosynthesis | Cell Line, Tumor | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | TNF-Related Apoptosis-Inducing Ligand - genetics
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2016, Volume 57, Issue 8, pp. 920 - 923
We present herein a novel and convenient route for the scaling-up of the dTuv fragment of pretubulysin. The newly conceived chemical path involves a practical... 
Pretubulysin | Deacetoxytubuvaline | Anticancer agents | Scalable synthesis | TARGET | CHEMISTRY, ORGANIC | IDENTIFICATION | POTENT | TUBULYSINS | ANTICANCER | INHIBITORS | TUBULIN | BIOLOGICAL-PROPERTIES | DERIVATIVES | MYXOBACTERIA | Cysteine | Cystine | Purification | Tetrahedrons | Exploration | Derivatives | Chromatography | Bearing | Versatility | Fragmentation
Journal Article